New learning discoveries about 4265-16-1

4265-16-1 Benzo[b]furan-2-carboxaldehyde 61341, abenzofuran compound, is more and more widely used in various.

4265-16-1, Benzo[b]furan-2-carboxaldehyde is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of aldehyde 1 (1 equiv.) in tetrahydrofuran (THF) was slowly added 1.0 M allyl magnesium bromide (2 equiv.) at 0 oC. Some of the aldehydes 1f-1m, 1w, and 1x were treated with the solution of zinc and allyl bromide instead of allyl magnesium bromide because allyl magnesium bromide did not work properly. The reaction mixture was warmed to room temperature and stirred for 2-12 h. Saturated NH4Cl aqueous solution was added to the mixture and it was poured into ethyl acetate and extracted with ethyl acetate 2 times. The combined organic layers were washed with brine, dried with Na2SO4, filtered, and concentrated. The residue was purified by silica gel column chromatography (Hexane/Ethyl acetate) to give compounds 2 (26-99% of yield).

4265-16-1 Benzo[b]furan-2-carboxaldehyde 61341, abenzofuran compound, is more and more widely used in various.

Reference£º
Article; Lee, Sun-Mi; Lee, Won-Gil; Kim, Young-Chul; Ko, Hyojin; Bioorganic and Medicinal Chemistry Letters; vol. 21; 19; (2011); p. 5726 – 5729;,
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Benzofuran | C8H6O – PubChem

Simple exploration of 69999-16-2

As the paragraph descriping shows that 69999-16-2 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.69999-16-2,2,3-Dihydrobenzofuranyl-5-acetic acid,as a common compound, the synthetic route is as follows.

EXAMPLE 6 Obtaining 2-(2,3-dihydrobenzofuran-5-yl)-acetamide [Show Image] 5 ml of DMF and a solution of 45 ml (0.617 moles) of thionyl chloride in 100 ml of acetonitrile were added consecutively to a solution of 100 g (0.560 moles) of (2,3-dihydrobenzofuran-5-yl)-acetic acid in 900 ml of acetonitrile. The reaction mixture was maintained at 45C for 4 hours. Once the reaction was finished, the obtained solution was cooled at 15C and was slowly added during approximately one hour to a mixture consisting of 800 ml of 25% NH3 aqueous solution and 400 ml of acetonitrile cooled at 5C. Once the reaction mixture was added, it was maintained at room temperature for 4 hours. Then 800 ml of water were added and it was stirred for 30 minutes; the obtained phases were separated and the aqueous phase was extracted with 2x 100 ml of acetonitrile. The combined extracts were concentrated under vacuum to a final volume of 500 ml. The obtained suspension was maintained under stirring at 5C for 30 minutes and the solid was isolated by filtration, obtaining 96.5 g (97% yield) of a white solid having the following spectroscopic properties: 1H NMR (400 MHz, DMSO): 3.09 (2H, t, J=8Hz), 3.26 (2H, s), 4.45 (2H, t, J=8Hz), 6.64 (1H, d, J=8Hz), 6.81 (1H, s), 6.93 (1H, d, J=8Hz), 7.09 (1H, s), 7.34 (1H, s) ppm. 13C NMR (100 MHz, DMSO): 29.12 (CH2), 41.69 (CH2), 70.79 (CH2), 108.39 (CH), 125.7 (CH), 127.09 (C), 128.21 (C), 128.33 (CH), 158.30 (C), 172.89 (C) ppm. LRMS (electrospray, positive ion): m/z [M++Na+] 199.8

As the paragraph descriping shows that 69999-16-2 is playing an increasingly important role.

Reference£º
Patent; Ragactives, S.L.; EP2236509; (2010); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Brief introduction of 610-93-5

As the paragraph descriping shows that 610-93-5 is playing an increasingly important role.

610-93-5, 6-Nitroisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a screw top vial (5 mL) under N2 containing freshly distilled toluene (0.6 mL) were successively added an aromatic nitro compound (0.60 mmol), InI3 (14.9 mg, 0.030 mmol), and TMDS (318 muL, 1.80 mmol). After the vial was sealed with a cap that contained a PTFE septum, the mixture was stirred at 60 C (bath temperature), and monitored via TLC analysis. Sat. aq NaHCO3 solution (5 mL) was added to the resultant mixture, which was then extracted with EtOAc (3 ¡Á 6 mL). The combined organic phases were dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (n-hexane-EtOAc, 9:1 to 4:1) to afford the corresponding aniline derivative.

As the paragraph descriping shows that 610-93-5 is playing an increasingly important role.

Reference£º
Article; Sakai, Norio; Asama, Shun; Konakahara, Takeo; Ogiwara, Yohei; Synthesis; vol. 47; 20; (2015); p. 3179 – 3185;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

New learning discoveries about 569-31-3

569-31-3 6,7-Dimethoxy-3H-1-isobenzofuranone 68437, abenzofuran compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.569-31-3,6,7-Dimethoxy-3H-1-isobenzofuranone,as a common compound, the synthetic route is as follows.

To a solution of compound 31a (6.31 g, 32.5 mmol) in acetonitrile (60 mL) was added NCS (4.77 g, 35.7 mmol). After stirring at 60 C. for 1 hour, the insoluble matter was collected by filtration, whereby Compound 31b was obtained.

569-31-3 6,7-Dimethoxy-3H-1-isobenzofuranone 68437, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXO GROUP LIMITED; YAMAWAKI, KENJI; YOKOO, KATSUKI; SATO, JUN; KUSANO, HIROKI; AOKI, TOSHIAKI; LIAO, XIANG MIN; PEARSON, NEIL DAVID; PENDRAK, ISRAIL; THALGI, REEMA; (373 pag.)JP6377570; (2018); B2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

New learning discoveries about 652-39-1

The synthetic route of 652-39-1 has been constantly updated, and we look forward to future research findings.

652-39-1, 4-Fluoroisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1: 5-fluoro-2-methyl-2,3-dihydrophthalazine-1,4-dione and 8-fluoro-2-methyl-2,3-dihydrophthalazine-1,4-dione A mixture of 4-fluoroisobenzofuran-1,3-dione (5.0 g, 30.10 mmol) and methylhydrazine (40percent aq., 3.5 g, 30.10 mmol) in ethanol (100 mL) was heated at reflux for 15 h, at which time LCMS indicated that the reaction had gone to completion. The mixture was concentrated under reduced pressure to give the mixture of title compounds (3.5 g, 60percent yield) (2 : 1 ratio of regioisomers) as a yellow solid. This crude material was used in the next step without further purification. LCMS M/Z (M+H) 195. Step 2: 4-chloro-5-fluoro-2-methylphthalazin-1(2H)-one and 4-chloro-8-fluoro-2-methylphthalazin-1(2H)-one A mixture of 5 or 8-fluoro-2-methyl-2,3-dihydrophthalazine-1,4-dione (3.5 g, 18.03 mmol) in POCl3 (50 mL) was heated at reflux for 15 h, at which time LCMS indicated that the reaction had gone to completion. The mixture was concentrated under reduced pressure, the residue was quenched by addition a saturated aqueous solution of NaHCO3 (100 mL), and then extracted with ethyl acetate (3 x 100 mL). The combined organic extracts were dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by silica gel chromatography (petroleum ether : Ethyl acetate = 5: 1) to give the title compounds (1.2 g, 31percent yield) (2 : 1 ratio of regioisomers) as a white solid. LCMS M/Z (M+H) 213.

The synthetic route of 652-39-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; COTE, Alexandre; CRAWFORD, Terry; DUPLESSIS, Martin; GOOD, Andrew, Charles; LEBLANC, Yves; MAGNUSON, Steven; NASVESCHUK, Christopher, G.; PASTOR, Richard; ROMERO, F. Anthony; TAYLOR, Alexander, M.; (179 pag.)WO2016/36954; (2016); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Brief introduction of 496-41-3

As the paragraph descriping shows that 496-41-3 is playing an increasingly important role.

496-41-3, Benzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a mixture of benzofuran-2-carboxylic acid (8) (1 eq) and 1,1?-carbodiimidazole (1.2 eq) in anhydrous THF was stirred for 1h then substituted aniline (0.9 eq) was added at room temperature. After stirring for 14 h, solvent was evaporated then the mixture acidified with 6N HCl to pH 2. The mixture was extracted with EtOAc (3 ¡Á 20 mL). The combined extracts were dried over anhydrous MgSO4 and the solvent was evaporated. After evaporation, the residue was purified by column chromatography (EtOAc/hexane = 1:2 – 1:50).

As the paragraph descriping shows that 496-41-3 is playing an increasingly important role.

Reference£º
Article; Choi, Minho; Jo, Hyeju; Park, Hyun-Jung; Sateesh Kumar, Arepalli; Lee, Joonkwang; Yun, Jieun; Kim, Youngsoo; Han, Sang-Bae; Jung, Jae-Kyung; Cho, Jungsook; Lee, Kiho; Kwak, Jae-Hwan; Lee, Heesoon; Bioorganic and Medicinal Chemistry Letters; vol. 25; 12; (2015); p. 2545 – 2549;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Simple exploration of 271-89-6

The synthetic route of 271-89-6 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.271-89-6,Benzofuran,as a common compound, the synthetic route is as follows.

1. To a solution of benzofuran (1.5 g, 12.69 mmol) in 60 mL of THF, was added 5.08 mL(12.69 mmol) of n-BuLi solution in hexanes (2.5 M) at -78 C. After 1 hr at -78 C, the reaction mixture was added DMF (3.43 mL). After overnight at RT, the reaction was quenched with saturated ammonium chloride, and extracted with EtOAc (x3). The combined organic extracts were dried (MgS04), filtered, and concentrated. Flash chromatography (10 %EtOAc/Hexanes) gave benzofuran-2-carbaldehyde (1.48 g, 80%). *H NMR (400 MHz, CDC13) delta ppm: 9.88 (s, IH), 7.76 (d, J=8.4 Hz, IH), 7.62 (d, J=8.4 Hz, IH), 7.57 (s, IH), 7.52 (td, J=7.2, 1.2 Hz IH), 7.35 (td, J=7.2, 1.2 Hz, IH).

The synthetic route of 271-89-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SRI INTERNATIONAL; JONG, Ling; CHANG, Chih-Tsung; PARK, Jaehyeon; (71 pag.)WO2016/114816; (2016); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

New learning discoveries about 641-70-3

The synthetic route of 641-70-3 has been constantly updated, and we look forward to future research findings.

641-70-3, 3-Nitrophthalic anhydride is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Et3N (23.27 g, 0.23 mol) was added dropwise into the solution of 3-nitro-phthalic anhydride (7, 44.0 g, 0.23 mol) and 3-aminopiperidine-2,6-dione hydrochloride (8, 37.9 g, 0.23 mol) in THF (600 ml). After reacting for 30 min below 20 C, the precipitation was filtered, washed with THF (30 mL¡Á3), and then dried in vacuo to give intermediate 11 (67.20 g, 91.0%) as a white solid (HPLC, 95.24%).

The synthetic route of 641-70-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Huang, Daowei; Shen, Chengwu; Wang, Wenya; Huang, Lei; Ni, Feng; Li, Jianqi; Synthetic Communications; vol. 46; 16; (2016); p. 1343 – 1348;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Simple exploration of 125-20-2

125-20-2 Thymolphthalein 31316, abenzofuran compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.125-20-2,Thymolphthalein,as a common compound, the synthetic route is as follows.

preparation steps are: thymolphtaleine (5) (4.3 g, 10 mmol), TBAHS (3.4 g, 10 mmol), acetobromo-alpha-D-glucuronic acid methyl ester (4) (4.0 g, 10 mmol) dissolved in 30 ml of dichloromethane and cooled to 10 C, 30 ml of 1N potassium carbonate aqueous solution was added and then stirred at room temperature for 3 hours, and the mixture was separated and dried over anhydrous sodium sulfate. The organic phase was concentrated to dryness to give thymolphtaleine-alpha-acetyl-D-glucuronic acid methyl ester (6) (yield: 3.4 g, yield 46.7%).

125-20-2 Thymolphthalein 31316, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; Guangdong Younide Biological Technology Co., Ltd.; Sai Chi Bio-technology (Shanghai) Co., Ltd.; Su Hongwen; Lai Hua; Liang Weiye; Liu Zhiwen; (7 pag.)CN108129530; (2018); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Some tips on 69999-16-2

As the paragraph descriping shows that 69999-16-2 is playing an increasingly important role.

69999-16-2, 2,3-Dihydrobenzofuranyl-5-acetic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

PREPARATION 30 5-(2-Hydroxyethyl)-2,3-dihydrobenzofuran STR136 A solution of (2,3-dihydrobenzofuran-5-yl)acetic acid (4.9 g–see EP-A-132130) in anhydrous tetrahydrofuran (50 ml) was added dropwise over 10 minutes to a stirred suspension of lithium aluminium hydride (1.57 g) in anhydrous tetrahydrofuran (50 ml) at 0 C. The mixture was allowed to warm to room temperature and stirred for 1 hour. Water (1.5 ml) was cautiously added dropwise followed by 10% aqueous sodium hydroxide (1.5 ml) and, finally, water (4.5 ml). The mixture was filtered and the inorganic salts washed with ethyl acetate (2*50 ml). The filtrate and washings were combined and concentrated in vacuo to give the title compound as as oil, (3.3 g). 1 H-n.m.r. (CDCl3) delta=7.10 (s, 1H); 7.00 (d, 1H); 6.75 (m, 1H); 4.65-4.55 (m, 2H); 3.90-3.75 (m, 2H); 3.30-3.15 (m, 2H); 2.90-2.80 (m, 2H); 1.85-1.75 (broad s, 1H) ppm.

As the paragraph descriping shows that 69999-16-2 is playing an increasingly important role.

Reference£º
Patent; Pfizer Inc.; US5089505; (1992); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem