Category: 60770-67-4

On March 1, 2009, Enz, Albert; Feuerbach, Dominik; Frederiksen, Mathias U.; Gentsch, Conrad; Hurth, Konstanze; Muller, Werner; Nozulak, Joachim; Roy, Bernard L. published an article.Name: 5-Iodobenzofuran The title of the article was Gamma-lactams-A novel scaffold for highly potent and selective α7 nicotinic acetylcholine receptor agonists. And the article contained the following:

A novel class of α7 nicotinic acetylcholine receptor (nAChR) agonists has been discovered through high-throughput screening. The cis γ-lactam scaffold has been optimized to reveal highly potent and selective α7 nAChR agonists with in vitro activity and selectivity and with good brain penetration in mice. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Name: 5-Iodobenzofuran

The Article related to nicotinic receptor a7 agonist mol modeling nachr, gamma lactam derivative sar preparation, Pharmacology: Structure-Activity and other aspects.Name: 5-Iodobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On February 21, 2013, Marom, Ehud; Mizhiritskii, Michael; Rubnov, Shai published a patent.Product Details of 60770-67-4 The title of the patent was Preparation of benzofurans and use thereof as synthetic intermediates. And the patent contained the following:

The present invention provides several synthetic methods for preparing N-(2-butylbenzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide, a compound of formula (3), an intermediate in the preparation of Dronedarone. The present invention further provides a process for preparing Dronedarone, comprising the steps of converting 2-butyl-5-bis(methanesulfon)-amidobenzofuran of formula (3) to Dronedarone, wherein the 2-butyl-5-bis(methanesulfon)-amidobenzofuran of formula (3) is prepared by the processes of the present invention. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Product Details of 60770-67-4

The Article related to preparation dronedarone benzofuran, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenofurans and other aspects.Product Details of 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On August 18, 2011, Marom, Ehud; Mizhiritskii, Michael; Rubnov, Shai published a patent.Related Products of 60770-67-4 The title of the patent was Process for preparation of Dronedarone and synthetic intermediates thereof. And the patent contained the following:

The present invention provides several synthetic methods for preparing N-(2-butylbenzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide, an intermediate in the preparation of Dronedarone. For example, a mixture of CuI, bis(methanesulfonyl)amine, N,N-dimethylglycine, K3PO4, 5-bromo-2-butylbenzofuran (preparation given), and DMF was refluxed for 24-48 h to afford N-(2-butylbenzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide. The intermediate obtained above was reacted with 4-[3-(dibutylamino)propoxy]benzoyl chloride hydrochloride in the presence of aluminum chloride in dry dichloromethane at 5 – 10 °C overnight to afford N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]benzofuran-5-yl]-N-methylsulfonylmethanesulfonamide, which was treated with 5 M NaOH in THF at room temperature for 3 h to give Dronedarone as the final product. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Related Products of 60770-67-4

The Article related to preparation dronedarone benzofuran, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenofurans and other aspects.Related Products of 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On September 25, 2008, Cai, Xiong; Qian, Changgeng; Zhai, Haixiao published a patent.Computed Properties of 60770-67-4 The title of the patent was Preparation of imidazo[4,5-c]pyridine derivatives as HSP90 inhibitors. And the patent contained the following:

Title compounds represented by the formula I [wherein U = N or CH; W = H, halo, amino, etc.; X = absent, O, S, etc.; Y = independently H, halo, NO2, CN or alkyl; Z = (alkylcarbonyl)amino or (di)alkylamino; Q = (un)substituted (hetero)aryl or (Hetero)cycloalkyl; V = H, (un)substituted aryl, alkenyl, etc.; and geometric isomers, enantiomers, diastereomers, racemates, pharmaceutically acceptable salts, prodrugs and solvates thereof] were prepared as HSP90 inhibitors. For example, II was provided in a multi-step synthesis starting from N-(4-pentynyl)phthalimide. I were tested for inhibiting HSP90 chaperone activity in vitro assay and HSP90 competition binding (Fluorescence Polarization) assay. Thus, I and their pharmaceutical compositions are useful as HSP90 inhibitors for the treatment of HSP90 related diseases and disorders such as cancer, an autoimmune disease, or a neurodegenerative disease. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Computed Properties of 60770-67-4

The Article related to imidazopyridine preparation hsp90 inhibitor cancer autoimmune neurodegenerative disease treatment, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Computed Properties of 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On August 15, 2019, Chen, Qingcai; Zhao, Jun; Zhao, Xiaowei; Chen, Xiangfeng; Zong, Zaiwei; Lu, Hui published a patent.Application of 60770-67-4 The title of the patent was Nitrogen-containing heterocyclic compound, preparation method and application. And the patent contained the following:

The invention disclosed a kind of nitrogen-containing heterocyclic compound,its preparation method and application as potassium ion competitive acid retardant or gastric acid secretion inhibitor. The claimed compound is shown in structure I (ring A = saturated or unsaturated five member ring; X1,X2,X3 = C, N, O, S, etc.; a,b = bridge atom C or N; R1 = -SO2R4, -(CH2)nR4, or -CHR4R5; R4 = aryl, arylalkyl, arylalkenyl, benzocyclo, etc.; R5 = halo, nitro, cyano, etc.; n = 0, 1-6 integers; R2 = aryl, arylalkyl, heteroaryl, etc.; R3 = H, alkyl cycloalkyl). The claimed compound is prepared via multiple steps (example procedure given). The prepared compound has proton pump H+/K+-ATP enzyme inhibition effect, and is used for preventing and treating diseases related to inhibition of gastric acid secretion, such as peptic ulcer, zollinger-ellison syndrome, gastritis, erosive esophagitis, reflux esophagitis, symptomatic gastroesophageal reflux disease and the like. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Application of 60770-67-4

The Article related to nitrogen containing heterocycle preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Application of 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On August 13, 2019, Chen, Qingcai; Zhao, Jun; Zhao, Xiaowei; Chen, Xiangfeng; Zong, Zaiwei; Lu, Hui published a patent.Application of 60770-67-4 The title of the patent was Nitrogen-containing heterocyclic compound, preparation method and application. And the patent contained the following:

The invention disclosed a kind of nitrogen-containing heterocyclic compound,its preparation method and application as potassium ion competitive acid retardant or gastric acid secretion inhibitor. The claimed compound is shown in structure I (ring A = saturated or unsaturated five member ring; X1,X2,X3 = C, N, O, S, etc.; a,b = bridge atom C or N; R1 = -SO2R4, -(CH2)nR4, or -CHR4R5; R4 = aryl, arylalkyl, arylalkenyl, benzocyclo, etc.; R5 = halo, nitro, cyano, etc.; n = 0, 1-6 integers; R2 = aryl, arylalkyl, heteroaryl, etc.; R3 = H, alkyl cycloalkyl). The claimed compound is prepared via multiple steps (example procedure given). The prepared compound has proton pump H+/K+-ATP enzyme inhibition effect, and is used for preventing and treating diseases related to inhibition of gastric acid secretion, such as peptic ulcer, zollinger-ellison syndrome, gastritis, erosive esophagitis, reflux esophagitis, symptomatic gastroesophageal reflux disease and the like. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Application of 60770-67-4

The Article related to nitrogen containing heterocycle preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Application of 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On August 29, 2013, Reiser, Ulrich; Bader, Gerd; Spevak, Walter; Steffen, Andreas; Parkes, Alastair L. published a patent.Recommanded Product: 60770-67-4 The title of the patent was Preparation of 5-alkynylpyridines as SMAC mimetics. And the patent contained the following:

This invention relates to 5-alkynyl-pyridines I [R1 = H or alkyl; R2, R21 = H, (fluoro)alkyl; R3 = (un)substituted C6-10 aryl, 5-14 membered heteroaryl; R4 = H, (un)substituted C6-10 aryl, 5-14 membered heteroaryl, etc.; R5 = H, halo, alkyl, etc.; or R4 and R5 taken together form C6-10 aryl, 5-14 membered heteroaryl], to their use as SMAC mimetics, pharmaceutical compositions containing them, and their use as a medicaments for the treatment and/or prevention of diseases characterized by excessive or abnormal cell proliferation and associated conditions such as cancer. Over two-hundred compounds I were prepared E.g., a multi-step synthesis of II, starting from 5,6-dibromopyridin-2-amine and ethynyl-tri(propan-2-yl)silane, was described. Exemplified compounds I were tested in XIAP BIR3 and cIAP1 BIR3 binding assays (data given). The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Recommanded Product: 60770-67-4

The Article related to alkynylpyridine preparation smac mimetic antitumor, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Recommanded Product: 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On March 10, 2010, Deng, Yong; Wu, Chenglong; Shen, Yi; Wan, Jie published a patent.Application of 60770-67-4 The title of the patent was Simple and green method for synthesis of (E)-3-(benzofuran-5-yl)acrylic acid ester. And the patent contained the following:

A process for preparation of (E)-3-(benzofuran-5-yl)acrylic acid ester from p-halophenol and 2-haloacetaldehyde or 2-haloacetal is disclosed. The claimed (E)-3-(benzofuran-5-yl)acrylic acid ester is shown in structure I (R = C1-12 alkyl or cycloalkyl, (un)substituted benzyl, allyl, (un)substituted C6-10 aryl). (E)-3-(benzofuran-5-yl)acrylic acid ester is prepared from p-halophenol and 2-haloacetaldehyde or 2-haloacetal via substitution reaction, Bronsted acid or Lewis acid catalyzed Friedel-Crafts reaction to form 5-halobenzofuran, further Heck reaction with acrylic acid ester to provide the title compound The obtained (E)-3-(benzofuran-5-yl)acrylic acid ester can be further reduced, hydrolyzed, or hydrogenized for give the corresponding derivatives The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Application of 60770-67-4

The Article related to benzofuranylacrylic acid ester preparation substitution friedel crafts heck, Heterocyclic Compounds (One Hetero Atom): Furans and other aspects.Application of 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Emmett, Edward J.; Hayter, Barry R.; Willis, Michael C. published an article in 2014, the title of the article was Palladium-catalyzed synthesis of ammonium sulfinates from aryl halides and a sulfur dioxide surrogate. A gas- and reductant-free process.SDS of cas: 60770-67-4 And the article contains the following content:

Described herein is a simple reaction system consisting of the sulfur dioxide surrogate DABSO, triethylamine, and a palladium(0) catalyst for effective conversion of a broad range of aryl and heteroaryl halides into the corresponding ammonium sulfinates. Key features of this gas- and reductant-free reaction include the low loadings of palladium (1 mol%) and ligand (1.5 mol%) which can be employed, and the use of iso-Pr alc. as both a solvent and formal reductant. The ammonium sulfinate products are converted in situ into a variety of sulfonyl-containing functional groups, including sulfones, sulfonyl chlorides, and sulfonamides. © Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).SDS of cas: 60770-67-4

The Article related to aryl halide dabso butyl bromoacetate sulfonylation palladium catalyst, bytylacetate sulfone preparation, alcohols, arenes, palladium, sulfonamides, synthetic methods, General Organic Chemistry: Synthetic Methods and other aspects.SDS of cas: 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Gravatt, Christopher S.; Johannes, Jeffrey W.; Ghosh, Avipsa published an article in 2021, the title of the article was Photoredox-mediated, nickel-catalyzed trifluoromethylthiolation of aryl and heteroaryl iodides.Electric Literature of 60770-67-4 And the article contains the following content:

The area of trifluoromethylthiolation of aryl halides RI (R = 4-CH3C6H4, 9H-fluoren-2-yl, 4-phenylmorpholine, etc.) has been extensively explored, the current methods require complex and/or air-sensitive catalysts. A method employing a bench-stable nickel(II) salt and an iridium photocatalyst that can mediate the trifluoromethylthiolation of a wide range of electronically diverse aryl and heteroaryl iodides, likely via a Ni(I)/Ni(III) catalytic cycle is reported. The reaction has broad functional group tolerance and potential for application in medicinal chem., as demonstrated by a latestage functionalization approach to access (racemic)-Monepantel. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Electric Literature of 60770-67-4

The Article related to trifluoro arene preparation, aryl iodide silver trifluoromethanethiolate trifluoromethylthiolation nickel catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Electric Literature of 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem