Category: 1207453-90-4

Chemistry is traditionally divided into organic and inorganic chemistry. name: 6-Fluoro-4-nitroisobenzofuran-1(3H)-one, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 1207453-90-4

TRIAZOLE INTERMEDIATES USEFUL IN THE SYNTHESIS OF PROTECTED N-ALKYLTRIAZOLECARBALDEHYDES

Described herein are compounds and methods of making such compounds useful in the synthesis of protected N-alkyl-triazolecarbaldehydes.

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Benzofuran – Wikipedia,
Benzofuran | C8H3320O – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. category: benzofuran, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 1207453-90-4, name is 6-Fluoro-4-nitroisobenzofuran-1(3H)-one. In an article£¬Which mentioned a new discovery about 1207453-90-4

METHODS OF USING DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY (ADP-RIBOSE)POLYMERASE (PARP)

Provided herein are methods of treating cancer comprising administering a topoisomerase inhibitor, temozolomide, or a platin in combination with a Compound of Formula (I) or Formula (II), where the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 1207453-90-4, help many people in the next few years.category: benzofuran

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Benzofuran – Wikipedia,
Benzofuran | C8H3323O – PubChem

1207453-90-4, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 1207453-90-4, molcular formula is C8H4FNO4, introducing its new discovery.

DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)

A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, 1207453-90-4, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 1207453-90-4

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Benzofuran – Wikipedia,
Benzofuran | C8H3321O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1207453-90-4,6-Fluoro-4-nitroisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

To a solution of 6-fluoro-4-nitroisobenzofuran-1(3H)-one (1) (10 g, 50.8 mmol), 2-methyl-2H-1,2,4-triazole-3-carbaldehyde (2) (11 g, 101.5 mmol) and Et3N (20 mL, 152.4 mmol) in anhydrous THF (150 mL) was added acetic anhydride (35 mL) drop-wise with stirring at room temperature in 3 minutes. The mixture was then stirred at reflux for 45 minutes when a green solid was precipitated from solvent. The solvent was concentrated to 15 mL and the resulting mixture was cooled to 0 C. and filtered, washed with 15 mL of ethyl acetate to obtain (Z)-6-fluoro-3((1-methyl-1H-1,2,4-triazol-5-yl)methylene)-4-nitroisobenzofuran-1(3H)-one (3) as a green solid (11.5 g, yield: 78%). LC-MS (ESI) m/z: 291 (M+1)+. 1H-NMR (400 MHz, DMSO-d6) delta (ppm): 3.94 (s, 3H), 7.15 (s, 1H), 8.10 (s, 1H), 8.40-8.42 (dd, J1=6.4 Hz, J2=2.4 Hz, 1H), 8.58-8.61 (dd, J1=8.8 Hz, J2=2.4 Hz, 1H).

1207453-90-4, The synthetic route of 1207453-90-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BioMarin Pharmaceutical, Inc.; Wang, Bing; Chu, Daniel; US2013/53365; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem