Synthesis of pyrimidines and pyrazoles from 3-acyl-5-halobenzofurans was written by Takagi, Kaname;Ueda, Takeo. And the article was included in Chemical & Pharmaceutical Bulletin in 1975.Application In Synthesis of 1-(5-Bromobenzofuran-2-yl)ethanone This article mentions the following:
Pyrimidines I (R = Cl, Br, R1 = Me, Ph, R2 = NH2, Me, NHCN) were prepared by treating the benzofurans II with R2C(:NH)NH2. III (X = S) were similarly obtained with thiourea. Hydrolysis of I (R = Cl, Br, R1 = Me, R2 = NHCN) gave III (X = O), whereas I (R = Cl, Br, R1 = Ph, R2 = NHCN) gave I (R2 = NHCONH2). Reaction of II with N2H4 gave the pyrazoles IV. II were prepared by treating 5,2-R(HO)C6H3CHO with ClCH2COMe, reducing the 2-acetyl-5-halobenzofurans, and the Friedel-Crafts acylation of the 2-ethyl-5-halobenzofurans. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Application In Synthesis of 1-(5-Bromobenzofuran-2-yl)ethanone).
1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Application In Synthesis of 1-(5-Bromobenzofuran-2-yl)ethanone
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem