Shan, Lingling et al. published their research in International Journal of Nanomedicine in 2015 | CAS: 3326-34-9

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Application of 3326-34-9

Multi-small molecule conjugations as new targeted delivery carriers for tumor therapy was written by Shan, Lingling;Liu, Ming;Wu, Chao;Zhao, Liang;Li, Siwen;Xu, Lisheng;Cao, Wengen;Gao, Guizhen;Gu, Yueqing. And the article was included in International Journal of Nanomedicine in 2015.Application of 3326-34-9 This article mentions the following:

In response to the challenges of cancer chemotherapeutics, including poor physicochem. properties, low tumor targeting ability, and harmful side effects, we developed a new tumor-targeted multi-small mol. drug delivery platform. Using paclitaxel (PTX) as a model therapeutic, we prepared two prodrugs, ie, folic acid-fluorescein-5(6)-isothiocyanate-arginine-paclitaxel (FA-FITC-Arg-PTX) and folic acid-5-aminofluorescein-glutamic-paclitaxel (FA-5AF-Glu-PTX), composed of folic acid (FA, target), amino acids (Arg or Glu, linker), and fluorescent dye (fluorescein in vitro or near-IR fluorescent dye in vivo) in order to better understand the mechanism of PTX prodrug targeting. In vitro and acute toxicity studies demonstrated the low toxicity of the prodrug formulations compared with the free drug. In vitro and in vivo studies indicated that folate receptor-mediated uptake of PTX-conjugated multi-small mol. carriers induced high antitumor activity. Notably, compared with free PTX and with PTX-loaded macromol. carriers from our previous study, this multi-small mol.-conjugated strategy improved the water solubility, loading rate, targeting ability, antitumor activity, and toxicity profile of PTX. These results support the use of multi-small mols. as tumor-targeting drug delivery systems. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9Application of 3326-34-9).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Application of 3326-34-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem