Category: benzofuran

763114-25-6, 2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

763114-25-6, Step 50.2: Synthesis of 2-Fluoro-5-[(4-oxo-3H-phthalazin-l-yl)methyl]benzoic Acid (5.2).[0242] As such, to a stirred suspension of 50.1 (-10 mmol) in water (20 mL) was added aqueous NaOH (10 N, 5 mL). The reaction was subsequently heated to 100 C for 1 h. After the reaction mixture was cooled to roughly 70 C and hydrazine hydrate (5.0 mL, 100 mmol) was added. The mixture was stirred at 70 C for 24 h. The reaction was cooled room temperature and acidified with HC1 (8 N, ca. 80 mL) to pH 4. After reaction was again cooled to room temperature, the solid was collected with filtration, washed with water (10 mL), ether (3 x 10 mL) and was dried to produce compound 50.2 (2.41 g) as a white solid. MS (ESI+) m/z = 299 (M+H).

As the paragraph descriping shows that 763114-25-6 is playing an increasingly important role.

Reference£º
Patent; NEWGEN THERAPEUTICS, INC.; SHEN, Wang; MAUNG, Jack; ZHANG, Aimin; ZHENG, Xiaoling; WO2012/166983; (2012); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.569-31-3,6,7-Dimethoxy-3H-1-isobenzofuranone,as a common compound, the synthetic route is as follows.,569-31-3

Example V — SYNTHESIS OF 3-[N(BENZODIOXAN-1,4 YL-6) AMINO] 6,7-DIMETHOXY 3H-ISOBENZOFURANONE A mixture of 30 g of 6,7-dimethoxy 3H-isobenzofuranone, prepared according to the method described in Example IV, 1 liter of ethanol and 300-400 cm3 of dimethylamine was agitated for several hours and then evaporated under vacuum at 30 – 35 C. The crystallized product was washed with heptane. The 2,3-dimethoxy N,N-dimethyl 6-hydroxymethyl benzamide was obtained in a yield of 100%. F = 90 C.

The synthetic route of 569-31-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Societe Cortial; US4122202; (1978); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

209256-42-8, 2,3-Dihydrobenzofuran-4-carbaldehyde is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirring solution of the aldehyde from step A Example 33 (400 mg, 2.7 mmol) in dichloromethane (40 mL) was added carbethoxymethylene-triphenylphosphorane (1.41 g, 4.05 mmol). The reaction was refluxed for 16 hrs. and the solvent was removed in vacuo. The title compound (white solid, 533 mg, 91% yield) was isolated from a silica gel column using 20% ethyl acetate in hexanes as the eluent., 209256-42-8

209256-42-8 2,3-Dihydrobenzofuran-4-carbaldehyde 18787449, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Bristol-Myers Squibb Company; US6887870; (2005); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.58546-89-7,Benzofuran-5-amine,as a common compound, the synthetic route is as follows.

Example 58 (2521) 3-(Benzofuran-5-ylamino)-7-chloro-5-hydroxy-2H-benzoreiri ,2,41thiadiazine 1 ,1 – dioxide (2522) To a suspension of of 3-bromo-7-chloro-5-hydroxy-4H-benzo[e][1 ,2,4]thiadiazine 1 ,1 – dioxide (lnt-3, 200 mg) and benzofuran-5-amine (103 mg) in t-BuOH (10 mL) stirred under nitrogen was added KH2P04 (105 mg) in one portion. The reaction mixture was stirred at 80 C for 24 hr. The reaction mixture was allowed to cool to RT, then was concentrated under reduced pressure, diluted with deionized water (15 mL) and allowed to stir for 15 min. The resulting precipitate was collected by filtration and washed with water (2 x 5 mL) and diethyl ether (3 x 5 mL), and dried to afford the titled compound (160 mg). LCMS m/z 364.00 (M+H). 1H NMR after D20 exchange(400 MHz, DMSO-c/6) delta ppm 7.02 (d, J=1 .53 Hz, 1 H) 7.10 (d, J=2.19 Hz, 1 H) 7.19 (d, J=1 .97 Hz, 1 H) 7.33 (dd, J=8.77, 2.19 Hz, 1 H) 7.63 (d, J=8.77 Hz, 1 H) 7.87 (d, J=2.19 Hz, 1 H) 8.00 (d, J=2.19 Hz, 1 H)., 58546-89-7

58546-89-7 Benzofuran-5-amine 1477152, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ADAMS, Jerry Leroy; ATOR, Laura E.; DUFFY, Kevin J.; GRAYBILL, Todd L.; KIESOW, Terence John; LIAN, Yiqian; MOORE, Michael Lee; RALPH, Jeffrey M.; RIDGERS, Lance Howard; (370 pag.)WO2017/98421; (2017); A1;,
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Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1207453-90-4,6-Fluoro-4-nitroisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

To a solution of 6-fluoro-4-nitroisobenzofuran-1(3H)-one (1) (10 g, 50.8 mmol), 2-methyl-2H-1,2,4-triazole-3-carbaldehyde (2) (11 g, 101.5 mmol) and Et3N (20 mL, 152.4 mmol) in anhydrous THF (150 mL) was added acetic anhydride (35 mL) drop-wise with stirring at room temperature in 3 minutes. The mixture was then stirred at reflux for 45 minutes when a green solid was precipitated from solvent. The solvent was concentrated to 15 mL and the resulting mixture was cooled to 0 C. and filtered, washed with 15 mL of ethyl acetate to obtain (Z)-6-fluoro-3((1-methyl-1H-1,2,4-triazol-5-yl)methylene)-4-nitroisobenzofuran-1(3H)-one (3) as a green solid (11.5 g, yield: 78%). LC-MS (ESI) m/z: 291 (M+1)+. 1H-NMR (400 MHz, DMSO-d6) delta (ppm): 3.94 (s, 3H), 7.15 (s, 1H), 8.10 (s, 1H), 8.40-8.42 (dd, J1=6.4 Hz, J2=2.4 Hz, 1H), 8.58-8.61 (dd, J1=8.8 Hz, J2=2.4 Hz, 1H).

1207453-90-4, The synthetic route of 1207453-90-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BioMarin Pharmaceutical, Inc.; Wang, Bing; Chu, Daniel; US2013/53365; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23681-89-2,2,3-Dihydrobenzofuran-6-ol,as a common compound, the synthetic route is as follows.

General procedure: NaH (12.0mmol) was added to a solution of 1 or 722 (1.88g, 10.0mmol) and substituted phenol (12.0mmol) in DMF (50mL) at room temperature under N2, and the mixture was stirred at 80¡ãC for 10h. Water was added to the cooled mixture, and the mixture was extracted with EtOAc several times. The combined organic layers were washed with water, dried over anhydrous Na2SO4, and concentrated under reduced pressure. The crude residue was purified by silica gel column chromatography to obtain purified compound 2, or crude 2 was used directly for the next reaction without further purification., 23681-89-2

23681-89-2 2,3-Dihydrobenzofuran-6-ol 12236540, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Shinozuka, Tsuyoshi; Tsukada, Tomoharu; Fujii, Kunihiko; Tokumaru, Eri; Shimada, Kousei; Onishi, Yoshiyuki; Matsui, Yumi; Wakimoto, Satoko; Kuroha, Masanori; Ogata, Tsuneaki; Araki, Kazushi; Ohsumi, Jun; Sawamura, Ryoko; Watanabe, Nobuaki; Yamamoto, Hideki; Fujimoto, Kazunori; Tani, Yoshiro; Mori, Makoto; Tanaka, Jun; Bioorganic and Medicinal Chemistry; vol. 26; 18; (2018); p. 5099 – 5117;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16859-59-9,3-Hydroxyisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

General procedure: 2-Formylbenzoic acid (1a; 1.0 equiv) was heated at reflux in SOCl2 (5?10 equiv) for 4 h at 100 ¡ãC. The remaining SOCl2 was removed in vacu-um and the obtained solid was dissolved in CH2Cl2 (10 mL). The mix-ture was cooled to 0 ¡ãC and the desired primary amine (2.0 equiv)was slowly added. The solution was stirred for 24 h at r.t. then thereaction mixture was diluted with EtOAc (70 mL), washed with citricacid (0.5 M), sat. aq Na2CO3 solution, and brine. The organic layer wasdried over MgSO4 and the solvent was removed under reduced pres-sure. The obtained products were used without further purification., 16859-59-9

The synthetic route of 16859-59-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Niedek, Dominik; Schuler, Soeren M.M.; Eschmann, Christian; Wende, Raffael C.; Seitz, Alexander; Keul, Felix; Schreiner, Peter R.; Synthesis; vol. 49; 2; (2017); p. 371 – 382;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

652-40-4, 4,7-Difluoroisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

652-40-4, (3) Methyl 3-(4,7-difluoro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-methyl-[1,3]dioxolan-2-yl)propionate Methyl 3-(4,7-difluoro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-methyl-[1,3]dioxolan-2-yl)propionate was prepared (0.27 g, 31percent) in the same manner as described in the above example 5. (1) from methyl 3-amino-2-(2-methyl-[1,3]dioxolan-2-yl)propionate (0.47 g, 2.47 mmol) and 3,6-difluorophthalic anhydride (0.50 g, 2.72 mmol), and the obtained product was identified with the following NMR data. 1H NMR (CDCl3, 300 MHz) delta 7.31 (t, 2H, ph, J=5.3 Hz), 3.95 (m, 6H, acetal H, -CHCH2NPht), 3.64 (s, 3H -CO2CH3), 3.20 (m, 1H, -CHCH2NPht), 1.42 (s, 3H, CH3) 3C NMR (CDCl3, 300 MHz) delta 171.9, 163.9, 155.8, 152.2, 125.5, 121.1, 120.6, 120.1, 108.9, 65.4, 60.9, 53.8, 51.7, 37.2, 22.0, 14.5

As the paragraph descriping shows that 652-40-4 is playing an increasingly important role.

Reference£º
Patent; Korea Institute of Science and Technology; US2003/139464; (2003); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127264-14-6,5-(2-Bromoethyl)-2,3-dihydrobenzofuran,as a common compound, the synthetic route is as follows.

Example 9:Preparation of darifenacin hydrochloride:To 3-(S)-(+)-(l-carbamoyl-l,l-diphenyl methyl) pyrrolidine tartrate (100 grams) taken in water (500 ml), a solution of aqueous sodium hydroxide was added till the pH reached 14. The reaction mixture was stirred for 20 min at 25-300C, sodium chloride(150 grams) was added to it and stirred further for 20min. The reaction mixture was heated to 55-600C and extracted with toluene. The toluene layer was washed with 5percent sodium chloride solution and the solvent distilled off under reduced pressure. The residue was dissolved in acetonitrile, 5-(2-bromoethyl) 2,3-dihydrobenzofuran (66 grams dissolved in 800 ml acetonitrile) and potassium hydroxide (13 grams) was added to it.The reaction mixture was heated to 40-500C and stirred for 18 hrs. The reaction mixture was cooled to 25-30¡ãC and filtered. The acetonitrile solvent was distilled off under reduced pressure. The residue was dissolved in acetone, cooled to 0-5 ¡ãC and hydrochloric acid (36 ml) was added to it. The temperature was raised to 25-30¡ãC and stirred for 12 hrs. The reaction mixture was cooled to 0-5¡ã C, the solid obtained was filtered, washed with acetone and dried. It was purified using methanol and acetone to provide the title compound as a white solid. Yield: 75 grams Example 11:Preparation of darifenacin hydrobromide:To 3 -(S)-(+)-(l -carbamoyl -1,1 diphenyl methyl) pyrrolidine tartrate (100 grams) taken in water (500 ml), a solution of aqueous sodium hydroxide was added till the pH reached 14. The reaction mixture was stirred for 20 min at 25-30¡ãC and sodium chloride(150 grams) was added to it and stirred for 20min. The reaction mixture was heated to55-6O0C and extracted with toluene. The toluene layer was washed with 5percent sodium chloride solution and the solvent distilled off under reduced pressure. The residue was dissolved in acetonitrile, 5-(2-bromoethyl)-2,3-dihydrobenzofuran (66 grams dissolved in 800 ml acetonitrile) and potassium hydroxide (13 grams) was added to it. The reaction mixture was heated to 40-50¡ãC and stirred for 18 hrs. The reaction mixture was cooled to 25-30¡ãC and filtered. The acetonitrile solvent was distilled off under reduced pressure. The residue was dissolved in acetone, cooled to 0-5¡ãC and hydrobromic acid (36 ml) was added to it. The temperature was raised to 25-30¡ãC and stirred for 12 hrs. The reaction mixture was cooled to 0-5¡ã C, the solid obtained was filtered, washed with acetone and dried. It was purified using methanol and acetone to provide the title compound as a white solid.Yield: 75 gramsSOR: +45 (C=I, dichloromethane)

127264-14-6, The synthetic route of 127264-14-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SATYANARAYANA REDDY, Manne; THIRUMALAI RAJAN, Srinivasan; VENKATESH, Mummadi; WO2008/126106; (2008); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

13414-56-7, 2,3-Dihydrobenzofuran-7-amine is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

At 0 deg.] C, the solid 2,3-dihydrobenzofuran-7-amine (5 g, 37 mmol) was dissolved in DMF (60 ml) in added portionwise NBS (7.2 g, 41 mmol), stirred for 10 minutes after natural warming stirred at 20 ~ 30 3 hours.Most of the solvent was distilled off under reduced pressure, and the residue was purified by silica gel chromatography to give the title compound through column (yellow solid, 6 g, 76% yield).LCMS (ESI) m / z: 214,216 (M + 1, M + 3).

13414-56-7, 13414-56-7 2,3-Dihydrobenzofuran-7-amine 12805950, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Shanghai Biological Technology Co., Ltd. opened Mai; yao, li; (18 pag.)CN105481841; (2016); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem