Brief introduction of 23145-07-5

23145-07-5, The synthetic route of 23145-07-5 has been constantly updated, and we look forward to future research findings.

23145-07-5, 5-Bromobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To toluene 3.0mL suspension of tert-butyl 2-amino-4-phenylbenzoate 0.10g, 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl 9mg, tris(dibenzylideneacetone)dipalladium(0) 3mg and cesium carbonate 0.24g was added 5-bromobenzofuran 0.18g, and it was heated and refluxed for 24 hours. After the reaction mixture was cooled to room temperature, 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl 9mg and tris(dibenzylideneacetone)dipalladium(0) 3mg were added to it, and it was heated and refluxed for 24 hours. After the reaction mixture was cooled to room temperature, 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl 9mg and tris(dibenzylideneacetone)dipalladium(0) 3mg were added to it, and it was heated and refluxed for 24 hours. After the reaction mixture was cooled to room temperature, insoluble matter was filtrated, and ethyl acetate and 10percent citric acid aqueous solution were added to it. The organic layer was separated and collected, dried over anhydrous magnesium sulfate after washing with saturated sodium chloride aqueous solution, and the solvent was removed under reduced pressure. The obtained residue was refined by silica gel column chromatography [Trikonex company, Flash Tube 2008, eluent; hexane:ethyl acetate=30:1] to give tert-butyl 2-((benzofuran-5-yl)amino)-4-phenylbenzoate. Trifluoroacetic acid 3.0mL solution of the obtained tert-butyl 2-((benzofuran-5-yl)amino)-4-phenylbenzoate was stirred at room temperature for 3 hours. The solvent of reaction mixture was removed under reduced pressure, and the obtained residue was refined by silica gel column chromatography [Trikonex company, Flash Tube 2008, eluent; hexane:ethyl acetate:acetic acid=30:10:1] to give 2-((benzofuran-5-yl)amino)-4-phenylbenzoic acid 42mg. 1H-NMR(DMSO-d6) delta value: 6.95(1H,dd,J=2.2,0.7Hz),7.01(1H,dd,J=8.3,1.7Hz),7.23(1H ,d,J=1.4Hz),7.28(1H,dd,J=8.8,2.2Hz),7.34-7.46(3H,m),7.52-7.54(2H,m),7.61-7.64(2H,m),7.98(1H,d,J=8.3Hz),8.01(1H,d,J=2.2Hz),9.64-9.76(1H,broad),12.88-13.20(1H,broad).

23145-07-5, The synthetic route of 23145-07-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TOYAMA CHEMICAL CO., LTD.; EP1860098; (2007); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem