Tag: M.W=300-400

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Hepatotoxicity of metahexamide》. Authors are Mucci, A.; Marco, G. Di; Lucchi, R..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).SDS of cas: 129-18-0. Through the article, more information about this compound (cas:129-18-0) is conveyed.

In diabetics treated for a year with metahexamide, Bromsulphalein retention and hippuric acid conjugation test, determination of the quantity of urobilinogen in the urine, and of serum alk. phosphatase, aldolase, and transaminase, as well as of blood levels of Fe and transferrin, and colloidal serum lability tests showed no liver damage. However, in rats treated for a month with the drug, histol. liver damage appeared; in rats treated with tolbutamide the liver remained normal.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide(SMILESS: O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+],cas:129-18-0) is researched.Safety of 1-(Bromomethyl)-4-ethylbenzene. The article 《Nonsteroidal antiinflammatory agents and the histamine-releasing agent 48/80》 in relation to this compound, is published in Annales Pharmaceutiques Francaises. Let’s take a look at the latest research on this compound (cas:129-18-0).

Orally administered metiazinic acid [13993-65-2], niflumic acid [4394-00-7], ibuprofen [15687-27-1], indomethacin [53-86-1], and phenylbutazone [50-33-9] had no effect against the ability of compound 48/80 to release histamine [51-45-6] from mast cells, to increase skin capillary permeability, or to cause rat paw edema. When administered locally, the antiinflammatory agents inhibited 48/80 activity at concentrations which could not be attained following oral administration.

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Benzofuran – Wikipedia,
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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Absorption of vitamin B12 by talc》. Authors are Dony, J.; Conter, J..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Application of 129-18-0. Through the article, more information about this compound (cas:129-18-0) is conveyed.

A study of mixtures containing 5-10 γ vitamin B12 (I) and 50 mg. to 1 g. talc indicates I is effectively absorbed by the talc, from which it is slowly and progressively eluted by H2O and is rapidly eluted by gastric media at 37° owing to the pepsin in the media. Tween 20, 1% solution, elutes I from talc in the same manner as does 0.32% pepsin solution and indicates the surface-active function of both compounds in the process.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Influence of various drugs on the tissue permeability. I, the main research direction is drug tissue diffusion; tissue drug diffusion.Recommanded Product: 129-18-0.

The effect of drugs, including antiinflammatory drugs, on permeability in s.c. and intracutaneous tissues was tested. The inhibitory activity on permeability was in the decreasing order: N-(ο-methoxybenzoyl)-glycine dimethylamide, 3-aminocamphor-N-acetic acid dimethylamide, Na phenylbutazone, rutin, and histamine-HCl.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Chemical Communications (Cambridge, United Kingdom) called Mechanistic interrogation of the asymmetric lithiation-trapping of N-thiopivaloyl azetidine and pyrrolidine, Author is Rayner, Peter J.; Smith, Joshua C.; Denneval, Charline; O’Brien, Peter; Clarke, Paul A.; Horan, Richard A. J., which mentions a compound: 767291-67-8, SMILESS is CN(CCC(C)(C)C)[C@@H]1[C@@H](N(CCC(C)(C)C)C)CCCC1, Molecular C20H42N2, Application In Synthesis of (1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine.

A fundamental mechanistic study of the s-BuLi/chiral diamine-mediated lithiation-trapping of N-thiopivaloyl azetidine and pyrrolidine is reported. We show that lithiated thiopivalamides are configurationally unstable at -78 °C. Reaction then proceeds via a dynamic resolution of diastereomeric lithiated intermediates and this accounts for the variable sense and degree of asym. induction observed compared to N-Boc heterocycles.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

HPLC of Formula: 129-18-0. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Structure of phenylbutazone and mofebutazone in the crystalline state and in solution. Author is Paradies, Henrich H..

The crystal structure of the keto form of phenylbutazone (I) was determined and compared with the mol. conformation of mofebutazone (II). The pronounced differences between these two structures are the conformation of the Bu side chain [which is extended and in trans conformation for II, however, bent at the Cγ-position with H bonding of the γ-H to the carbonyl C(3)-O(1) for I], and the in-plane conformation of the Ph group with respect to the heterocyclic ring system in II compared with two benzene rings at N(1) and N(2) which are almost perpendicular to the pyrazolidine-(3,5)-dione ring. Preliminary x-ray data reveal that the structures of the alkali enolates of both compounds are difficult to solve because the crystal quality is insufficient and highly disordered. However, the large unit cells are consistent with chelated structures of the alkali enolates with solvent. Na and K enolates of I in nonpolar solvents (e.g., benzene and cyclohexane) exist as inverse micelles comprised of 30-40 monomer units. In contrast, the salt appears to be essentially monomeric in 1,2-dimethoxyethane, and, in water for I, the critical micelle concentration (CMC) is >0.30M. II salts, however, reveal a CMC of 1.5 × 10-3M in water, where the basic unit of micellar aggregation seems to be the dimer. The micellar properties of I and II enolates are strongly dependent on the nature of solvents, solvation of the enolate, and size of the cation. However, Na and K enolates of II in nonpolar solvents exist as small inverse micelles comprised of 8-10 monomer units only. In aqueous solution, weight average mol. weights of 13,100 were determined, with a radius of gyration of 12.85 Å.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 129-18-0, is researched, SMILESS is O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+], Molecular C19H19N2NaO2Journal, Article, Experientia called Comparative dominant lethal studies with phenylbutazone, thio-TEPA, and methyl methanesulfonate [MMS] in the mouse, Author is Machemer, L.; Hess, R., the main research direction is phenylbutazone lethal mutation; thio TEPA lethal mutation; methanesulfonate lethal mutation; spermatogenesis thio TEPA; spermatozoa methanesulfonate.Safety of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide.

Thio-TEPA (I) [52-24-4] (5 and 10 mg/kg) and Me methanesulfonate (II) [66-27-3] (50 and 100 mg/kg) given i.p. to male rats before mating induced dominant lethal effects, whereas Na phenylbutazone (III Na salt) [129-18-0] (50 and 100 mg/kg, i.p.) did not. I was highly effective on the postmeiotic stages of spermatogenesis, whereas I was highly effective on epididymal and testicular spermatozoa.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Safety of (1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine, is researched, Molecular C20H42N2, CAS is 767291-67-8, about Asymmetric Lithiation Trapping of N-Boc Heterocycles at Temperatures above -78 °C. Author is Gelardi, Giacomo; Barker, Graeme; O’Brien, Peter; Blakemore, David C..

The asym. lithiation trapping of N-Boc heterocycles using s-BuLi/chiral diamines at temperatures up to -20 °C is reported. Depending on the N-Boc heterocycle, lithiation is accomplished using s-BuLi and (-)-sparteine or the (+)-sparteine surrogate in the temperature range -50 to -20 °C for short reaction times (2-20 min). Subsequent electrophilic trapping or transmetalation-Negishi coupling delivered functionalized N-Boc heterocycles in 47-95% yield and 77:23-93:7 er. With N-Boc pyrrolidine, trapped products can be generated in ∼90:10 er even at -20 °C [e.g., 2 min reaction time at -20 °C afforded I (50% yield, 89:11 er) and II (23% yield, 91:9 er)].

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Reid, M. E.; Bieri, J. G.; Plack, P. A.; Andrews, E. L. published the article 《Nutritional studies with the guinea pig. X. Determination of the linoleic acid requirement》. Keywords: CHROMATOGRAPHY; CITRATES; DERMATITIS; DIETARY FATS; ERYTHROCYTES; EXPERIMENTAL LAB STUDY; FATTY ACIDS, ESSENTIAL; GROWTH; GUINEA PIGS; KETOGLUTARIC ACID; LINOLEIC ACID; LIPID METABOLISM.They researched the compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide( cas:129-18-0 ).Application In Synthesis of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:129-18-0) here.

cf. CA 59, 9144d. Young male guinea pigs were reared for 6-14 weeks with purified diets containing varying levels of linoleic acid as corn oil, safflower oil, or methyl linoleate. A dietary level of about 1% of calories as linoleic acid was necessary for normal growth and skin condition. The fatty acid composition of erythrocytes from animals fed safflower oil was determined and the ratios of 5,8,11-eicosatrienoic-to-arachidonic (20:3/20:4) or oleic-to-linoleic ( 18:1/18:2) acids compared with the performance of the animals with respect to growth and dermal symptoms. One per cent of calories as linoleic acid gave a 20:3/20:4 ratio of 0.13 to 0.17, and a 18:1/18:2 ratio of 1.41 to 1.14. Homogenates of liver from linoleic acid-deficient guinea pigs had an elevated rate of oxidation of citrate and α-ketoglutarate.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Histamine release inhibition in antiinflammatory mechanism.Safety of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide.

Sinomenine (50 mg/kg, i.p., twice daily, increasing daily dose by 100 mg/kg for 6 days) depleted skin histamine by >80%, inhibited induced egg-white edema by 68%, and decreased the wall weight of croton oil-induced granuloma pouches in rats. Antiinflammatory drugs, sodium salicylate, aminopyrine, sodium butazolidine, cortisone, and guaiazulene, inhibited both degranulation and histamine release induced by compound 48/80 of mast cells isolated from rat peritoneal fluid, and this inhibitory action was decreased in the presence of glucose, dinitrophenol, dicumarol, and warfarin. Prevention of edema provoked by anti-rat serum was roughly correlated to the potency of degranulation-inhibiting effect of the antiinflammatory agents. Antiinflammatory agents may prevent histamine release from the tissue, mainly by inhibiting mast cell degranulation, and prevent the contraction of endothelial cells by their uncoupling activities.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem