Tag: 35700-40-4

Brief introduction of 35700-40-4

35700-40-4, As the paragraph descriping shows that 35700-40-4 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35700-40-4,2,3-Dihydrobenzofuran-7-carboxylic acid,as a common compound, the synthetic route is as follows.

1M Borane-THF complex THF solution (193 mL, 193.35 mmol) was slowly added to a solution of 2,3-dihydrobenzofuran-7-carboxylic acid (10.58 g, 64.45 mmol) in THF (65 mL) over 30 min while the reaction solution was maintained at room temperature. The reaction mixture was stirred at 60C for 3.5 hr, and poured into ice (about 400 g). The mixture was stirred at room temperature for 30 min, and extracted three times with ethyl acetate. The organic layer was washed with aqueous sodium hydrogen carbonate solution and brine, and dried over magnesium sulfate, and the solvent was evaporated under reduced pressure to give (2,3-dihydrobenzofuran-7-yl)methanol (9.76 g, 65.0 mmol, quant.) as a colorless oil.

35700-40-4, As the paragraph descriping shows that 35700-40-4 is playing an increasingly important role.

Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; YAMAMOTO, SATOSHI; SHIRAI, JUNYA; WATANABE, HIROYUKI; FUKUMOTO, SHOJI; ODA, TSUNEO; TOKUHARA, HIDEKAZU; TOMATA, YOSHIHIDE; ISHII, NAOKI; TAWADA, MICHIKO; KOUNO, MITSUNORI; OCHIDA, ATSUKO; IMADA, TAKASHI; FUKASE, YOSHIYUKI; YUKAWA, TOMOYA; (719 pag.)TW2016/2105; (2016); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

New learning discoveries about 35700-40-4

35700-40-4 2,3-Dihydrobenzofuran-7-carboxylic acid 2795014, abenzofuran compound, is more and more widely used in various.

35700-40-4, 2,3-Dihydrobenzofuran-7-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A suspension of 2,3-dihydro-benzofiran-7-carboxylic acid, (TCI, 20.0 g, 121.8 mmol) in 600 mL of dry acetonitrile was cooled to 0 0C and treated with N,O-dirnethylhydroxylamine hydrochloride (14.25 g, 146.1 mmol). The reaction was allowed to stirfor 10 minutes and EDCI (24.6 g, 158.3 mmol) was added, followed by HOBT (3.2 g, 24.2 mmol) and the resulting mixture was allowed to stirfor 5 minutes. Triethylamine (365.4 mmol) was then added and the reaction mixture was allowed to stirfor 18 hours at room temperature, then diluted with aqueous IN HCl (250 mL) and extracted with ethyl acetate (1.0 L). The organic layer was sequentially washed with aqueous 10% potassium carbonate (200 mL), aqueous IN HCl (200 mL), and brine (200 mL). The organic layer was then dried over magnesium sulfate, filtered and concentrated in vacuo to provide compound 2A (23.37 g, 93 %) as a colorless oil. M.S. found for CnHnNO3: 230.1 1 (M^Na)+.

35700-40-4 2,3-Dihydrobenzofuran-7-carboxylic acid 2795014, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; SCHERING CORPORATION; WO2009/152200; (2009); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem