Synthesis and Anti-Cholinesterase Activity of Novel Glycosyl Benzofuranylthiazole Derivatives was written by Cao, L.;Jiang, K.;Shao, Zh.;Wang, Y.;Liu, Sh.;Lu, X.;Wu, Y.;Chen, Ch.;Su, Z.;Wang, L.;Liu, W.;Shi, D.;Cao, Zh.. And the article was included in Russian Journal of Organic Chemistry in 2021.Quality Control of 1-(5-Bromobenzofuran-2-yl)ethanone This article mentions the following:
A new series of glycosyl benzofuranylthiazole derivatives, e.g. I, were designed, synthesized, characterized, and evaluated as potential candidates to treat Alzheimer’s disease. The compounds have been synthesized by the cyclocondensation of glycosyl thiourea with a variety of 2-(bromoacetyl)benzofurans. The reaction conditions have been optimized, and good yields (79-95%) have been obtained. The synthesized compounds showed different degrees of cholinesterase inhibitory activity. Compound I was the most active inhibitor against acetylcholinesterase AChE with an inhibition rate of 37%. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Quality Control of 1-(5-Bromobenzofuran-2-yl)ethanone).
1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Quality Control of 1-(5-Bromobenzofuran-2-yl)ethanone
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem