de Castro, S. L. published the artcileScreening of natural and synthetic drugs against Trypanosoma cruzi. 1. Establishing a structure/activity relationship, Safety of 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, the publication is Microbios (1994), 78(315), 83-90, database is CAplus and MEDLINE.
The activity of 45 compounds against bloodstream forms of Trypanosoma cruzi was investigated. The aim was to consider new agents which might subsequently be assayed for chemoprophylaxis in donated blood. In a preliminary screening the drugs were assayed (50 to 1,000 μM at 29°C) and those active against bloodstream forms at concentrations below 600 μM were selected for further assays under blood-bank conditions (4°C/24 h). Three compounds isolated from natural sources and six synthetic agents were selected. The active compounds of plant origin included purpurin (I), a member of the trihydroxylated anthraquinone group, which is known to exhibit trypanocidal activity. Among the active synthetic compounds, five displayed a common structural feature in that they were potentially one-electron acceptors, via reductive functional groups. All five compounds form tricentered C or N intermediates, joined in a hypothetical Y radical pattern. It is possible that the trypanocidal mechanisms initiated by these compounds are similar to those found with crystal violet (II) , since this dye, which is already used in endemic areas for the treatment of banked blood, also conforms to this general Y structural pattern.
Microbios published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Safety of 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one.
Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem