Category: 38220-75-6

Novel bis(benzothiazole-oxime)-based Pd(II)-complex: synthesis, characterization, quantum chemical calculations, and catalytic significance in Suzuki-Miyaura and Heck-Mizoroki cross coupling reactions was written by Darweesh, Ahmed F.;Mansour, Ahmed M.;Elwahy, Ahmed H. M.. And the article was included in Monatshefte fuer Chemie in 2016.Application of 38220-75-6 This article mentions the following:

In the present work, a novel binuclear benzothiazole-oxime Pd(II) complex was synthesized, characterized (elemental anal., IR spectroscopy, thermogravimetric anal., UV-visible spectroscopy, NMR, and conductance measurements), and explored for its catalytic activity in Suzuki-Miyaura and Heck-Mizoroki cross-coupling reactions of different aryl- and heteroaryl halides with arylboronic acids and styrene, resp., using the microwave irradiation conditions. The electronic arrangement, type of hybridization, and nature of bonding in the Pd-complex were investigated by natural bond orbital anal. Time-dependent d. functional theory calculations were carried out to understand the electronic transitions in the related exptl. observations. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Application of 38220-75-6).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Application of 38220-75-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis and Anti-Cholinesterase Activity of Novel Glycosyl Benzofuranylthiazole Derivatives was written by Cao, L.;Jiang, K.;Shao, Zh.;Wang, Y.;Liu, Sh.;Lu, X.;Wu, Y.;Chen, Ch.;Su, Z.;Wang, L.;Liu, W.;Shi, D.;Cao, Zh.. And the article was included in Russian Journal of Organic Chemistry in 2021.Quality Control of 1-(5-Bromobenzofuran-2-yl)ethanone This article mentions the following:

A new series of glycosyl benzofuranylthiazole derivatives, e.g. I, were designed, synthesized, characterized, and evaluated as potential candidates to treat Alzheimer’s disease. The compounds have been synthesized by the cyclocondensation of glycosyl thiourea with a variety of 2-(bromoacetyl)benzofurans. The reaction conditions have been optimized, and good yields (79-95%) have been obtained. The synthesized compounds showed different degrees of cholinesterase inhibitory activity. Compound I was the most active inhibitor against acetylcholinesterase AChE with an inhibition rate of 37%. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Quality Control of 1-(5-Bromobenzofuran-2-yl)ethanone).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Quality Control of 1-(5-Bromobenzofuran-2-yl)ethanone

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis, characterization, and thermal degradation of novel poly(2-(5-bromo benzofuran-2-yl)-2-oxoethyl methacrylate) was written by Koca, Murat;Kurt, Adnan;Kirilmis, Cumhur;Aydogdu, Yildirim. And the article was included in Polymer Engineering & Science in 2012.Category: benzofurans This article mentions the following:

A novel methacrylate monomer containing benzofuran side group, 2-(5-bromo benzofuran-2-yl)-2-oxoethyl methacrylate (BOEMA), was synthesized from esterification reaction of 2-bromo-1-(5-bromo benzofuran-2-yl) ethanone with sodium methacrylate at 85°C in the presence of 1,4-dioxane solvent. After characterization with Fourier transform IR spectrophotometer, NMR (¹H-NMR and ¹³C-NMR), its homopolymerization was carried out by free radical polymerization at 60°C in the presence of benzoyl peroxide initiator and 1,4-dioxane solvent. The glass transition temperature (T_g) of the synthesized novel polymer, poly(2-(5-bromo benzofuran-2-yl)-2-oxoethyl methacrylate) [poly(BOEMA)], was determined to be 137°C with differential scanning calorimetry technique. Thermal degradation kinetics of poly(BOEMA) was investigated by thermogravimetric anal. method at different heating rates with 5°C/min intervals between measurements. From dynamic measurements, the anal. of each process mechanism of Coats-Redfern and Van Krevelen methods showed that the most probable model for the decomposition process of poly(BOEMA) homopolymer agrees with the random nucleation, F₁ mechanism. The apparent decomposition activation energies of poly(BOEMA) by Kissinger’s and Flynn-Wall-Ozawa methods in the studied conversion range were 188.47 and 180.13 kJ/mol, resp. POLYM. ENG. SCI., 2011. © 2011 Society of Plastics Engineers. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Category: benzofurans).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis, characterization and biological evaluation of some pyrido[3,4-c]coumarins was written by Shaikh, Parin V.;Brahmbhatt, Dinkar I.. And the article was included in International Journal of Pharmaceutical Research and Bio-Science in 2017.Safety of 1-(5-Bromobenzofuran-2-yl)ethanone This article mentions the following:

The synthesis of some 2-(benzofuran-2-yl)-4-Ph pyrido[3,4-c]coumarins and 2- (furan/thiophen-2-yl)-4-Ph pyrido[3,4-c]coumarins was carried out. The compounds were synthesized by reacting various 3-benzoyl coumarins with an appropriate 2-acetylbenzofuran and 2-acetylfuran/thiophene under Kroenhke’s reaction condition. The structures of all the synthesized compounds were supported by anal. and spectral data like IR, ¹H-NMR, ¹³C-NMR and mass. All the synthesized compounds were screened for their antimicrobial activities. The antibacterial activities were carried out against Escherichia coli and Candida albicans (Gram -ve bacteria) and Bacillus subtillis and Staphylococcus aureus (Gram +ve bacteria), while antifungal activities were carried out against fungi Candida albicans and Aspergillis niger. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Safety of 1-(5-Bromobenzofuran-2-yl)ethanone).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Safety of 1-(5-Bromobenzofuran-2-yl)ethanone

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis of Heterocycle-fused Pyridine N-Oxides from Oximes and Diazo Compounds via Rh^III-Catalyzed C-H Activation and Annulation was written by Sun, Peng;Wu, Youzhi;Yang, Tie;Wu, Xiaoming;Xu, Jinyi;Lin, Aijun;Yao, Hequan. And the article was included in Advanced Synthesis & Catalysis in 2015.Product Details of 38220-75-6 This article mentions the following:

A Rh^III-catalyzed tandem C-H activation and C-N bond formation reaction between oximes and diazo compounds for the synthesis of heterocycle-fused pyridine N-oxides was developed. The reaction exhibited good functional group tolerance and regioselectivity. After simple transformation, the 1-substituted, 1,3-disubstituted, 1,4-disubstituted and 1,3,4-trisubstituted heterocycle-fused pyridines were obtained in high efficiency. The strategy was expanded to the synthesis of a key intermediate for the construction of one potential anti-HIV agent. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Product Details of 38220-75-6).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Product Details of 38220-75-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A facile synthesis of bromo-substituted benzofuran containing thiazolidinone nucleus bridged with quinoline derivatives. Potent analgesic and antimicrobial agents was written by Bhovi, Venkatesh K.;Bodke, Yadav D.;Biradar, S.;Swamy, B. E. Kumara;Umesh, S.. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 2010.Electric Literature of C10H7BrO2 This article mentions the following:

Treatment of 5-bromo-2-acetylbenzofuran with hydrazine followed by condensation of the resulting hydrazone with different quinoline derivatives gave the corresponding Schiff bases. Reaction of these Schiff bases with thioacetic acid furnished the target thiazolidinone mol. Some of the newly synthesized compounds show promising analgesic and antimicrobial activity. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Electric Literature of C10H7BrO2).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Electric Literature of C10H7BrO2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis and biological activities of some new benzofuranopyrazoles was written by Tirlapur, Vijay Kumar;Prasad, Y. Rajendra;Basawaraj, Raga. And the article was included in Indian Journal of Heterocyclic Chemistry in 2010.Electric Literature of C10H7BrO2 This article mentions the following:

1-(5-Bromo-1-benzofur-2-yl)ethanone hydrazone upon treatment with Vilsmeier-Haack reagent underwent cyclization to give 3-(5-bromo-1-benzofur-2-yl)-1H-pyrazole-4-carbaldehyde (I), which further on treatment with acetophenones afforded the corresponding 1-aryl-3-[3-(5-bromo-1-benzofur-2-yl)-1H-pyrazol-4-yl]prop-2-en-1-ones. The reaction of I with aromatic amines in MeOH and also with aromatic amines in the presence of CH₂O in dioxan (Mannich reaction) furnished pyrazoles. All newly synthesized compounds were characterized by IR, ¹H NMR, and mass spectra and were screened for analgesic, antibacterial, and antifungal activity. Some of the compounds showed good activity when compared with standard drugs. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Electric Literature of C10H7BrO2).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Electric Literature of C10H7BrO2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Design, synthesis and biological evaluation of benzofuran appended benzothiazepine derivatives as inhibitors of butyrylcholinesterase and antimicrobial agents was written by Mostofi, Manizheh;Mohammadi Ziarani, Ghodsi;Lashgari, Negar. And the article was included in Bioorganic & Medicinal Chemistry in 2018.Reference of 38220-75-6 This article mentions the following:

A series of benzofuran appended 1,5-benzothiazepine compounds I (R¹ = H, 5-Br, 5-NO₂, 7-OMe; R² = 4-OH, 1-naphthyl, 3-indolyl, etc.) was designed, synthesized and evaluated as cholinesterase inhibitors. The biol. assay experiments showed that most of the compounds displayed a clearly selective inhibition for butyrylcholinesterase (BChE), while a weak or no effect towards acetylcholinesterase (AChE) was detected. All analogs exhibited varied BChE inhibitory activity with IC₅₀ value ranging between 1.0 +/- 0.01 and 72 +/- 2.8 μM when compared with the standard donepezil (IC₅₀, 2.63 +/- 0.28 μM). Among the synthesized derivatives, compounds I (R¹ = 5-Br; R² = 2-MeO, 3-MeO, 4-MeO) exhibited the highest BChE inhibition with IC₅₀ values of 1.0, 1.0 and 1.8 μM, resp. The results from a Lineweaver-Burk plot indicated a mixed-type inhibition for compound I (R¹ = 5-Br; R² = 3-MeO) with BChE. In addition, docking studies confirmed the results obtained through in vitro experiments and showed that most potent compounds bind to both the catalytic anionic site (CAS) and peripheral anionic site (PAS) of BChE active site. The synthesized compounds were also evaluated for their in vitro antibacterial and antifungal activities. The results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms and showed high activity against both gram pos. and gram neg. bacteria and fungi. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Reference of 38220-75-6).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Reference of 38220-75-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis of pyrimidines and pyrazoles from 3-acyl-5-halobenzofurans was written by Takagi, Kaname;Ueda, Takeo. And the article was included in Chemical & Pharmaceutical Bulletin in 1975.Application In Synthesis of 1-(5-Bromobenzofuran-2-yl)ethanone This article mentions the following:

Pyrimidines I (R = Cl, Br, R1 = Me, Ph, R2 = NH2, Me, NHCN) were prepared by treating the benzofurans II with R2C(:NH)NH2. III (X = S) were similarly obtained with thiourea. Hydrolysis of I (R = Cl, Br, R1 = Me, R2 = NHCN) gave III (X = O), whereas I (R = Cl, Br, R1 = Ph, R2 = NHCN) gave I (R2 = NHCONH2). Reaction of II with N2H4 gave the pyrazoles IV. II were prepared by treating 5,2-R(HO)C6H3CHO with ClCH2COMe, reducing the 2-acetyl-5-halobenzofurans, and the Friedel-Crafts acylation of the 2-ethyl-5-halobenzofurans. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Application In Synthesis of 1-(5-Bromobenzofuran-2-yl)ethanone).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Application In Synthesis of 1-(5-Bromobenzofuran-2-yl)ethanone

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis and biological activities of some new substituted benzofuranopyridines was written by Tirlapur, Vijay Kumar;Basawaraj, Raga;Prasad, Y. Rajendra. And the article was included in Indian Journal of Heterocyclic Chemistry in 2010.Safety of 1-(5-Bromobenzofuran-2-yl)ethanone This article mentions the following:

The condensation of 2-acetyl-5-bromobenzofuran, aldehydes, and Et cyanoacetate or malononitrile in EtOH in the presence of NH₄OAc gave 2-oxo-1,2-dihydro- and 2-amino-4-aryl-6-(5-bromobenzofur-2-yl)nicotinonitriles, resp. All the newly synthesized compounds were characterized by IR, ¹H NMR and mass spectra and were evaluated for their antitubercular, antibacterial, and antifungal activity. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Safety of 1-(5-Bromobenzofuran-2-yl)ethanone).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Safety of 1-(5-Bromobenzofuran-2-yl)ethanone

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem