Simple One-Pot Synthesis of Disulfide Fragments for Use in Disulfide-Exchange Screening was written by Burlingame, Mark A.;Tom, Christopher T. M. B.;Renslo, Adam R.. And the article was included in ACS Combinatorial Science in 2011.HPLC of Formula: 4790-79-8 This article mentions the following:
Disulfide exchange screening is a method for evaluating the binding of small mol. fragments to proteins that have at least one accessible cysteine. While operationally simple, it does require a large library of small fragment mols. bearing disulfide-containing side chains. These specialized fragments are not available com. and this has limited the adoption of the method. We report here a convenient one-pot procedure that enables facile preparation of disulfide screening fragments while also producing less of an environmental impact. The new synthetic method involves the initial formation of sym. disulfides, followed by a disulfide exchange reaction in which the sym. dimer is converted into the final screening fragment by introduction of a solubilizing “cap”. The method is amenable to parallel synthetic methods and can be carried out in air without the need for the specialized equipment typically required for performing organic synthesis. In the experiment, the researchers used many compounds, for example, 7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8HPLC of Formula: 4790-79-8).
7-Methoxybenzofuran-2-carboxylic acid (cas: 4790-79-8) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.HPLC of Formula: 4790-79-8
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem