“One-Pot” Synthesis of γ-Pyrones from Aromatic Ketones/Heteroarenes and Carboxylic Acids was written by Sun, Xiangyu;Gong, Ming;Huang, Mengmeng;Li, Yabo;Kim, Jung Keun;Kovalev, Vladimir;Shokova, Elvira;Wu, Yangjie. And the article was included in Journal of Organic Chemistry in 2020.Related Products of 38220-75-6 This article mentions the following:
Despite the various attractive properties of γ-pyrones, there are still some deficiencies in their synthetic approaches such as lower atom economy, multistep processes, and prefunctionalization of the reagents. In this work, an efficient and simple (CF3CO)2O/CF3SO3H-mediated “one-pot” approach was realized to produce γ-pyrones by applying aromatic ketones/heteroarenes and carboxylic acids as the starting materials. The target products were isolated in moderate to excellent yields. The reaction mechanism was studied by d. functional theory calculational methods. The results of exptl. and theor. investigations not only helped us explain the reason of high selectivity formation of β-diketones but also proved that 1,3,5-ketones might be important intermediates for the cyclization to afford γ-pyrones. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Related Products of 38220-75-6).
1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Related Products of 38220-75-6
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem