Category: 38220-75-6

“One-Pot” Synthesis of γ-Pyrones from Aromatic Ketones/Heteroarenes and Carboxylic Acids was written by Sun, Xiangyu;Gong, Ming;Huang, Mengmeng;Li, Yabo;Kim, Jung Keun;Kovalev, Vladimir;Shokova, Elvira;Wu, Yangjie. And the article was included in Journal of Organic Chemistry in 2020.Related Products of 38220-75-6 This article mentions the following:

Despite the various attractive properties of γ-pyrones, there are still some deficiencies in their synthetic approaches such as lower atom economy, multistep processes, and prefunctionalization of the reagents. In this work, an efficient and simple (CF₃CO)₂O/CF₃SO₃H-mediated “one-pot” approach was realized to produce γ-pyrones by applying aromatic ketones/heteroarenes and carboxylic acids as the starting materials. The target products were isolated in moderate to excellent yields. The reaction mechanism was studied by d. functional theory calculational methods. The results of exptl. and theor. investigations not only helped us explain the reason of high selectivity formation of β-diketones but also proved that 1,3,5-ketones might be important intermediates for the cyclization to afford γ-pyrones. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Related Products of 38220-75-6).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Related Products of 38220-75-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis, characterization and biological activities of some new azetidin-2-ones and thiazolidin-4-ones bearing benzofuran moiety was written by Tiriapur, Vijay Kumar;Basawaraj, Raga. And the article was included in Indian Journal of Heterocyclic Chemistry in 2012.Application In Synthesis of 1-(5-Bromobenzofuran-2-yl)ethanone This article mentions the following:

1-(5-Bromo-1-benzofuran-2-yl)ethanone hydrazone (I) was obtained by condensation of 5-bromo-2-acetylbenzofuran with NH₂NH₂. The compound I on treatment with substituted aldehydes in presence of ethanol gave azine compounds The reaction of these azine compounds with chloroacetyl chloride and few drops of Et₃N in presence of dry benzene afforded the corresponding 1-{[1-(5-bromo-1-benzofuran-2-yl)ethylidene]amino}-3-chloro-4-(substituted phenyl)azetidine-2-ones. The treatment of the azine compounds with mercaptoacetic acid in presence of DMF furnished 3-{[1-(5-bromo-1-benzofuran-2-yl)ethylidene]amino}-2-(substituted phenyl)-1,3-thiazolidine-4-ones, resp. All newly synthesized compounds were characterized on the basis of IR, ¹H NMR and mass spectral data and screened for their antitubercular, antibacterial, and antifungal activities. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Application In Synthesis of 1-(5-Bromobenzofuran-2-yl)ethanone).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application In Synthesis of 1-(5-Bromobenzofuran-2-yl)ethanone

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Facile access to biaryls and 2-acetyl-5-arylbenzofurans via Suzuki coupling in water under thermal and microwave conditions was written by Darweesh, Ahmed F.;Shaaban, Mohamed R.;Farag, Ahmad M.;Metz, Peter;Dawood, Kamal M.. And the article was included in Synthesis in 2010.Application In Synthesis of 1-(5-Bromobenzofuran-2-yl)ethanone This article mentions the following:

Phosphine-free Suzuki-Miyaura C-C cross-coupling reactions of activated and deactivated aryl halides and 2-acetyl-5-bromobenzofuran with various aryl- or heteroarylboronic acids were investigated. A benzothiazole-based Pd(II) complex was used as a pre-catalyst for the reactions under both thermal and microwave conditions in air using water as a solvent. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Application In Synthesis of 1-(5-Bromobenzofuran-2-yl)ethanone).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Application In Synthesis of 1-(5-Bromobenzofuran-2-yl)ethanone

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Syntheses of biscationic, trypanocidal 1-benzofuran compounds was written by Dann, Otto;Char, Helmut;Griessmeier, Helmut. And the article was included in Liebigs Annalen der Chemie in 1982.Synthetic Route of C10H7BrO2 This article mentions the following:

Benzofurans I [R = CN, H₂N, C(:NH)NH₂ (Am), 2-imidazolidinyl, NHC(:NH)NH₂, NHCH:NMe₂, R¹ = NH₂, NHC(:NH)NH₂, NHCH:NMe₂, Br, CN, Am, 2-imidazolidinyl] were prepared by substitution of 2,5-(OH)RC₆H₃CHO with 4-R¹C₆H₄CH₂X (X = Cl, Br) followed by intramol. cyclocondensation. Addnl. obtained were II (R² = CO₂H, Ac, CO₂Et, CO₂Me, CHO, CH₂OH, CH₂Br, CH₂CN, CH₂CO₂H, R³ = Br, CN), II (R² = CONHC₆H₄R¹-4), and III [R = CN, Am, C(OEt):NH, X = NNHAm, NNHCSNH₂, NNHC₆H₄CN-4, NNHC₆H₄Am-4, O] and a number of alkenylene and alkylene bis(benzofurans). Arylated formamidine derivatives were prepared by reacting amine hydrochlorides with DMF in the presence of cyanamide. Selected derivatives had trypanosomicidal activity. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Synthetic Route of C10H7BrO2).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Synthetic Route of C10H7BrO2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis and antimicrobial activity of fused isatin and diazepine derivatives derived from 2-acetyl benzofuran was written by Kenchappa, R.;Bodke, Y. D.;Telkar, S.;Nagaraja, O.. And the article was included in Russian Journal of General Chemistry in 2017.Formula: C10H7BrO2 This article mentions the following:

Acetyl benzofurans reacted with isatins in the presence of pyridine to give corresponding 3-[2-(1-benzofuran-2-yl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one derivatives I [R = H, Br; R¹ = H, Cl, MeO, etc.]. Dehydration of the latter in acidic media led to the corresponding α,β-unsaturated ketones II. The structures of newly synthesized compounds I and II were established on the basis of anal. and spectral data. The synthesized benzofuranyl(phenyl)dihydrospiro[1,4-diazepine]indolones III were screened for their antibacterial and antifungal activities. Compounds III [R = R¹ = Br; R = Br, R¹ = Cl; R = Br, R¹ = O₂N] displayed excellent antimicrobial activity. The synthesized compounds III were studied for docking on the enzyme glucosamine-6-phosphate synthase. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Formula: C10H7BrO2).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Formula: C10H7BrO2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

TBAI/TBHP mediated oxidative cross coupling of ketones with phenols and carboxylic acids: Direct access to benzofurans was written by Santhosh Kumar, P.;Ravikumar, B.;Chinna Ashalu, K.;Rajender Reddy, K.. And the article was included in Tetrahedron Letters in 2018.Electric Literature of C10H7BrO2 This article mentions the following:

TBAI/TBHP mediated oxidative cross coupling of phenols and carboxylic acids with ketones has been reported under metal-free, base free, solvent free conditions enabling environmentally benign synthesis of aryloxyketones, acyloxy ketones and benzofurans. Phenoxyketones and acyloxylcarbonyl compounds were synthesized in good to high yields, where as benzofurans were synthesized in moderate yields. This method is operationally simple, works under mild conditions, using com. available as well as inexpensive TBAI and an oxidant TBHP. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Electric Literature of C10H7BrO2).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Electric Literature of C10H7BrO2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Inhibitory effect of amidino-substituted heterocyclic compounds on the amidase activity of plasmin and of high and low molecular weight urokinase and on urokinase-induced plasminogen activation was written by Geratz, J. D.;Shaver, S. R.;Tidwell, R. R.. And the article was included in Thrombosis Research in 1981.Electric Literature of C10H7BrO2 This article mentions the following:

A number of heterocyclic mono- and diamidines were examined for their inhibitory effect on urokinase and on plasmin. Interaction with both enzymes was competitive in nature, and a comparison of the inhibition constants revealed similarities as well as differences in the binding conditions between the 2 active sites. The most potent inhibitor in the series was represented by bis(5-amidino-2-benzimidazolyl)methane with K_i values of 2.3 × 10^-6M and 2.6 × 10^-6M for high-mol.-weight urokinase and plasmin, resp.,. The high- and low-mol.-weight forms of urokinase were very similar in their susceptibility to inhibition by amidines. In plasminogen activation assays, the inhibitory influence of the compounds did not parallel antiurokinase potency as expressed by the K_i values. This paradoxical behavior is still unexplained, but addnl. interaction of the compounds with plasminogen has to be considered. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Electric Literature of C10H7BrO2).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Electric Literature of C10H7BrO2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem