Ohishi, Yoshitaka et al. published their research in Chemical & Pharmaceutical Bulletin in 1989 | CAS: 4790-79-8

7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Category: benzofurans

Synthesis and aldose reductase-inhibitory activity of benzo[b]furan derivatives possessing a carboxymethylsulfamoyl group was written by Ohishi, Yoshitaka;Mukai, Teruo;Nagahara, Michiko;Yajima, Motoyuki;Kajikawa, Norio. And the article was included in Chemical & Pharmaceutical Bulletin in 1989.Category: benzofurans This article mentions the following:

Various benzo[b]furan derivatives with a carboxymethylsulfamoyl group e.g. I [R = (CH2)nMe, CH2C6H4NO2-4, CH2COMe, CH2CO2H; n = 0-6], were prepared and evaluated for aldose reductase-inhibitory potency. Most of the compounds displayed significant inhibitory activities (IC50, 10-8-10-7 M). Among the test compounds, the compounds having a carboxymethylsulfamoyl group at the 3- or 4-position exhibited the greatest inhibitory potency. Structure-activity trends of the tested compounds are discussed. In the experiment, the researchers used many compounds, for example, 7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8Category: benzofurans).

7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Musser, John H. et al. published their research in Journal of Medicinal Chemistry in 1987 | CAS: 4790-79-8

7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.COA of Formula: C10H8O4

Synthesis and antilipolytic activities of quinolyl carbanilates and related analogs was written by Musser, John H.;Chakraborty, Utpal;Bailey, Kevin;Sciortino, Stan;Whyzmuzis, Carol;Amin, Dilip;Sutherland, Charles A.. And the article was included in Journal of Medicinal Chemistry in 1987.COA of Formula: C10H8O4 This article mentions the following:

A series of quinolyl carbanilates (e.g., I and II) was prepared and tested as antilipolytic agents. These compounds inhibited production of glycerol from rat adipocytes and inhibited liberation of free fatty acids from triolein by canine cardiac triglyceride lipases. An extensive structure-activity relationship study indicated that 8-quinolyl 4-methoxycarbanilate (I) contained features necessary for maximum potency in vitro. Substituting a benzofuranyl group for the quinolyl group of I provided the most interesting compound on the basis of both potency and structural novelty. 7-Benzofuranyl 4-methoxycarbanilate (III) has IC50‘s of 16 and 0.3 μM in the myocardial lipase and rat adipocyte assays, resp. In vivo, III was orally active as an inhibitor (97% at 25 mg/kg) of lipolysis in the rat. In the experiment, the researchers used many compounds, for example, 7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8COA of Formula: C10H8O4).

7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.COA of Formula: C10H8O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Burlingame, Mark A. et al. published their research in ACS Combinatorial Science in 2011 | CAS: 4790-79-8

7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.HPLC of Formula: 4790-79-8

Simple One-Pot Synthesis of Disulfide Fragments for Use in Disulfide-Exchange Screening was written by Burlingame, Mark A.;Tom, Christopher T. M. B.;Renslo, Adam R.. And the article was included in ACS Combinatorial Science in 2011.HPLC of Formula: 4790-79-8 This article mentions the following:

Disulfide exchange screening is a method for evaluating the binding of small mol. fragments to proteins that have at least one accessible cysteine. While operationally simple, it does require a large library of small fragment mols. bearing disulfide-containing side chains. These specialized fragments are not available com. and this has limited the adoption of the method. We report here a convenient one-pot procedure that enables facile preparation of disulfide screening fragments while also producing less of an environmental impact. The new synthetic method involves the initial formation of sym. disulfides, followed by a disulfide exchange reaction in which the sym. dimer is converted into the final screening fragment by introduction of a solubilizing “cap”. The method is amenable to parallel synthetic methods and can be carried out in air without the need for the specialized equipment typically required for performing organic synthesis. In the experiment, the researchers used many compounds, for example, 7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8HPLC of Formula: 4790-79-8).

7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.HPLC of Formula: 4790-79-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Abdel-Rahman, Hamdy M. et al. published their research in Bulletin of Pharmaceutical Sciences, Assiut University in 2005 | CAS: 4790-79-8

7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Electric Literature of C10H8O4

Allophenylnorstatine-containing HIV-1 protease inhibitors: design, synthesis and structure-activity relationships for selected P2 ligands was written by Abdel-Rahman, Hamdy M.;El-Koussi, Nawal A.;Alkaramany, Gamal S.;Youssef, Adel F.;Kiso, Yoshiaki. And the article was included in Bulletin of Pharmaceutical Sciences, Assiut University in 2005.Electric Literature of C10H8O4 This article mentions the following:

The design and development of potent HIV protease inhibitors remain an attractive target for antiviral therapy. A novel class of HIV protease inhibitors containing allophenylnorstatine [Apns; (2S,3S)-3-amino-2-hydroxy-4 phenylbutyric acid] as a transition state mimic have been reported. In this work we fixed P2‘ (as tert-butylamino or 2-methylbenzylamino) and changed P2 moiety to provide two series of dipeptide analogs. Preliminary evaluation of the activity of the synthesized derivatives were determined as percentage of enzyme inhibition at 5 μM level. The results showed that the introduction of 2-methylbenzylamino moiety as P2‘ ligands considerably improved HIV inhibitory activity in comparison with the tert-Bu amino analogs. It was found that compounds in both series retained activity still less than the lead compounds KNI-577 and KNI-727. In the experiment, the researchers used many compounds, for example, 7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8Electric Literature of C10H8O4).

7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Electric Literature of C10H8O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Tap, Fatahiya Mohamed et al. published their research in IOP Conference Series: Materials Science and Engineering in 2021 | CAS: 4790-79-8

7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Category: benzofurans

Structure base virtual screening for identifying inflammatory inhibitors was written by Tap, Fatahiya Mohamed;Khairudin, Nurul Bahiyah Ahmad;Mustafa, Iswaibah. And the article was included in IOP Conference Series: Materials Science and Engineering in 2021.Category: benzofurans This article mentions the following:

Phospholipase A2 (PLA2) is an enzyme that induces inflammation, making PLA2 activity an effective approach to reduce inflammation. Therefore, investigating natural compounds for this PLA2 inhibitory activity has important therapeutic potential. The objective of this study was to investigate the potential inhibitors for inflammatory diseases through a virtual screening approach. Out of 10,000 compounds from zinc database, only five compounds were selected based on the lowest free energy binding and further used for mol. interaction anal. These five compounds were Metacetamol (-11.43 kcal/mol), 7-Methoxybenzofuran2-carboxylic acid (-10.22 kcal/mol), 6-nitro-4H-1,3-benzodioxine-8-carbaldehyde (- 10.08kcal/mol), 4-(2-Amino-1,3-thiazol-4-yl)benzene-1,3-diol (-9.86 kcal/mol), and 1-Ethyl1H-indole-3-carbaldehyde (-9.53 kcal/mol). These findings also provide insight on valuable implications for the use of these five compounds in treating inflammation, and may help researchers develop more natural bioactive compounds in daily foods as anti-inflammatory agent. In the experiment, the researchers used many compounds, for example, 7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8Category: benzofurans).

7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Gambini, Luca et al. published their research in ACS Chemical Biology in 2018 | CAS: 4790-79-8

7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Recommanded Product: 7-Methoxybenzofuran-2-carboxylic acid

Structure-Based Design of Novel EphA2 Agonistic Agents with Nanomolar Affinity in Vitro and in Cell was written by Gambini, Luca;Salem, Ahmed F.;Udompholkul, Parima;Tan, Xiao-Feng;Baggio, Carlo;Shah, Neh;Aronson, Alexander;Song, Jikui;Pellecchia, Maurizio. And the article was included in ACS Chemical Biology in 2018.Recommanded Product: 7-Methoxybenzofuran-2-carboxylic acid This article mentions the following:

EphA2 overexpression is invariably associated with poor prognosis and development of aggressive metastatic cancers in pancreatic, prostate, lung, ovarian, and breast cancers and melanoma. Recent efforts from our laboratories identified a number of agonistic peptides targeting the ligand-binding domain of the EphA2 receptor. The individual agents, however, were still relatively weak in affinities (micromolar range) that precluded detailed structural studies on the mode of action. Using a systematic optimization of the 12-mer peptide mimetic 123B9, we were able to first derive an agent that displayed a submicromolar affinity for the receptor. This agent enabled cocrystn. with the EphA2 ligand-binding domain providing for the first time the structural basis for their agonistic mechanism of action. In addition, the at. coordinates of the complex enabled rapid iterations of structure-based optimizations that resulted in a novel agonistic agent, named 135H11, with a nanomolar affinity for the receptor, as demonstrated by in vitro binding assays (isothermal titration calorimetry measurements), and a biochem. displacement assay. As we have recently demonstrated, the cellular activity of these agents is further increased by synthesizing dimeric versions of the compounds Hence, we report that a dimeric version of 135H11 is extremely effective at low nanomolar concentrations to induce cellular receptor activation, internalization, and inhibition of cell migration in a pancreatic cancer cell line. Given the pivotal role of EphA2 in tumor growth, angiogenesis, drug resistance, and metastasis, these agents, and the associated structural studies, provide significant advancements in the field for the development of novel EphA2-targeting therapeutics or diagnostics. In the experiment, the researchers used many compounds, for example, 7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8Recommanded Product: 7-Methoxybenzofuran-2-carboxylic acid).

7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Recommanded Product: 7-Methoxybenzofuran-2-carboxylic acid

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Mewshaw, Richard E. et al. published their research in Journal of Medicinal Chemistry in 2004 | CAS: 4790-79-8

7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.SDS of cas: 4790-79-8

Studies toward the Discovery of the Next Generation of Antidepressants. 3. Dual 5-HT1A and Serotonin Transporter Affinity within a Class of N-Aryloxyethylindolylalkylamines was written by Mewshaw, Richard E.;Zhou, Dahui;Zhou, Ping;Shi, Xiaojie;Hornby, Geoffrey;Spangler, Taylor;Scerni, Rosemary;Smith, Deborah;Schechter, Lee E.;Andree, Terrance H.. And the article was included in Journal of Medicinal Chemistry in 2004.SDS of cas: 4790-79-8 This article mentions the following:

N-Aryloxylethylindolealkylamines (5) having dual 5-HT transporter and 5-HT1A affinity are described. These compounds represent truncated analogs of our previously reported piperidinyl derivatives (3). Compounds in this investigation were found to have more similar affinities and functional activities for the 5-HT1A receptor and 5-HT transporter. Though 5-HT1A antagonism is not consistently observed throughout series 5, several mol. features were found to be essential to obtain high and balanced activities. The proper placement of a heteroatom in the aryl ring and the length of the linkage used to tether the indole moiety had significant influence on 5-HT1A and 5-HT transporter affinities. Introduction of a halogen into the aryl ring usually lowered intrinsic activity and in some cases led to full 5-HT1A antagonists. Compounds 33 and 34 were observed to be full 5-HT1A antagonists with Ki values of approx. 30 nM for the 5-HT1A receptor and Ki values of 5 and 0.5 nM for the 5-HT transporter, resp. Unfortunately, similar to our previous series (3), compounds in this report also had high affinity for the α1 receptor. In the experiment, the researchers used many compounds, for example, 7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8SDS of cas: 4790-79-8).

7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.SDS of cas: 4790-79-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Mewshaw, Richard E. et al. published their research in Journal of Medicinal Chemistry in 2004 | CAS: 4790-79-8

7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.SDS of cas: 4790-79-8

Studies toward the Discovery of the Next Generation of Antidepressants. 3. Dual 5-HT1A and Serotonin Transporter Affinity within a Class of N-Aryloxyethylindolylalkylamines was written by Mewshaw, Richard E.;Zhou, Dahui;Zhou, Ping;Shi, Xiaojie;Hornby, Geoffrey;Spangler, Taylor;Scerni, Rosemary;Smith, Deborah;Schechter, Lee E.;Andree, Terrance H.. And the article was included in Journal of Medicinal Chemistry in 2004.SDS of cas: 4790-79-8 This article mentions the following:

N-Aryloxylethylindolealkylamines (5) having dual 5-HT transporter and 5-HT1A affinity are described. These compounds represent truncated analogs of our previously reported piperidinyl derivatives (3). Compounds in this investigation were found to have more similar affinities and functional activities for the 5-HT1A receptor and 5-HT transporter. Though 5-HT1A antagonism is not consistently observed throughout series 5, several mol. features were found to be essential to obtain high and balanced activities. The proper placement of a heteroatom in the aryl ring and the length of the linkage used to tether the indole moiety had significant influence on 5-HT1A and 5-HT transporter affinities. Introduction of a halogen into the aryl ring usually lowered intrinsic activity and in some cases led to full 5-HT1A antagonists. Compounds 33 and 34 were observed to be full 5-HT1A antagonists with Ki values of approx. 30 nM for the 5-HT1A receptor and Ki values of 5 and 0.5 nM for the 5-HT transporter, resp. Unfortunately, similar to our previous series (3), compounds in this report also had high affinity for the α1 receptor. In the experiment, the researchers used many compounds, for example, 7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8SDS of cas: 4790-79-8).

7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.SDS of cas: 4790-79-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem