Month: October 2022

On March 31, 1991, Suzuki, Tsuneo published an article.Electric Literature of 53724-96-2 The title of the article was The reaction of ethyl 2-acetyl-5-methoxyphenoxyacetate with some bases in various solvents. And the article contained the following:

The reaction of the title compound (I) with KOH, NaOH, KOCMe3, EtONa, NaH, or NaNH2 in dioxane, THF, DMF, Me2SO, MeOH, EtOH, or Me3COH was reported. E.g., reaction of I with KOH in dioxane gave 19% benzofuran II, 44% benzofuran III, and 25% benzoxepin III. The experimental process involved the reaction of Ethyl 6-methoxy-3-methylbenzofuran-2-carboxylate(cas: 53724-96-2).Electric Literature of 53724-96-2

The Article related to acetylmethoxyphenoxyacetate cyclization solvent effect, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenofurans and other aspects.Electric Literature of 53724-96-2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On July 1, 2007, Salih, Kifah S. M.; Ayoub, Mikdad T.; Saadeh, Haythem A.; Al-Masoudi, Najim A.; Mubarak, Mohammad S. published an article.COA of Formula: C13H14O4 The title of the article was Synthesis, characterization, and biological activities of new benzofuran derivatives. And the article contained the following:

New benzofuran derivatives, Et 3-[(alkylamino)methyl]-6-methoxy-1-benzofuran-2-carboxylates, e.g., I, were obtained via the reaction between Et 3-(bromomethyl)-6-methoxy-1-benzofuran-2-carboxylate (II) and amines or amino acid Et esters. In addition, 1,4-bis[(Et 6-methoxy-1-benzofuran-3-yl-2-carboxylate)methyl]piperazine, N,N’-diethyl-N,N’-bis[(6-methoxy-1-benzofuran-3-yl-2-carboxylate) methyl]but-2-ene-1,4-diamine, and 1,2-bis[(Et 6-methoxy-1-benzofuran-3-yl-2-carboxylate)methyl]-1,2-dimethylhydrazine were also obtained from the reaction of II with diamines. Their in vitro anti-HIV-1 (strain IIIB) and HIV-2 (strain ROD) activities of the synthesized compounds in human T-lymphocyte were tested; II displayed an ability to inhibit HIV-1 and HIV-2 replication in cell culture at non-toxic concentrations The experimental process involved the reaction of Ethyl 6-methoxy-3-methylbenzofuran-2-carboxylate(cas: 53724-96-2).COA of Formula: C13H14O4

The Article related to benzofurancarboxylate derivative preparation antihiv activity, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenofurans and other aspects.COA of Formula: C13H14O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Cagniant, Paul; Kirsch, Gilbert published an article in 1976, the title of the article was Method for the synthesis of mono- or polysubstituted 3(2H)-benzofuranones and benzo[b]furans.Name: 5-Iodobenzofuran And the article contains the following content:

Benzofurans I (R = H, Me; R1 = 7-Me, 6-Me, 6-OMe, 5-OMe, 5-SMe, 5-F, 5-I; R2 = H) were prepared by alkylating the salicyclic esters II (R3 = H) with BrCHRCO2Et, hydrolyzing II (R3 = CHRCO2Et), cyclizing the diacids with AcONa-AcOH-Ac2O, hydrolyzing I (R2 = OAc), reducing III (X =O), and dehydrating III (X = H,OH). I (R = Ac, R2 = OAc) were obtained as byproducts of I (R = H,Me, R2 = OAc). The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Name: 5-Iodobenzofuran

The Article related to benzofuran, salicylate carboxyalkoxy cyclization, carboxyalkoxysalicyclate cyclization, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenofurans and other aspects.Name: 5-Iodobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On March 31, 1990, Suzuki, Tsuneo published an article.Computed Properties of 53724-96-2 The title of the article was The reaction of ethyl (2-acetyl-5-methoxyphenoxy)acetate with potassium hydroxide. And the article contained the following:

The reaction of title ester I (R = Et) with KOH gave benzofurans, benzoxepindione II, and I (R = H). The experimental process involved the reaction of Ethyl 6-methoxy-3-methylbenzofuran-2-carboxylate(cas: 53724-96-2).Computed Properties of 53724-96-2

The Article related to acetylphenoxyacetate cyclization hydroxide, benzofuran derivative, benzoxepindione derivative, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenofurans and other aspects.Computed Properties of 53724-96-2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Rene, Loic; Buisson, Jean P.; Royer, Rene published an article in 1975, the title of the article was Reactions induced by pyridinium halides. XX. First examples of dealkylation by pyridinium hydrochloride in quinoline.Formula: C13H14O4 And the article contains the following content:

Benzofuranols I-VI (R = R1 = H, R2 = H, Me) were prepared in improved yields by demethylating I-VI (R1 = Me) with pyridine-HCl in quinoline. I-VI (R1 = Me) were prepared by formylating coumarilic acid esters, hydrolyzing I-VI (R = CO2Me, CO2Et, R1 = Me), and decarboxylating I-VI (R = CO2H). The experimental process involved the reaction of Ethyl 6-methoxy-3-methylbenzofuran-2-carboxylate(cas: 53724-96-2).Formula: C13H14O4

The Article related to benzofuranol formyl, demethylation methoxybenzofuran pyridine hydrochloride, quinoline demethylation solvent, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenofurans and other aspects.Formula: C13H14O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Chen, Wei; Zhou, Zhao-Hui; Chen, Hong-Bin published an article in 2017, the title of the article was Efficient synthesis of chiral benzofuryl β-nitro alcohols via a catalytic asymmetric Henry reaction.Formula: C13H14O4 And the article contains the following content:

Chiral β-amino alc. ligands were found to be effective for the copper(II)-catalyzed asym. Henry reaction of benzofuran-2-carboxaldehydes with nitromethane, which led to the formation of (S)-enriched benzofuryl β-nitro alcs. with satisfactory enantioselectivities (up to 98% ee). The experimental process involved the reaction of Ethyl 6-methoxy-3-methylbenzofuran-2-carboxylate(cas: 53724-96-2).Formula: C13H14O4

The Article related to benzofuran carboxaldehyde nitromethane copper acetate catalyst enantioselective henry reaction, benzofuryl nitro ethanol preparation, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenofurans and other aspects.Formula: C13H14O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On April 30, 1992, Suzuki, Tsuneo; Tanemura, Kiyoshi; Horaguchi, Takaaki; Shimizu, Takahachi; Sakakibara, Tohru published an article.SDS of cas: 53724-96-2 The title of the article was Benzofuran derivatives. Part 4. Synthesis of benzofurans and 2,3,4,5-tetrahydro-1-benzoxepin-3,5-diones. And the article contained the following:

By treatment of Et 4- or 5-substituted 2-acetylphenoxyacetates I (R = 4-Me, H, 5-Cl, etc.) with potassium hydroxide in dry dioxane, benzofurans II-VII and 2,3,4,5-tetrahydro-1-benzoxepin-3,5-diones VIII were obtained. The relative yields of benzofurans II-VII and 2,3,4,5-tetrahydro-1-benzoxepin-3,5-diones VIII varied with the types of 4- or 5-substituents. The electron-donating 4-methoxy group favored the formation of benzoxepins. On the other hand, electron-withdrawing substituents such as the 4-nitro group favored the formation of benzofurans. When esters I were treated with sodium amide, 2,3-dihydrobenzofurans II were obtained exclusively regardless of 4- or 5-substituents. The experimental process involved the reaction of Ethyl 6-methoxy-3-methylbenzofuran-2-carboxylate(cas: 53724-96-2).SDS of cas: 53724-96-2

The Article related to acetylphenoxyacetate cyclization, phenoxyacetate acetyl cyclization, benzofuran, tetrahydrobenzoxepindione, benzoxepindione tetrahydro, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenofurans and other aspects.SDS of cas: 53724-96-2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Royer, Rene; Lamotte, Genevieve; Demerseman, Pierre; Platzer, Nicole; Cavier, Raymond published an article in 1974, the title of the article was Nitro derivatives of biological interest. VIII. Comparative orientations of nitration and acetylation of 3-methyl-4-methoxyl ethyl coumarilates.Safety of Ethyl 6-methoxy-3-methylbenzofuran-2-carboxylate And the article contains the following content:

Nitration of the 4 methoxycoumarilates I occurred mainly in the benzene ring, although in some cases the nitromethyl derivative was also detected. I were also acetylated in the benzene ring and the acetylated or nitrated esters hydrolyzed and decarboxylated, and the decarboxylation products again nitrated. Only the 2-nitro derivatives were amebicides and trichomonacides. The experimental process involved the reaction of Ethyl 6-methoxy-3-methylbenzofuran-2-carboxylate(cas: 53724-96-2).Safety of Ethyl 6-methoxy-3-methylbenzofuran-2-carboxylate

The Article related to benzofurancarboxylate nitration acetylation, structure activity nitrobenzofuran, amebicide nitro benzofurancarboxylate, trichomonacide nitro benzofurancarboxylate, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenofurans and other aspects.Safety of Ethyl 6-methoxy-3-methylbenzofuran-2-carboxylate

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On July 22, 2022, Bai, Jiaxing; Xu, Nengni; Wang, Hui; Luan, Xinjun published an article.Computed Properties of 60770-67-4 The title of the article was Palladium(II)-Catalyzed [2+2+1] Annulation of Alkynes and Hydroxylamines: A Rodox-Neutral Approach to Fully Substituted Pyrroles. And the article contained the following:

A palladium-catalyzed [2+2+1] annulation of alkynes and hydroxylamines was developed for the rapid construction of fully substituted pyrroles. This transformation involves sequential nucleophilic-addition of hydroxylamine to alkyne, alkyne migratory insertion, and synergistic demetallization cyclization, which provides a redox-neutral annulation approach to pyrrole derivatives Moreover, the strategy enabled alteration of the photophys. properties of pyrrole products by varying the aryl substituents, thus leading to the development of N-functionalized tetraarylpyrroles as new fluorophores. The experimental process involved the reaction of 5-Iodobenzofuran(cas: 60770-67-4).Computed Properties of 60770-67-4

The Article related to hydroxylamine aryl alkyne palladium catalyst regioselective cycloaddition, pyrrole preparation, Heterocyclic Compounds (One Hetero Atom): Pyrroles and Pyrrolizines and other aspects.Computed Properties of 60770-67-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On May 26, 2016, Hirasawa, Hideaki; Kawamura, Naohiro; Kobayashi, Junichi published a patent.Application In Synthesis of (S)-2,3-Dihydrobenzofuran-3-amine hydrochloride The title of the patent was TRPMB inhibitors containing α-substituted glycine amides. And the patent contained the following:

Disclosed is a pharmaceutical composition containing a compound I [A1 = C6-10 aryl (optionally substituted with halo, hydroxy, C1-6 alkyl, etc.), 5-membered heterocyclyl (optionally substituted with halo, hydroxy, C1-6 alkyl, etc.) or 6-membered heterocyclyl (optionally substituted with halo, hydroxy, C1-6 alkyl, etc.); A2 = C6-10 aryl (optionally substituted with halo, hydroxy, C1-6 alkyl, etc.), heterocyclyl (optionally substituted with halo, hydroxy, C1-6 alkyl, etc.) or C3-6 cycloalkyl; X = CH or N; Y = -CR1R2- or oxygen atom; R1, R2 = independently H, halo or C1-6 alkyl; R3, R4 = independently H, halo, C1-6 alkyl, etc., wherein R3 and R4 cannot be H together when X = CH and R1 = R2 = H; n = 1 or 2], or pharmaceutically acceptable salt thereof as an active component. The composition is claimed useful for the treatment of diseases or conditions associated with afferent nerve hyperexcitability or injury, e.g. LUTS (lower urinary tract symptoms). For example, a compound (II) showed potent inhibitory effect on icilin-induced wet-dog shaking in rat. The experimental process involved the reaction of (S)-2,3-Dihydrobenzofuran-3-amine hydrochloride(cas: 1459793-02-2).Application In Synthesis of (S)-2,3-Dihydrobenzofuran-3-amine hydrochloride

The Article related to glycine amide preparation trpm8 inhibitor, nerve hyperexcitability disease treatment glycine amide trpm8 inhibition, Pharmacology: Other (All Agents and Effects Not Otherwise Assignable) and other aspects.Application In Synthesis of (S)-2,3-Dihydrobenzofuran-3-amine hydrochloride

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem