Heterocyclic Building Block-benzofuran

Toxicokinetics of mono-(2-ethylhexyl) phthalate with low-dose exposure applying fluorescence tracing technique was written by Yuan, Yi-Zhen;Ye, Chong;Sun, Jia-Hui;Hu, Meng-Yuan;Huo, Shao-Jie;Zhu, Yu-Ting;Xiang, Su-Yun;Yu, Shu-Qin. And the article was included in Toxicology and Applied Pharmacology in 2022.Name: 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

Di(2-ethylhexyl) phthalate (DEHP) belongs to environmental endocrine disrupting chems. (EEDCs) and can be rapidly hydrolyzed into the ultimate toxicant mono-2-ethylhexyl phthalate (MEHP). In this study, we used 5-aminofluorescein modified MEHP (MEHP-AF) as a fluorescence tracer to explore the toxicokinetics, including toxicokinetic parameters, absorption and transport across the intestinal mucosal barrier, distribution and pathol. changes of organs. While the dose was as lower than 10 mg/kg by intragastric administration, the toxicokinetic parameters obtained by fluorescence microplate method were similar to those with the literatures by chromatog. MEHP-AF can be rapidly absorbed through the intestinal mucosal barrier in rats. In situ organ distribution in mice showed that MEHP-AF was mainly concentrated in the liver, kidney and testis. Our results suggested that the fluorescence tracing technique had the advantages with easy processing, less time-consuming, higher sensitivity for the quant. determination, In addition, this technol. also avoids the interference of exogenous or endogenous DEHP and MEHP in the exptl. system. It also can be utilized to the visualization detection of MEHP in situ localization in the absorption organ and the toxic target organ. The results show that this may be a more feasible MEHP toxicol. research method. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9Name: 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Name: 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Fluorescent benzothiazinone analogues efficiently and selectively label DprE1 in Mycobacteria and Actinobacteria was written by Sommer, Raphael;Neres, Joao;Piton, Jeremie;Dhar, Neeraj;van der Sar, Astrid;Mukherjee, Raju;Laroche, Thierry;Dyson, Paul J.;McKinney, John D.;Bitter, Wilbert;Makarov, Vadim;Cole, Stewart T.. And the article was included in ACS Chemical Biology in 2018.Computed Properties of C25H15NO9 This article mentions the following:

Benzothiazinones (BTZ) are highly potent bactericidal inhibitors of mycobacteria and the lead compound, BTZ043, and the optimized drug candidate, PBTZ169, have potential for the treatment of tuberculosis. Here, we exploited the tractability of the BTZ scaffold by attaching a range of fluorophores to the 2-substituent of the BTZ ring via short linkers. We show by means of fluorescence imaging that the most advanced derivative, JN108, is capable of efficiently labeling its target, the essential flavoenzyme DprE1, both in cell-free extracts and after purification as well as in growing cells of different actinobacterial species. DprE1 displays a polar localization in Mycobacterium tuberculosis, M. marinum, M. smegmatis, and Nocardia farcinica but not in Corynebacterium glutamicum. Finally, mutation of the cysteine residue in DprE1 in these species, to which BTZ covalently binds, abolishes completely the interaction with JN108, thereby highlighting the specificity of this fluorescent probe. In the experiment, the researchers used many compounds, for example, 2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7Computed Properties of C25H15NO9).

2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Computed Properties of C25H15NO9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Asymmetric Dearomative (3+2)-Cycloaddition Involving Nitro-Substituted Benzoheteroarenes under H-Bonding Catalysis was written by Saktura, Maciej;Skrzynska, Anna;Frankowski, Sebastian;Wodka, Sylwia;Albrecht, Lukasz. And the article was included in Molecules in 2021.Category: benzofurans This article mentions the following:

In our studies, the organocatalytic 1,3-dipolar cycloaddition between 2-nitrobenzofurans or 2-nitrobenzothiophene and N-2,2,2-trifluoroethyl-substituted isatin imines has been developed. The reaction has been realized by employing bifunctional organocatalysis, with the use of squaramide derivative being crucial for the stereochem. efficiency of the process. The usefulness of the cycloadducts obtained has been confirmed in selected transformations, including aromative and non-aromative removal of the nitro group. In the experiment, the researchers used many compounds, for example, 2-Nitrobenzofuran (cas: 33094-66-5Category: benzofurans).

2-Nitrobenzofuran (cas: 33094-66-5) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Hydrophobic Organic Components of Ambient Fine Particulate Matter (PM_2.5) Associated with Inflammatory Cellular Response was written by Jiang, Xing;Xu, Fanfan;Qiu, Xinghua;Shi, Xiaodi;Pardo, Michal;Shang, Yu;Wang, Junxia;Rudich, Yinon;Zhu, Tong. And the article was included in Environmental Science & Technology in 2019.COA of Formula: C16H10O This article mentions the following:

Nowadays, knowledge regarding component-specific inflammatory effect of fine particulate matter (PM_2.5) is limited. In this study, an omics approach based on time-of-flight mass spectrometry was established to identify the key hydrophobic components of PM_2.5 associated with pro-inflammatory cytokines released by macrophages after in vitro exposure. Of 764 compounds, 62 components were robustly screened with firmly identified 37 specific chems. In addition to polycyclic aromatic hydrocarbons (PAHs) and their methylated congeners, novel oxygen- and nitrogen-containing PAHs and, especially, oxygenated PAHs (Oxy-PAHs) were identified. Interleukin (IL)-6 was associated with Oxy-PAHs of 1,8-naphthalic anhydride, xanthone, and benzo[h]quinolone, especially, whereas IL-1β and tumor necrosis factor (TNF)-α were associated with most species. Most species were related to IL-1β, which was significantly higher in the heating season, with a monotonic dose-response pattern mainly for Oxy-PAHs and a U-shaped dose-response pattern for primary species. On the basis of the identified components, four sources of pollution (coal combustion, traffic emissions, biomass burning, and secondary formation, traced by Oxy-PAHs such as 1,8-naphthalic anhydride and quinones) were resolved by the pos. matrix factorization model. TNF-α was associated with primary sources, whereas IL-1β and IL-6 were associated with both primary and secondary sources, suggesting different inflammatory effects between primary and secondary sources when assessing the toxicity-driven disparities of known and unknown PM_2.5 components. In the experiment, the researchers used many compounds, for example, Naphtho[2,1-b]benzofuran (cas: 205-39-0COA of Formula: C16H10O).

Naphtho[2,1-b]benzofuran (cas: 205-39-0) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.COA of Formula: C16H10O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Postoperative ileus-An ongoing conundrum. was written by Wattchow, David;Heitmann, Paul;Smolilo, David;Spencer, Nick J;Parker, Dominic;Hibberd, Timothy;Brookes, Simon S J;Dinning, Phil G;Costa, Marcello. And the article was included in Neurogastroenterology and motility in 2021.Product Details of 179474-81-8 This article mentions the following:

BACKGROUND: Postoperative ileus is common and is a major clinical problem. It has been widely studied in patients and in experimental models in laboratory animals. A wide variety of treatments have been tested to prevent or modify the course of this disorder. PURPOSE: This review draws together information on animal studies of ileus with studies on human patients. It summarizes some of the conceptual advances made in understanding the mechanisms that underlie paralytic ileus. The treatments that have been tested in human subjects (both pharmacological and non-pharmacological) and their efficacy are summarized and graded consistent with current clinical guidelines. The review is not intended to provide a comprehensive overview of ileus, but rather a general understanding of the major clinical problems associated with it, how animal models have been useful to elucidate key mechanisms and, finally, some perspectives from both scientists and clinicians as to how we may move forward with this debilitating yet common condition. In the experiment, the researchers used many compounds, for example, 4-Amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide (cas: 179474-81-8Product Details of 179474-81-8).

4-Amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide (cas: 179474-81-8) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Product Details of 179474-81-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Rapid determination of 93 banned industrial dyes in beverage, fish, cookie using solid-supported liquid-liquid extraction and ultrahigh-performance liquid chromatography quadrupole orbitrap high-resolution mass spectrometry was written by Chen, Shubing;Li, Shuang;Fang, Keyi;Wang, Yongjian;Yang, Yan;Han, Chao;Shen, Yan. And the article was included in Food Chemistry in 2022.Application In Synthesis of Crystal violet lactone This article mentions the following:

Banned industrial dyes are composed of a large number of chems. with diverse phys. and chem. properties, making their simultaneous determination a challenging task. A one-step extraction and purification of 93 banned industrial dyes from beverage, fish and cookie sample methods was proposed by using solid supported liquid-liquid extraction (SLE). The extract was analyzed by ultrahigh-performance liquid chromatog. quadrupole orbitrap high-resolution mass spectrometry (UPLC-Q-Orbitrap-HRMS). The quant. and qual. mode adopts Q-Orbitrap-HRMS full scan MS (full scan MS¹) and data-dependent MS/MS (dd-MS²) acquisition mode. The mass resolution was screened under 70,000 FWHM for full-scan MS¹ and 35,000 FWHM for dd-MS². Linearity was observed in the range of 0.01 ∼ 0.5 μg/mL and the limits of quantification were 0.04 ∼ 0.2 mg/kg for 93 dyes. The average recoveries were 70.5-105.8%, with RSD ≤ 10%. The proposed method has the ability to simultaneously screen many banned dyes in foods with high throughput, sensitivity and reliability. In the experiment, the researchers used many compounds, for example, Crystal violet lactone (cas: 1552-42-7Application In Synthesis of Crystal violet lactone).

Crystal violet lactone (cas: 1552-42-7) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Application In Synthesis of Crystal violet lactone

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Microwave-granular activated carbon (MW-GAC) system for carbofuran degradation: Analysis of characteristics and recyclability of the spent GAC was written by Remya, Neelancherry;Lin, Jih-Gaw. And the article was included in Desalination and Water Treatment in 2015.Reference of 1563-38-8 This article mentions the following:

Granular activated carbon (GAC) is frequently used to remove pollutants from wastewater. However, the mechanism of pollutant removal by GAC is by adsorption and hence spent GAC should be regenerated and used for several cycles for minimizing the cost of treatment. In the present study, the characteristics of GAC and carbofuran removal mechanism were explored in a microwave-GAC (MW-GAC) system. Carbofuran removal by adsorption was 52% at a GAC loading of 0.8 g/L. However, complete carbofuran degradation from aqueous solution as well as from GAC surface was obtained within 30 min in a MW-GAC system. In addition, A COD removal efficiency of 72% was observed in the MW-GAC system at pH 8 and 80!!!C after 30 min. The degradation occurred mainly through cleavage of carbamate group and oxidation of furan ring. Carbofuran removal by adsorption was enhanced with MW exposed GAC due to the improvement in the surface property on exposure to MW. On the other hand, recyclability of MW exposed GAC in the MW-GAC system indicated > 99% degradation of carbofuran in all the three cycles tested. As a whole, complete degradation of carbofuran and the effective recycling of the spent GAC could be achieved in the MW-GAC system. In the experiment, the researchers used many compounds, for example, 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8Reference of 1563-38-8).

2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Reference of 1563-38-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A review on spectrum of pharmacologial activities of ficus palmata forssk was written by Negi, A.;Dobhal, K.;Rawat, A.. And the article was included in World Journal of Pharmacy and Pharmaceutical Sciences in 2019.Product Details of 905954-17-8 This article mentions the following:

Ficus palmate Forssk. (Moraceae) called as “Anjiri” is bushy tree found in many parts of India, Nepal, and westwards. The tree and its parts (leaves, fruits etc.) are used traditionally to treat many diseases. The plant possesses antibacterial, antimicrobial, hypoglycemic, nephroprotective, anticalcinogenic, antiulcer, antiproliferative, antioxidant, antihyperlipidimic activities. The plant has shown the presence of chem. constituents such as psoralene, bergapten, vanillic acid, psoralenoside, β-sitosterol, stigmasterol, α-amyrin, β-amyrin, lupeol acetate, di-Et acetate etc. It also has been used for various remedies such as laxatives, to treat warts, demulcent, emolient. The fruit and leaves are as used as food for its nutritive values. These spectrums of pharmacol. activities and a bunch of phytochems. indicate a scope for further work to be carried out on Ficus palmate Forssk. In the experiment, the researchers used many compounds, for example, (Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid (cas: 905954-17-8Product Details of 905954-17-8).

(Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid (cas: 905954-17-8) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Product Details of 905954-17-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Non-toxic fluorescent alanine-fluorescein probe with green emission for dual colorimetric/fluorimetric sensing was written by Oliveira, Elisabete;Lorenzo, Julia;Cid, Antonio;Capelo, Jose Luis;Lodeiro, Carlos. And the article was included in Journal of Photochemistry and Photobiology, A: Chemistry in 2013.COA of Formula: C20H13NO5 This article mentions the following:

Two new fluorescent bio-inspired dyes 1 and 2 containing a fluorescein unit linked to a protected with a Boc group (N-tert-butyloxycarbonyl), and unprotected alanine residue were synthesized and characterized. The acid-base behavior was studied in water/ethanol (60/40) and at pH = 8 a strong emission fluorescence, followed by a color change from colorless to yellow was observed Photophys. studies in water HEPES buffered solution toward alk., alk. earth, transition, and post- transition metal ions were performed. Compounds 1 and 2 revealed to be very sensitive to Hg²⁺ with colorimetric changes from yellow to pink in the presence of HEPES buffer. Moreover, compound 1 show a color change from yellow to orange in the presence of the neurotransmitter mol. dopamine. Compound 2 also reveals to be sensitive to Cu²⁺ and Ni²⁺, being able to detected and quantified in HEPES buffer ca. 0.37 ppm and ca. 1.50 ppm of Cu²⁺, resp. Very small silver nanoparticles coated with compound 2 of ca. 3.68 ± 0.93 nm were successfully synthesized and characterized. Toxicol. studies with both compounds were also carried out. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9COA of Formula: C20H13NO5).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.COA of Formula: C20H13NO5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Electrochemical benzylic C-H arylation of xanthenes and thioxanthenes without a catalyst and oxidant was written by Gao, Hui;Chen, Xinyu;Wang, Pei-Long;Shi, Meng-Meng;Shang, Ling-Long;Guo, Heng-Yi;Li, Hongji;Li, Pinhua. And the article was included in Organic Chemistry Frontiers in 2022.SDS of cas: 496-16-2 This article mentions the following:

A catalyst-free and oxidant-free C-H arylation of xanthenes and thioxanthenes I (R¹ = H, Me, OH, Cl, etc.; R² = H, OMe; R³R⁴ = -CH=CH-CH=CH-; X = O, S) using electrochem. has been developed, which affords a number of cross-coupling products II (R⁵ = 4-methoxyphenyl, 4-methoxy-3-methylphenyl, 4-methoxy-3,5-dimethylphenyl, 2H-1,3-benzodioxol-5-yl, etc.) in moderate to good yields. This method is atom- and step-economical as it uses cheap and easily available arenes and heteroarenes as partners directly and the C(sp²)-H/C(sp³)-H type cross-coupling reaction. In the experiment, the researchers used many compounds, for example, 2,3-Dihydrobenzo[b]furan (cas: 496-16-2SDS of cas: 496-16-2).

2,3-Dihydrobenzo[b]furan (cas: 496-16-2) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.SDS of cas: 496-16-2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem