Category: benzofuran

16859-59-9, 3-Hydroxyisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,16859-59-9

General procedure: To a stirred solution of phthalaldehydic acid 2 (3 mmol) and furan 3 (2.7 mmol;3.3 mmol for 4ab) in acetic acid (8 mL for 4aa, ab?ad; 13 mL for 4ba, ea, fa;20 mL for 4ca, da; 25 mL for 4ga) at room temperature CuBr2 (1.35 mmol;0.27 mmol for 4ea; 0.54 mmol for 4ab) was added. The resulting reactionmixture was stirred for 24 h (18 h for 4aa; 48 h for 4fa) and after reactioncompletion (TLC) was poured into water (150 mL), neutralized with NaHCO3and extracted using DCM (3 40 mL). The combined organic extracts weredried over anhydrous Na2SO4, and the solvent was removed under vacuum.The residue was purified by flash chromatography over silica gel using DCM/petroleum ether (1:1.5, v/v then 2:1, v/v (1:3, v/v for 4ad; 1:6, v/v for 4ac) aseluent and recrystallized from DCM/petroleum ether to afford 3-(fur-2-yl)-3Hisobenzofuran-1-ones 4aa?ad.

16859-59-9 3-Hydroxyisobenzofuran-1(3H)-one 3804259, abenzofuran compound, is more and more widely used in various.

Reference£º
Article; Shcherbinin, Vitaly A.; Shpuntov, Pavel M.; Konshin, Valery V.; Butin, Alexander V.; Tetrahedron Letters; vol. 57; 13; (2016); p. 1473 – 1475;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.652-39-1,4-Fluoroisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

652-39-1, A mixture of 3-fluorophthalic anhydride (1 equiv.), 1-amino-3-azabicyclo[4. 1.0]heptane- 2,4-dione (1 equiv.), and potassium acetate (2.5 equiv.) in acetic acid is stirred at 120 ¡ãC overnight. The dark mixture is cooled and filtered. The filter cake is dissolved in DCM and washed with saturated NaHCO3 and brine. The organic layer is dried (Na2504) and concentrated to provide 2-(2,4-dioxo-3 -azabicyclo[4. 1 .0]heptan- 1 -yl)-4-fluoroisoindoline- 1,3 -dione.

652-39-1 4-Fluoroisobenzofuran-1,3-dione 69551, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; C4 THERAPEUTICS, INC.; PHILLIPS, Andrew, J.; NASVESCHUK, Chris, G.; HENDERSON, James, A.; LIANG, Yanke; FITZGERALD, Mark, E.; MICHAEL, Ryan, E.; (790 pag.)WO2017/197056; (2017); A1;,
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Benzofuran | C8H6O – PubChem

652-39-1, 4-Fluoroisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

652-39-1, General procedure: A 10 mL round bottomed flask was charged with 1 (1.00 mmol), 2 (1.00 mmol), acetic acid (5 mL) and provided with a reflux condenser. The reaction mixture was heated to reflux and stirred for an appropriate period. TLC was used to monitor the progress of the reaction. After completion of the reaction, the mixture was diluted with water (20 mL) and extracted with ethyl acetate (3 x 20 mL). The combined organic layers were washed with water (2 x 20 mL), brine (20 mL), dried over anhydrous Na2SO4, filtered and evaporated in a rotary evaporator under reduced pressure. The crude mixture was purified by column chromatography to afford the pure products (3a-3g?).

652-39-1 4-Fluoroisobenzofuran-1,3-dione 69551, abenzofuran compound, is more and more widely used in various.

Reference£º
Article; Cheng, Hua; Fu, Yan; Chang, Qing; Zhang, Ni; Bu, Mengwei; Niu, Yan; Wu, Qiongyou; Chen, Cheng; Verpoort, Francis; Chinese Chemical Letters; vol. 29; 12; (2018); p. 1897 – 1900;,
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Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23145-07-5,5-Bromobenzofuran,as a common compound, the synthetic route is as follows.

23145-07-5, Under a nitrogen stream, 5-bromo-benzofuran (25g, 0.126mol), 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi-(1,3,2-dioxaborolane) (38.67g, 0.152mol), Pd(dppf)Cl2 (3.11g, 3mol%), KOAc (37.36g, 0.381mol) and 1,4-dioxane (500ml) were mixed, and the mixture was stirred for 12 hours at 130 C. After completion of the reaction, and extracted with ethyl acetate, to remove water with MgSO4, KaramukuroMatogurafi By (hexane:: EA = 10 1 (v / v)), 2-(benzofuran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(23.23g, 75% yield).

As the paragraph descriping shows that 23145-07-5 is playing an increasingly important role.

Reference£º
Patent; DOOSAN CORPORATION; KIM, HOE MOON; KIM, SUNG MOO; KIM, YOUNG BAE; KIM, TAE HYUNG; PARK, HO CHEOL; LEE, CHANG JUN; BACK, YOUNG MI; SHIN, JIN YONG; (222 pag.)JP2016/40292; (2016); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166599-84-4,Benzofuran-4-carboxylic acid,as a common compound, the synthetic route is as follows.

Benzofuran-4-carboxylic acid (10.0 g, 61.7 mmol) was hydrogenated (60 psi) in acetic acid (100 mL) over 10% Pd/C (2 g) for 12 hr. The mixture was filtered and the filtrate was diluted with water (500 mL) to give 2,3-dihydrobenzofuran-4-carboxylic acid as a white powder (8.4 g, 83%). A sample was recrystallized from isopropanol to give fine white needles (mp: 185.5-187.5C)., 166599-84-4

The synthetic route of 166599-84-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bristol-Myers Squibb Company; EP1027043; (2004); B1;,
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Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35700-40-4,2,3-Dihydrobenzofuran-7-carboxylic acid,as a common compound, the synthetic route is as follows.

1M Borane-THF complex THF solution (193 mL, 193.35 mmol) was slowly added to a solution of 2,3-dihydrobenzofuran-7-carboxylic acid (10.58 g, 64.45 mmol) in THF (65 mL) over 30 min while the reaction solution was maintained at room temperature. The reaction mixture was stirred at 60C for 3.5 hr, and poured into ice (about 400 g). The mixture was stirred at room temperature for 30 min, and extracted three times with ethyl acetate. The organic layer was washed with aqueous sodium hydrogen carbonate solution and brine, and dried over magnesium sulfate, and the solvent was evaporated under reduced pressure to give (2,3-dihydrobenzofuran-7-yl)methanol (9.76 g, 65.0 mmol, quant.) as a colorless oil.

35700-40-4, As the paragraph descriping shows that 35700-40-4 is playing an increasingly important role.

Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; YAMAMOTO, SATOSHI; SHIRAI, JUNYA; WATANABE, HIROYUKI; FUKUMOTO, SHOJI; ODA, TSUNEO; TOKUHARA, HIDEKAZU; TOMATA, YOSHIHIDE; ISHII, NAOKI; TAWADA, MICHIKO; KOUNO, MITSUNORI; OCHIDA, ATSUKO; IMADA, TAKASHI; FUKASE, YOSHIYUKI; YUKAWA, TOMOYA; (719 pag.)TW2016/2105; (2016); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

763114-25-6, 2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,763114-25-6

(b) 2-Fluoro-5-[(4-oxo-3, 4-dihydrophthalazin-1-yl)methyl]benzonitrile (ED) 2-Fluoro-5-[(E/Z)-(3-oxo-2-benzofuran-1 (3/-/)-ylidene)methyl]benzonitrile (E)(20g, 75.40 mmol) and tetrahydrofuran (200 ml) were stirred at room temperature under a nitrogen atmosphere for 30 minutes. Hydrazine monohydrate (4.40 ml, 90.53 mmol) was added, followed by a line wash of tetrahydrofuran (4 ml). The reaction mixture was stirred at room temperature for 1 hour 45 minutes. Acetic acid (1.10 ml, 19.20 mmol) was added and the reaction mixture warmed to 600C. The reaction mixture was held at 600C overnight. The reaction mixture was cooled to 50¡ãC and water (200 ml) added dropwise. The temperature was maintained at 45¡ãC throughout the addition. The reaction mixture was cooled to 200C1 filtered, washed with a mixture of water (30 ml) and tetrahydrofuran (30 ml), and then dried in vacuo at up to 4O0C to give the title compound (18.7 g).Mass spectrum: MH+ 2801 H NMR (400MHz. DMSO-d6) delta: 4.38 (s, 2H), 7.46 (t, 1 H), 7.72 (m, 1 H), 7.85 (dt, 1 H), 7.92 (m, 2H), 7.99 (d, 1 H), 8.27 (dd, 1 H), 12.57 (s, 1 H).

As the paragraph descriping shows that 763114-25-6 is playing an increasingly important role.

Reference£º
Patent; KUDOS PHARMACEUTICALS LIMITED; WO2008/47082; (2008); A2;,
Benzofuran – Wikipedia
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7168-85-6, 7-Methoxybenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,7168-85-6

Preparation 13 Benzofuran-7-ol To 7-methoxy benzofuran (6.3 g, 42.5 mmol) in a 0.5 M solution of CH2Cl2 at -78 C. is added tetrabutylammonium iodide (18.9 g, 51 mmol). To this stirred solution, BCl3 (100 mL of a 1.0 M solution in CH2Cl2, 100 mmol) was added dropwise via addition funnel. The reaction mixture was stirred at -78 C. for 6 h. Water is added dropwise very slowly to quench. The resulting mixture was stirred overnight at rt, basified with 6 N NaOH (pH=10), stirred for 1 h, neutralized with 2 N HCl (pH=7), and extracted with CH2Cl2 (5*). The combined extracts were dried (MgSO4), filtered, concentrated, and chromatographed (10% EtOAc in hexanes) to provide 5.3 grams of benzofuran-7-ol as an oil. 1H NMR (400 MHz, CDCl3): delta 7.61 (d, 1, J=2.1), 7.19 (d, 1, J=7.7), 7.13 (t, 1, J=7.7), 6.88 (d, 1, J=7.7), 6.79 (d, 1, J=2.1), 6.04 (bs, 1). Previously prepared but no data reported: Musser, J. H.; Chakraborty, U.; Bailey, K.; Sciortino, S.; Whyzmuzis, C.; Amin, D.; Sutherland, C. A. J. Med. Chem. 1987, 30, 62-67.

As the paragraph descriping shows that 7168-85-6 is playing an increasingly important role.

Reference£º
Patent; Pfizer Inc; US2006/58361; (2006); A1;,
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Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.700-85-6,5-Fluoroisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.,700-85-6

250ml single-mouth bottle to join5-F-benzofuran-1 (3H) ketone 2g, absolute ethanol 120ml, dropping thionyl chloride 4.8ml, drop complete, reflux 14h, vacuum evaporated.

As the paragraph descriping shows that 700-85-6 is playing an increasingly important role.

Reference£º
Patent; Chongqing Institute of Pharmaceutical Industry Co., Ltd.; Dan, Chunyan; Cai, Pengfei; Zuo, Xiaoyong; Luo, Bin; Xie, Shouquan; Liu, Caiping; Yang, Qiaobin; (8 pag.)CN105524044; (2016); A;,
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Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.69999-16-2,2,3-Dihydrobenzofuranyl-5-acetic acid,as a common compound, the synthetic route is as follows.,69999-16-2

Step 3. N-[2-(2, 3-dihydro-l-benzofiiotaran-5~ylmethyl)-l-(3-methylbutyl)-lH-benzimidazol-5-yl]~ N, 3-dimethylbutanamide[0171] To a mixture of N-{3-amino-4-[(3-methylbutyl)amino]phenyl}-N,3-dimethylbutanamide (Step 2 of Example 2, 0.097g, 0.33 mmol, lequiv), 2,3-dihydro-l-benzofuran-5-ylacetic acid (0.065g, 0.36 mmol, 1.1 equiv) and HATU (0.139g, 0.366 mmol, 1.1 equiv) was added a solution of DIPEA (116 muL, 0.666 mmol, 2equiv) in DMF (5 mL). The mixture was stirred overnight at room temperature. Complete consumption of the starting material was confirmed by LC-MS. DMF was removed under reduced pressure. Ethyl acetate was added to the resulting residue. The organic layer was washed once with a saturated aqueous NaHCO3 solution, once with brine and dried over anhydrous Na2SO4. Ethyl acetate was removed under reduce pressure. The resulting residue was dissolved in dichloroethane and a few drops of concentrated HCl were added. The mixture was stirred at 80 C for a few hours. Complete consumption of the starting material was confirmed by LC-MS. Dichloromethane was added. The organic layer was washed once with a 2M aqueous NaOH solution, once with brine and dried over anhydrous Na2SO4. Dichloromethane was removed under reduced pressure. The resulting residue was purified by reversed-phase HPLC and lyophilized to afford N-[2-(2,3-dihydro-l-benzofuran-5-yhnethyl)-l- (3-methylbutyl)-lH-benzimidazol-5-yl]-N,3-dimethylbutanamide as the corresponding TFA salt (0.110 mg) in 58% yield. 1H NMR (400 MHz, METHANOL-D4) delta ppm 0.72 – 0.89 (m, 6 H) 0.96 (d, /=6.64 Hz, 6 H) 1.47 – 1.54 (m, 2 H) 1.64 – 1.76 (m, 1 H) 1.91 – 2.14 (m, 3 H) 3.19 (t, /=8.69 Hz, 2 H) 4.36 – 4.43 (m, 2 H) 4.50 (s, 2 H) 4.55 (t, /=8.69 Hz, 2 H) 6.76 (d, /=8.20 Hz, 1 H) 7.08 (dd, /=8.30, 1.86 Hz, 1 H) 7.21 (s, 1 H) 7.46 (dd, /=8.79, 1.95 Hz, 1 H) 7.65 (d, /=1.37 Hz, 1 H) 7.85 (d, /=8.59 Hz, 1 H); MS (ESI) m/z 434.0 (M+H)+; Anal. Calcd (%) for C27H35N3O2 + 1.1 TFA + 0.1 H2O: C, 62.54; H3 6.52; N, 7.49. Found: C, 62.51; H, 6.59; N 7.46.

As the paragraph descriping shows that 69999-16-2 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; WO2007/91950; (2007); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem