Month: February 2023

Preparation of low-temperature reversible discoloration microcapsule and the application in water-based coating was written by Wu, Luoyi;Hu, Zirong;Li, Yushu;Shao, Guang. And the article was included in Tuliao Gongye in 2002.Computed Properties of C26H29N3O2 This article mentions the following:

Crystal violet lactone/diphenylol propane was serviced as discoloration constituents and dodecanol as solvent, which were dispersed into 10-100 μm size in water. By coating the drops with gelatin/arabic, reversible discoloration microcapsule was prepared, which oiliness pigment was changed in powder, and so overcome the short-comings that the oiliness pigment cannot be compatible with water based paint. In the experiment, the researchers used many compounds, for example, Crystal violet lactone (cas: 1552-42-7Computed Properties of C26H29N3O2).

Crystal violet lactone (cas: 1552-42-7) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Computed Properties of C26H29N3O2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

An improved method for the synthesis of γ-lactones using sodium bromate and sodium hydrogen sulfite was written by Hayat, S.;Atta-ur-Rahman;Choudhary, M. I.;Khan, K. M.;Bayer, E.. And the article was included in Tetrahedron Letters in 2001.Safety of 5-Methylisobenzofuran-1(3H)-one This article mentions the following:

2-Alkylbenzoic acids are treated with a NaBrO₃/NaHSO₃ reagent under in a 2-phase system using AcOEt as solvent, under mild conditions to give the corresponding phthalides in moderate to satisfactory yield. Intermediately, α-brominated alkylbenzoic acids are formed by in-situ generated HOBr. These α-brominated acids undergo an intramol. nucleophilic substitution to afford the corresponding γ-lactones. In the experiment, the researchers used many compounds, for example, 5-Methylisobenzofuran-1(3H)-one (cas: 54120-64-8Safety of 5-Methylisobenzofuran-1(3H)-one).

5-Methylisobenzofuran-1(3H)-one (cas: 54120-64-8) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Safety of 5-Methylisobenzofuran-1(3H)-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A novel strategy integrating gas phase fractionation with staggered mass range and LC-MS/MS molecular network for comprehensive metabolites profiling of Gui Ling Ji in rats was written by Zhang, Yuhao;Gao, Ziqing;Cai, Yingli;Dou, Xiuxiu;Liang, Yanlin;Zhang, Weidong;Wu, Gaosong;Ye, Ji. And the article was included in Journal of Pharmaceutical and Biomedical Analysis in 2023.Electric Literature of C17H18O9 This article mentions the following:

Metabolite detection from complex biol. samples faces challenges due to interference from endogenous substrates and the inherent limitation of multiple subsequent tandem scanning rates of instruments. Here, a new integrated approach based on gas-phase fractionation with a staggered mass range (sGPF) and a liquid chromatog.-tandem mass spectrometry (LC-MS/MS) mol. network was developed to accelerate the data processing of the targeted and untargeted constituents absorbed in rats after oral administration of the traditional Chinese medicine (TCM) prescription Gui Ling Ji (GLJ). Compared with three conventional acquisition methods, sGPF at 3, 5, and 7 mass fractions could enhance MS/MS coverage with an increased MS/MS triggering rate of 29.4-206.2% over data-dependent acquisition (DDA), fast DDA and gas-phase fractionation. A mass range fraction setting of five optimized the performance. Based on the similar diagnostic fragment ions and characteristic neutral loss behaviors in the DDA-MS/MS spectrum, an initial mol. network of GLJ was created with the help of the global natural products social mol. networking (GNPS) platform. Furthermore, to remove the endogenous interference nodes, Cytoscape software was adopted to produce a clean and concise mol. network of prototype compounds and their corresponding metabolites. Using this strategy, a total of 210 compounds, including 59 prototype constituents and 151 metabolites, was unambiguously or tentatively identified in GLJ. This first systematic metabolic study of GLJ in vivo elucidated the potential pharmacodynamic basis of GLJ in clin. treatment. More importantly, this work can serve as a practical example and establish a guide for rapidly identifying TCM metabolites in biol. matrixes. In the experiment, the researchers used many compounds, for example, (Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid (cas: 905954-17-8Electric Literature of C17H18O9).

(Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid (cas: 905954-17-8) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Electric Literature of C17H18O9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

TEMPO as a Hydrogen Atom Transfer Catalyst for Aerobic Dehydrogenation of Activated Alkanes to Alkenes was written by Ito, Tasuku;Seidel, Falk William;Jin, Xiongjie;Nozaki, Kyoko. And the article was included in Journal of Organic Chemistry in 2022.SDS of cas: 496-16-2 This article mentions the following:

2,2,6,6-Tetramethylpiperidine-N-oxyl (TEMPO) has been extensively utilized as a radical scavenger or an oxidation catalyst. In contrast, TEMPO as a hydrogen atom transfer (HAT) catalyst has rarely been studied. Here, authors report that TEMPO, as the HAT catalyst, homolytically cleaves benzylic or allylic C-H bonds to give the corresponding alkyl radicals. Benefiting from the dual roles played by TEMPO as the HAT catalyst and the radical scavenger, the highly challenging aerobic dehydrogenation of activated alkanes to alkenes is successfully developed. In the experiment, the researchers used many compounds, for example, 2,3-Dihydrobenzo[b]furan (cas: 496-16-2SDS of cas: 496-16-2).

2,3-Dihydrobenzo[b]furan (cas: 496-16-2) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.SDS of cas: 496-16-2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Manganese- and Borane-Mediated Synthesis of Isobenzofuranones from Aromatic Esters and Oxiranes via C-H Bond Activation was written by Sueki, Shunsuke;Wang, Zijia;Kuninobu, Yoichiro. And the article was included in Organic Letters in 2016.Name: 5-Methoxyisobenzofuran-1(3H)-one This article mentions the following:

A manganese- and borane-mediated synthesis of isobenzofuranones from esters and oxiranes is developed. The reaction proceeded at aromatic, heteroaromatic, and olefinic C-H bonds with high functional group tolerance. This is the first example of a manganese-catalyzed C-H transformation using an oxygen-directing group. Triphenylborane played an important role in this reaction to cooperatively promote the annulation reaction. Kinetic isotope effect experiments revealed that C-H bond activation of the aromatic rings was the rate-determining step. In the experiment, the researchers used many compounds, for example, 5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2Name: 5-Methoxyisobenzofuran-1(3H)-one).

5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Name: 5-Methoxyisobenzofuran-1(3H)-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Cobalt-catalyzed borylation of aryl halides and pseudohalides was written by Yao, Wubing;Fang, Huaquan;Peng, Sihan;Wen, Huanan;Zhang, Lei;Hu, Aiguo;Huang, Zheng. And the article was included in Organometallics in 2016.Reference of 519054-55-8 This article mentions the following:

We report the first Co-catalyzed borylation of aryl halides and pseudohalides with bis(pinacolato)diboron (B₂pin₂). The synthesis of two new Co(II) complexes of oxazolinylferrocenylphosphine ligands 1-R₂P-2-(4-Me-2-Ox) (2-Ox = 2-oxazolinyl; L¹, R = Ph, L², R = ⁱPr) and their cobalt complexes [(Lⁿ)CoCl₂] (2a, R = Ph, 2b, R = ⁱPr) is described. Crystal structures of 2a,b were determined Upon activation with LiMe, the Co complex catalyzes the borylation reactions of aryl bromides, iodides, sulfonates, arenediazonium salts, and even aryl chlorides under mild conditions, providing the borylated products ArBpin in excellent to moderate yields and with high functional group tolerance. In the experiment, the researchers used many compounds, for example, 2-(Benzofuran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 519054-55-8Reference of 519054-55-8).

2-(Benzofuran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 519054-55-8) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Reference of 519054-55-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Metabotropic 5-HT receptor-mediated effects in the human submucous plexus was written by Annahazi, Anita;Berger, Thomas Erwin;Demir, Ihsan Ekin;Zeller, Florian;Mueller, Michael;Anneser, Markus;Skerra, Arne;Michel, Klaus;Schemann, Michael. And the article was included in Neurogastroenterology & Motility in 2022.Application of 179474-81-8 This article mentions the following:

Serotonin (5-HT) is an important mediator in the gastrointestinal tract, acting on different neuronal 5-HT receptors. The ionotropic 5-HT₃ receptor mediates immediate but transient spike discharge in human enteric neurons. We studied the role of the metabotropic 5-HT_1P, 5-HT₄, and 5-HT₇ receptors to activate human submucous neurons. Neuroimaging using the voltage sensitive dye Di-8-ANEPPS was performed in submucous plexus preparations from human surgical specimens of the small and large intestine. We synthesized a new, stable 5-HT_1P agonist, 5-benzyloxyhydrazonoindalpine (5-BOHIP). 5-HT evoked a fast and late-onset spike discharge in enteric neurons. The fast component was blocked by the 5-HT₃ receptor antagonist cilansetron, while the remaining sustained response was significantly reduced by the 5-HT1P receptor antagonist 5-hydroxytryptophanyl-5-hydroxytryptophan amide (5-HTP-DP). The newly synthesized 5-HT_1P agonist 5-BOHIP induced a slowly developing, long-lasting activation of submucous neurons, which was blocked by 5-HTP-DP. We could not demonstrate any 5-HT₇ receptor-induced spike discharge based on the lack of response to 5-carboxamidotryptamine. Similarly, the 5-HT₄ agonists 5-methoxytryptamine and prucalopride evoked no immediate or late-onset spike discharge. Our work demonstrated for the first time the presence of functional 5-HT_1P receptors on human submucous neurons. Furthermore, we found no evidence for a role of 5-HT₄ or 5-HT₇ receptors in the postsynaptic activation of human submucous neurons by 5-HT. In the experiment, the researchers used many compounds, for example, 4-Amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide (cas: 179474-81-8Application of 179474-81-8).

4-Amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide (cas: 179474-81-8) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application of 179474-81-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Two New Limonoids from the Root Bark of Chinese Medicinal Plant Dictamnus dasycarpus was written by Wang, Li-Li;Jiang, Cheng-Shi;Fu, Yan;Chen, Fei-Fei;Lan, Le-Fu;Zhang, Hai-Yan;Guo, Yue-Wei. And the article was included in Helvetica Chimica Acta in 2014.Recommanded Product: 28808-62-0 This article mentions the following:

Two new limonoids, kihadanin C (I) and 23-methoxydasylactone A (II), together with seven related known ones, were isolated from the root bark of the plant Dictamnus dasycarpus. The structures of the new compounds were elucidated on the basis of extensive analyses of their spectroscopic data (1D- and 2D-NMR, MS) and by comparison of their NMR data with those reported in the literature. To the best of our knowledge, I presents the first example of A,D-seco limonoid with an unusual 3,4-dihydroxy-2,5-dimethoxytetrahydrofuran moiety as ring E. In the bioassay in vitro, dasylactone B7 showed moderate antibacterial activity against Staphylococcus aureus, while fraxinellone and isofraxinellone displayed neuroprotective activities against H₂O₂-induced injury in SH-SY5Y cells. In the experiment, the researchers used many compounds, for example, (3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one (cas: 28808-62-0Recommanded Product: 28808-62-0).

(3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one (cas: 28808-62-0) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Recommanded Product: 28808-62-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Rifaximin modulates TRH and TRH-like peptide expression throughout the brain and peripheral tissues of male rats was written by Pekary, Albert Eugene;Sattin, Albert. And the article was included in BMC Neuroscience in 2022.Electric Literature of C43H51N3O11 This article mentions the following:

Abstract: Background: The TRH/TRH-R1 receptor signaling pathway within the neurons of the dorsal vagal complex is an important mediator of the brain-gut axis. Mental health and protection from a variety of neuropathologies, such as autism, Attention Deficit Hyperactivity Disorder, Alzheimer’s and Parkinson’s disease, major depression, migraine and epilepsy are influenced by the gut microbiome and is mediated by the vagus nerve. The antibiotic rifaximin (RF) does not cross the gut-blood barrier. It changes the composition of the gut microbiome resulting in therapeutic benefits for traveler’s diarrhea, hepatic encephalopathy, and prostatitis. TRH and TRH-like peptides, with the structure pGlu-X-Pro-NH₂, where “X” can be any amino acid residue, have reproduction-enhancing, caloric-restriction-like, anti-aging, pancreatic-β cell-, cardiovascular-, and neuroprotective effects. TRH and TRH-like peptides occur not only throughout the CNS but also in peripheral tissues. To elucidate the involvement of TRH-like peptides in brain-gut-reproductive system interactions 16 male Sprague-Dawley rats, 203 ± 6 g, were divided into 4 groups (n = 4/group): the control (CON) group remained on ad libitum Purina rodent chow and water for 10 days until decapitation, acute (AC) group receiving 150 mg RF/kg powd. rodent chow for 24 h providing 150 mg RF/kg body weight for 200 g rats, chronic (CHR) animals receiving RF for 10 days; withdrawal (WD) rats receiving RF for 8 days and then normal chow for 2 days. Results: Significant changes in the levels of TRH and TRH-like peptides occurred throughout the brain and peripheral tissues in response to RF. The number of significant changes in TRH and TRH-like peptide levels in brain resulting from RF treatment, in descending order were: medulla (16), piriform cortex (8), nucleus accumbens (7), frontal cortex (5), striatum (3), amygdala (3), entorhinal cortex (3), anterior (2), and posterior cingulate (2), hippocampus (1), hypothalamus (0) and cerebellum (0). The corresponding ranking for peripheral tissues were: prostate (6), adrenals (4), pancreas (3), liver (2), testis (1), heart (0). Conclusions: The sensitivity of TRH and TRH-like peptide expression to RF treatment, particularly in the medulla oblongata and prostate, is consistent with the participation of these peptides in the therapeutic effects of RF. In the experiment, the researchers used many compounds, for example, (2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-25-(Acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione (cas: 80621-81-4Electric Literature of C43H51N3O11).

(2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-25-(Acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione (cas: 80621-81-4) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Electric Literature of C43H51N3O11

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Use of tetraethyl dimethylaminomethylenediphosphonate in the synthesis of benzothiophene-2-acetic acid and other carboxylic acids was written by Degenhardt, Charles R.. And the article was included in Synthetic Communications in 1982.Computed Properties of C10H8O3 This article mentions the following:

Aldehydes I (R = H, Me) reacted with Me₂NCH[P(O)(OEt)₂]₂ (II) to yield condensation products III, which were hydrolyzed to acids IV. I (R = H) was treated with II and NaH, and the III (R = H) obtained was heated with HCl to give IV (R = H). Similarly, 2-benzofuranacetic acid and Me(CH₂)₈CH₂CHO were prepared from 2-benzofurancarboxaldehye and Me(CH₂)₈CHO. In the experiment, the researchers used many compounds, for example, 2-Benzofuranacetic acid (cas: 62119-70-4Computed Properties of C10H8O3).

2-Benzofuranacetic acid (cas: 62119-70-4) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Computed Properties of C10H8O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem