Category: 60770-67-4

On April 3, 2019, Holt, Connor; Alachouzos, Georgios; Frontier, Alison J. published an article.Quality Control of 5-Iodobenzofuran The title of the article was Leveraging the Halo-Nazarov Cyclization for the Chemodivergent Assembly of Functionalized Haloindenes and Indanones. And the article contained the following:

In this report, we describe a halo-Prins/aryl halo-Nazarov cyclization strategy that employs readily available starting materials, inexpensive reagents, and convenient reaction procedures to generate functionalized haloindenes and indanones. The scope and limitations of the method are outlined, demonstrating that aromatic systems readily react under mild, catalytic conditions when this strategy is implemented. Furthermore, we present both exptl. and computational data supporting the notion that cyclizations of 3-halopentadienyl cationic intermediates are more kinetically accessible, as well as more thermodynamically favorable, than cyclizations of the analogous 3-oxypentadienyl cationic systems. The energetic advantage imparted by the halo-Nazarov cyclization design was found to be especially valuable in the cyclizations of arylallyl cationic intermediates, which require disruption of aromaticity. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Quality Control of 5-Iodobenzofuran

The Article related to chemodivergent haloindene indanone preparation, halo prins aryl halo nazarov cyclization computational study, General Organic Chemistry: Synthetic Methods and other aspects.Quality Control of 5-Iodobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On September 16, 2022, Shao, Xinxin; Zhang, Yan; Liu, Wen published a patent.Application of 60770-67-4 The title of the patent was Preparation of S-(methyl-d3)phenyl sulfide as deuterated thiomethylation reagents. And the patent contained the following:

The invention discloses a preparation of S-(methyl-d3)phenyl sulfide shown in general formula I [R2=2-naphthyl, 1-quinolinyl or substituted phenyl] as deuterated thiomethylation reagents, which has the advantages of low cost, simple preparation and good structure controllability. For example, S-(methyl-d3) 4-methylbenzenesulfonothioate was prepared by thioetherification of methyl-d3 4-methylbenzenesulfonate and sodium 4-methylbenzenesulfonothioate. The title compound is used as an electrophilic tri-deuterium methylation reagent for reductive coupling reaction with aryl iodine derivatives or cross coupling reaction with terminal alkyne derivatives The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Application of 60770-67-4

The Article related to preparation deuterated methyl phenyl sulfide thiomethylation reagent thioetherification coupling, Placeholder for records without volume info and other aspects.Application of 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On October 31, 2018, Wang, Xuan; Ma, Guobin; Peng, Yu; Pitsch, Chloe E.; Moll, Brenda J.; Ly, Thu D.; Wang, Xiaotai; Gong, Hegui published an article.Product Details of 60770-67-4 The title of the article was Ni-Catalyzed Reductive Coupling of Electron-Rich Aryl Iodides with Tertiary Alkyl Halides. And the article contained the following:

This work illustrates the reductive coupling of electron-rich aryl halides with tertiary alkyl halides under Ni-catalyzed cross-electrophile coupling conditions, which offers an efficient protocol for the construction of all carbon quaternary stereogenic centers. The mild and easy-to-operate reaction tolerates a wide range of functional groups. The utility of this method is manifested by the preparation of cyclotryptamine derivatives, wherein successful incorporation of 7-indolyl moieties is of particular interest as numerous naturally occurring products are composed of these key scaffolds. DFT calculations have been carried out to investigate the proposed radical chain and double oxidative addition pathways, which provide useful mechanistic insights into the part of the reaction that takes place in solution The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Product Details of 60770-67-4

The Article related to all carbon quaternary stereogenic center synthesis, reductive coupling electron rich haloarene tertiary alkyl halide mechanism, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.Product Details of 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Cagniant, Paul; Kirsch, Gilbert published an article in 1976, the title of the article was Method for the synthesis of mono- or polysubstituted 3(2H)-benzofuranones and benzo[b]furans.Name: 5-Iodobenzofuran And the article contains the following content:

Benzofurans I (R = H, Me; R1 = 7-Me, 6-Me, 6-OMe, 5-OMe, 5-SMe, 5-F, 5-I; R2 = H) were prepared by alkylating the salicyclic esters II (R3 = H) with BrCHRCO2Et, hydrolyzing II (R3 = CHRCO2Et), cyclizing the diacids with AcONa-AcOH-Ac2O, hydrolyzing I (R2 = OAc), reducing III (X =O), and dehydrating III (X = H,OH). I (R = Ac, R2 = OAc) were obtained as byproducts of I (R = H,Me, R2 = OAc). The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Name: 5-Iodobenzofuran

The Article related to benzofuran, salicylate carboxyalkoxy cyclization, carboxyalkoxysalicyclate cyclization, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenofurans and other aspects.Name: 5-Iodobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On July 22, 2022, Bai, Jiaxing; Xu, Nengni; Wang, Hui; Luan, Xinjun published an article.Computed Properties of 60770-67-4 The title of the article was Palladium(II)-Catalyzed [2+2+1] Annulation of Alkynes and Hydroxylamines: A Rodox-Neutral Approach to Fully Substituted Pyrroles. And the article contained the following:

A palladium-catalyzed [2+2+1] annulation of alkynes and hydroxylamines was developed for the rapid construction of fully substituted pyrroles. This transformation involves sequential nucleophilic-addition of hydroxylamine to alkyne, alkyne migratory insertion, and synergistic demetallization cyclization, which provides a redox-neutral annulation approach to pyrrole derivatives Moreover, the strategy enabled alteration of the photophys. properties of pyrrole products by varying the aryl substituents, thus leading to the development of N-functionalized tetraarylpyrroles as new fluorophores. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Computed Properties of 60770-67-4

The Article related to hydroxylamine aryl alkyne palladium catalyst regioselective cycloaddition, pyrrole preparation, Heterocyclic Compounds (One Hetero Atom): Pyrroles and Pyrrolizines and other aspects.Computed Properties of 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Saxena, Paridhi; Maida, Neha; Kapur, Manmohan published an article in 2019, the title of the article was Dioxazolones as masked ester surrogates in the Pd(II)-catalyzed direct C-H arylation of 6,5-fused heterocycles.Formula: C8H5IO And the article contains the following content:

A simple and effective Pd(II)-catalyzed regioselective C(2)-H arylation of 6,5-fused heterocycles with dioxazolones as a masked ester surrogate under mild conditions was reported. The significance of the arylation was highlighted by the new reactivity demonstrated in dioxazolones via proximal C-H activation of the cyclic carbonate of the hydroxamic acid functionality under protic conditions. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Formula: C8H5IO

The Article related to dioxazolonyl benzene benzofuran alkanol palladium catalyst regioselective arylation, benzofuranyl benzoate preparation, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenothiophenes and other aspects.Formula: C8H5IO

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On February 20, 2003, Gerlach, Matthias; Przewosny, Michael; Englberger, Werner Guenter; Reissmueller, Elke; Bloms-Funke, Petra; Maul, Corinna; Jagusch, Utz-Peter published a patent.Name: 5-Iodobenzofuran The title of the patent was Preparation of 5,6,6a,11b-tetrahydro-7-oxa-5-aza-benzo[c]fluoren-6-carboxylic acids as NMDA antagonists for the treatment of pain. And the patent contained the following:

Title compounds I [R1, R2, R3, R4 = H, halo, CN, etc.; R5 = H, alkyl, alkenyl, etc.; R6 = R12, ZR12; R12 = H, alkyl, alkenyl, etc.; Z = (un)substituted alkyl, alkenyl, alkynyl; R7, R8, R9, R10 = H, halo, CN, etc.] and their pharmaceutically acceptable salts were prepared For example, acid catalyzed three-component coupling of benzofuran, oxoacetic acid and 3,5-dichlorobenzenamine provided claimed benzo[c]fluorene II (no data provided). In glycine binding site studies of the NMDA receptor channel, one specific example of compound I, benzo[c]fluorene II exhibited a Ki = 0.053 μM. Compounds I are claimed useful as analgesic agents for the treatment of pain. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Name: 5-Iodobenzofuran

The Article related to preparation benzofluorenecarboxylic acid analgesic agent pain, benzofluorenecarboxylic acid preparation nmda antagonist glutamate receptor, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Name: 5-Iodobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On February 2, 2021, Chen, Haifeng; Ye, Zhonghua; Zhang, Zhaochao; Li, Chong published a patent.COA of Formula: C8H5IO The title of the patent was Preparation of benzoxazole or benzothiazole derivatives containing carbazole structure for organic light emitting devices. And the patent contained the following:

The invention relates to the preparation of benzoxazole or benzothiazole derivatives with general formula I containing carbazole structure for organic electroluminescent devices [where L1, L2, L3 = single bond, substituted or unsubstituted C6-C30 arylene, substituted or unsubstituted C2-C30 heteroarylene; X = O or S; R1 = substituted or unsubstituted 5-60 membered heteroaryl containing one or more heteroatoms], which has the following advantages: high glass transition temperature, low evaporation temperature, good thermal stability, low extinction coefficient, high refractive index, high luminous efficiency, and low energy consumption. For example, 2,2′-(9-(4-(benzo[d]oxazol-2-yl)phenyl)-9H-carbazole-3,6-diyl)bis(benzo[d]oxazole) was prepared by condensation reaction of 3,6-dibromo-9H-carbazole with 2-(4-iodophenyl)benzo[d]oxazole, and then condensation reaction with benzo[d]oxazole. The title compounds can be used to prepare organic light emitting devices. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).COA of Formula: C8H5IO

The Article related to condensation suzuki coupling preparation benzoxazole benzothiazole carbazole oled, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.COA of Formula: C8H5IO

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On February 4, 2020, Mao, Jianyou; Ling, Bo; Yang, Wenjun published a patent.Name: 5-Iodobenzofuran The title of the patent was Synthetic method of β,β-disubstituted propionate derivatives from aldehyde, iodide and alcohol by one-pot process. And the patent contained the following:

The invention is related to the synthetic method of β,β-disubstituted propionate derivatives from aldehyde, iodide and alc. by one-pot process. The title method includes subjecting aldehyde (cinnamaldehyde, 3-(4-chloro-phenyl)-propenal, etc.), iodide (iodobenzene, 4-tert-butyliodobenzene, etc.) and alc. (methanol, etc.) to a one-pot process in the presence of catalyst (N-heterocyclic carbene catalysts (1,3-bis(2, 6-diisopropylphenyl)imidazolium chloride, 1,3-dicyclohexyl-imidazolium chloride, etc.) and transition metal catalysts (tetrakis(triphenylphosphine)palladium, palladium acetate, etc.)), strong base (potassium methoxide, cesium carbonate, etc.) and ligand (2,2′:6′,2”-terpyridine, L6, etc.) to obtain the β,β-disubstituted propionate derivatives (Me 3,3-diphenylpropionate, Me 3-naphthalen-1-yl-3-phenyl-propionate, etc.). The method realizes the arylation of β-position and the esterification of carbonyl of α,β-unsaturated aldehydes to synthesize Me β,β-disubstituted propionate. The method reduces the synthetic steps of the conventional process, improves the reaction yield, has the advantages of cheap raw materials, simple operation steps and mild reaction conditions, and greatly enriches the applicability of the substrate for the reaction. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Name: 5-Iodobenzofuran

The Article related to synthetic disubstituted propionate derivative aldehyde iodide alc, Aliphatic Compounds: Esters, Linear Anhydrides, Acyl Peroxides, and Acyl Halides and other aspects.Name: 5-Iodobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On July 26, 2021, Boehm, Philip; Martini, Tristano; Lee, Yong Ho; Cacherat, Bastien; Morandi, Bill published an article.Recommanded Product: 5-Iodobenzofuran The title of the article was Palladium-Catalyzed Decarbonylative Iodination of Aryl Carboxylic Acids Enabled by Ligand-Assisted Halide Exchange. And the article contained the following:

An efficient and broadly applicable palladium-catalyzed iodination of inexpensive and abundant aryl and vinyl carboxylic acids via in situ activation to the acid chloride and formation of a phosphonium salt is reported. The use of 1-iodobutane as iodide source in combination with a base and a deoxychlorinating reagent gives access to a wide range of aryl and vinyl iodides under Pd/Xantphos catalysis, including complex drug-like scaffolds. Stoichiometric experiments and kinetic anal. suggest a unique mechanism involving C-P reductive elimination to form the Xantphos phosphonium chloride, which subsequently initiates an unusual halogen exchange by outer sphere nucleophilic substitution. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Recommanded Product: 5-Iodobenzofuran

The Article related to aryl vinyl carboxylic acid decarbonylative iodination palladium catalyst, iodination, ligand non-innocence, palladium, reaction mechanism, shuttle catalysis, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.Recommanded Product: 5-Iodobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem