Day: February 9, 2023

miR-381-3p inhibits high glucose-induced vascular smooth muscle cell proliferation and migration by targeting HMGB1 was written by Zhu, Xiao-Shan;Zhou, Han-Yun;Yang, Feng;Zhang, Hong-Shen;Ma, Ke-Zhong. And the article was included in Journal of Gene Medicine in 2021.Computed Properties of C20H10Cl2O5 This article mentions the following:

Hyperglycemia increases the risk of many cardiovascular diseases (CVD), and the dysregulation of proliferation and migration in vascular smooth muscle cells (VSMCs) also participates in the pathogenesis of CVD. miR-381-3p is known to suppress the proliferation and migration of multiple human cell types. Nevertheless, the function of miR-381-3p in VSMCs remains largely indistinct. A quant. real-time polymerase chain reaction (qRT-PCR) was employed to investigate miR-381-3p expression in high-glucose-induced VSMCs. Inflammatory cytokines tumor necrosis factor-α, interleukin-1β and interleukin-6, as well as oxidative stress markers SOD and MDA, were determined by an ELISA. Reactive oxygen species generation was examined using a 2,7′-dichlorofluorescein kit. The proliferation, migration and apoptosis of VSMCs were monitored by 3-(4,5-dimethylthiazl2-yl)-2,5-diphenyltetazolium bromide (MTT), transwell and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) assays. The TargetScan database (http://www.targetscan. org) was employed to seek the potential target gene of miR-381-3p. Interaction between miR-381-3p and HMGB1 was determined by a qRT-PCR, western blotting and a luciferase reporter assay. MiR-381-3p expression was significantly reduced in a VSMCs dysfunction model induced by high-glucose in a dose- and time-dependent manner. Transfection of miR-381-3p mimics suppressed the inflammation, oxidative stress, proliferation and migration of VSMCs, whereas apoptosis of VSMCs was promoted, and the transfection of miR-381-3p inhibitors had the opposite effect. Mechanistically, HMGB1, an important factor in inflammation response, was confirmed as a target gene of miR-381-3p. MiR-381-3p targets HMGB1 to suppress the inflammation, oxidative stress, proliferation and migration of high-glucose-induced VSMCs by targeting HMGB1. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Computed Properties of C20H10Cl2O5).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Computed Properties of C20H10Cl2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis and biological activities of some new substituted benzofuranopyridines was written by Tirlapur, Vijay Kumar;Basawaraj, Raga;Prasad, Y. Rajendra. And the article was included in Indian Journal of Heterocyclic Chemistry in 2010.Safety of 1-(5-Bromobenzofuran-2-yl)ethanone This article mentions the following:

The condensation of 2-acetyl-5-bromobenzofuran, aldehydes, and Et cyanoacetate or malononitrile in EtOH in the presence of NH₄OAc gave 2-oxo-1,2-dihydro- and 2-amino-4-aryl-6-(5-bromobenzofur-2-yl)nicotinonitriles, resp. All the newly synthesized compounds were characterized by IR, ¹H NMR and mass spectra and were evaluated for their antitubercular, antibacterial, and antifungal activity. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Safety of 1-(5-Bromobenzofuran-2-yl)ethanone).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Safety of 1-(5-Bromobenzofuran-2-yl)ethanone

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Dual-mode chemosensor for the fluorescence detection of zinc and hypochlorite on a fluorescein backbone and its cell-imaging applications was written by Maity, Sibaprasad;Maity, Annada C.;Das, Avijit kumar;Bhattacharyya, Nandan. And the article was included in Analytical Methods in 2022.Product Details of 76-54-0 This article mentions the following:

Fluorescein coupled with 3-(aminomethyl)-4,6-dimethylpyridin-2(1H)-one (FAD) was synthesized for the selective recognition of Zn²⁺ over other interfering metal ions in acetonitrile/aqueous buffer (1 : 1). Interestingly, there was a significant fluorescence enhancement of FAD in association with Zn²⁺ at 426 nm by strong chelation-induced fluorescence enhancement (CHEF) without interrupting the cyclic spirolactam ring. A binding stoichiometric ratio of 1 : 2 for the ligand FAD with metal Zn²⁺ was proven by a Jobs plot. However, the cyclic spirolactam ring was opened by hypochlorite (OCl-) as well as oxidative cleavage of the imine bond, which resulted in the emission enhancement of the wavelength at 520 nm. The binding constant and detection limit of FAD towards Zn²⁺ were determined to be 1 x 104 M^-1 and 1.79 μM, resp., and the detection limit for OCl^– was determined as 2.24 μM. We introduced here a dual-mode chemosensor FAD having both the reactive functionalities for the simultaneous detection of Zn²⁺ and OCl^– by employing a metal coordination (Zn²⁺) and analytes (OCl^–) induced chemodosimetric approach, resp. Furthermore, for the practical application, we studied the fluorescence imaging inside HeLa cells by using FAD, which demonstrated it can be very useful as a selective and sensitive fluorescent probe for zinc. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Product Details of 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Product Details of 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Ester-Directed Regioselective Borylation of Heteroarenes Catalyzed by a Silica-Supported Iridium Complex was written by Kawamorita, Soichiro;Ohmiya, Hirohisa;Sawamura, Masaya. And the article was included in Journal of Organic Chemistry in 2010.Quality Control of Methyl benzofuran-2-carboxylate This article mentions the following:

The ester-directed regioselective borylation of arenes catalyzed by a silica-supported monophosphine-Ir complex displayed a significantly broad substrate scope toward heteroaromatic compounds, including thiophene, pyrrole, furan, benzothiophene, benzofuran, indole, and carbazole derivatives The regioselectivity is complementary to the selectivities observed in the heteroarene C-H borylation with the dtbpy-Ir catalyst system. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Quality Control of Methyl benzofuran-2-carboxylate).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Quality Control of Methyl benzofuran-2-carboxylate

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

“One-Pot” Synthesis of γ-Pyrones from Aromatic Ketones/Heteroarenes and Carboxylic Acids was written by Sun, Xiangyu;Gong, Ming;Huang, Mengmeng;Li, Yabo;Kim, Jung Keun;Kovalev, Vladimir;Shokova, Elvira;Wu, Yangjie. And the article was included in Journal of Organic Chemistry in 2020.Related Products of 38220-75-6 This article mentions the following:

Despite the various attractive properties of γ-pyrones, there are still some deficiencies in their synthetic approaches such as lower atom economy, multistep processes, and prefunctionalization of the reagents. In this work, an efficient and simple (CF₃CO)₂O/CF₃SO₃H-mediated “one-pot” approach was realized to produce γ-pyrones by applying aromatic ketones/heteroarenes and carboxylic acids as the starting materials. The target products were isolated in moderate to excellent yields. The reaction mechanism was studied by d. functional theory calculational methods. The results of exptl. and theor. investigations not only helped us explain the reason of high selectivity formation of β-diketones but also proved that 1,3,5-ketones might be important intermediates for the cyclization to afford γ-pyrones. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Related Products of 38220-75-6).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Related Products of 38220-75-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

One-pot synthesis of 2-aryl-3-alkoxycarbonyl chromones through a cascade Lewis acid-catalyzed aldehyde olefination/oxa-Michael addition/oxidation was written by Wang, Ningning;Cai, Shuying;Zhou, Chao;Lu, Ping;Wang, Yanguang. And the article was included in Tetrahedron in 2013.Computed Properties of C10H8O3 This article mentions the following:

2-Aryl-3-alkoxycarbonyl chromones were effectively constructed from aryl aldehydes and 3-(2-(methoxymethoxy)phenyl)propiolates via a cascade Lewis acid catalyzed phenol ether deprotection/aldehyde olefination/intramol. oxa-Michael addition reaction, and a sequential oxidation This four-step reaction could be conducted in one-pot with high atom efficiency. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Computed Properties of C10H8O3).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Computed Properties of C10H8O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Effects of phonophoresis with diclofenac linked gold nanoparticles in model of traumatic muscle injury was written by Haupenthal, Daniela Pacheco dos Santos;Zortea, Diogo;Zaccaron, Rubya Pereira;Silveira, Gustavo de Bem;Correa, Maria Eduarda Anastacio Borges;Mendes, Carolini;Casagrande, Laura de Roch;Duarte, Mariane Bernardo;Pinho, Ricardo Aurino;Feuser, Paulo Emilio;Machado-de-Avila, Ricardo Andrez;Silveira, Paulo Cesar Lock. And the article was included in Materials Science & Engineering, C: Materials for Biological Applications in 2020.Application of 76-54-0 This article mentions the following:

Thus, the objective of this study was to investigate the therapeutic effect of phonophoresis using diclofenac (DC) linked to gold nanoparticles (GNPs) in the skeletal muscle of rats used as a model of traumatic muscular injury. Wistar rats were divided into eight groups: Sham, Muscle injury (MI), MI + TPU, MI + DC, MI + GNPs, MI + TPU + DC, MI + TPU + GNPs, and MI + TPU + DC-GNPs. The traumatic injury was performed in the gastrocnemius with a single direct traumatic impact via an injuring press. The animals received daily treatment for 5 consecutive days with TPU and gel with DC and/or GNPs. Two hours after the last treatment session, animals were euthanized and the gastrocnemius muscle surgically removed for histol. and biochem. anal. Reactive species production and protein damage resulting from oxidative damage was lower for the group exposed to all tested therapies had lower production Lower protein damage was also observed in the TPU + GNPs group. The group that underwent all tested therapies combined showed a significant increase in antioxidants compared to the MI group. During histol. anal., the MI group showed large amounts of cell infiltration and centralized nuclei, whereas the MI + TPU + DC-GNPs group showed structural improvements. Pain levels in the MI + TPU + DC-GNPs group were lower than those of the MI group. We believe that the association of TPU with DC linked to GNPs decreases the inflammation caused by traumatic muscle injury and accelerates tissue repair. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Application of 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application of 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Differential in vitro interactions of the Janus kinase inhibitor ruxolitinib with human SLC drug transporters was written by Bruyere, Arnaud;Le Vee, Marc;Jouan, Elodie;Molez, Stephanie;Nies, Anne T.;Fardel, Olivier. And the article was included in Xenobiotica in 2021.HPLC of Formula: 76-54-0 This article mentions the following:

The present study was therefore designed to investigate this issue. The interactions of ruxolitinib with SLCs were analyzed using transporter-overexpressing human embryonic kidney HEK293 cells. Substrate accumulation was detected by spectrofluorimetry, liquid chromatog. coupled to tandem mass spectrometry or scintillation counting. Ruxolitinib was found to potently inhibit the activities of organic anion transporter 3 (OAT3), organic cation transporter 2 (OCT2), multidrug and toxin extrusion 1 (MATE1) and MATE2-K (half maximal inhibitory concentration (IC50) < 10μM). It blocked OAT1, OAT4, OATP1B1, OATP1B3, OATP2B1 and OCT3, but in a weaker manner (IC50 > 10μM), whereas OCT1 was not impacted. No time-dependent inhibition was highlighted. When applying the US Food and Drug Administration (FDA) criteria for transporters-related drug-drug interaction risk, OCT2 and MATE2-K, unlike MATE1 and OAT3, were predicted to be in vivo inhibited by ruxolitinib. Cellular uptake studies addnl. indicated that ruxolitinib is a substrate for MATE1 and MATE2-K, but not for OAT3 and OCT2. Ruxolitinib in vitro blocked activities of most of SLC transporters. Only OCT2 and MATE-2K may be however clin. inhibited by the JAK inhibitor, with the caution for OCT2 that in vitro inhibition data were generated with an FDA-non recommended fluorescent substrate. Ruxolitinib MATEs-mediated transport may addnl. deserve attention for its possible pharmacol. consequences in MATE-pos. cells. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0HPLC of Formula: 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.HPLC of Formula: 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

An examination of analysis of histamine in food for health risk management was written by Hanaishi, Ryuji;Yamamoto, Akemi. And the article was included in Aomori-ken Kankyo Hoken Senta Kenkyu Hokoku in 2019.Formula: C17H10O4 This article mentions the following:

A rapid anal. method of histamine in food for health risk management cases was explored. As a basic technique, the present authors adopted a method already reported by Kikuchi et al. (Hiroyuki Kikuchi et al., 2012), in which the eluted solution purified by solid-phase extraction using a C18 cartridge and a strongly acidic cation exchange resin cartridge was derivatized with fluorescamine. The method was modified using tetrabutylammonium hydroxide (TBAH) as a base in the eluted solution in the purification step to shorten the time required for anal. At the time of drawing a calibration line based on the results of standard solution measurement, percent differences were calculated and the ranges of the calibration line were determined, and spike recovery rates were calculated using sardine dried whole. Using the TBAH method, sufficient recovery rates were obtained, suggesting that the TBAH method was useful as an anal. method in health risk management. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Formula: C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Formula: C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

All in one theranostic nanoagent based on MoSe₂/Au@PEG hollow nanospheres for the enhanced synergetic antitumor was written by Li, Yang;Wang, Limin;Kang, Keke;Ma, Yajie;Yu, Kai;Lu, Tong;Qu, Fengyu;Lin, Huiming. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2022.HPLC of Formula: 76-54-0 This article mentions the following:

MoSe2/Au@PEG nanoheterostructure were synthesized to integrate multi-imaging and therapeutic strategies into one nanoplatform. These Au nanoparticles were deposited on the surface of MoSe2 hollow nanospheres (250 nm) to reveal the enhanced NIR harvest owing to localized surface plasma resonance of Au, which could be varied with the particle sizes and the distance of Au nanoparticles. Therefore, MoSe2/Au@PEG nanocomposites revealed the great photothermal conversion efficiency to 73.0 %. In addition, they also exhibited the promoted reactive oxygen species (ROS) generation about 4-times as the pure sample, owing to the plasmon-mediated electron-transfer between the two components. Besides, the peroxidase and catalase activity of MoSe2 could convert the intracellular H2O2 to ·OH and O2 for chemotherapy. In addition, the glucose oxidase activity of Au made the H2O2 supplement for promoted chemodynamic therapy (CDT) and the glucose consumption for starvation therapy. It noted that the MoSe2/Au@PEG heterostructure also increased the nanozyme activity (2 times), ascribing to the decreased resistant of the charge transfer. The photothermal/photodynamic/starvation therapy combined with CDT could bring the immunogenic cell death that was associated with anti-CTLA4 to further arouse immune response to eliminate the primary as well as metastatic tumors. In addition, the novel biodegradation of the nanocomposite made the elimination via urine and feces within 18 d. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0HPLC of Formula: 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.HPLC of Formula: 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem