Category: 58546-89-7

Electric Literature of 58546-89-7, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 58546-89-7, Benzofuran-5-amine, introducing its new discovery.

BENZOTHIADIAZINE COMPOUNDS

The invention is directed to substituted benzothiadiazine derivatives. Specifically, the invention is directed to compounds according to Formula (I):wherein R, R1, R2, R3, R4 and R5 are as defined herein. The compounds of the invention are inhibitors of CD73 and can be useful in the treatment of cancer, pre-cancerous syndromes and diseases associated with CD73 inhibition, such as AIDS, autoimmune diseases, infections, atherosclerosis, and ischemia-reperfusion injury. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting CD73 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 58546-89-7. In my other articles, you can also check out more blogs about 58546-89-7

Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H359O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: 58546-89-7, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 58546-89-7, Name is Benzofuran-5-amine, molecular formula is C8H7NO

Tetrahydro-3: H -pyrazolo[4,3- a] phenanthridine-based CDK inhibitor

Cyclin-dependent kinases have emerged as important targets for cancer therapy. HSD992, containing a novel scaffold based on the tetrahydro-3H-pyrazolo[4,3-a]phenanthridine core, inhibits CDK2/3 but not other CDKs and also potently inhibits several cancer cell lines.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Recommanded Product: 58546-89-7, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 58546-89-7

Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H388O – PubChem

Application of 58546-89-7, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 58546-89-7, Benzofuran-5-amine, introducing its new discovery.

TRIAZINE DERIVATIVES FOR TREATING DISEASES RELATING TO NEUROTROPHINS

There is provided herein a compound of formula (I) wherein R1, R2, n, X, Q, L, m, R3 and p are as defined herein, which compounds are useful in the treatment of treatment of diseases characterised by impaired signalling of neurotrophins and/or other trophic factors, such as Alzheimer’s disease and the like.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 58546-89-7. In my other articles, you can also check out more blogs about 58546-89-7

Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H371O – PubChem

58546-89-7, Benzofuran-5-amine is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,58546-89-7

PREPARATION VIII N-(4-fluorobenzoyl)-5-aminobenzofuran The title compound is obtained from 4-fluorobenzoyl chloride and 5-aminobenzofuran by the procedure of Preparation VI.

58546-89-7 Benzofuran-5-amine 1477152, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; ELI LILLY AND COMPANY; EP875513; (1998); A1;; ; Patent; Eli Lilly and Company; US5874427; (1999); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.58546-89-7,Benzofuran-5-amine,as a common compound, the synthetic route is as follows.

58546-89-7, To a solution of benzofuran-5-amine (CAS No. 58546-89-7, 200 mg, 1.5 mmol) in acetic acid (8 mL) was added ammonium thiocyanate (456 mg, 6.0 mmol) at RT under nitrogen atmosphere. After stirring for 10 min, bromine (480 mg, 3.0 mmol) was added dropwise at about 10 C. The resulting mixture was slowly warmed to RT and stirred for 12 h. The precipitate was collected by filtration to afford the title compound as pale brown solid (200 mg, 70%). LC/MS (ES+) calcd for C9H6N2OS: 190.0; found: 193.0 [M+3]. 1H NMR (400 MHz, DMSO-d6): delta 8.01 (d, J=2.0 Hz, 1H), 7.46 (d, J=8.4 Hz, 1H), 7.36 (s, 2H), 7.32 (d, J=8.4 Hz, 1H), 6.99 (d, J=2.0 Hz, 1H).

As the paragraph descriping shows that 58546-89-7 is playing an increasingly important role.

Reference£º
Patent; Kineta Immuno-Oncology LLC; Goldberg, Daniel R.; Probst, Peter; Bedard, Kristin M.; (72 pag.)US2020/55871; (2020); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.58546-89-7,Benzofuran-5-amine,as a common compound, the synthetic route is as follows.

Example 58 (2521) 3-(Benzofuran-5-ylamino)-7-chloro-5-hydroxy-2H-benzoreiri ,2,41thiadiazine 1 ,1 – dioxide (2522) To a suspension of of 3-bromo-7-chloro-5-hydroxy-4H-benzo[e][1 ,2,4]thiadiazine 1 ,1 – dioxide (lnt-3, 200 mg) and benzofuran-5-amine (103 mg) in t-BuOH (10 mL) stirred under nitrogen was added KH2P04 (105 mg) in one portion. The reaction mixture was stirred at 80 C for 24 hr. The reaction mixture was allowed to cool to RT, then was concentrated under reduced pressure, diluted with deionized water (15 mL) and allowed to stir for 15 min. The resulting precipitate was collected by filtration and washed with water (2 x 5 mL) and diethyl ether (3 x 5 mL), and dried to afford the titled compound (160 mg). LCMS m/z 364.00 (M+H). 1H NMR after D20 exchange(400 MHz, DMSO-c/6) delta ppm 7.02 (d, J=1 .53 Hz, 1 H) 7.10 (d, J=2.19 Hz, 1 H) 7.19 (d, J=1 .97 Hz, 1 H) 7.33 (dd, J=8.77, 2.19 Hz, 1 H) 7.63 (d, J=8.77 Hz, 1 H) 7.87 (d, J=2.19 Hz, 1 H) 8.00 (d, J=2.19 Hz, 1 H)., 58546-89-7

58546-89-7 Benzofuran-5-amine 1477152, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ADAMS, Jerry Leroy; ATOR, Laura E.; DUFFY, Kevin J.; GRAYBILL, Todd L.; KIESOW, Terence John; LIAN, Yiqian; MOORE, Michael Lee; RALPH, Jeffrey M.; RIDGERS, Lance Howard; (370 pag.)WO2017/98421; (2017); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

58546-89-7, Benzofuran-5-amine is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

58546-89-7, Reference Example 1-14-(Benzofuran-5-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid ethyl ester hydrochloride To a solution of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid ethyl ester (0.383 g, 1.70 mmol) in isopropanol (15 ml) was added 5-aminobenzo[b]furan (0.250 g, 1.88 mmol), and the mixture was heated for 1 hour under reflux.After the completion of the reaction, the reaction mixture was cooled to 0 C., and then the precipitated solid was collected by filtration, washed with diethyl ether, and dried under reduced pressure to give the compound of the Reference Example 1-1 (0.528 g, 1.47 mmol, yield 87%).Mass (EI, m/z): 322 [M]+.1H-NMR (DMSO-d6) delta: 12.95 (1H, br s), 11.06 (1H, s), 8.39 (1H, s), 8.24 (1H, d, J=1.7 Hz), 8.15 (1H, s), 8.02 (1H, d, J=2.0 Hz), 7.65 (1H, d, J=8.8 Hz), 7.56 (1H, dd, J=8.8, 2.0 Hz), 7.02 (1H, d, J=1.7 Hz), 4.40 (2H, q, J=7.1 Hz), 1.37 (3H, t, J=7.1 Hz).

58546-89-7 Benzofuran-5-amine 1477152, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; UBE INDUSTRIES, LTD.; US2012/149902; (2012); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

58546-89-7,58546-89-7, Benzofuran-5-amine is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution uf benzofuran-5-amine (CAS No. 58546-89-7, 200 mg, 1.5 mmol) in acetic acid (8 mL) was added ammonium thiocyanate (456 mg, 6.0 mmol) at RT under nitrogen atmosphere. After stirring for 10 min, bromine (480 mg, 3.0 mmol) was added dropwise at about 10 C. The resulting mixture was slowly warmed to RT and stirred for 12 h. The precipitate was collected by filtration to afford the title compound as pale brown solid (200 mg, 70%). LC/MS (ES+) calcd for C9H6N2OS: 190.0; found: 193.0 [M+3] NMR (400 MHz, DMSO-c/d): d 8.01 (d, J= 2.0 Hz, 1H), 7.46 (d, J= 8.4 Hz, 1H), 7.36 (s, 2H), 7.32 (d, J= 8.4 Hz, 1H), 6.99 (d, J= 2.0 Hz, 1H).

The synthetic route of 58546-89-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; KINETA, INC.; GOLDBERG, Daniel R.; PROBST, Peter; BEDARD, Kristin M.; (172 pag.)WO2020/36574; (2020); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem