Day: November 23, 2022

Kachur, Alexander V. published the artcileSynthesis of ¹⁸F-labeled phenolphthalein and naphtholphthalein, Category: benzofurans, the publication is Journal of Fluorine Chemistry (2013), 1-6, database is CAplus and MEDLINE.

The fluorination of phenolphthalein and naphtholphthalein was performed with diluted fluorine gas under acidic conditions. For both compounds the authors observed an electrophilic fluorination into ortho position to the hydroxyl group. Through the use of this reaction the authors synthesized and characterized mono- and difluorinated derivatives of phenolphthalein and naphtholphthalein. The compounds were also prepared in the ¹⁸F labeled form, which are usable as a new type of probe for in vivo pH measurement in biol. objects using Cerenkov imaging or combination of light absorption and PET.

Journal of Fluorine Chemistry published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Category: benzofurans.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

de Castro, S. L. published the artcileScreening of natural and synthetic drugs against Trypanosoma cruzi. 1. Establishing a structure/activity relationship, Safety of 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, the publication is Microbios (1994), 78(315), 83-90, database is CAplus and MEDLINE.

The activity of 45 compounds against bloodstream forms of Trypanosoma cruzi was investigated. The aim was to consider new agents which might subsequently be assayed for chemoprophylaxis in donated blood. In a preliminary screening the drugs were assayed (50 to 1,000 μM at 29°C) and those active against bloodstream forms at concentrations below 600 μM were selected for further assays under blood-bank conditions (4°C/24 h). Three compounds isolated from natural sources and six synthetic agents were selected. The active compounds of plant origin included purpurin (I), a member of the trihydroxylated anthraquinone group, which is known to exhibit trypanocidal activity. Among the active synthetic compounds, five displayed a common structural feature in that they were potentially one-electron acceptors, via reductive functional groups. All five compounds form tricentered C or N intermediates, joined in a hypothetical Y radical pattern. It is possible that the trypanocidal mechanisms initiated by these compounds are similar to those found with crystal violet (II) , since this dye, which is already used in endemic areas for the treatment of banked blood, also conforms to this general Y structural pattern.

Microbios published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Safety of 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Roncaglioni, A. published the artcileBinary classification models for endocrine disrupter effects mediated through the estrogen receptor, Application of 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, the publication is SAR and QSAR in Environmental Research (2008), 19(7-8), 697-733, database is CAplus and MEDLINE.

Endocrine disrupters (EDs) form an interesting field of application attracting great attention in the recent years. They represent a number of exogenous substances interfering with the function of the endocrine system, including the interfering with developmental processes. In particular EDs are mentioned as substances requiring a more detailed control and specific authorization within REACH, the new European legislation on chems., together with other groups of chems. of particular concern. QSAR represents a challenging method to approach data gap which is foreseen by REACH. The aim of this study was to provide an insight into the use of QSAR models to address ED effects mediated through the estrogen receptor (ER). New predictive models were derived to assess estrogenicity for a very large and heterogeneous dataset of chem. compounds QSAR binary classifiers were developed based on different data mining techniques such as classification trees, decision forest, fuzzy logic, neural networks and support vector machines. The focus was given to multiple endpoints to better characterize the effects of EDs evaluating both binding (RBA) and transcriptional activity (RA). A possible combination of the models was also explored. A very good accuracy was reached for both RA and RBA models (higher than 80%).

SAR and QSAR in Environmental Research published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Application of 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Tathe, Akash G. published the artcileLigand-Enabled Gold-Catalyzed C(sp²)-S Cross-Coupling Reactions, COA of Formula: C8H5IO, the publication is Organic Letters (2022), 24(24), 4459-4463, database is CAplus and MEDLINE.

C(sp²)-S cross-coupling reactions of aryl iodides and arylsulfonyl hydrazides under ligand-enabled, Au(I)/Au(III) redox catalysis was reported. This strategy operates under mild reaction conditions, requires no prefunctionalized aryl coupling partner and works across several aryl iodides. The reaction mechanism was supported with control experiments, mass spectrometry, and NMR studies.

Organic Letters published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C20H17FO4S, COA of Formula: C8H5IO.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Dej-adisai, Sukanya published the artcileDetermination of phytochemical compounds, and tyrosinase inhibitory and antimicrobial activities of bioactive compounds from Streblus ilicifolius (s vidal) corner, Computed Properties of 56317-21-6, the publication is Tropical Journal of Pharmaceutical Research (2016), 15(3), 497-506, database is CAplus.

Purpose: To determine the phytochem. content, and tyrosinase inhibitory and antimicrobial activities of the wood from S treblus ilicifolius (S. Vidal) Corner Methods: The dried wood of S. ilicifolius (8.70 kg) was extracted by maceration to give petroleum ether, Et acetate, ethanol and water extracts, resp. Dopachrome method was used to determine antityrosinase activity. Agar disk diffusion and modified broth microdilution methods were used to determine antimicrobial activity. Chromatog. techniques were used for phytochem. investigation. The structures elucidation of isolated compounds were identified by phys. properties and spectroscopic data including UV, IR, NMR and MS data and confirmed by comparison with previously reports. Results: The ethanol extract exhibited tyrosinase inhibition and antimicrobial activity against the Grampos. bacteria, Staphylococcus epidermidis and S. aureus. Phytochem. investigation showed five compounds, namely, (E)-2,4-dihydroxy-3-(3,7-dimethyl-2,6-octadienyl) benzaldehyde (1), phydroxybenzoic acid Me ester (2), umbelliferone (3), moracin M (4), trans-resveratrol (5). Compound 4 exhibited tyrosinase inhibition with half maximal inhibitory concentration (IC50) of 67.69 μg/mL, while compound 1 displayed strong activity against S. epidermidis, S. aureus and methicillin-resistant S. aureus (MRSA) with min. inhibitory concentration (MIC) of 8, 4 and 8 μg/mL, resp. and min. bactericidal concentration (MBC) of 32, 16 and 64 μg/mL, resp. Conclusion: This is the first report of the biol. activities and phytochem. composition of S. ilicifolius and the results indicate the high potentials of the plant for com. applications such as in facial whitening and anti-acne cream.

Tropical Journal of Pharmaceutical Research published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Computed Properties of 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem