With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1207453-90-4,6-Fluoro-4-nitroisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.
To a solution of 6-fluoro-4-nitroisobenzofuran-1(3H)-one (1) (10 g, 50.8 mmol), 2-methyl-2H-1,2,4-triazole-3-carbaldehyde (2) (11 g, 101.5 mmol) and Et3N (20 mL, 152.4 mmol) in anhydrous THF (150 mL) was added acetic anhydride (35 mL) drop-wise with stirring at room temperature in 3 minutes. The mixture was then stirred at reflux for 45 minutes when a green solid was precipitated from solvent. The solvent was concentrated to 15 mL and the resulting mixture was cooled to 0 C. and filtered, washed with 15 mL of ethyl acetate to obtain (Z)-6-fluoro-3((1-methyl-1H-1,2,4-triazol-5-yl)methylene)-4-nitroisobenzofuran-1(3H)-one (3) as a green solid (11.5 g, yield: 78%). LC-MS (ESI) m/z: 291 (M+1)+. 1H-NMR (400 MHz, DMSO-d6) delta (ppm): 3.94 (s, 3H), 7.15 (s, 1H), 8.10 (s, 1H), 8.40-8.42 (dd, J1=6.4 Hz, J2=2.4 Hz, 1H), 8.58-8.61 (dd, J1=8.8 Hz, J2=2.4 Hz, 1H).
1207453-90-4, The synthetic route of 1207453-90-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BioMarin Pharmaceutical, Inc.; Wang, Bing; Chu, Daniel; US2013/53365; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem