Chemotherapeutic studies on 2-nitrobenzofuran derivatives was written by Kuriyama, Kiyoshi;Matsuzawa, Mikihiko;Uno, Masae;Ohishi, Yoshitaka;Ikemoto, Masahiko. And the article was included in Yakugaku Zasshi in 1978.Related Products of 33094-66-5 This article mentions the following:
Antibacterial activities of 2-nitrobenzofuran derivatives (NBFD) against 8 strains of gram-pos. and -neg. bacteria were comparable to nitrofurantoin. Elongated cells were occasionally observed in the culture medium containing NBFD. When NBFD (12.5-100 mg/kg) was orally administered to rats, the metabolites excreted in urine also showed antibacterial activity. The antibacterial spectrum of the urinary metabolites, however, was different from that of the intact compound The cytotoxicity of NBFD and nitrofurantoin was examined using cultured chick embryo fibroblasts. The inhibition of cell multiplication appeared in the concentration range of 0.39-25 μg/mL. In the case of 7-substituted NBFD, the compound which possessed a high antibacterial activity indicated a low cytotoxicity. A reverse relation between antibacterial activity and cytotoxicity seemed to depend on the size of a substituent in the 7-position of NBFD. In the experiment, the researchers used many compounds, for example, 2-Nitrobenzofuran (cas: 33094-66-5Related Products of 33094-66-5).
2-Nitrobenzofuran (cas: 33094-66-5) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Related Products of 33094-66-5
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem