Month: February 2023

Potential Diagnostic Imaging of Alzheimer’s Disease with Copper-64 Complexes That Bind to Amyloid-β Plaques was written by McInnes, Lachlan E.;Noor, Asif;Kysenius, Kai;Cullinane, Carleen;Roselt, Peter;McLean, Catriona A.;Chiu, Francis C. K.;Powell, Andrew K.;Crouch, Peter J.;White, Jonathan M.;Donnelly, Paul S.. And the article was included in Inorganic Chemistry in 2019.Electric Literature of C9H9BO4 This article mentions the following:

Amyloid-β plaques, consisting of aggregated amyloid-β peptides, are one of the pathol. hallmarks of Alzheimer’s disease. Copper complexes formed using positron-emitting copper radionuclides that cross the blood-brain barrier and bind to specific mol. targets offer the possibility of noninvasive diagnostic imaging using positron emission tomog. New thiosemicarbazone-pyridylhydrazone based ligands that incorporate pyridyl-benzofuran functional groups designed to bind amyloid-β plaques have been synthesized. The ligands form stable complexes with copper(II) (K_d = 10^-18 M) and can be radiolabeled with copper-64 at room temperature Subtle changes to the periphery of the ligand backbone alter the metabolic stability of the complexes in mouse and human liver microsomes, and influenced the ability of the complexes to cross the blood-brain barrier in mice. A lead complex was selected based on possessing the best metabolic stability and brain uptake in mice. Synthesis of this lead complex with isotopically enriched copper-65 allowed us to show that the complex bound to amyloid-β plaques present in post-mortem human brain tissue using laser ablation-inductively coupled plasma-mass spectrometry. This work provides insight into strategies to target metal complexes to amyloid-β plaques, and how small modifications to ligands can dramatically alter the metabolic stability of metal complexes as well as their ability to cross the blood-brain barrier. In the experiment, the researchers used many compounds, for example, (5-Methoxybenzofuran-2-yl)boronic acid (cas: 551001-79-7Electric Literature of C9H9BO4).

(5-Methoxybenzofuran-2-yl)boronic acid (cas: 551001-79-7) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Electric Literature of C9H9BO4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Metal-Organic Framework-Based Nanoagents for Effective Tumor Therapy by Dual Dynamics-Amplified Oxidative Stress was written by Chen, Jiajie;Wang, Yitong;Niu, Huicong;Wang, Yuwei;Wu, Aijun;Shu, Chaoqin;Zhu, Yufang;Bian, Yuhai;Lin, Kaili. And the article was included in ACS Applied Materials & Interfaces in 2021.Formula: C20H10Cl2O5 This article mentions the following:

Overproduction of reactive oxygen species (ROS) within tumors can cause oxidative stress on tumor cells to induce death, which has motivated us to develop ROS-mediated tumor therapies, such as typical photodynamic therapy (PDT) and Fenton reaction-mediated chemodynamic therapy (CDT). However, these therapeutic modalities suffer from compromised treatment efficacy owing to their limited generation of highly reactive ROS in a tumor microenvironment (TME). In this work, a nanoscale iron-based metal-organic framework, MIL-101(Fe), is synthesized as a Fenton nanocatalyst to perform the catalytic conversion of hydroxyl radicals (·OH) from hydrogen peroxide (H2O2) under the acidic environment and as a biocompatible and biodegradable nanocarrier to deliver a 5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin (TCPP) photosensitizer for light-activated singlet oxygen (1O2) generation. By coupling such chemodynamic/photodynamic effects, the photosensitizer-integrated nanoagents (MIL-101(Fe)@TCPP) could enable more ROS production within tumors to induce amplified oxidative damage for tumor-specific synergistic therapy. In vitro results show that MIL-101(Fe)@TCPP nanoagents achieve the acid-responsive CDT and effective PDT, and synergistic CDT/PDT provides an enhanced therapeutic effect. Ultimately, based on such synergistic therapy, MIL-101(Fe)@TCPP nanoagents cause a significant tumor growth inhibition in vivo without severe side effects, showing great potential for anti-tumor application. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Formula: C20H10Cl2O5).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Formula: C20H10Cl2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Highly selective and sensitive ‘on-off’ fluorescent chemosensor for Fe³⁺ ions crafted by benzofuran moiety in both experimental and theoretical methods was written by Madhu, P.;Sivakumar, P.;Sribalan, Rajendran;Arumugam, Senthil M.. And the article was included in Luminescence in 2022.Category: benzofurans This article mentions the following:

A benzofuran glycinamide-based chemosensor, 3-(2-([4-fluorobenzyl]amino)acetamido)benzofuran-2-carboxamide (BGA) was developed and synthesized for the selective and sensitive detection of Fe³⁺ ions. The photophys. properties of the probe BGA were studied using UV-visible light absorption and fluorescence spectrophotometers. The chemosensor BGA showed a marked ‘on-off’ fluorescence response toward Fe³⁺ ions in the presence of other metal ions in DMSO/H₂O solution (9/1, volume/volume). The very low limits of detection (LOD) were calculated to be 10 nM and 43 nM using UV-visible light absorption and fluorescence spectrophotometers, resp. Job’s plot anal. revealed the formation of a BGA-Fe³⁺ complex with a 1:1 binding stoichiometry ratio using UV-visible light spectroscopy. The sensing mechanism was also demonstrated using d. functional theory calculation In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Category: benzofurans).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Pyrocatalysis-The DCF assay as a pH-robust tool to determine the oxidation capability of thermally excited pyroelectric powders was written by Raufeisen, Sascha;Stelter, Michael;Braeutigam, Patrick. And the article was included in PLoS One in 2020.Category: benzofurans This article mentions the following:

Pyrocatalysis uses thermally excited pyroelec. materials for the generation of reactive oxygen species in water. This unique feature allows it to harvest energy in the form of natural temperature gradients or waste heat from industrial processes in order to degrade organic pollutants at low costs. Its further development into an advanced oxidation process for water remediation is dependent on the availability of pH-robust and nonspecific redox assays for the determination of its oxidation capability. Nevertheless, previous studies neglected the influence of pH changes and they were focused mainly on the degradation of one organic compound or specific chem. dosimetries. In this study, a pH-robust and nonspecific reaction protocol of the dichlorofluorescein assay was established for the investigation of the oxidation capability of the pyrocatalytic process. This reaction protocol was tested on three pyroelec. powders (LiNbO3, LiTaO3, BaTiO3) in different amounts and it overcomes major constraints of a previously used dichlorodihydrofluorescein diacetate-based reaction protocol. Instead of its diacetate, dichlorodihydrofluorescein was used as fluorogenic probe and its concentration was drastically reduced to 1 μM. For the first time, these changes enable the determination and comparison of the oxidation capability independently of pH-rising processes, which are present for all investigated pyroelec. powders up to a pH of 11. Addnl., the precision of the dichlorofluorescein assay was drastically increased and the determination and consideration of autoxidation processes was enabled. Of all three pyroelec. powders, BaTiO3 exhibited the highest oxidation capability with a linear increase with respect to the powder amount In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Category: benzofurans).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The design, synthesis, and biological evaluation of PIM kinase inhibitors was written by Tsuhako, Amy Lew;Brown, David S.;Koltun, Elena S.;Aay, Naing;Arcalas, Arlyn;Chan, Vicky;Du, Hongwang;Engst, Stefan;Franzini, Maurizio;Galan, Adam;Huang, Ping;Johnston, Stuart;Kane, Brian;Kim, Moon H.;Douglas Laird, A.;Lin, Rui;Mock, Lillian;Ngan, Iris;Pack, Michael;Stott, Gordon;Stout, Thomas J.;Yu, Peiwen;Zaharia, Cristiana;Zhang, Wentao;Zhou, Peiwen;Nuss, John M.;Kearney, Patrick C.;Xu, Wei. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Product Details of 54802-10-7 This article mentions the following:

A series of substituted benzofuropyrimidinones with pan-PIM activities and excellent selectivity against a panel of diverse kinases is described. Initial exploration identified aryl benzofuropyrimidinones that were potent, but had cell permeability limitations. Using X-ray crystal structures of the bound PIM-1 complexes with I, II, and III, the authors were able to guide the SAR and identify alkyl benzofuropyrimidinone IV with good PIM potencies, permeability, and oral exposure. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Product Details of 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Product Details of 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Titration of lysine residues on adenine nucleotide translocase by fluorescamine induces permeability transition was written by Buelna-Chontal, Mabel;Pavon, Natalia;Correa, Francisco;Hernandez-Esquivel, Luz;Chavez, Edmundo. And the article was included in Cell Biology International in 2014.HPLC of Formula: 38183-12-9 This article mentions the following:

Chem. modification of primary amino groups of mitochondrial membrane proteins by the fluorescent probe, fluorescamine (I), induced nonspecific membrane permeabilization. Titration of the Lys ε-amino group promoted efflux of accumulated Ca²⁺, collapse of transmembrane potential, and mitochondrial swelling. Ca²⁺ release was inhibited by cyclosporin A. Considering the latter, the authors assumed that I induced the permeability transition. Carboxyatractyloside also inhibited the reaction. Using a polyclonal antibody for adenine nucleotide translocase, Western blot anal. showed that the carrier appeared labeled with I. The results pointed out the importance of the ε-amino group of Lys residues, located in the adenine nucleotide carrier, on the modulation of membrane permeability, since its blockage suffices to promote opening of the nonspecific nanopore. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9HPLC of Formula: 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.HPLC of Formula: 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Design, synthesis and biological evaluation of benzofuran appended benzothiazepine derivatives as inhibitors of butyrylcholinesterase and antimicrobial agents was written by Mostofi, Manizheh;Mohammadi Ziarani, Ghodsi;Lashgari, Negar. And the article was included in Bioorganic & Medicinal Chemistry in 2018.Reference of 38220-75-6 This article mentions the following:

A series of benzofuran appended 1,5-benzothiazepine compounds I (R¹ = H, 5-Br, 5-NO₂, 7-OMe; R² = 4-OH, 1-naphthyl, 3-indolyl, etc.) was designed, synthesized and evaluated as cholinesterase inhibitors. The biol. assay experiments showed that most of the compounds displayed a clearly selective inhibition for butyrylcholinesterase (BChE), while a weak or no effect towards acetylcholinesterase (AChE) was detected. All analogs exhibited varied BChE inhibitory activity with IC₅₀ value ranging between 1.0 +/- 0.01 and 72 +/- 2.8 μM when compared with the standard donepezil (IC₅₀, 2.63 +/- 0.28 μM). Among the synthesized derivatives, compounds I (R¹ = 5-Br; R² = 2-MeO, 3-MeO, 4-MeO) exhibited the highest BChE inhibition with IC₅₀ values of 1.0, 1.0 and 1.8 μM, resp. The results from a Lineweaver-Burk plot indicated a mixed-type inhibition for compound I (R¹ = 5-Br; R² = 3-MeO) with BChE. In addition, docking studies confirmed the results obtained through in vitro experiments and showed that most potent compounds bind to both the catalytic anionic site (CAS) and peripheral anionic site (PAS) of BChE active site. The synthesized compounds were also evaluated for their in vitro antibacterial and antifungal activities. The results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms and showed high activity against both gram pos. and gram neg. bacteria and fungi. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Reference of 38220-75-6).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Reference of 38220-75-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Computational Predictions of Glass-Forming Ability and Crystallization Tendency of Drug Molecules was written by Alhalaweh, Amjad;Alzghoul, Ahmad;Kaialy, Waseem;Mahlin, Denny;Bergstroem, Christel A. S.. And the article was included in Molecular Pharmaceutics in 2014.Recommanded Product: 38183-12-9 This article mentions the following:

Amorphization is an attractive formulation technique for drugs suffering from poor aqueous solubility as a result of their high lattice energy. Computational models that can predict the material properties associated with amorphization, such as glass-forming ability (GFA) and crystallization behavior in the dry state, would be a time-saving, cost-effective, and material-sparing approach compared to traditional exptl. procedures. This article presents predictive models of these properties developed using support vector machine (SVM) algorithm. The GFA and crystallization tendency were investigated by melt-quenching 131 drug mols. in situ using differential scanning calorimetry. The SVM algorithm was used to develop computational models based on calculated mol. descriptors. The analyses confirmed the previously suggested cutoff mol. weight (MW) of 300 for glass-formers, and also clarified the extent to which MW can be used to predict the GFA of compounds with MW < 300. The topol. equivalent of Grav3_3D, which is related to mol. size and shape, was a better descriptor than MW for GFA; it was able to accurately predict 86% of the data set regardless of MW. The potential for crystallization was predicted using mol. descriptors reflecting Hückel pi at. charges and the number of hydrogen bond acceptors. The models developed could be used in the early drug development stage to indicate whether amorphization would be a suitable formulation strategy for improving the dissolution and/or apparent solubility of poorly soluble compounds In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Recommanded Product: 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Recommanded Product: 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Studies on benzofurans. Part IV: Synthesis of some 2-substituted and 2,3-disubstituted 3,4-dihydro-4-oxobenzofuro[3,2-d]pyrimidines was written by Mahajan, S. B.;Agasimundin, Y. S.. And the article was included in Journal of the Indian Chemical Society in 1977.Related Products of 54802-10-7 This article mentions the following:

The acylaminofurancarboxylic acids I (R = Me, Et, Ph, PhCH₂) were cyclized to give the benzofurooxazines II, which were treated with amines to give the benzofuropyrimidines III (R = Me, Et, PhCH₂, R¹ = H; R = Me, R¹ = Ph, substituted Ph, 2-naphthyl). In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Related Products of 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Related Products of 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

N,B-Bidentate Boryl Ligand-Supported Iridium Catalyst for Efficient Functional-Group-Directed C-H Borylation was written by Wang, Guanghui;Liu, Li;Wang, Hong;Ding, You-Song;Zhou, Jing;Mao, Shuai;Li, Pengfei. And the article was included in Journal of the American Chemical Society in 2017.COA of Formula: C10H8O3 This article mentions the following:

Convenient silylborane precursors for introducing N,B-bidentate boryl ligands onto transition metals were designed, prepared, and employed in ready formation of iridium(III) complexes via Si-B oxidative addition A practical, efficient catalytic ortho-borylation reaction of arenes with a broad range of directing groups was developed using an in situ generated catalyst from the silylborane preligand 3c and [IrCl(COD)]₂. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1COA of Formula: C10H8O3).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.COA of Formula: C10H8O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem