Month: February 2023

Conjugation of amino-bioactive glasses with 5-aminofluorescein as probe molecule for the development of pH sensitive stimuli-responsive biomaterials was written by Aina, Valentina;Malavasi, Gianluca;Magistris, Claudio;Cerrato, Giuseppina;Martra, Gianmario;Viscardi, Guido;Menabue, Ledi;Lusvardi, Gigliola. And the article was included in Journal of Materials Science: Materials in Medicine in 2014.Reference of 3326-34-9 This article mentions the following:

Bioceramics, such as silica-based glasses, are widely used in bone and teeth restoration. Nowadays, the association between nanotechnol. and pharmacol. is one of the most promising research fields in cancer therapy. The advanced processing methods and new chem. strategies allow the incorporation of drugs within them or on their functionalized surfaces. Bioceramics can act as local drug delivery systems to treat bone and teeth diseases. The present paper reports data related to the development of a pH-stimuli responsive bioactive glass. The glass conjugation with 5-aminofluorescein (5-AF), through a pH-sensitive organic spacer, allows to produce a pH-responsive bioactive biomaterial: when it is exposed to specific pH changes, it can favor the release of 5-AF directly at the target site. 5-AF has been chosen as a simple, low cost, non toxic model to simulate doxorubicin, an anticancer drug. As doxorubicin, 5-AF contains an amino group in its structure to form an amide bond with the carboxylic functionalities of the glass. Raman spectroscopy and thermal anal. confirm the glass conjugation of 5-AF by an amide bond; the amount of 5-AF loaded was very high (≈65 and 44%). The release tests at two different pH (4.2 and 7.4) show that the amount of released 5-AF is higher at acid pH with respect to physiol. one. This preliminary datum evidenced that a pH-sensitive drug delivery system has been developed. The low amount of 5-AF released (<1% of the total 5-AF) is due to the very low solubility of 5-AF in aqueous medium. This disadvantage, may be overcome in a dynamic environment (physiol. conditions), where it is possible to obtain a drug release system ensuring an effective therapeutic dose for long times and, at the same time, avoiding the drug toxicity. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9Reference of 3326-34-9).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Reference of 3326-34-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A theoretical study of 2-nitrofuran vs 3-nitrofuran as dienophilic electrophile in polar cycloaddition reaction: comparison of the reactivity and reaction mechanism was written by Cainelli, Mauro;Ormachea, Carla M.;Mancini, Pedro M. E.;Kneeteman, Maria N.. And the article was included in International Research Journal of Pure and Applied Chemistry in 2016.Name: Benzofuran-5-ol This article mentions the following:

In this study, we analyzed in a theor. form the behavior of 2-nitrofuran and 3-nitrofuran acting as dienophilic electrophiles in polar cycloaddition reactions joint to different dienes. The reactivity and regioselectivity was discussed employing global and local reactivity indexes, resp. The reaction mechanisms of these cycloadditions were compared through the transition state structures and energies calculated In the experiment, the researchers used many compounds, for example, Benzofuran-5-ol (cas: 13196-10-6Name: Benzofuran-5-ol).

Benzofuran-5-ol (cas: 13196-10-6) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Name: Benzofuran-5-ol

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Dextran-based fluorescent nanoprobes for sentinel lymph node mapping was written by Dai, Tingting;Zhou, Shuyan;Yin, Chuyang;Li, Shengli;Cao, Weigang;Liu, Wei;Sun, Kang;Dou, Hongjing;Cao, Yilin;Zhou, Guangdong. And the article was included in Biomaterials in 2014.Formula: C20H13NO5 This article mentions the following:

Biopsy of sentinel lymph node (SLN) has become a common practice to predict whether tumor metastasis has occurred, so proper SLN positioning tracers are highly required. Due to many drawbacks of SLN tracers currently used, developing ideal, biosafe SLN imaging agents is always an urgent issue. The current study designed a novel fluorescent nanoprobe for accurate SLN mapping. Dextran-based nanogel (DNG) was prepared through a highly efficient self-assembly assisted approach and serves as a multi-functional platform for conjugating wide spectra emitting fluorescent agents. The newly fabricated fluorescent DNG (FDNG) could be designed with optimum size and stable fluorescent intensity for specific SLN imaging. Furthermore, a long-term dynamic course in vivo (from 1 min to 72 h) revealed the satisfactory specificity, sensitivity, and stability for SLN mapping. Most importantly, both in vitro and in vivo evaluations indicated that FDNG had fine biosafety and biocompatibility with lymphatic endothelial cells. All these results supported that FDNG could be used as highly efficient mol. imaging probes for specific, sensitive, stable, non-invasive, and safe SLN mapping, which provides efficient and accurate location for SLN biopsy and thus predicts tumor metastasis as well as directs therapies. Besides, our recent studies further demonstrated that DNG could also serve as a specific and controllable drug carrier, indicating a potential application for specific therapies of various lymph-associated diseases. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9Formula: C20H13NO5).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Formula: C20H13NO5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The synthesis and transition temperatures of 5-(4-alkyl- and 4-alkoxy-phenyl)-2-cyanobenzo[b]furans and a 5-(4′-alkylbiphenyl-4-yl)-2-cyanobenzo[b]furan: a comparison with their biphenyl and terphenyl analogues was written by Friedman, Mark R.;Toyne, Kenneth J.;Goodby, John W.;Hird, Michael. And the article was included in Liquid Crystals in 2001.Synthetic Route of C9H5BrO3 This article mentions the following:

The synthesis and transition temperatures of 5-(4-alkyl- and 4-alkoxy-phenyl)-2-cyanobenzo[b]furans and a 5-(4′-alkylbiphenyl-4-yl)-2-cyanobenzo[b]furan are presented. The 2-cyanobenzo[b]furans show similar mesophase types to the analogous biphenyl and terphenyl compounds, which were obtained by replacing the benzo[b]furan unit with a Ph ring. The transition temperatures for the 2-cyanobenzo[b]furan compounds are always higher than for their biphenyl and terphenyl counterparts, but they are much lower than for the corresponding phenylnaphthalenes. Five mesogenic benzo[b]furans without a cyano group were prepared as intermediates and these compounds have lower clearing points than their biphenyl analogs. In the experiment, the researchers used many compounds, for example, 5-Bromobenzofuran-2-carboxylic acid (cas: 10242-11-2Synthetic Route of C9H5BrO3).

5-Bromobenzofuran-2-carboxylic acid (cas: 10242-11-2) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Synthetic Route of C9H5BrO3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Multi-small molecule conjugations as new targeted delivery carriers for tumor therapy was written by Shan, Lingling;Liu, Ming;Wu, Chao;Zhao, Liang;Li, Siwen;Xu, Lisheng;Cao, Wengen;Gao, Guizhen;Gu, Yueqing. And the article was included in International Journal of Nanomedicine in 2015.Application of 3326-34-9 This article mentions the following:

In response to the challenges of cancer chemotherapeutics, including poor physicochem. properties, low tumor targeting ability, and harmful side effects, we developed a new tumor-targeted multi-small mol. drug delivery platform. Using paclitaxel (PTX) as a model therapeutic, we prepared two prodrugs, ie, folic acid-fluorescein-5(6)-isothiocyanate-arginine-paclitaxel (FA-FITC-Arg-PTX) and folic acid-5-aminofluorescein-glutamic-paclitaxel (FA-5AF-Glu-PTX), composed of folic acid (FA, target), amino acids (Arg or Glu, linker), and fluorescent dye (fluorescein in vitro or near-IR fluorescent dye in vivo) in order to better understand the mechanism of PTX prodrug targeting. In vitro and acute toxicity studies demonstrated the low toxicity of the prodrug formulations compared with the free drug. In vitro and in vivo studies indicated that folate receptor-mediated uptake of PTX-conjugated multi-small mol. carriers induced high antitumor activity. Notably, compared with free PTX and with PTX-loaded macromol. carriers from our previous study, this multi-small mol.-conjugated strategy improved the water solubility, loading rate, targeting ability, antitumor activity, and toxicity profile of PTX. These results support the use of multi-small mols. as tumor-targeting drug delivery systems. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9Application of 3326-34-9).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Application of 3326-34-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Case Report of COVID-19 Infection After Kidney Transplant Treated With Casirivimab-Imdevimab and Mycophenolate Mofetil Changed to Everolimus was written by Kijima, Yu;Shimizu, Tomokazu;Kato, Shinya;Kano, Kana;Horiuchi, Toshihide;Nozaki, Taiji;Omoto, Kazuya;Inui, Masashi;Toma, Hiroshi;Iida, Shoichi;Takagi, Toshio. And the article was included in Transplantation Proceedings in 2022.SDS of cas: 24280-93-1 This article mentions the following:

Casirivimab-imdevimab is a cocktail of 2 monoclonal antibodies designed to prevent infection by SARS-CoV-2, the virus that causes COVID-19. Casirivimab-imdevimab has been approved in Japan for treating mild to moderate COVID-19; however, to our knowledge, there are no reports of its use after kidney transplant from a live donor. Everolimus, an antineoplastic chemotherapy drug, is expected to be effective in inhibiting the spread of SARS-CoV-2 and preventing its replication, which may facilitate treatment. Here, we report a case of COVID-19 infection after kidney transplant that was initially treated with casirivimab-imdevimab and mycophenolate mofetil but was later changed to everolimus. A 47-yr-old man underwent living donor kidney transplant from his mother in 2017. Immunosuppression therapy was underway through the administration of tacrolimus, mycophenolate mofetil, and methylprednisolone. In early Sept. 2021, he was diagnosed as having COVID-19 and was hospitalized on day 3. On hospitalization, mycophenolate mofetil was discontinued and casirivimab-imdevimab and heparin were started. The patient started an everolimus regimen on day 5. The clin. course was successful without rejection. There was no exacerbation of COVID-19; the patient’s serum creatinine levels and renal function had otherwise remained stable. We could safely treat a patient with casirivimab-imdevimab after kidney transplant. It is suggested that casirivimab-imdevimab can prevent COVID-19 from becoming severe and can be administered without worsening renal function. In addition, everolimus may have inhibited the spread of the virus and prevented it from replicating. In the experiment, the researchers used many compounds, for example, (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid (cas: 24280-93-1SDS of cas: 24280-93-1).

(E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid (cas: 24280-93-1) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.SDS of cas: 24280-93-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Prucalopride: For functional constipation only? was written by Bellini, M;Gambaccini, D;Bassotti, G. And the article was included in Techniques in coloproctology in 2016.HPLC of Formula: 179474-81-8 This article mentions the following:

Prucalopride is a new prokinetic agent, recently available in Europe for the treatment of functional constipation in adults in whom treatment with laxatives failed to provide adequate relief. However, due to its intrinsic properties (highly selective agonist activity and high affinity for 5-HT4 receptors, neuroprotection), this drug has shown the potential to be used in other pathologic conditions, in and outside of the gastrointestinal tract. We performed a systematic review of the evidence supporting these possible alternative uses of prucalopride. Further studies in this area are, however, mandatory. In the experiment, the researchers used many compounds, for example, 4-Amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide (cas: 179474-81-8HPLC of Formula: 179474-81-8).

4-Amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide (cas: 179474-81-8) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.HPLC of Formula: 179474-81-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

An all-solid-state Z-scheme NaNbO₃-Au-Sn₃O₄ photocatalyst for effective degradation of carbofuran under sunlight irradiation was written by Li, Shuguang;Liu, Zhiyu;Qu, Zhihui;Piao, Congcong;Liu, Jize;Xu, Duo;Li, Xiaojing;Wang, Jun;Song, Youtao. And the article was included in Journal of Photochemistry and Photobiology, A: Chemistry in 2020.Reference of 1563-38-8 This article mentions the following:

It is first reported that an all-solid-state Z-scheme NaNbO₃-Au-Sn₃O₄ nanocomposite photocatalyst can be prepared by ultrasonic dispersion and calcination methods. In NaNbO₃-Au-Sn₃O₄, NaNbO₃ and Sn₃O₄ form a Z-scheme photocatalytic system, Au as an electron transfer channel accelerates the flow rate of the photo-induced electrons. Their effective combination can not only improve the utilization ratio of sunlight but also achieve the effective segregation of photo-induced electron-hole pairs. The fabricated samples were characterized by XRD, Raman spectra, SEM, TEM, UV-vis DRS, XPS and PL. In addition, the activity of the NaNbO₃-Au-Sn₃O₄ photocatalyst was researched via the photocatalytic degradation of carbofuran in wastewater under sunlight irradiation The sunlight illumination time, NaNbO₃ and Sn₃O₄ mole ratio, cycle number and pesticides types as influence factors on the photocatalytic degradation efficiency of Z-scheme NaNbO₃-Au-Sn₃O₄ photocatalyst are investigated in detail. The possible mechanism and degradation pathways for the photocatalytic degradation of carbofuran caused by Z-scheme NaNbO₃-Au-Sn₃O₄ photocatalyst under sunlight irradiation are put forward. The research results show that the all-solid-state Z-scheme NaNbO₃-Au-Sn₃O₄ photocatalyst displays a wonderful activity for degradation of carbofuran in wastewater. In the experiment, the researchers used many compounds, for example, 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8Reference of 1563-38-8).

2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Reference of 1563-38-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Polarization and color-change with the adsorption of surface-active substances. III was written by Weitz, Ernst;Schmidt, Fritz;Singer, Josef. And the article was included in Zeitschrift fuer Elektrochemie und Angewandte Physikalische Chemie in 1940.Safety of 3′,6′-Dimethoxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

Ph₃COMe is adsorbed with a yellow color by silica gel (I) or by acid-washed Al₂O₃ (II) from its colorless benzene solution, and decolorized by alc. [Me₂NC₆H₄]₃COMe is adsorbed from its colorless benzene solution by I and by Brockmann’s Al₂O₃ (III) with an intense blue-violet color. Ph₃COCOMe is adsorbed by I with an intense brown-tinged yellow, by III with a pale yellow. Dimethylaniline phthalein (IV), colorless in benzene solution, gives an intense green-blue adsorbate on I, III, Al(OH)₃, kaolin, AlPO₄ and Ca₃(PO₄)₂. If acetone vapors are poured over the blue adsorbate on kaolin, the color vanishes and returns when the vapor is dispersed. The colorless compound is malachite green lactone, the colored substance malachite green betaine. Powdered IV is adsorbed as the colored betaine by the adsorbents above, and the colored adsorbate is formed when the fused lactone is stirred with clay or kieselguhr, but not with KCl. The lactone form of rhodamine B is polarized to the colored (intensely red) form by all those substances that cause a similar transformation in IV, and in addition by CaCO₃, MgO, paraformaldehyde and starch, from benzene solution, and also by rubbing with KCl, Na₂SO₄.10H₂O, Na₂CO₃.10H₂O, Na₂S₂O₃.5H₂O, paraformaldehyde, sugar or urea. Also tabulated is the color of the benzene solution, of the adsorbate on I, II and III, and the ease of elution with alc. for p-hydroxydiphenylphthalide, phenolphthalein, phenolphthalein di-Me ether, tetrabromophenolphthalein, fluorescein (in ether), fluorescein diacetate, fluorescein mono-Me ether, fluoroescein di-Me ether, benzylidene acetone, benzylideneacetophenone, cinnamylideneacetone, cinnamylideneacetophenone, anisylideneacetophenone and ω-nitrophenylethylene. The lactone-betaine tautomerism of thymol blue indicator is strikingly affected by temperature change. The unsaturated hydrocarbon 1,8-diphenyloctatetraene is adsorbed by I with a green color. In the experiment, the researchers used many compounds, for example, 3′,6′-Dimethoxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 36886-76-7Safety of 3′,6′-Dimethoxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

3′,6′-Dimethoxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 36886-76-7) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Safety of 3′,6′-Dimethoxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Rifaximin-α reduces gut-derived inflammation and mucin degradation in cirrhosis and encephalopathy: RIFSYS randomised controlled trial was written by Patel, Vishal C.;Lee, Sunjae;McPhail, Mark J. W.;Da Silva, Kevin;Guilly, Susie;Zamalloa, Ane;Witherden, Elizabeth;Stoey, Sidsel;Manakkat Vijay, Godhev Kumar;Pons, Nicolas;Galleron, Nathalie;Huang, Xaiohong;Gencer, Selin;Coen, Muireann;Tranah, Thomas Henry;Wendon, Julia Alexis;Bruce, Kenneth D.;Le Chatelier, Emmanuelle;Ehrlich, Stanislav Dusko;Edwards, Lindsey Ann;Shoaie, Saeed;Shawcross, Debbie Lindsay. And the article was included in Journal of Hepatology in 2022.Formula: C43H51N3O11 This article mentions the following:

Rifaximin-α is efficacious for the prevention of recurrent hepatic encephalopathy (HE), but its mechanism of action remains unclear. We postulated that rifaximin-α reduces gut microbiota-derived endotoxemia and systemic inflammation, a known driver of HE.In a placebo-controlled, double-blind, mechanistic study, 38 patients with cirrhosis and HE were randomised 1:1 to receive either rifaximin-α (550 mg BID) or placebo for 90 days. Primary outcome: 50% reduction in neutrophil oxidative burst (OB) at 30 days. Secondary outcomes: changes in psychometric hepatic encephalopathy score (PHES) and neurocognitive functioning, shotgun metagenomic sequencing of saliva and feces, plasma and fecal metabolic profiling, whole blood bacterial DNA quantification, neutrophil toll-like receptor (TLR)-2/4/9 expression and plasma/fecal cytokine anal.Patients were well-matched: median MELD (11 rifaximin-α vs. 10 placebo). Rifaximin-α did not lead to a 50% reduction in spontaneous neutrophil OB at 30 days compared to baseline (p = 0.48). However, HE grade normalized (p = 0.014) and PHES improved (p = 0.009) after 30 days on rifaximin-α. Rifaximin-α reduced circulating neutrophil TLR-4 expression on day 30 (p = 0.021) and plasma tumor necrosis factor-α (TNF-α) (p <0.001). Rifaximin-α suppressed oralisation of the gut, reducing levels of mucin-degrading sialidase-rich species, Streptococcus spp, Veillonella atypica and parvula, Akkermansia and Hungatella. Rifaximin-α promoted a TNF-α- and interleukin-17E-enriched intestinal microenvironment, augmenting antibacterial responses to invading pathobionts and promoting gut barrier repair. Those on rifaximin-α were less likely to develop infection (odds ratio 0.21; 95% CI 0.05-0.96).Rifaximin-α led to resolution of overt and covert HE, reduced the likelihood of infection, reduced oralisation of the gut and attenuated systemic inflammation. Rifaximin-α plays a role in gut barrier repair, which could be the mechanism by which it ameliorates bacterial translocation and systemic endotoxemia in cirrhosis. In this clin. trial, we examined the underlying mechanism of action of an antibiotic called rifaximin-α which has been shown to be an effective treatment for a complication of chronic liver disease which effects the brain (termed encephalopathy). We show that rifaximin-α suppresses gut bacteria that translocate from the mouth to the intestine and cause the intestinal wall to become leaky by breaking down the protective mucus barrier. This suppression resolves encephalopathy and reduces inflammation in the blood, preventing the development of infection. In the experiment, the researchers used many compounds, for example, (2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-25-(Acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione (cas: 80621-81-4Formula: C43H51N3O11).

(2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-25-(Acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione (cas: 80621-81-4) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Formula: C43H51N3O11

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem