Inhibitory effect of amidino-substituted heterocyclic compounds on the amidase activity of plasmin and of high and low molecular weight urokinase and on urokinase-induced plasminogen activation was written by Geratz, J. D.;Shaver, S. R.;Tidwell, R. R.. And the article was included in Thrombosis Research in 1981.Electric Literature of C10H7BrO2 This article mentions the following:
A number of heterocyclic mono- and diamidines were examined for their inhibitory effect on urokinase and on plasmin. Interaction with both enzymes was competitive in nature, and a comparison of the inhibition constants revealed similarities as well as differences in the binding conditions between the 2 active sites. The most potent inhibitor in the series was represented by bis(5-amidino-2-benzimidazolyl)methane with Ki values of 2.3 × 10-6M and 2.6 × 10-6M for high-mol.-weight urokinase and plasmin, resp.,. The high- and low-mol.-weight forms of urokinase were very similar in their susceptibility to inhibition by amidines. In plasminogen activation assays, the inhibitory influence of the compounds did not parallel antiurokinase potency as expressed by the Ki values. This paradoxical behavior is still unexplained, but addnl. interaction of the compounds with plasminogen has to be considered. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Electric Literature of C10H7BrO2).
1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Electric Literature of C10H7BrO2
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem