Category: benzofurans

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Actions of 5-(1,3-dimethylbutyl)-5-ethylbarbituric acid, pentobarbital, amobarbital and thiopental on the sinoatrial nodal activity of the isolated heart》. Authors are Schaer, Hansjuerg.The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Related Products of 129-18-0. Through the article, more information about this compound (cas:129-18-0) is conveyed.

The convulsant barbiturate, Na 5-(1,3-dimethylbutyl)-5-ethyl barbiturate (DMBEB) exerts a dual action on isolated spontaneously beating guinea pig atria suspended in Krebs-Henseleit solution at 37°. At concentrations from 0.001 to 0.01 mg./ml., it has predominantly a transient rate-increasing effect, whereas at higher concentrations, an addnl. neg. chronotropic action appears. Experiments with atria of reserpine-pretreated guinea pigs (3 mg./kg., 24 hrs.) and experiments with β-receptor blockade have shown that the rate-increasing effect of DMBEB is not mediated by released norepinephrine and the DMBEB probably has no direct action on adrenergic β-receptors. Na pentobarbital and Na amobarbital, though structurally related to DMBEB, exhibit exclusively a neg. chronotropic action. Their neg. chronotropic effect is identical; it occurs in the same concentration range in which DMBEB manifests its rate-decreasing effect on the sino-atrial node. Na thiopental is more potent in its rate-decreasing effect than are Na pentobarbital and Na amobarbital.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Formula: C6H11ClO3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about Asymmetric synthesis of ethyl 4-chloro-(R)-3-hydroxybutyrate with baker’s yeast. Author is Yi, Ming-jun; Song, Guang-liang; Zhu, Hong-jun; Wang, Jin-tang.

Optically active Et 4-chloro-(R)-3-hydroxybutyrate was prepared by stereoselective bioreduction of Et 4-chloro-acetoacetate with baker’s yeast. Its structure was elucidated by IR,GC-MS and 1HNMR.The factors influencing the synthesis were investigated. The results showed that the optimal reaction condition as follows: baker’s yeast 600 g/L, mass concentration of glucose 20 g/L, feeding rate of substrate 16 mL/L,pH 5, reaction time 48 h, temperature 34 °C. The sp. rotation of the product was [α]20D = +13.9°.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about Asymmetric reduction of ethyl 4-chloroacetoacetate to ethyl (R)-(+)-4-chloro-3-hydroxybutyrate by recombinant Escherichia coli.Electric Literature of C6H11ClO3.

The NADPH-dependent aldehyde reductase gene was cloned from the genome of Sporobolomyces salmonicolor ZJU0105, and the recombinant E. coli BL21 (pET28-ALR0105) strain was constructed. The asym. reduction of Et 4-chloroacetoacetate (COBE) to Et (R)-(+)-4-chloro-3-hydroxybutyrate ((R)-CHBE) by the recombinant cells in an aqueous phase was investigated. The product is optically pure (R)-CHBE, and both the (R)-CHBE yield and stereoselectivity are higher than those in the reaction catalyzed by Sporobolomyces salmonicolor. The glucose dehydrogenase, NADPH and glucose are required for the recombinant cells to regenerate NADPH. The reaction is also inhibited by high concentration of COBE and CHBE, but high d. of recombinant cells can decrease this inhibitory effect. A yield of 96.5% and ee of 99% for (R)-CHBE are obtained under the appropriate reaction conditions.

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Benzofuran – Wikipedia,
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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 70539-42-3, is researched, SMILESS is O=C(ON1C(CCC1=O)=O)CCC(OCCOC(CCC(ON2C(CCC2=O)=O)=O)=O)=O, Molecular C18H20N2O12Journal, Article, Research Support, U.S. Gov’t, P.H.S., Biochemistry called Isolation of a proteolytically derived domain of the insulin receptor containing the major site of cross-linking/binding, Author is Waugh, Stephen M.; DiBella, Elsie E.; Pilch, Paul F., the main research direction is insulin receptor binding crosslinking site.HPLC of Formula: 70539-42-3.

Radiolabeled insulin was affinity crosslinked to purified insulin receptor with 6 sep. bifunctional N-hydroxysuccinimde esters of different lengths. Results were qual. identical for each crosslinker in that insulin was predominantly crosslinked through its B chain to the receptor’s α subunit. The maximum efficiencies of crosslinking were 10-15% for the most effective reagents, and this value was dependent upon the concentration and length of the crosslinker. In an effort to locate the crosslinking site, monoiodoinsulin was crosslinked to affinity-purified insulin receptor with disuccinimidyl suberate. Limited proteolysis of the hormone/receptor adduct with Staphylococcus aureus V8 protease, chymotrypsin, or thermolysin in an SDS-containing buffer rapidly generated a 55-kDa, insulin-labeled fragment as shown by SDS-PAGE. It was reported earlier that the 55-kDa chymotryptic fragment contained multiple internal SS bonds as evidenced by its shifting mobility on an SDS gel after dithiothreitol treatment. The 55-kDa fragment is also formed by proteolysis of the receptor in the absence of prior insulin crosslinking. This fragment was prepared in amounts sufficient for sequence anal. and was purified by passage successively over gel-permeation and reverse-phase HPLC columns. The sequence of the fragment’s N terminus corresponds to that of the N terminus of the receptor’s α subunit. This fragment also reacts with an antibody raised against a synthetic peptide corresponding to residues 242-253 of the receptor’s α subunit. On the basis of the fragment’s size, N-terminal sequence, and immunoreactivity, the results indicate that the fragment extends from the α subunit’s N terminus through the SS-rich region of this subunit, i.e., residues 155-312. These results are consistent with this region containing the insulin-binding site.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Application In Synthesis of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Leukocyte migration inhibition test on agarose – a rational test method for cell-mediated immune reactivity. Author is Emmrich, F..

The agarose plate leukocyte migration inhibition test of J. E. Clausens (1973) was used to detect iatrogenic allergy in skin-test pos. patients. Plates were prepared from 0.9% agarose, and patients’ leukocyte migration response to drugs (antigens) determined after 1hr incubation at 37°. Thus, 10-50 mg/mL PPD gave 1.0-0.8 migration inhibition index with leukocytes from skin-tes pos., active tuberculosis patients. Similar results were obtained with patients allergic to nitrazepam, sulfamerazine, and phenylbutazone. It is concluded that the this agarose method may be used to detect cellular hypersensitivity.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Testing of the antiphlogistic effect of antirheumatic drugs》. Authors are Seidel, K.; Eckstein, M..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Name: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide. Through the article, more information about this compound (cas:129-18-0) is conveyed.

Various anti-rheumatic drugs were measured for their antiphlogistic activity on human skin erythemas induced by uv light. Prednisone (30 mg. per os, daily), wofapyrine (1.5 g./day, i.m.), nicopyrone (1.5 g.) plus metamizol (1.5 g.) (1 tablet daily), nicopyrone (1.2 g.) plus prednisone (9.0 mg.) (1 tablet daily), and nicopyrone (1.2 g.) plus prednisone (4.5 mg.) (1 tablet daily), all for 4 days, reduced the skin inflammation inducible by uv light by 42.8, 41.1, 41.4, 46.2, and 43.6%, resp. 16 references

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Product Details of 2923-28-6. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Silver(I) trifluoromethanesulfonate, is researched, Molecular CAgF3O3S, CAS is 2923-28-6, about Gas sorption of nano-porous supramolecules formed by multi-hydrogen bonded coordination capsules.

[{ReI(CO)3(Hbim)}3(tpta)]2 (1, Hbim- = 2,2′-biimidazolate monoanion, tpta = 2,4,6-tripyridyl-1,3,5-triazine) was prepared as a nano-space supramol. by using a new group of H-bonded coordination capsules. The hamburger bun-shaped half unit [{ReI(CO)3(Hbim)}3(tpta)] contains six intermol. H-bonds of Hbim- ligands with complementary dual NH···N types, and three [ReI(CO)3(Hbim)] are coordinated by bridging tridentate tpta. Interestingly, mech. grinding easily would convert single crystals of 1 to an amorphous state with minor crystallinity while maintaining the nano-space pores. The ground sample can reversibly uptake and release small mols. such as CO2 and (CH2Cl)2.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 6-Fluoronicotinonitrile, is researched, Molecular C6H3FN2, CAS is 3939-12-6, about Discovery of PIPE-359, a Brain-Penetrant, Selective M1 Receptor Antagonist with Robust Efficacy in Murine MOG-EAE, the main research direction is PIPE359 muscarinic M1 receptor antagonist EAE multiple sclerosis remyelination.Electric Literature of C6H3FN2.

The discovery of PIPE-359, a brain-penetrant and selective antagonist of the muscarinic acetylcholine receptor subtype 1 is described. Starting from a literature-reported M1 antagonist, linker replacement and structure-activity relationship investigations of the eastern 1-(pyridinyl)piperazine led to the identification of a novel, potent, and selective antagonist with good MDCKII-MDR1 permeability. Continued semi-iterative positional scanning facilitated improvements in the metabolic and hERG profiles, which ultimately delivered PIPE-359. This advanced drug candidate exhibited robust efficacy in mouse myelin oligodendrocyte glycoprotein (MOG)-induced exptl. autoimmune encephalitis (EAE), a preclin. model for multiple sclerosis.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Covalent bonds immobilization of cofacial Mn porphyrin dimers on an ITO electrode for efficient water oxidation in aqueous solutions, published in 2017-08-31, which mentions a compound: 1260795-42-3, mainly applied to covalent bond immobilization cofacial manganese porphyrin dimer electrocatalyst; ITO electrode water oxidation catalytic oxygen evolution, Electric Literature of C9H7BrO3.

The authors previously reported several Mn porphyrin dimers as the 1st Mn-containing mol. catalysts for H2O oxidation, however, in nonaqueous MeCN solution containing 5% H2O. Here, the authors successfully fabricated these dimers with mono- and hexaphosphonic acid groups, Mn2DP-PO3H2 and Mn2DP-(PO3H2)6, to covalently assemble them on the surface of ITO electrode (ITO = In-doped Sn oxide) and use the Mn2DP-PO3H2 and Mn2DP-(PO3H2)6|ITO assemblies as heterogeneous catalysts for electrochem. H2O oxidation in aqueous buffer solutions The mono-phosphonic acid fabricated assemblies showed unprecedent high turnover frequencies (TOFs) (up to 44.9 s-1) at a low overpotential (η = 0.47 V) in a neutral buffer solution In acidic buffered solutions (pH = 1.5), they showed higher TOFs (up to 47.4 s-1) at a very low overpotential (η = 0.26 V). The robustness of the mono-phosphonic acid fabricated catalysts, Mn2DP-PO3H2|ITO, was tested at a high overpotential (η = 0.80 V). Although they showed an O evolution with 178.3 s-1 TOF, the O evolution completely stopped after 11 h electrolysis. UV-visible spectra monitored during the electrolysis clearly indicated the gradual detachment of the catalysts from the ITO surface is likely the main reason of stopping the O evolution. The hexa-phosphonic acid catalyst assembly, Mn2DP-(PO3H2)6|ITO, however, showed a continuous O evolution without stopping even after 23 h of electrolysis with 199.3 s-1 TOF. Tafel plots in different pHs give insights on the mechanism of H2O oxidation

There is still a lot of research devoted to this compound(SMILES：O=C(C1C(C=O)=CC(Br)=CC=1)OC)Electric Literature of C9H7BrO3, and with the development of science, more effects of this compound(1260795-42-3) can be discovered.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Imamura, Yorishige; Shigemori, Keiko; Ichibagase, Hisashi researched the compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide( cas:129-18-0 ).Recommanded Product: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide.They published the article 《Effects of simultaneous administration of drugs on absorption and excretion. V. Effect of phenylbutazone on antibacterial activity and distribution of sulfadimethoxine in rabbits》 about this compound( cas:129-18-0 ) in Chemical & Pharmaceutical Bulletin. Keywords: sulfadimethoxine bactericide pharmacokinetics phenylbutazone; sulfanilamide pharmacokinetics phenylbutazone; salicylate sulfanilamide pharmacokinetics. We’ll tell you more about this compound (cas:129-18-0).

The antibacterial activities of sulfadimethoxine [122-11-2] (25 mg/kg, i.v.) in rabbit plasma were significantly increased by concomitant injection of Na phenylbutazone (Na I) [129-18-0] (50 mg/kg, i.v.). The levels of unchanged sulfadimethoxine in rabbit plasma were significantly reduced by concomitant injection of phenylbutazone. These results suggest that phenylbutazone increases the transfer of sulfadimethoxine from plasma to tissues in rabbits.

There is still a lot of research devoted to this compound(SMILES：O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+])Recommanded Product: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, and with the development of science, more effects of this compound(129-18-0) can be discovered.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem