Tag: 7168-85-6

7168-85-6, 7-Methoxybenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,7168-85-6

Preparation 13 Benzofuran-7-ol To 7-methoxy benzofuran (6.3 g, 42.5 mmol) in a 0.5 M solution of CH2Cl2 at -78 C. is added tetrabutylammonium iodide (18.9 g, 51 mmol). To this stirred solution, BCl3 (100 mL of a 1.0 M solution in CH2Cl2, 100 mmol) was added dropwise via addition funnel. The reaction mixture was stirred at -78 C. for 6 h. Water is added dropwise very slowly to quench. The resulting mixture was stirred overnight at rt, basified with 6 N NaOH (pH=10), stirred for 1 h, neutralized with 2 N HCl (pH=7), and extracted with CH2Cl2 (5*). The combined extracts were dried (MgSO4), filtered, concentrated, and chromatographed (10% EtOAc in hexanes) to provide 5.3 grams of benzofuran-7-ol as an oil. 1H NMR (400 MHz, CDCl3): delta 7.61 (d, 1, J=2.1), 7.19 (d, 1, J=7.7), 7.13 (t, 1, J=7.7), 6.88 (d, 1, J=7.7), 6.79 (d, 1, J=2.1), 6.04 (bs, 1). Previously prepared but no data reported: Musser, J. H.; Chakraborty, U.; Bailey, K.; Sciortino, S.; Whyzmuzis, C.; Amin, D.; Sutherland, C. A. J. Med. Chem. 1987, 30, 62-67.

As the paragraph descriping shows that 7168-85-6 is playing an increasingly important role.

Reference£º
Patent; Pfizer Inc; US2006/58361; (2006); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7168-85-6,7-Methoxybenzofuran,as a common compound, the synthetic route is as follows.

EXAMPLE 1C 7-Hydroxybenzofuran A mixture of 7methoxybenzofuran (1.8 g.) and pyridine hydrochloride (4.6 g.) was heated at 220 C. for 21/2 hours. The reaction was cooled and diluted with methylene chloride. The solution was washed with 5% aqueous hydrochloric acid (six times); dried (MgSO4) and concentrated to an oil, 0.8 g. (50% yield).

As the paragraph descriping shows that 7168-85-6 is playing an increasingly important role.

Reference£º
Patent; USV Pharmaceutical Corp.; US4579865; (1986); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem