Tag: 200-300

Synthesis of Heterocycle-fused Pyridine N-Oxides from Oximes and Diazo Compounds via Rh^III-Catalyzed C-H Activation and Annulation was written by Sun, Peng;Wu, Youzhi;Yang, Tie;Wu, Xiaoming;Xu, Jinyi;Lin, Aijun;Yao, Hequan. And the article was included in Advanced Synthesis & Catalysis in 2015.Product Details of 38220-75-6 This article mentions the following:

A Rh^III-catalyzed tandem C-H activation and C-N bond formation reaction between oximes and diazo compounds for the synthesis of heterocycle-fused pyridine N-oxides was developed. The reaction exhibited good functional group tolerance and regioselectivity. After simple transformation, the 1-substituted, 1,3-disubstituted, 1,4-disubstituted and 1,3,4-trisubstituted heterocycle-fused pyridines were obtained in high efficiency. The strategy was expanded to the synthesis of a key intermediate for the construction of one potential anti-HIV agent. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Product Details of 38220-75-6).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Product Details of 38220-75-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Enzymatic vitreolysis using reengineered Vibrio mimicus-derived collagenase was written by Santra, Mithun;Sharma, Maryada;Katoch, Deeksha;Jain, Sahil;Saikia, Uma Nahar;Dogra, Mangat R.;Luthra-Guptasarma, Manni. And the article was included in Molecular Vision in 2021.Reference of 38183-12-9 This article mentions the following:

Collagen is a key player contributing to vitreoelasticity and vitreoretinal adhesions. Mol. reorganization causes spontaneous weakening of these adhesions with age, resulting in the separation of the posterior hyaloid membrane (PHM) from the retina in what is called complete posterior vitreous detachment (PVD). Incomplete separation of the posterior hyaloid or tight adherence or both can lead to retinal detachment, vitreomacular traction syndrome, or epiretinal membrane formation, which requires surgical intervention. Pharmacol. vitrectomy has the potential of avoiding surgical vitrectomy; it is also useful as an adjunct during retinal surgery to induce PVD. Previously studied enzymic reagents, such as collagenase derived from Clostridium histolyticum, are nonspecific and potentially toxic. We studied a novel collagenase from Vibrio mimicus (VMC) which remains active (VMA), even after deletion of 51 C-terminal amino acids. To limit the activity of VMA to the vitreous cavity, a fusion construct (inhibitor of hyaluronic acid-VMA [iHA-VMA]) was made in which a 12-mer peptide (iHA, which binds to HA) was fused to the N-terminus of VMA. The construct was evaluated in the context of PVD. VMA and iHA-VMA were expressed in Escherichia coli, purified, and characterized with gelatin zymog., collagen degradation assay, fluorescamine-based assay, and cell-based assays. Two sets of experiments were performed in New Zealand albino rabbits. Group A (n = 10) received iHA-VMA, while group B (n = 5) received the equivalent dose of VMA. In both groups, saline was injected as a control in the contralateral eyes. Animals were monitored with indirect ophthalmoscopy, optical coherence tomog. (OCT), and B-scan ultrasonog. Retinal toxicity was assessed with hematoxylin and eosin (H&E) staining of retinal tissue. The activity of iHA-VMA and VMA was comparable and 65-fold lower than that of C. histolyticum collagenase Type IV. In the iHA-VMA group, all the rabbits (n = 10) developed PVD, with complete PVD seen in six animals. No statistically significant histomorphol. changes were seen. In the VMA group, four of the five rabbits developed complete PVD; however, retinal morphol. changes were seen in two animals. IHA-VMA displays targeted action confined to the vitreous and shows potential for safe pharmacol. vitreolysis. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Reference of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Reference of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A Free-Standing Self-Assembled Tubular Conjugated Polymer Sensor was written by Oh, Seungwhan;Uh, Kyungchan;Jeon, Seongho;Kim, Jong-Man. And the article was included in Macromolecules (Washington, DC, United States) in 2016.Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione This article mentions the following:

Tubular materials created by self-assembly of small organic mols. have gained great attention recently. Fabrication of tubular structures that have precise dimensions by using conventional self-assembly approaches is extremely challenging. Herein we describe fabrication of a free-standing tubular polydiacetylene (PDA) sensor based on the meniscus-guided self-assembly and polymerization of diacetylene (DA) monomers. The free-standing single PDA tube can be utilized as an unprecedented microcapillary-based sensor system, which requires only a min. amount (70-140 nL) of an analyte solution We have observed 4 orders of magnitude more sensitive to analytes than is a conventional PDA sensor when a biotin-functionalized PDA tube is exposed to streptavidin. The microcapillary-based anal. method developed in this study should find great utility not only for PDA sensors but also for other free-standing wire sensor systems. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Computational Predictions of Glass-Forming Ability and Crystallization Tendency of Drug Molecules was written by Alhalaweh, Amjad;Alzghoul, Ahmad;Kaialy, Waseem;Mahlin, Denny;Bergstroem, Christel A. S.. And the article was included in Molecular Pharmaceutics in 2014.Recommanded Product: 38183-12-9 This article mentions the following:

Amorphization is an attractive formulation technique for drugs suffering from poor aqueous solubility as a result of their high lattice energy. Computational models that can predict the material properties associated with amorphization, such as glass-forming ability (GFA) and crystallization behavior in the dry state, would be a time-saving, cost-effective, and material-sparing approach compared to traditional exptl. procedures. This article presents predictive models of these properties developed using support vector machine (SVM) algorithm. The GFA and crystallization tendency were investigated by melt-quenching 131 drug mols. in situ using differential scanning calorimetry. The SVM algorithm was used to develop computational models based on calculated mol. descriptors. The analyses confirmed the previously suggested cutoff mol. weight (MW) of 300 for glass-formers, and also clarified the extent to which MW can be used to predict the GFA of compounds with MW < 300. The topol. equivalent of Grav3_3D, which is related to mol. size and shape, was a better descriptor than MW for GFA; it was able to accurately predict 86% of the data set regardless of MW. The potential for crystallization was predicted using mol. descriptors reflecting Hückel pi at. charges and the number of hydrogen bond acceptors. The models developed could be used in the early drug development stage to indicate whether amorphization would be a suitable formulation strategy for improving the dissolution and/or apparent solubility of poorly soluble compounds In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Recommanded Product: 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Recommanded Product: 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Design, synthesis and biological evaluation of benzofuran appended benzothiazepine derivatives as inhibitors of butyrylcholinesterase and antimicrobial agents was written by Mostofi, Manizheh;Mohammadi Ziarani, Ghodsi;Lashgari, Negar. And the article was included in Bioorganic & Medicinal Chemistry in 2018.Reference of 38220-75-6 This article mentions the following:

A series of benzofuran appended 1,5-benzothiazepine compounds I (R¹ = H, 5-Br, 5-NO₂, 7-OMe; R² = 4-OH, 1-naphthyl, 3-indolyl, etc.) was designed, synthesized and evaluated as cholinesterase inhibitors. The biol. assay experiments showed that most of the compounds displayed a clearly selective inhibition for butyrylcholinesterase (BChE), while a weak or no effect towards acetylcholinesterase (AChE) was detected. All analogs exhibited varied BChE inhibitory activity with IC₅₀ value ranging between 1.0 +/- 0.01 and 72 +/- 2.8 μM when compared with the standard donepezil (IC₅₀, 2.63 +/- 0.28 μM). Among the synthesized derivatives, compounds I (R¹ = 5-Br; R² = 2-MeO, 3-MeO, 4-MeO) exhibited the highest BChE inhibition with IC₅₀ values of 1.0, 1.0 and 1.8 μM, resp. The results from a Lineweaver-Burk plot indicated a mixed-type inhibition for compound I (R¹ = 5-Br; R² = 3-MeO) with BChE. In addition, docking studies confirmed the results obtained through in vitro experiments and showed that most potent compounds bind to both the catalytic anionic site (CAS) and peripheral anionic site (PAS) of BChE active site. The synthesized compounds were also evaluated for their in vitro antibacterial and antifungal activities. The results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms and showed high activity against both gram pos. and gram neg. bacteria and fungi. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Reference of 38220-75-6).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Reference of 38220-75-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Titration of lysine residues on adenine nucleotide translocase by fluorescamine induces permeability transition was written by Buelna-Chontal, Mabel;Pavon, Natalia;Correa, Francisco;Hernandez-Esquivel, Luz;Chavez, Edmundo. And the article was included in Cell Biology International in 2014.HPLC of Formula: 38183-12-9 This article mentions the following:

Chem. modification of primary amino groups of mitochondrial membrane proteins by the fluorescent probe, fluorescamine (I), induced nonspecific membrane permeabilization. Titration of the Lys ε-amino group promoted efflux of accumulated Ca²⁺, collapse of transmembrane potential, and mitochondrial swelling. Ca²⁺ release was inhibited by cyclosporin A. Considering the latter, the authors assumed that I induced the permeability transition. Carboxyatractyloside also inhibited the reaction. Using a polyclonal antibody for adenine nucleotide translocase, Western blot anal. showed that the carrier appeared labeled with I. The results pointed out the importance of the ε-amino group of Lys residues, located in the adenine nucleotide carrier, on the modulation of membrane permeability, since its blockage suffices to promote opening of the nonspecific nanopore. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9HPLC of Formula: 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.HPLC of Formula: 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis and biological activities of some new benzofuranopyrazoles was written by Tirlapur, Vijay Kumar;Prasad, Y. Rajendra;Basawaraj, Raga. And the article was included in Indian Journal of Heterocyclic Chemistry in 2010.Electric Literature of C10H7BrO2 This article mentions the following:

1-(5-Bromo-1-benzofur-2-yl)ethanone hydrazone upon treatment with Vilsmeier-Haack reagent underwent cyclization to give 3-(5-bromo-1-benzofur-2-yl)-1H-pyrazole-4-carbaldehyde (I), which further on treatment with acetophenones afforded the corresponding 1-aryl-3-[3-(5-bromo-1-benzofur-2-yl)-1H-pyrazol-4-yl]prop-2-en-1-ones. The reaction of I with aromatic amines in MeOH and also with aromatic amines in the presence of CH₂O in dioxan (Mannich reaction) furnished pyrazoles. All newly synthesized compounds were characterized by IR, ¹H NMR, and mass spectra and were screened for analgesic, antibacterial, and antifungal activity. Some of the compounds showed good activity when compared with standard drugs. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Electric Literature of C10H7BrO2).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Electric Literature of C10H7BrO2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Aminodextran-coated potassium niobate (KNbO₃) nanocrystals for second harmonic bio-imaging was written by Ladj, Rachid;Magouroux, Thibaud;Eissa, Mohamed;Dubled, Marc;Mugnier, Yannick;Dantec, Ronan Le;Galez, Christine;Valour, Jean-Pierre;Fessi, Hatem;Elaissari, Abdelhamid. And the article was included in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2013.Application In Synthesis of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione This article mentions the following:

Potassium niobate (KNbO₃) nanocrystals exhibiting good second harmonic generation properties were coated with dextran derivatives containing primary amine groups. The surface modification results from attractive electrostatic interaction between the aminodextran mols. and the neg. charged surface of bare KNbO₃ nanocrystals. To avoid flocculation, a suspension of KNbO₃ nanocrystals was firstly prepared and then added drop-wise to an aqueous solution of aminodextran. The as-prepared hybrid (AD-coated KNbO₃) nanoparticles were then characterized by using various techniques including transmission electron microscopy (TEM), IR anal. (FTIR), dynamic light scattering (DLS) and zeta potential measurements as a function of pH of the dispersion medium. Then, the prepared AD- coated KNbO₃ nanoparticles were evaluated in vitro diagnostic application as biomarker for non-tumor lung-derived human cells. The obtained results showed that the aminodextran-coated KNbO₃ nanoparticles were efficiently bound to the non-tumor lung-derived human cells, which was proved by using a com. Nikon multi-photon imaging platform. In addition, AD-coated KNbO₃ nanoparticles showed good optical contrast for the investigated cells, and consequently they can be efficiently used as contrast agents in the bio-imaging diagnostic domain. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Application In Synthesis of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Application In Synthesis of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Surface functionalization of silica nanoparticles to enhance aging resistance of asphalt binder was written by Karnati, Sidharth Reddy;Oldham, Daniel;Fini, Elham H.;Zhang, Lifeng. And the article was included in Construction and Building Materials in 2019.HPLC of Formula: 38183-12-9 This article mentions the following:

Oxidation aging of asphalt pavement is among most prevalent factors causing pavement distresses. Introduction of silica nanoparticles (SNPs) has been found promising to reduce oxidation aging of asphalt binder. However, the effectiveness of SNPs is limited by their poor dispersion caused mainly by SNP agglomeration requiring significant mech. energy in processing to ensure dispersion. This paper examined merits of surface functionalization of SNPs with (3-aminopropyl) triethoxysilane (APTES) to improve its dispersion in asphalt binder using conventional processing techniques at relatively high loading of SNPs with low mech. energy input. The morphol., size, amount of amine functional groups of APTES surface-modified SNPs (APTES-SNPs) were characterized and optimized by scanning electron microscope (SEM), dynamic light scattering (DLS), Fourier-transform IR spectroscopy (FTIR) and fluorescence measurement. The comparison between the surface-modified and pristine SNPs on the anti-aging and rheol. properties of asphalt binder was conducted. The asphalt binders which contained APTES-SNPs demonstrated much better resistance to oxidative aging as evidenced by enhanced rheol. properties compared to those containing pristine SNPs. The findings from this research provides insights as to the effect of APTES-SNPs on aging resistance of asphalt binder. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9HPLC of Formula: 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.HPLC of Formula: 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Microstructural Aspects of Particle-Assisted Breath Figures in Polystyrene-Alumina Hybrid Free Standing Film was written by Vijaya, Lakshmi;Rajan, Ramya;Raju, Annu;Rajan, Thazhavilai Ponnu Devaraj;Pavithran, Chorappan. And the article was included in Journal of Physical Chemistry C in 2017.Recommanded Product: 38183-12-9 This article mentions the following:

Polystyrene-alumina hybrid free standing films with amino-functionalized breath figure (BF) cavities were fabricated from a suspension of the amino-functionalized amphiphilic-modified alumina particles in polystyrene/chloroform solution by employing a one-step casting process. The role of the film thickness and the particle concentration on the BF microstructural aspects such as the pore size, pore d., amino group surface d., etc. was reported. The dry film thickness increased from 0.91 to 5.6 μm on increasing the wet film thickness from 0.2 to 1 mm. The pore size increased with the film thickness, while the pore d. and the porosity decreased. Relatively uniform pore size was observed for an ∼3 μm thick film in which the moderately ordered BF pattern was more or less maintained up to a particle concentration of 5 wt % of the polystyrene content. While the 0.91 μm thick film exhibited through-pore structure, concavities were formed in thicker films. The particle-assisted BF formation favored the formation of amino-functionalized cavities. The surface d. of the amino functionality reduced on increasing the film thickness, whereas the d. increased with the particle concentration The implications were discussed. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Recommanded Product: 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Recommanded Product: 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem