Heterocyclic Building Block-benzofuran

Decarboxylative Fluorination of Electron-Rich Heteroaromatic Carboxylic Acids with Selectfluor was written by Yuan, Xi;Yao, Jian-Fei;Tang, Zhen-Yu. And the article was included in Organic Letters in 2017.COA of Formula: C9H5BrO3 This article mentions the following:

A transition-metal-free decarboxylative fluorination of electron-rich five-membered heteroaromatics, including furan-, pyrazole-, isoxazole-, thiophene-, indole-, benzofuran- and indazolecarboxylic acids, with Selectfluor is reported. Fluorinated dimer products were observed for nitrogen-containing heteroaromatic carboxylic acids, such as indole and pyrazole. An effective method has been developed to synthesize the monomer of 2- and 3-fluoroindoles with Li₂CO₃ as base at low temperature In the experiment, the researchers used many compounds, for example, 5-Bromobenzofuran-2-carboxylic acid (cas: 10242-11-2COA of Formula: C9H5BrO3).

5-Bromobenzofuran-2-carboxylic acid (cas: 10242-11-2) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.COA of Formula: C9H5BrO3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Crystal Violet Lactone Salicylaldehyde Hydrazone Zn(II) Complex: a Reversible Photochromic Material both in Solution and in Solid Matrix was written by Li, Kai;Li, Yuanyuan;Tao, Jing;Liu, Lu;Wang, Lili;Hou, Hongwei;Tong, Aijun. And the article was included in Scientific Reports in 2015.COA of Formula: C26H29N3O2 This article mentions the following:

Crystal violet lactone (CVL) is a classic halochromic dye which has been widely used as chromogenic reagent in thermochromic and piezochromic systems. In this work, a very first example of CVL-based reversible photochromic compound was developed, which showed distinct color change upon UV-visible light irradiation both in solution and in solid matrix. Moreover, metal complex of CVL salicylaldehyde hydrozone was facilely synthesized, exhibiting reversible photochromic properties with good fatigue resistance. It was served as promising solid material for photo-patterning. In the experiment, the researchers used many compounds, for example, Crystal violet lactone (cas: 1552-42-7COA of Formula: C26H29N3O2).

Crystal violet lactone (cas: 1552-42-7) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.COA of Formula: C26H29N3O2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Promising post-consumer PET-derived activated carbon electrode material for non-enzymatic electrochemical determination of carbofuran hydrolysate was written by Ayyalusamy, Sureshkumar;Mishra, Susmita;Suryanarayanan, Vembu. And the article was included in Scientific Reports in 2018.Product Details of 1563-38-8 This article mentions the following:

In this work, activated carbon (AC) materials, prepared from polyethylene terephthalate (PET) waste bottles were used as the sensing platform for the indirect detection of carbofuran. The morphol. and surface properties of the PET-derived AC (PET-AC) were characterized by N₂ adsorption/desorption isotherm, X-ray diffraction (XRD), field-emission scanning/transmission electron microscopy (FE-SEM/TEM) and Raman spectroscopy. The electrochem. activity of the PET-AC modified glassy carbon electrode (GCE) (PET-AC/GCE) was measured by cyclic voltammetry and amperometry. The enhanced surface area and desirable porosities of PET-AC are attributed for the superior electrocatalytic activity on the detection of carbofuran phenol, where, the proposed sensor shows low detection limit (0.03μM) and remarkable sensitivity (0.11μA μM^-1 cm^-2). The PET-AC/GCE holds high selectivity towards potentially interfering species. It also provides desirable stability, repeatability and reproducibility on detection of carbofuran phenol. Furthermore, the proposed sensor is utilized for the detection of carbofuran phenol in real sample applications. The above mentioned unique properties and desirable electrochem. performances suggest that the PET-derived AC is the most suitable carbonaceous materials for cost-effective and non-enzymic electrochem. sensor. In the experiment, the researchers used many compounds, for example, 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8Product Details of 1563-38-8).

2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Product Details of 1563-38-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Reactivity of intein thioesters: appending a functional group to a protein was written by Kalia, Jeet;Raines, Ronald T.. And the article was included in ChemBioChem in 2006.Formula: C25H15NO9 This article mentions the following:

The success of genome sequencing has heightened the demand for new means to manipulate proteins. An especially desirable goal is the ability to modify a target protein at a specific site with a functional group of orthogonal reactivity. Here, we achieve that goal by exploiting the intrinsic electrophilicity of the thioester intermediate formed during intein-mediated protein splicing. Detailed kinetic analyses of the reaction of nitrogen nucleophiles with a chromogenic small-mol. thioester revealed that the α-hydrazino acetyl group was the optimal nucleophile for attacking a thioester at neutral pH to form a stable linkage. A bifunctional reagent bearing an α-hydrazino acetamido and azido group was synthesized in high overall yield. This reagent was used to attack the thioester linkage between a target protein and intein, and thereby append an azido group to the target protein in a single step. The azido protein retained full biol. activity. Furthermore, its azido group was available for chem. modification by Huisgen 1,3-dipolar azide-alkyne cycloaddition Thus, the mechanism of intein-mediated protein splicing provides the means to install a useful functional group at a specific site-the C terminus-of virtually any protein. In the experiment, the researchers used many compounds, for example, 2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7Formula: C25H15NO9).

2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Formula: C25H15NO9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Selective retina therapy and thermal stimulation of the retina: different regenerative properties – implications for AMD therapy was written by Richert, Elisabeth;Papenkort, Julia;von der Burchard, Claus;Klettner, Alexa;Arnold, Philipp;Lucius, Ralph;Brinkmann, Ralf;Framme, Carsten;Roider, Johann;Tode, Jan. And the article was included in BMC Ophthalmology in 2021.HPLC of Formula: 1461-15-0 This article mentions the following:

Selective Retina Therapy (SRT), a photodisruptive micropulsed laser modality that selectively destroys RPE cells followed by regeneration, and Thermal Stimulation of the Retina (TSR), a stimulative photothermal continuous wave laser modality that leads to an instant sublethal temperature increase in RPE cells, have shown therapeutic effects on Age-related Macular Degeneration (AMD) in mice. We investigate the differences between both laser modalities concerning RPE regeneration. For PCR array, 6 eyes of murine AMD models, apolipoprotein E and nuclear factor erythroid-derived 2- like 2 knock out mice resp., were treated by neuroretina-sparing TSR or SRT. Untreated litter mates were controls. Eyes were enucleated either 1 or 7 days after laser treatment. For morphol. anal., porcine RPE/choroid organ cultures underwent the same laser treatment and were examined by calcein vitality staining 1 h and 1, 3 or 5 days after irradiation TSR did not induce the expression of cell-mediators connected to cell death. SRT induced necrosis associated cytokines as well as inflammation 1 but not 7 days after treatment. Morphol., 1 h after TSR, there was no cell damage. One and 3 days after TSR, dense chromatin and cell destruction of single cells was seen. Five days after TSR, there were signs of migration and proliferation. In contrast, 1 h after SRT a defined necrotic area within the laser spot was seen. This lesion was closed over days by migration and proliferation of adjacent cells. SRT induces RPE cell death, followed by regeneration within a few days. It is accompanied by necrosis induced inflammation, RPE proliferation and migration. TSR does not induce immediate RPE cell death; however, migration and mitosis can be seen a few days after laser irradiation, not accompanied by necrosis-associated inflammation. Both might be a therapeutic option for the treatment of AMD. In the experiment, the researchers used many compounds, for example, 2,2′,2”,2”’-(((3′,6′-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-2′,7′-diyl)bis(methylene))bis(azanetriyl))tetraacetic acid (cas: 1461-15-0HPLC of Formula: 1461-15-0).

2,2′,2”,2”’-(((3′,6′-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-2′,7′-diyl)bis(methylene))bis(azanetriyl))tetraacetic acid (cas: 1461-15-0) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.HPLC of Formula: 1461-15-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Flavonoids and phenolic acids from the roots of Sophora tonkinensis Gagnep was written by Hou, Mengyang;Hu, Wenzhong;Hao, Kexin;Xiu, Zhilong. And the article was included in Biochemical Systematics and Ecology in 2020.Product Details of 6807-83-6 This article mentions the following:

Phytochem. study on the roots of Sophora tonkinensis Gagnep. led to the isolation of fifteen compounds, including eleven flavonoids (1-11) and four phenolic acids (12-15). The structures of these compounds were elucidated based on NMR and HR-ESIMS anal., further supported by comparison with previous literatures. Among them, compounds 2, 3, 4, 6, 9, 12 and 13 were firstly discovered from S. tonkinensis, compound 8 was firstly discovered from the genus Sophora. Furthermore, the chemotaxonomic significance of the obtained compounds was discussed in detail. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6Product Details of 6807-83-6).

(2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Product Details of 6807-83-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Facile and Large-scale Fabrication of Biodegradable Thermochromic Fibers Based on Poly(lactic acid) was written by Chen, Xiao-Xiong;Yu, Jin-Chao;Chen, Kang;Ji, Peng;Chen, Xiang-Ling;Pan, Zhi-Juan. And the article was included in Chinese Journal of Polymer Science in 2022.SDS of cas: 36886-76-7 This article mentions the following:

To investigate the feasibility of developing biobased and biodegradable thermochromic fibers, poly(lactic acid) (PLA) fibers with visual temperature indicator functionality were fabricated using a scalable melt spinning technique (spinning speed 800 m/min), where PLA and thermochromic microcapsules were used as fiber-forming polymers and color indicators, resp. The effect of thermochromic microcapsules on the mech. properties and reversible color-changing function of PLA fibers was systematically investigated to achieve high tenacity and sensitive color-changing function. The difference in the fiber performance was connected to changes in the multilayer structure. The results show that PLA fibers exhibit excellent tenacity of 3.7-4.7 cN/dtex and reversible and stable thermochromic behavior over 31°C. The high fraction of mesophase within TPLA-1 fiber plays an important role in its tenacity. Meanwhile, the low-concentration of microcapsules (∼1 weight%) with good dispersion could act as a nucleating agent inside the PLA matrix and contribute to the formation of microcrystals in the amorphous between primary lamellae, which is also beneficial to maintain the tenacity of the fibers. The agglomeration of high-concentration microcapsules within PLA fibers hampered the formation of mesophase, resulting in a decrease in fiber tenacity. Aside from the content of microcapsules, the agglomeration of high-concentration microcapsules (>5 weight%) is the main reason that limits the substantial increase in fiber color depth. This study opens up new possibilities for degradable thermochromic fibers produced using standard industrial spinning technol. In the experiment, the researchers used many compounds, for example, 3′,6′-Dimethoxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 36886-76-7SDS of cas: 36886-76-7).

3′,6′-Dimethoxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 36886-76-7) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.SDS of cas: 36886-76-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Cine substitution of arenes using the aryl carbamate as a removable directing group was written by Mesganaw, Tehetena;Fine Nathel, Noah F.;Garg, Neil K.. And the article was included in Organic Letters in 2012.SDS of cas: 1563-38-8 This article mentions the following:

An efficient and controlled means to achieve a rare cine substitution of arenes is reported. The methodol. relies on the strategic use of aryl O-carbamates as readily removable directing groups for arene functionalization. The removal of aryl carbamates is achieved by employing an air-stable Ni(II) precatalyst, along with an inexpensive reducing agent, to give synthetically useful yields across a range of substrates. The net cine substitution process offers a new strategy for analog synthesis, which complements the well-established logic for achieving arene functionalization by ipso substitution. In the experiment, the researchers used many compounds, for example, 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8SDS of cas: 1563-38-8).

2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.SDS of cas: 1563-38-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Polymer-supported eosin Y as a reusable photocatalyst for visible light mediated organic transformations was written by Sridhar, Arunasalam;Rangasamy, Rajmohan;Selvaraj, Mari. And the article was included in New Journal of Chemistry in 2019.HPLC of Formula: 13196-10-6 This article mentions the following:

A novel polymer-supported recyclable photocatalyst was developed for visible light mediated oxidation reactions. The organic dye eosin Y was loaded on macroporous com. available Amberlite IRA 900 chloride resin and exploited as a photocatalyst for visible light mediated oxidation of thioethers to sulfoxides and phenylboronic acids to phenols under open atm. air. Varieties of functional groups were well tolerated during oxidation The catalyst is recyclable for six cycles without significant loss in its efficiency. Furthermore, gram-scale oxidation of sulfides to sulfoxides was demonstrated to prove the com. viability of the method. In the experiment, the researchers used many compounds, for example, Benzofuran-5-ol (cas: 13196-10-6HPLC of Formula: 13196-10-6).

Benzofuran-5-ol (cas: 13196-10-6) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.HPLC of Formula: 13196-10-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Benzaldehyde decorated octadecylamine for tailor-made molecular firefighting and efficient thermal energy management was written by Zhao, Pan-Pan;Deng, Cong;Zhao, Ze-Yong;Li, Xing-Yu;Chen, Hong;Wang, Yu-Zhong. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2022.Recommanded Product: 1552-42-7 This article mentions the following:

More than 40% of the energy generated globally is consumed by residential and com. buildings, so energy efficient materials for buildings are urgently needed at present. On-demand thermal energy storage/release using phase change materials (PCMs) can improve thermal energy utilization efficiency, however, they are facing low adaptability to temperature and easy flammability in the case of fulfilling high thermal management capacity. Herein, we report octadecylamine-based PCMs with tailor-made mol. firefighting and thermal energy management capability. These synthesized octadecylamine-based Schiff base-containing PCMs (SB-PCMs) may self-extinguish while encountering short-time fire and possess variable phase transition temperatures of 33, 42, 92, and 101°C. Meanwhile, these SB-PCMs own high phase transition enthalpies of 161.4-183.4 J g^-1 and excellent cyclic stability. When SB-PCMs as thermal energy management materials in wood plastic-based building materials, they show high adaptability to ambient temperature and excellent thermal management capability, achieving temperature regulation of 9.0°C. Meanwhile, fire safety of the composite wood plastic materials is significantly improved. Detailed anal. confirms that the incorporated benzaldehyde with various positional substituted hydroxyl may induce noncovalent interactions (mainly hydrogen bond and π-π stacking) of SB-PCMs and further control their self-assembling processes, thus achieving multiple thermal responses of SB-PCMs; self-crosslinking charring of benzaldehyde-based Schiff base structure may retard fire spreading, therefore presenting mol. firefighting. Addnl. multistage thermochromic behaviors of SB-PCMs may extend their application in temperature-sensitive paint, intelligent fabric, etc. This work firstly represents a method for manipulating the multistage thermal and fire responses of PCM in the case of fulfilling high thermal energy management capacity and confirms its mol.-firefighting and energy efficient application in building materials. In the experiment, the researchers used many compounds, for example, Crystal violet lactone (cas: 1552-42-7Recommanded Product: 1552-42-7).

Crystal violet lactone (cas: 1552-42-7) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Recommanded Product: 1552-42-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem