The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 6-Fluoronicotinonitrile, is researched, Molecular C6H3FN2, CAS is 3939-12-6, about Discovery of PIPE-359, a Brain-Penetrant, Selective M1 Receptor Antagonist with Robust Efficacy in Murine MOG-EAE, the main research direction is PIPE359 muscarinic M1 receptor antagonist EAE multiple sclerosis remyelination.Electric Literature of C6H3FN2.
The discovery of PIPE-359, a brain-penetrant and selective antagonist of the muscarinic acetylcholine receptor subtype 1 is described. Starting from a literature-reported M1 antagonist, linker replacement and structure-activity relationship investigations of the eastern 1-(pyridinyl)piperazine led to the identification of a novel, potent, and selective antagonist with good MDCKII-MDR1 permeability. Continued semi-iterative positional scanning facilitated improvements in the metabolic and hERG profiles, which ultimately delivered PIPE-359. This advanced drug candidate exhibited robust efficacy in mouse myelin oligodendrocyte glycoprotein (MOG)-induced exptl. autoimmune encephalitis (EAE), a preclin. model for multiple sclerosis.
There is still a lot of research devoted to this compound(SMILES：N#CC1=CC=C(F)N=C1)Electric Literature of C6H3FN2, and with the development of science, more effects of this compound(3939-12-6) can be discovered.
Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem