Month: February 2023

Dermatologic management of ocular mucous membrane (cicatricial) pemphigoid with mycophenolate mofetil in 38 patients was written by Hrin, Matthew L.;Jorizzo, Joseph L.;Feldman, Steven R.;Shah, Rajiv E.;Huang, William W.. And the article was included in Journal of the American Academy of Dermatology in 2022.Application In Synthesis of (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid This article mentions the following:

This article describes about dermatol. management of ocular mucous membrane (cicatricial) pemphigoid with mycophenolate mofetil in 38 patients. In the experiment, the researchers used many compounds, for example, (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid (cas: 24280-93-1Application In Synthesis of (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid).

(E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid (cas: 24280-93-1) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Application In Synthesis of (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Chemical constituents from aerial part of Rumex patientia was written by Zeng, Yong;Luo, Jian-jun;Li, Chong. And the article was included in Zhongyaocai in 2013.Formula: C22H22O10 This article mentions the following:

The chem. constituents from aerial part of Rumex patientia were studied. The compounds were isolated and purified by silica gels and polyamide column chromatog. Their structures were elucidated by physicochem. and spectroscopic evidences. Twelve compounds were identified as: chrysophanol (1), chrysophanol-8-O-β-D-glucopyranoside (2), physcion (3), emodin (4), emodin-8-O-β-D-glucopyranoside (5), maackiain (6), maackiain-3-O-β-D-glucopyranoside (7), quercetin-3-O-β-D-glucopyranoside (8), quercetin-3-O-β-D-glucuronide(9), 2-O-methylinositol(10), torachrysone-8-O-β-D-glucopyranoside(11) and nepodin-8-O-β-D-glucopyranoside (12). Compounds 6,7,10 are isolated from this genus for the first time, and compound 9 is isolated from this plant for the first time. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6Formula: C22H22O10).

(2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Formula: C22H22O10

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Biomembrane-embedded catalysts for membrane-associated protein labeling on red blood cells was written by Yasueda, Yuki;Tamura, Tomonori;Kuwara, Keiko;Takaoka, Yousuke;Hamachi, Itaru. And the article was included in Chemistry Letters in 2015.Synthetic Route of C25H15NO9 This article mentions the following:

Membrane proteins play crucial roles in fundamental biol. processes. Here, we propose a new chem. strategy to label and characterize membrane proteins on cell surface. In this study, 4-dimethylaminopyridine (DMAP) is embedded and concentrated on plasma membrane surface (biomembrane-embedded DMAP: BeD), allowing to selectively modify membrane proteins with synthetic probes such as a fluorophore and an affinity tag. We applied this strategy to human red blood cells, which demonstrated that membrane proteins such as PAS-1 and Band-3 were selectively labeled. In the experiment, the researchers used many compounds, for example, 2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7Synthetic Route of C25H15NO9).

2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Synthetic Route of C25H15NO9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Review article of indications, dose & dosage and use of rifaximin in special population was written by Devadi, Rama Lakshmi. And the article was included in World Journal of Pharmaceutical Research in 2021.SDS of cas: 80621-81-4 This article mentions the following:

Rifaximin, an oral antimicrobial, has many advantages because it is selective intestine, has minimal adverse effects and is used for the treatment of some diseases such as hepatic encephalopathy, irritable bowel syndrome, travelers’ diarrhea, ulcerative colitis, Clostridium difficile and acute diarrhea. Rifaximin in the form of 200 mg tablets is com. available. The crystalline a form is therapeutically safe and effective. In most of the official compendia, rifaximin has no monograph and in none of them is there a monograph for rifaximin tablets. The literature, however, contemplates this gap with varied methods. The literature presents some methods for evaluation of rifaximin in both biol. fluid and pharmaceutical product. High performance liquid chromatog. stands out for the evaluation of rifaximin. Most of the methods reported in the literature are for pharmaceuticals products. In the experiment, the researchers used many compounds, for example, (2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-25-(Acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione (cas: 80621-81-4SDS of cas: 80621-81-4).

(2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-25-(Acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione (cas: 80621-81-4) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.SDS of cas: 80621-81-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Development of a highly sensitive fluorescence probe for peptidyl arginine deiminase (PAD) activity was written by Kunieda, Kazuki;Kawaguchi, Mitsuyasu;Ieda, Naoya;Nakagawa, Hidehiko. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2019.Recommanded Product: 3326-34-9 This article mentions the following:

Peptidyl arginine deiminases (PADs) catalyze the post-translational deimination of arginine residues to citrulline residues. Aberrant levels of PAD activity are associated with various diseases, such as rheumatoid arthritis, Alzheimer’s disease, and multiple sclerosis, so there is a need for simple and convenient high-throughput screening systems to discover PAD inhibitors as candidate therapeutic agents. Here, we report a highly sensitive off/on-type fluorescence probe for PAD activity based on the donor-excited photoinduced electron transfer (d-PeT) mechanism, utilizing the specific cycloaddition reaction between the benzil group of the probe and the ureido group of the PAD product, citrulline, under acidic conditions. We synthesized and functionally evaluated a series of probes bearing substituents on the benzil Ph group, and found that 4MEBz-FluME could successfully detect citrulline with higher sensitivity and broader dynamic range than our previously reported fluorescence probe, FGME. Moreover, we succeeded in establishing multiple assay systems for PAD subtypes activities, including PAD2 and PAD4, with 4MeBz-FluME thanks to its high sensitivity. We expect that our fluorescence probes will become a powerful tool for discovering PAD inhibitors of several subtypes. Thus, it should be suitable for high-throughput screening of chem. libraries for inhibitors of PADs. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9Recommanded Product: 3326-34-9).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Recommanded Product: 3326-34-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Chemotherapeutic studies on 2-nitrobenzofuran derivatives was written by Kuriyama, Kiyoshi;Matsuzawa, Mikihiko;Uno, Masae;Ohishi, Yoshitaka;Ikemoto, Masahiko. And the article was included in Yakugaku Zasshi in 1978.Related Products of 33094-66-5 This article mentions the following:

Antibacterial activities of 2-nitrobenzofuran derivatives (NBFD) against 8 strains of gram-pos. and -neg. bacteria were comparable to nitrofurantoin. Elongated cells were occasionally observed in the culture medium containing NBFD. When NBFD (12.5-100 mg/kg) was orally administered to rats, the metabolites excreted in urine also showed antibacterial activity. The antibacterial spectrum of the urinary metabolites, however, was different from that of the intact compound The cytotoxicity of NBFD and nitrofurantoin was examined using cultured chick embryo fibroblasts. The inhibition of cell multiplication appeared in the concentration range of 0.39-25 μg/mL. In the case of 7-substituted NBFD, the compound which possessed a high antibacterial activity indicated a low cytotoxicity. A reverse relation between antibacterial activity and cytotoxicity seemed to depend on the size of a substituent in the 7-position of NBFD. In the experiment, the researchers used many compounds, for example, 2-Nitrobenzofuran (cas: 33094-66-5Related Products of 33094-66-5).

2-Nitrobenzofuran (cas: 33094-66-5) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Related Products of 33094-66-5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Preparation of photosensitive color-producing microcapsules utilizing in situ polymerization method was written by Sawada, K.;Urakawa, H.. And the article was included in Dyes and Pigments in 2004.Name: Crystal violet lactone This article mentions the following:

The photosensitive color-producing microcapsules were prepared from melamine/formalin resin by in situ polymerization method. The leuco-compound and the photoacid generator dissolved in diisopropylnaphthalene were successfully loaded in the interior of microcapsules. Preparation of microcapsules that have uniform particle size could also be attained. Irreversible development of microcapsules was examined by an irradiation of UV light. The leuco-compound in the microcapsule was sensitively reacted with the acid produced from the photoacid generator without destruction of capsule walls. It has also been found that the development in the microcapsule progresses quickly compared to the bulk condition. In the experiment, the researchers used many compounds, for example, Crystal violet lactone (cas: 1552-42-7Name: Crystal violet lactone).

Crystal violet lactone (cas: 1552-42-7) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Name: Crystal violet lactone

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Parent, Alkylated, and Sulfur/Oxygen-Containing Polycyclic Aromatic Hydrocarbons in Mainstream Smoke from 13 Brands of Chinese Cigarettes was written by Gao, Bo;Du, Xueqing;Wang, Xinming;Tang, Jianhui;Ding, Xiang;Zhang, Yanli;Bi, Xinhui;Zhang, Gan. And the article was included in Environmental Science & Technology in 2015.Formula: C16H10O This article mentions the following:

China has the world’s largest population of smokers with serious health consequences, yet the authors know a very limited spectrum of hazardous chems. in cigarette smoke even for carcinogenic polycyclic aromatic hydrocarbons (PAHs). Here, the authors chose 13 popular cigarette brands sold in China markets, collected particulate matters in mainstream smoke using filter pads and an automatic smoking machine, and analyzed 56 PAHs, including 31 parent, 18 alkylated, and 7 sulfur/oxygen-containing PAHs (S/O PAHs). The 56 PAHs in mainstream smoke totaled from 244.2 to 10254.8 ng cig^-1; parent, alkylated, and S/O PAHs shared 16-23%, 64-74%, and 6-18%, resp. Benzo[a]pyrene (BaP) ranged 1.1-41.6 ng cig^-1, while BaP equivalent concentrations (BaP_eq) ranged 3.6-120.2 ng cig^-1, but contributions to BaP_eq by individual carcinogenic PAH species varied with cigarette brands. When these cigarette smoke source profiles were pooled together with those of other combustion ones available in the literature, the authors found that widely used diagnostic ratios of parent PAHs failed to distinguish cigarette smoke from other combustion sources, except that the ratio indeno[1,2,3-cd]pyrene/(indeno[1,2,3-cd]pyrene + benzo[g,h,i]perylene) can largely sep. cigarette smoke from vehicular emissions and that the ratio of Retene/(Retene + chrysene) can further discriminate cigarette smoke from coal combustion when alkylated PAHs are involved. In the experiment, the researchers used many compounds, for example, Naphtho[2,1-b]benzofuran (cas: 205-39-0Formula: C16H10O).

Naphtho[2,1-b]benzofuran (cas: 205-39-0) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Formula: C16H10O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis and antilipolytic activities of quinolyl carbanilates and related analogs was written by Musser, John H.;Chakraborty, Utpal;Bailey, Kevin;Sciortino, Stan;Whyzmuzis, Carol;Amin, Dilip;Sutherland, Charles A.. And the article was included in Journal of Medicinal Chemistry in 1987.COA of Formula: C10H8O4 This article mentions the following:

A series of quinolyl carbanilates (e.g., I and II) was prepared and tested as antilipolytic agents. These compounds inhibited production of glycerol from rat adipocytes and inhibited liberation of free fatty acids from triolein by canine cardiac triglyceride lipases. An extensive structure-activity relationship study indicated that 8-quinolyl 4-methoxycarbanilate (I) contained features necessary for maximum potency in vitro. Substituting a benzofuranyl group for the quinolyl group of I provided the most interesting compound on the basis of both potency and structural novelty. 7-Benzofuranyl 4-methoxycarbanilate (III) has IC₅₀‘s of 16 and 0.3 μM in the myocardial lipase and rat adipocyte assays, resp. In vivo, III was orally active as an inhibitor (97% at 25 mg/kg) of lipolysis in the rat. In the experiment, the researchers used many compounds, for example, 7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8COA of Formula: C10H8O4).

7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.COA of Formula: C10H8O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Nickel-catalyzed methylation of aryl halides/tosylates with methyl tosylate was written by Wang, Jiawang;Zhao, Jianhong;Gong, Hegui. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.Application of 54120-64-8 This article mentions the following:

This work describes the cross-electrophile methylation of aryl bromides and aryl tosylates with Me tosylate. The mild reaction conditions allow effective methylation of a wide set of heteroaryl electrophiles and dimethylation of dibromoarenes. In the experiment, the researchers used many compounds, for example, 5-Methylisobenzofuran-1(3H)-one (cas: 54120-64-8Application of 54120-64-8).

5-Methylisobenzofuran-1(3H)-one (cas: 54120-64-8) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Application of 54120-64-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem