Tag: M.W=300-400

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Analytical study of phenylbutazone》. Authors are Breugelmans, J. G.; Braun, J..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Product Details of 129-18-0. Through the article, more information about this compound (cas:129-18-0) is conveyed.

A review of tests, standards, and assay procedures for phenylbutazone (I) and its Na salt. Adapted methods are given for the determination of I in binary association with antipyrine, aminopyrine, phenacetin, novalgin, aspirin, atophan, caffeine, medonine, and quaternary mixtures in suppositories containing I, aminopyrine, medonine, codeine phosphate, and neutral fat.

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Benzofuran – Wikipedia,
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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Actions of anti-inflammatory drugs on smooth muscle.Name: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide.

The concentration-dependent relaxation of guinea pig tracheal muscle for a number of antiinflammatory drugs such as phenylbutazone Na salt (I) [129-18-0] was demonstrated. The concentration-response curves obtained with these drugs were parallel, and the progressive decrease in tone of tracheal muscle appeared to be due to the inhibition of prostaglandin synthesis.

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HPLC of Formula: 129-18-0. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Effect of some antipyretic drugs on Herpes simplex virus infection in tissue culture. Author is Olkowska, Danuta; Wroblewska-Mularczykowa, Zofia.

Among 8 analgesic, antipyretic drugs tested for activity against herpesvirus in epithelial monkey kidney cell cultures, acetylsalicylic acid (I) [50-78-2], sodium salicylate [54-21-7], phenylbutazone sodium salt [129-18-0], and a combination of the latter and aminopyrine (II) [58-15-1] were cytotoxic at concentrations higher than those which were virustatic. Sodium salicylate and I were active only 1-4 hr after infection, or after adsorption and penetration of the virus through the cellular membrane.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Journal of the American Chemical Society called Preparation and Reactions of Enantiomerically Pure α-Functionalized Grignard Reagents, Author is Rayner, Peter J.; O’Brien, Peter; Horan, Richard A. J., which mentions a compound: 767291-67-8, SMILESS is CN(CCC(C)(C)C)[C@@H]1[C@@H](N(CCC(C)(C)C)C)CCCC1, Molecular C20H42N2, Recommanded Product: (1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine.

A strategy for the generation of enantiomerically pure α-functionalized chiral Grignard reagents is presented. The approach involves the synthesis of α-alkoxy and α-amino sulfoxides in ≥99:1 dr and ≥99:1 er via asym. deprotonation (s-BuLi/chiral diamine) and trapping with Andersen’s sulfinate (menthol derived). Subsequent sulfoxide → Mg exchange (room temperature, 1 min) and electrophilic trapping delivers a range of enantiomerically pure α-alkoxy and α-amino substituted products. Using this approach, either enantiomer of products can be accessed in 99:1 er from asym. deprotonation protocols without the use of (-)-sparteine as the chiral ligand. Two addnl. discoveries are noteworthy: (i) for the deprotonation and trapping with Andersen’s sulfinate, there is a lack of stereospecificity at sulfur due to attack of a lithiated intermediate onto the α-alkoxy and α-amino sulfoxides as they form, and (ii) the α-alkoxy-substituted Grignard reagent is configurationally stable at room temperature for 30 min.

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Category: benzofurans. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about The effect of bradykinin and anti-inflammatory agents on isolated arteries. Author is Starr, M. S.; West, Geoffrey Buckle.

All artery preparations (pulmonary, ear, femoral, mesenteric, brachial, and carotid arteries) from guinea pigs were constricted by bradykinin (0.1-10 γ), but only those of the pulmonary vessels of the rat and rabbit responded in this way. The vasoconstrictor action of bradykinin on the isolated mammalian arteries was antagonized by Na phenylbutazone, Na mefenamate, Na flufenamate, Na meclofenamate, and Ca acetylsalicylate when the latter were administered by slow infusion (0.1-2.5 mg./min.) However, the same concentrations of the antagonists also antagonized the vasoconstrictor responses to histamine, 5-hydroxytryptamine, acetylcholine, noradrenaline, and kallidin, thus indicating that the antagonism was nonspecific.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Solberg, Claus O.; Allred, Craig D.; Hill, Harry R. researched the compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide( cas:129-18-0 ).Name: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide.They published the article 《Influence of phenylbutazone on leukocyte chemiluminescence and function》 about this compound( cas:129-18-0 ) in Acta Pathologica et Microbiologica Scandinavica, Section C: Immunology. Keywords: phenylbutazone leukocyte chemiluminescence. We’ll tell you more about this compound (cas:129-18-0).

The effect of Na phenylbutazone (I Na salt) [129-18-0] on human leukocyte chemiluminescence, phagocytosis and intracellular killing of bacteria was examined A marked reduction of chemiluminescence and intracellular killing of bacteria was observed The effect on phagocytosis was less pronounced. High drug concentrations nearly abolished light emission, and concentrations equivalent to those obtained in plasma during therapy caused a 25-30% reduction The effect occurred within less than 10 min after I administration. No permanent effect upon resting cells was observed I reduced the effect of Na azide on leukocyte chemiluminescence, indicating that the drug might also inhibit myeloperoxidase dependent chemiluminescence. Whether these impairments of leukocyte function also take place in vivo resulting in enhanced susceptibility to infection remains unknown.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine( cas:767291-67-8 ) is researched.COA of Formula: C20H42N2.Gu, Xiaoyu; Tang, Yan; Zhang, Xiang; Luo, Zinbin; Lu, Hongfei published the article 《Organocatalytic Knoevenagel condensation by chiral C2-symmetric tertiary diamines》 about this compound( cas:767291-67-8 ) in New Journal of Chemistry. Keywords: aldehyde malonate chiral diaminocyclohexane enantioselective Knoevenagel condensation organocatalyst; unsaturated diester stereoselective preparation dynamic kinetic resolution. Let’s learn more about this compound (cas:767291-67-8).

The efficient Knoevenagel condensation catalyzed by (1S,2S)-1,2-diaminocyclohexane derivatives is presented and investigated. Various aliphatic aldehydes undergo condensation with active methylene compounds to yield the corresponding products in high yields. α-Branched aldehydes were found to be efficiently converted to the corresponding enantiomerically enriched products by using these chiral tertiary diamine catalysts.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The antianaphylactic activity of pyrazolone derivatives in the rabbit》. Authors are Lecomte, J..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Recommanded Product: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide. Through the article, more information about this compound (cas:129-18-0) is conveyed.

Intravenous injection of 1,5-dimethyl-2-phenyl-3-pyrazolone (antipyrine), 4-dimethylamino-1,5-dimethyl-2-phenyl-3-pyrazolone (pyramidon), Na (antipyrinylmethylamino)methanesulfonate (Noval-gin), or 4-butyl-1-phenyl-3,5-dioxopyrazolidine piperazine salt (I) (all at 10 mg./kg.) into rabbits produced a decrease in blood pressure of 1-2 cm., which lasted for 2 min. A similar injection of phenylbutazone II, 4-butyl-1,2-diphenyl-3,5-dioxopyrazolidine piperazine salt (III), or irgapyrine (a 1:1 mixture of pyramidon and phenylbutazone) produced a hypotension of 2-4 cm.; II produced generalized convulsions in some rabbits. Intravenous injection of II or III; irgapyrine; pyramidon, antipyrine, or Novalgin; or I (in order of decreasing activity) (all at 100 mg./kg.) suppressed or reduced arterial hypotension during anaphylactic shock in rabbits previously sensitized with egg white albumin. Only the diphenyl derivatives of pyrazolone completely suppressed the hypotension, which was often replaced by hypertension; this latter effect depends on a direct stimulation of the adrenal medulla by antigen-antibody reactions. The piperazine salt of II showed the same protective activity as the Na salt of II, while I was less active than III. Intravenous injection of 150 mg. II/kg. also showed antiallergic action in rabbits sensitized with human erythrocytes, which shows that this action is independent of the nature of the antigen. However, II did not suppress all the effects of anaphylactic shock, since the formation of clumps of erythrocytes in the blood and thrombopenia were not inhibited. The protective action of II is not directed against immunological phenomena in the plasma, but probably lies in a modification of tissue reactions during shock. 15 references.

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Application of 129-18-0. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Objective and timing of drug disposition studies. IV. Phenylbutazone formulations. In vitro dissolution and in vivo performance.

GP 26872 [129-18-0] (a glycerin solution of phenylbutazone Na salt) produced a more rapid onset of plasma levels of phenylbutazone (I) [50-33-9] as well as higher maximum concentration than pure I but the amount of drug absorbed was not significantly different. The dissolution rate of capsules was in the following decreasing order: pure GP 26872 > pure I > formulated I > formulated GP 26872. A film coated I tablet gave an average plasma level of ∼15 μg/ml in 30 min, whereas with a sugar coated tablet these peak levels were not attained until 3 hr. Peak levels were 34 and 57 μg/ml with the film coated tablet and 19 and 32 μg/ml with the sugar coated tablet. I was pure I in capsules.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide(SMILESS: O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+],cas:129-18-0) is researched.Related Products of 1265884-98-7. The article 《Influence of various drugs on the tissue permeability. II》 in relation to this compound, is published in Nippon Yakurigaku Zasshi. Let’s take a look at the latest research on this compound (cas:129-18-0).

The effects of drugs containing antiinflammatory agents administrated systemically on the dermal connective tissue permeability in rats were tested by a spreading method based on the rate of diffusion of Evans blue solution after intradermal injection. Antiinflammatory agents decreased the tissue permeability following s.c. and oral administration. In most cases, there were dose-response relations. Intensity of the inhibitory effect of the tissue permeability was in the order: dexamethasone, indometacin (I), prednisolone, phosphate, Na bucolome (II), hydrocortisone acetate (III), Na, phenylbutazone, flufenamic acid, N-(o-methoxybenzoyl)glycine dimethylamide, benzydamine-HCl (IV), 4-chloro-5-sulfamoyl-anthranilic acid, mefenamic acid, aminopyrine (V), acetylsalicylic acid (VI), Na salicylate (VII), pronase AS, and bromelain. When II, III, V, and VII were combined with l-ascorbic acid their inhibitory effects were enhanced in both s.c. and oral administration, while the inhibitory effect in oral administration of I, IV, and VI was enhanced.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem