Tag: 200-300

In vivo vocal fold augmentation using an injectable polyethylene glycol hydrogel based on click chemistry was written by Kwon, Soonmin;Choi, Hyunsu;Park, Changhee;Choi, Sangkee;Kim, Eunha;Kim, Sung Won;Kim, Choung-Soo;Koo, Heebeom. And the article was included in Biomaterials Science in 2021.Name: 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione This article mentions the following:

It is important to focus on urgent needs in clinics and develop optimal materials. For successful augmentation of vocal folds, the ideal filler should be injectable through a syringe, and should stably maintain its volume for a long time without toxicity. To achieve these criteria, a click chem.-based PEG (polyethylene glycol) hydrogel was developed and applied for vocal fold augmentation in vivo. The PEG hydrogel enables fast gelation in vivo after injection and provides long-term stability. Azide- and dibenzocyclooctyne (DBCO)-modified 4-arm PEG were crosslinked by chem. conjugation via click chem. and yielded gelation within several minutes. After s.c. injection into mice and rats, the PEG hydrogel showed higher stability after 1 mo compared to the traditionally used calcium hydroxyapatite-CM-cellulose (CaHA-CMC) filler. In rabbit models with vocal fold paralysis, the PEG hydrogel stably fixed the paralyzed vocal fold in 4 mo and minimized the glottic gap. It was an improved therapeutic result compared to CaHA-CMC, demonstrating the potential of a click chem.-based PEG hydrogel for vocal fold therapy. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Name: 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Name: 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Fluorogenic Quantification of Albumin was written by Low, Michelle;Win, Khin Yin;Ye, Enyi;Liu, Shuhua;Ng, Soon Huat;Zhou, Xiaoqun;Han, Ming-Yong. And the article was included in Australian Journal of Chemistry in 2014.Recommanded Product: 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione This article mentions the following:

By optimizing various fluorogenic dyes, non-fluorescent fluorescamine can react with primary amines to form highly fluorescent products, which is a simple, fast, and sensitive method for the quantification of albumin. The effects of pH, temperature, and chems. were studied systematically to quantify albumin. The quantification method is more sensitive at alk. pHs, affording measurement of proteins concentrations as low as 15 μg mL^-1. Denaturation of albumin at elevated temperatures and/or use of chems., such as ethanol and acetone, can greatly improve the sensitivity of the albumin detection method. The simple, accurate, and reliable anal. of albumin contents under favorable conditions can be developed as an important method for early diagnosis of kidney disease. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Recommanded Product: 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Recommanded Product: 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Fluorescamine Labeling for Assessment of Protein Conformational Change and Binding Affinity in Protein-Nanoparticle Interaction was written by Duan, Yaokai;Liu, Yang;Shen, Wen;Zhong, Wenwan. And the article was included in Analytical Chemistry (Washington, DC, United States) in 2017.Recommanded Product: 38183-12-9 This article mentions the following:

Protein adsorption alters the “biol. identity” of nanoparticles (NPs) and could affect how biosystems respond to invading NPs. Study of protein-NP interaction can help understand how the physicochem. properties of NPs impact the interaction and thus potentially guide the design of safer and more effective NPs for biomedical or other applications. Binding affinity between proteins and NPs and the occurrence of protein conformational change upon binding to NPs are two important aspects to be learned, but few methods are currently available to assess both simultaneously in a simple way. Herein, the fluorescamine labeling method developed by the authors’ group not only could reveal protein conformational change upon adsorption to NPs, owing to its capability to label the primary amines exposed on protein surface, but also could be applied to measure the binding affinity. By screening the interaction between a large number of proteins and four types of NPs, the present study also revealed that protein adsorption onto NPs could be strongly affected by structure flexibility. The proteins with high structure flexibility experienced high degrees of conformation change when binding to the polystyrene NPs, which could potentially influence protein function. Overall, the authors’ assay is a quick, simple, and high-throughput tool to reveal potential impacts on protein activity and evaluate the strength of protein-NP binding. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Recommanded Product: 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Recommanded Product: 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Nontargeted detection and identification of (aromatic) amines in environmental samples based on diagnostic derivatization and LC-high resolution mass spectrometry was written by Muz, Melis;Ost, Norbert;Kuehne, Ralph;Schueuermann, Gerrit;Brack, Werner;Krauss, Martin. And the article was included in Chemosphere in 2017.Name: 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione This article mentions the following:

The presence of aromatic amines in the environment has been in the focus of research, as many of these compounds are known or suspected mutagens and carcinogens. To facilitate the detection of aromatic amines in complex environmental samples by LC-high resolution mass spectrometry, an online-post-column and a pre-column derivatization method to label (in an ideal case) all aromatic amines was evaluated by applying different derivatization reagents. 4-Fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F) was found to be the most promising labeling reagent due to its high reactivity with both primary and secondary amines and its low signal in pos. mode electrospray ionization (ESI+). Post-column online derivatization did not result in sufficient signal intensities of derivatives With pre-column derivatization most of the selected aromatic amines resulted in a derivative that shows common fragments of diagnostic value. The selectivity of NBD-F was studied in depth with a data set of 220 compounds with different functional groups showing that also aliphatic amines and some thiols yield a derivative The developed method was successfully applied to wastewater effluent samples and several derivatives were confirmed by diagnostic neutral losses. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Name: 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Name: 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Diarylpyrrolone based fluorophore for the selective spectrofluorometric method for determination of Linagliptin antidiabetic drug in pharmaceutical tablets was written by Omar, Mahmoud A.;Haredy, Ahmed M.;Saleh, Gamal A.;Naggar, A. H.;Derayea, Sayed M.. And the article was included in Microchemical Journal in 2019.Formula: C17H10O4 This article mentions the following:

Linagliptin (LNG) is a type 2 antidiabetic drug which belongs to dipeptidyl peptidase 4 inhibitors. In this paper a simple and sensitive spectrofluorometric method was developed and validated for the determination of LNG. The method employed the interaction of the primary amino group of the cited drug with fluorescamine reagent in aqueous borate buffer (pH 8.5) to produce a highly fluorescent product. The emission of the formed product was measured at 479 nm after excitation at 390 nm. Different exptl. parameters that may affect the product formation or its fluorescence intensity were investigated and adjusted. The method has a good linearity in the concentration range of 0.2 – 2.0 μg mL^-1of LNG with a detection limit of 0.079 μg mL^-1. The performance of the developed method was evaluated according to the International Conference for Harmonization (ICH). The method was successfully applied for the anal. of tablets dosage form that contained the cited drug. The results of the anal. were compared with the reported method and indicated good accuracy and precision of the proposed procedure. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Formula: C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Formula: C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A sequential injection fluorimetric methodology with in-line solid phase extraction for biogenic amines screening in water was written by Ribas, Tania C. F.;Toth, Ildiko V.;Rangel, Antonio O. S. S.. And the article was included in International Journal of Environmental Analytical Chemistry in 2019.Reference of 38183-12-9 This article mentions the following:

A method for the screening of biogenic amines in waters, whose presence at some concentration levels potentially cause adverse effects on humans, was developed for the first time. A suitable and easy to operate system, with low reagent consumption was devised. The proposed flow-based system was divided into two anal. parts, preconcentration and derivatization of the biogenic amines. Solid phase extraction, using a Chelex 100 resin, was the newly chosen strategy for preconcentration of the analyte and also removal of possible matrix interferences. Fluorescamine was used as derivatization reagent for biogenic amines followed by fluorimetric detection. The influence of different sorbent materials for preconcentration and flow system parameters such as pH of standards and buffer, composition of the eluent solution, flow-rates, standard/sample volume, were studied. The interference of ammonia was assessed, and no interference was observed The limits of detection and quantification were 1.7 and 5.6μmol L^-1, resp. The developed system was applied to water samples and the recovery results were 98 ± 7%. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Reference of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Reference of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A pantetheinase-resistant pantothenamide with potent, on-target, and selective antiplasmodial activity was written by Macuamule, Cristiano J.;Tjhin, Erick T.;Jana, Collins E.;Barnard, Leanne;Koekemoer, Lizbe;de Villiers, Marianne;Saliba, Kevin J.;Strauss, Erick. And the article was included in Antimicrobial Agents and Chemotherapy in 2015.Category: benzofurans This article mentions the following:

Pantothenamides inhibit blood-stage Plasmodium falciparum with potencies (50% inhibitory concentration [IC50], ∼20 nM) similar to that of chloroquine. They target processes dependent on pantothenate, a precursor of the essential metabolic cofactor CoA. However, their antiplasmodial activity is reduced due to degradation by serum pantetheinase. Minor modification of the pantothenamide structure led to the identification of α-methyl-N-phenethyl-pantothenamide, a pantothenamide resistant to degradation, with excellent antiplasmodial activity (IC50, 52 ± 6 nM), target specificity, and low toxicity. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Category: benzofurans).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A facile synthesis of bromo-substituted benzofuran containing thiazolidinone nucleus bridged with quinoline derivatives. Potent analgesic and antimicrobial agents was written by Bhovi, Venkatesh K.;Bodke, Yadav D.;Biradar, S.;Swamy, B. E. Kumara;Umesh, S.. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 2010.Electric Literature of C10H7BrO2 This article mentions the following:

Treatment of 5-bromo-2-acetylbenzofuran with hydrazine followed by condensation of the resulting hydrazone with different quinoline derivatives gave the corresponding Schiff bases. Reaction of these Schiff bases with thioacetic acid furnished the target thiazolidinone mol. Some of the newly synthesized compounds show promising analgesic and antimicrobial activity. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Electric Literature of C10H7BrO2).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Electric Literature of C10H7BrO2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Salvage parenteral antibiotics for multidrug-resistant (MDR) Gram-negative bacteria; a fluorescamine-based technique for ultrasensitive spectrofluorimetric measurement of Polymyxins; human plasma application was written by Badr El-Din, Khalid M.;Abdelmajed, Mahmoud A.;Omar, Mahmoud A.;Attia, Tamer Z.. And the article was included in Luminescence in 2022.Computed Properties of C17H10O4 This article mentions the following:

Polymyxins (PMS), namely Colistin (CS) and polymyxin B (poly B), are antimicrobial drugs that have been recently used to treat multiresistant Gram-neg. bacteria infections and their resurgence, owing to a lack of new antibiotics. A speedy, simple, and ultrasensitive spectrofluorimetric screening of PMS in pharmaceutical formulations and biol. fluids was urgently required from this point forwards. A reaction between fluorescamine and the aliphatic amino moiety found in both drugs was performed in a slightly alk. borate buffer (pH 8.5) resulted in highly fluorescent products measured at λ_em 460 (after λ_ex 390.5 nm). Linear calibration curves were constructed over the concentration range 70-1800 ng ml^-1 and 100 to 1400 ng ml^-1, with slope values of 0.273 and 0.286, correlation coefficients of 0.9998 and 0.9997, and determination coefficient of 0.9997 and 0.9994 for poly B and CS, resp. The ultrasensitivity of the proposed method was demonstrated by the very low limit of quantification values of 67.56 ng ml^-1 and 94.89 ng ml^-1 for poly B and CS, resp. The cited drugs were successfully determined in their i.v. market preparations by the prescribed method. Moreover, due to the high sensitivity, the suggested method was used to assay the investigated drugs in biol. fluids. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Computed Properties of C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Computed Properties of C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Electrochemical Detection of Ammonia in Aqueous Solution Using Fluorescamine: A Comparison of Fluorometric Versus Voltammetric Analysis was written by Panchompoo, Janjira;Compton, Richard G.. And the article was included in Dianhuaxue in 2012.Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione This article mentions the following:

Fluorescamine is a non-fluorescent reagent widely used for the quant. determination o f primary amines by fluorescence spectroscopy as it reacts readily with primary amines to form a fluorescent product. In this work, a new sensitive voltammetric method for the detection of ammonia in aqueous solution by the reaction with fluorescamine was developed. First, the electrochem. behavior of fluorescamine in the absence and presence o f ammonia was investigated in 0.1 mol·L^-1 borate buffer solution (pH 9.0) by cyclic voltammetry using a glassy carbon (GC) electrode. As for fluorescamine itself, a well-defined irreversible oxidation peak could be observed at ∼0.70 V vs. SCE. When ammonia was added to the fluorescamine solution, another irreversible oxidation peak corresponding to the oxidation o f the reaction product formed between fluorescamine and ammonia could be observed at ∼0.46 V vs. SCE. Upon the addition of ammonia, the oxidation peak o f fluorescamine became smaller while the oxidation peak o f the reaction product formed increased in height, due to the stoichiometric chem. consumption o f fluorescamine by ammonia and the formation o f the product during the reaction, resp. These two anodic peaks corresponding to the oxidation of fluorescamine and its fluorescent product formed were then used for the quant. detection o f ammonia, explored by square wave voltammetry and by fluorescence spectroscopy. The square wave voltammetric response o f the reaction product formed showed a linear response over ammonia concentration range o f 0 to 60 μmol-L^-1. The limits o f detection (LOD) was 0.71 μmol·L^-1 and 3.17 μmol-L^-1 determined based upon Signal/Noise (S/N) = 3 and 3cr, resp. These limits o f detection are similar to those obtained with the fluorometric method. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem