Heterocyclic Building Block-benzofuran

Activation energy and frequency factor in the alkaline hydrolysis of phthalides was written by Vene, Jean;Tirouflet, Jean;Carrie, Robert. And the article was included in Compt. rend. in 1952.Application In Synthesis of 5-Methoxyisobenzofuran-1(3H)-one This article mentions the following:

The alk. (0.002 M) hydrolysis is studied at 15°, 25°, 35°, and 45° in 20% EtOH (by weight) of phthalides (0.002 M) mono-substituted in the benzene nucleus in the 4, 5, 6, or 7 position by the groups: NH₂, OCH₃, Cl, and Br. For each of the derivatives in the 5, 6, and 7 positions and for the 4-methoxy-phthalide the factors PZ and E of the Arrhenius equation, k = PZ e^-E/RT, remain constant within the limit of exptl. error. The ortho effect of substituents halogenated in the 7 position, responsible for the low value of the factor PZ in the case of o-halobenzoic esters, is considerably lessened for the phthalides. In the experiment, the researchers used many compounds, for example, 5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2Application In Synthesis of 5-Methoxyisobenzofuran-1(3H)-one).

5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Application In Synthesis of 5-Methoxyisobenzofuran-1(3H)-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Electro-Fenton, solar photoelectro-Fenton and UVA photoelectro-Fenton: Degradation of Erythrosine B dye solution was written by Clematis, Davide;Panizza, Marco. And the article was included in Chemosphere in 2021.Recommanded Product: 16423-68-0 This article mentions the following:

The treatment of Erythrosine B, selected as a model compound, has been comparatively studied by electrochem. advanced oxidation processes (EAOPs) such as electro-Fenton, UVA photoelectro-Fenton and solar photoelectro-Fenton at constant c.d. Experiments are performed in a one-compartment cell with a BDD anode, and a com. carbon felt cathode at pH = 3, treating a volume of 0.3 L in each test. The irradiation plays a crucial role in the increasing of hydroxyl radical production and in the recover of iron catalyst. A faster color and COD removal degradation are achieved under the light application. UVA photoelectro-Fenton and solar photoelectro-Fenton processes allow degrading COD entirely in 90 min, while a conventional electro-Fenton does not reach 90% COD removal after 2 h. Energy consumptions are a substantial factor in process selection. Photo electro-Fenton with a UVA-100 W lamp has one of the best removal performance, but it becomes not suitable for application due to high energy demand, up to 515.6 kWh m-3, and the UVA system requires the main fraction of this energy. Possible alternatives are proposed to contain costs: the first is the reduction of UVA lamp power to 25 W, maintaining a high-performance removal with an Ec decreasing to 187.9 kWh m-3. Nevertheless, the lowest and competitive energy demands is obtained working with a solar photoelectro-Fenton system, where energy consumption are only related to the electrochem. process (20.9 kWh m^-3), and removal is complete. In the experiment, the researchers used many compounds, for example, Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate) (cas: 16423-68-0Recommanded Product: 16423-68-0).

Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate) (cas: 16423-68-0) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Recommanded Product: 16423-68-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Iridium(III)-bis(imidazolinyl)phenyl catalysts for enantioselective C-H functionalization with ethyl diazoacetate was written by Weldy, N. Mace;Schafer, A. G.;Owens, C. P.;Herting, C. J.;Varela-Alvarez, A.;Chen, S.;Niemeyer, Z.;Musaev, D. G.;Sigman, M. S.;Davies, H. M. L.;Blakey, S. B.. And the article was included in Chemical Science in 2016.Product Details of 52771-99-0 This article mentions the following:

The intermol. enantioselective C-H functionalization with acceptor-only metallocarbenes is reported using a new family of Ir(III)-bis(imidazolinyl)phenyl catalysts, developed based on the interplay of exptl. and computational insights. The reaction is tolerant of a variety of diazoacetate ROC(O)CH=N₂ (R = CH₂CH₃, CH₂CCl₃, C₆H₅, etc.) precursors and is found to be heavily influenced by the steric and electronic properties of the substrate. Phthalans I [R¹ = 7-OCH₃, 4-Br, 5-(pyrrolidin-1-yl), etc.] and dihydrofurans II (R² = H, C₆H₅, CH₂C₆H₅) are functionalized in good yields and excellent enantioselectivities. In the experiment, the researchers used many compounds, for example, 5-Nitro-1,3-dihydroisobenzofuran (cas: 52771-99-0Product Details of 52771-99-0).

5-Nitro-1,3-dihydroisobenzofuran (cas: 52771-99-0) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Product Details of 52771-99-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Lithiated benzothiophenes and benzofurans require 2-silyl protection to avoid anion migration was written by Hansen, Marvin M.;Clayton, Marcella T.;Godfrey, Alexander G.;Grutsch, John L. Jr.;Keast, Sandra S.;Kohlman, Dan T.;McSpadden, Andreea R.;Pedersen, Steven W.;Ward, Jeffrey A.;Xu, Yao-Chang. And the article was included in Synlett in 2004.Product Details of 253429-31-1 This article mentions the following:

2-Trimethylsilyl protection of benzothiophenes and benzofurans prevents anion migration to the 2-position when lithiated species are formed. These lithiated benzothiophenes and benzofurans provide superior results in additions to piperidones. Deprotection is conveniently achieved under acidic conditions. Direct C-7 metalation of benzothiophene is enabled by 2-triisopropylsilyl protection at C-2. In the experiment, the researchers used many compounds, for example, 7-Bromo-4-fluorobenzofuran (cas: 253429-31-1Product Details of 253429-31-1).

7-Bromo-4-fluorobenzofuran (cas: 253429-31-1) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Product Details of 253429-31-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Peripheral blood gene expression profiling shows predictive significance for response to mycophenolate in systemic sclerosis-related interstitial lung disease was written by Assassi, Shervin;Volkmann, Elizabeth R.;Zheng, W. Jim;Wang, Xuan;Wilhalme, Holly;Lyons, Marka A.;Roth, Michael D.;Tashkin, Donald P.. And the article was included in Annals of the Rheumatic Diseases in 2022.Application In Synthesis of (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid This article mentions the following:

To characterize the peripheral blood cell (PBC) gene expression changes ensuing from mycophenolate mofetil (MMF) or cyclophosphamide (CYC) treatment and to determine the predictive significance of baseline PBC transcript scores for response to immunosuppression in systemic sclerosis (SSc)-related interstitial lung disease (ILD). PBC RNA samples from baseline and 12-mo visits, corresponding to the active treatment period of both arms in Scleroderma Lung Study II, were investigated by global RNA sequencing. Joint models were created to examine the predictive significance of baseline composite modular scores for the course of forced vital capacity (FVC) per cent predicted measurements from 3 to 12 mo. Total 134 patients with SSc-ILD (CYC = 69 and MMF = 65) were investigated. CYC led to an upregulation of erythropoiesis, inflammation and myeloid lineage-related modules and a downregulation of lymphoid lineage-related modules. The modular changes resulting from MMF treatment were more modest and included a downregulation of plasmablast module. In the longitudinal anal., none of the baseline transcript module scores showed predictive significance for FVC% course in the CYC arm. In contrast, in the MMF arm, higher baseline lymphoid lineage modules predicted better subsequent FVC% course, while higher baseline myeloid lineage and inflammation modules predicted worse subsequent FVC% course. Consistent with the primary mechanism of action of MMF on lymphocytes, patients with SSc-ILD with higher baseline lymphoid module scores had better FVC% course, while those with higher myeloid cell lineage activation score had poorer FVC% course on MMF. In the experiment, the researchers used many compounds, for example, (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid (cas: 24280-93-1Application In Synthesis of (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid).

(E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid (cas: 24280-93-1) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Application In Synthesis of (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Effect of Thiocarbonylthio Compounds on Visible-Light-Mediated 3D Printing was written by Zhang, Zhiheng;Corrigan, Nathaniel;Boyer, Cyrille. And the article was included in Macromolecules (Washington, DC, United States) in 2021.Formula: C20H6I4Na2O5 This article mentions the following:

Photoinduced electron/energy transfer-reversible addition-fragmentation chain transfer (PET-RAFT) polymerization has been successfully employed in three-dimensional (3D) printing to synthesize materials with controlled architecture and diverse functions. However, there is a lack of understanding of the impact of various RAFT agents on the 3D printing process, as only trithiocarbonate RAFT agents were used in the previous systems. In this work, RAFT agents with different activating Z groups and leaving R groups are incorporated in resin formulations and applied to open-air 3D printing systems under mild green light irradiation (λ_max = 525 nm, I₀ = 0.32 mW/cm²). The Z and R groups of RAFT agents influence the polymerization kinetics and 3D printing process (cure time) and affect the mech. properties of 3D-printed materials. The impact of the concentration of trithiocarbonates on mech. properties is also investigated. The 3D-printed materials containing RAFT agents are easily postmodified after printing via one-pot in situ aminolysis and thiol-Michael additions The RAFT-mediated photoinduced polymerization appears a promising method for producing novel and functional materials. In the experiment, the researchers used many compounds, for example, Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate) (cas: 16423-68-0Formula: C20H6I4Na2O5).

Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate) (cas: 16423-68-0) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Formula: C20H6I4Na2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis and pharmacological activity of benzofurylhydroxyureas and benzofurylhydroxamic acids was written by Onuchina, O. A.;Zaitsev, S. A.;Arzamastsev, A. P.;Kalinkina, M. A.;Granik, V. G.. And the article was included in Pharmaceutical Chemistry Journal in 2006.Computed Properties of C11H10O3 This article mentions the following:

A series of benzofuran derivatives of hydroxyurea, e.g. I (R = NH₂), and hydroxamic acid, e.g. I (R = Me), has been obtained. Hydroxyureas have been O-alkylated with 3-bromomethyl-4-methylfuroxane. The antiinflammatory and antiulcer properties of these compounds have been investigated. In the experiment, the researchers used many compounds, for example, 1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone (cas: 28241-99-8Computed Properties of C11H10O3).

1-(5-Hydroxy-2-methylbenzofuran-3-yl)ethanone (cas: 28241-99-8) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Computed Properties of C11H10O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Unexpected Reactivity of N-Acyl-Benzotriazoles with Aromatic Amines in Acidic Medium (ABAA Reaction) was written by Laconde, Guillaume;Amblard, Muriel;Martinez, Jean. And the article was included in European Journal of Organic Chemistry in 2019.Computed Properties of C20H13NO5 This article mentions the following:

Despite the large number of methods for the synthesis of amides, formation of the amide bond from aromatic amines has always been a challenge for organic chemists due to their weak nucleophile character. The authors describe here a new efficient method of amide formation from N-Acyl-Benzotriazoles and Aromatic Amines (ABAA reaction) including aniline derivatives, in acidic conditions. This reaction is selective for aromatic amines, since aliphatic amines did not react under the same exptl. conditions. Using the ABAA reaction, the authors synthesized a series of aromatic amide compounds including labeled enzyme substrates, in excellent yield. The ABAA reaction also allowed the one-pot synthesis of Nordiazepam, which is a precursor of the anxiolytic Diazepam (Valium). This procedure opens new ways of synthesis of amides from aromatic amines, and of heterocyclic structures. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9Computed Properties of C20H13NO5).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Computed Properties of C20H13NO5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Design and synthesis of fluorescent SGLT2 inhibitors was written by Lansdell, Mark I.;Burring, Denise J.;Hepworth, David;Strawbridge, Matthew;Graham, Emily;Guyot, Thierry;Betson, Mark S.;Hart, James D.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Product Details of 92557-80-7 This article mentions the following:

The design and synthesis of the first fluorophore-conjugated SGLT2 inhibitors is described. The mode of linking the fluorophore to the SGLT2 pharmacophore was crucial in achieving optimum potency. Superior potency to phlorizin was provided by examples containing TAMRA, BODIPY, Cy3B and NBD fluorophores. In the experiment, the researchers used many compounds, for example, 2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7Product Details of 92557-80-7).

2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Product Details of 92557-80-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Application of random forests method to predict the retention indices of some polycyclic aromatic hydrocarbons was written by Goudarzi, N.;Shahsavani, D.;Emadi-Gandaghi, F.;Chamjangali, M. Arab. And the article was included in Journal of Chromatography A in 2014.Electric Literature of C16H10O This article mentions the following:

A quant. structure-retention relation (QSRR) study was carried out based on the new method of random forests (RF) for prediction of the retention indexes (RIs) of some polycyclic aromatic hydrocarbon (PAH) compounds The RIs of these compounds were calculated using the theor. descriptors generated from their mol. structures. Effects of the important parameters affecting the ability of the RF prediction power such as the number of trees (n_t) and the number of randomly selected variables to split each node (m) were studied. Optimization of these parameters showed that in the point m = 70, n_t = 460, the RF method can give the best results. Also, performance of the RF model was compared with that of the artificial neural network (ANN) and multiple linear regression (MLR) techniques. The results obtained show the relative superiority of the RF method over the MLR and ANN ones. In the experiment, the researchers used many compounds, for example, Naphtho[2,1-b]benzofuran (cas: 205-39-0Electric Literature of C16H10O).

Naphtho[2,1-b]benzofuran (cas: 205-39-0) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Electric Literature of C16H10O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem