With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.58546-89-7,Benzofuran-5-amine,as a common compound, the synthetic route is as follows.
Example 58 (2521) 3-(Benzofuran-5-ylamino)-7-chloro-5-hydroxy-2H-benzoreiri ,2,41thiadiazine 1 ,1 – dioxide (2522) To a suspension of of 3-bromo-7-chloro-5-hydroxy-4H-benzo[e][1 ,2,4]thiadiazine 1 ,1 – dioxide (lnt-3, 200 mg) and benzofuran-5-amine (103 mg) in t-BuOH (10 mL) stirred under nitrogen was added KH2P04 (105 mg) in one portion. The reaction mixture was stirred at 80 C for 24 hr. The reaction mixture was allowed to cool to RT, then was concentrated under reduced pressure, diluted with deionized water (15 mL) and allowed to stir for 15 min. The resulting precipitate was collected by filtration and washed with water (2 x 5 mL) and diethyl ether (3 x 5 mL), and dried to afford the titled compound (160 mg). LCMS m/z 364.00 (M+H). 1H NMR after D20 exchange(400 MHz, DMSO-c/6) delta ppm 7.02 (d, J=1 .53 Hz, 1 H) 7.10 (d, J=2.19 Hz, 1 H) 7.19 (d, J=1 .97 Hz, 1 H) 7.33 (dd, J=8.77, 2.19 Hz, 1 H) 7.63 (d, J=8.77 Hz, 1 H) 7.87 (d, J=2.19 Hz, 1 H) 8.00 (d, J=2.19 Hz, 1 H)., 58546-89-7
58546-89-7 Benzofuran-5-amine 1477152, abenzofuran compound, is more and more widely used in various fields.
Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ADAMS, Jerry Leroy; ATOR, Laura E.; DUFFY, Kevin J.; GRAYBILL, Todd L.; KIESOW, Terence John; LIAN, Yiqian; MOORE, Michael Lee; RALPH, Jeffrey M.; RIDGERS, Lance Howard; (370 pag.)WO2017/98421; (2017); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem