Synthesis and antimicrobial activity of fused isatin and diazepine derivatives derived from 2-acetyl benzofuran was written by Kenchappa, R.;Bodke, Y. D.;Telkar, S.;Nagaraja, O.. And the article was included in Russian Journal of General Chemistry in 2017.Formula: C10H7BrO2 This article mentions the following:
Acetyl benzofurans reacted with isatins in the presence of pyridine to give corresponding 3-[2-(1-benzofuran-2-yl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one derivatives I [R = H, Br; R1 = H, Cl, MeO, etc.]. Dehydration of the latter in acidic media led to the corresponding α,β-unsaturated ketones II. The structures of newly synthesized compounds I and II were established on the basis of anal. and spectral data. The synthesized benzofuranyl(phenyl)dihydrospiro[1,4-diazepine]indolones III were screened for their antibacterial and antifungal activities. Compounds III [R = R1 = Br; R = Br, R1 = Cl; R = Br, R1 = O2N] displayed excellent antimicrobial activity. The synthesized compounds III were studied for docking on the enzyme glucosamine-6-phosphate synthase. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Formula: C10H7BrO2).
1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Formula: C10H7BrO2
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem