With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23145-07-5,5-Bromobenzofuran,as a common compound, the synthetic route is as follows.
23145-07-5, Under a nitrogen stream, 5-bromo-benzofuran (25g, 0.126mol), 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi-(1,3,2-dioxaborolane) (38.67g, 0.152mol), Pd(dppf)Cl2 (3.11g, 3mol%), KOAc (37.36g, 0.381mol) and 1,4-dioxane (500ml) were mixed, and the mixture was stirred for 12 hours at 130 C. After completion of the reaction, and extracted with ethyl acetate, to remove water with MgSO4, KaramukuroMatogurafi By (hexane:: EA = 10 1 (v / v)), 2-(benzofuran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(23.23g, 75% yield).
As the paragraph descriping shows that 23145-07-5 is playing an increasingly important role.
Reference£º
Patent; DOOSAN CORPORATION; KIM, HOE MOON; KIM, SUNG MOO; KIM, YOUNG BAE; KIM, TAE HYUNG; PARK, HO CHEOL; LEE, CHANG JUN; BACK, YOUNG MI; SHIN, JIN YONG; (222 pag.)JP2016/40292; (2016); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem