One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 66357-35-5, Name is Ranitidine, formurla is C13H22N4O3S. In a document, author is Chu, Ming-Ming, introducing its new discovery. Product Details of 66357-35-5.
Organocatalytic asymmetric [4+1] annulation of in situ generated ortho-quinomethanes with 4-halo pyrazolones: straightforward access to chiral spiro-benzofuran pyrazolones
A highly straightforward route to enantiomerically enriched spiro-benzofuran pyrazolones has been achieved via chiral amine squaramide catalyzed [4 + 1] annulation of in situ generated ortho-quinomethanes with the novel C1 synthons of 4-halo pyrazolones. In oil-water biphases, high yields (up to 95%) and high to excellent stereoselectivities (up to 99 : 1 dr, 99% ee) of the resulting 4-spiropyrazolones with a wide substrate scope could be achieved. Furthermore, the present protocol provided an arbitrary access to all four possible stereoisomers of the spiro-benzofuran pyrazolones via an appropriate choice of C1 synthons and chiral catalysts.
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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem