Month: April 2022

Formula: C19H19N2NaO2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Influence of nonsteroid antiinflammatory and immunosuppressive drugs on hepatic tryptophan pyrrolase activity in rats. Author is Reinicke, Claus; Guttmacher, Hansjuergen; Ulbricht, Wolfgang.

Orally administered indomethacin [53-86-1] (3 mg/kg), sodium salicylate [54-21-7] (120 mg/kg), acetylsalicylic acid [50-78-2] (300 mg/kg), salicylamide [65-45-2] (160 mg/kg), mefenamic acid [61-68-7] (340 mg/kg), flufenamic acid (I) [530-78-9] (90 mg/kg), amidopyrine [58-15-1] (340 mg/kg), sodium phenylbutazone [129-18-0] (50 mg/kg), and benzydamine-HCl [132-69-4] (200 mg/kg) administered repeatedly did not alter tryptophan pyrrolase [9014-51-1] activity in the liver of intact rats. Orally administerd I increased tyrosine aminotransferase [9014-55-5] activity. Of the nonsteroidal inflammation inhibitors tested, only I and benzydamine blocked the induction of tryptophan pyrrolase by cortisol [50-23-7]. Orally administered cyclophosphamide [50-18-0] (140 mg/kg), triaziquone [68-76-8] (0.45 mg/kg), and azathioprine [446-86-6] increased tryptophan pyrrolase activity, whereas chloroquine diphosphate [50-63-5] (20 mg/kg), 6-mercaptopurine [50-44-2] (75 mg/kg), 6-azauridine [54-25-1] (100 mg/kg), and amethopterin [59-05-2] (2 mg/kg) did not. Induction of tryptophan pyrrolase by cortisol was blocked by azathioprine, 6-mercaptopurine, 6-azauridine, and amethopterin. Enzyme induction is not an essential property of nonsteroidal inflammation inhibitors.

From this literature《Influence of nonsteroid antiinflammatory and immunosuppressive drugs on hepatic tryptophan pyrrolase activity in rats》,we know some information about this compound(129-18-0)Formula: C19H19N2NaO2, but this is not all information, there are many literatures related to this compound(129-18-0).

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate( cas:90866-33-4 ) is researched.Related Products of 90866-33-4.Ni, Yan; Li, Chun-Xiu; Ma, Hong-Min; Zhang, Jie; Xu, Jian-He published the article 《Biocatalytic properties of a recombinant aldo-keto reductase with broad substrate spectrum and excellent stereoselectivity》 about this compound( cas:90866-33-4 ) in Applied Microbiology and Biotechnology. Keywords: biocatalysis aldo keto reductase substrate spectrum enantiomer stereoselectivity. Let’s learn more about this compound (cas:90866-33-4).

In the screening of 11 E. coli strains overexpressing recombinant oxidoreductases from Bacillus sp. ECU0013, an NADPH-dependent aldo-keto reductase (YtbE) was identified with capability of producing chiral alcs. The protein (YtbE) was overexpressed, purified to homogeneity, and characterized of biocatalytic properties. The purified enzyme exhibited the highest activity at 50°C and optimal pH at 6.5. YtbE served as a versatile reductase showing a broad substrate spectrum towards different aromatic ketones and keto esters. Furthermore, a variety of carbonyl substrates were asym. reduced by the purified enzyme with an addnl. coupled NADPH regeneration system. The reduction system exhibited excellent enantioselectivity (>99% ee) in the reduction of all the aromatic ketones and high to moderate enantioselectivity in the reduction of α-keto esters and β-keto esters. Among the ketones tested, Et 4,4,4-trifluoroacetoacetate was found to be reduced to Et (R)-4,4,4-trifluoro-3-hydroxy butanoate, an important pharmaceutical intermediate, in excellent optical purity. To the best of our knowledge, this is the first report of ytbE gene-encoding recombinant aldo-keto reductase from Bacillus sp. used as biocatalyst for stereoselective reduction of carbonyl compounds This study provides a useful guidance for further application of this enzyme in the asym. synthesis of chiral alc. enantiomers.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Application of 129-18-0. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Pharmacological studies of tectoridin and tectorigenin. Author is Esaki, Shunji.

Tectoridin (I) and tectorigenin (II) were observed to be hyaluronidase inhibitory both in vitro and in vivo. The hyaluronidase inhibition in vitro was not reversed with cysteine, in contrast to that with rutin (III) and quercetin (IV). The nonsteroidal, antiinflammatory drugs, 5-butyl-1-cyclohexyl-2,4,6-trioxo-perhydropyrimidine Na and phenylbutazone Na, were observed to have hyaluronidase inhibitory activity in vivo but not in vitro. The hyaluronidase edema in rat hind paw was inhibited with I and II but not the carrageenin edema. The exudation of ascites induced in rats by mustard was slightly inhibited with I and II. The stretching induced by HOAc and the permeability of dye into the peritoneum was inhibited by I and II but not so markedly as by IV. It was considered that I and II have weak estrogenlike action. The acute toxicity of I and II was very weak, almost the same as III and IV.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Application In Synthesis of Methyl 4-bromo-2-formylbenzoate. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Methyl 4-bromo-2-formylbenzoate, is researched, Molecular C9H7BrO3, CAS is 1260795-42-3, about Highly Enantioselective Synthesis of 2,3-Dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-ones via Catalytic Asymmetric Intramolecular Cascade Imidization-Nucleophilic Addition-Lactamization.

Highly enantioselective catalytic asym. intramol. cascade imidization-nucleophilic addition-lactamization of N1-alkylethane-1,2-diamine with Me 2-formylbenzoate catalyzed by a chiral phosphoric acid represents the first efficient method for the preparation of medicinally interesting chiral 2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-ones, e.g., I, with high yields and excellent enantioselectivities. This strategy has been shown to be quite general toward various Me 2-formylbenzoates.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Chemical characterization of the products of drug decomposition. IV. Mechanism of phenylbutazone decomposition in pharmaceutical preparations.HPLC of Formula: 129-18-0.

Injections of phenylbutazone (I) sodium were analyzed by various chromatographic techniques. The decomposition products detected were 4-butyl-4-hydroxy-1,2-diphenylpyrazolidine-3,5-dione (II), PhN(NHPh)COCHBuCO2H (III), trans- and cis-PhN:NPh, and BuCH(CO2H)2. A similar anal. of overdue suppositories containing I revealed the presence of II, III, PhN(NHPh)COC5H11, and PhN(NHPh)CBu(OH)CO2H. (m. 148°). Hydrolytic decomposition was predominant in injections, and oxidative decomposition, in suppositories.

From this literature《Chemical characterization of the products of drug decomposition. IV. Mechanism of phenylbutazone decomposition in pharmaceutical preparations》,we know some information about this compound(129-18-0)HPLC of Formula: 129-18-0, but this is not all information, there are many literatures related to this compound(129-18-0).

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Yuan, Shang-Fu; Lei, Zhen; Guan, Zong-Jie; Wang, Quan-Ming published an article about the compound: Silver(I) trifluoromethanesulfonate( cas:2923-28-6,SMILESS:O=S(C(F)(F)F)([O-])=O.[Ag+] ).Category: benzofurans. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:2923-28-6) through the article.

Gold nanoclusters with surface open sites are crucial for practical applications in catalysis. We have developed a surface geometric mismatch strategy by using mixed ligands of different type of hindrance. When bulky phosphine Ph3P and planar dipyridyl amine (Hdpa) are simultaneously used, steric repulsion between the ligands will reduce the ligand coverage of gold clusters. A well-defined access granted gold nanocluster [Au23(Ph3P)10(dpa)2Cl](SO3CF3)2 (Au23, dpa=dipyridylamido) has been successfully synthesized. Single crystal structural determination reveals that Au23 has eight uncoordinated gold atoms in the shape of a distorted bicapped triangular prism. The accessibility of the exposed Au atoms has been confirmed quant. by luminescent titration with 2-naphthalenethiol. This cluster has excellent performance toward selective oxidation of benzyl alc. to benzaldehyde and demonstrates excellent stability due to the protection of neg. charged multidentate ligand dpa.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Formula: C18H20N2O12. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, is researched, Molecular C18H20N2O12, CAS is 70539-42-3, about Location of crosslinks in chemically stabilized horseradish peroxidase: implications for design of crosslinks.

The bifunctional compound, ethylene-glycol bis(N-hydroxysuccinimidylsuccinate) (EGNHS), stabilizes horseradish peroxidase C (HRP) by reaction with the enzyme’s lysine residues. In this study we compare native and modified HRP by proteolytic fragmentation, peptide sequencing, and mass spectroscopy, and identify the sites of modification. Most significantly, EGNHS is shown to form a crosslink between Lys232 and Lys241 of HRP and modifies Lys174 without formation of a crosslink. These findings are in agreement with the lysine side-chain reactivities predicted from the surface accessibility of the amino groups, and the maximal span of 16 Å of the EGNHS crosslinker.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Related Products of 2923-28-6. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Silver(I) trifluoromethanesulfonate, is researched, Molecular CAgF3O3S, CAS is 2923-28-6, about Photoswitchable fluorescent self-assembled metallacycles with high photostability. Author is Chen, Shangjun; Chen, Lijun; Cai, Yunsong; Zhu, Wei-Hong.

In this study, photoswitchable fluorescent supramol. metallacycles with high fatigue-resistance have been constructed by coordination-driven self-assembly by using bithienylethene with dipyridyl units (BTE) as a coordination donor and a fluorescent di-platinum(II) (Pt-F) as a coordination acceptor. The photo-triggered reversible transformation between the ring-open and ring-closed form of the metallacycles was confirmed by 1H NMR, 31P NMR, and UV/Vis spectroscopy. This unique property enabled a reversible noninvasive “”off-on”” switching of fluorescence through efficient Foerster resonance energy transfer (FRET). Importantly, the metallacycles remained structurally intact after up to 10 photoswitching cycles. The photoresponsive property and exceptional photostability of the metallacycles posit their potential promising application in optical switching, image storage, and super-resolution microscopy.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Asanin, Darko P.; Bogojevic, Sanja Skaro; Perdih, Franc; Andrejevic, Tina P.; Milivojevic, Dusan; Aleksic, Ivana; Nikodinovic-Runic, Jasmina; Glisic, Biljana D.; Turel, Iztok; Djuran, Milos I. published the article 《Structural characterization, antimicrobial activity and BSA/DNA binding affinity of new silver(I) complexes with thianthrene and 1,8-naphthyridine》. Keywords: silver complex thianthrene naphthyridine antibacterial antifungal DNA binding; 1,8-naphthyridine; Caenorhabditis elegans; DNA/BSA interaction; antimicrobial activity; silver(I) complexes; thianthrene.They researched the compound: Silver(I) trifluoromethanesulfonate( cas:2923-28-6 ).Application of 2923-28-6. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:2923-28-6) here.

Three new silver(I) complexes [Ag(NO3)(tia)(H2O)]n (Ag1), [Ag(CF3SO3)(1,8-naph)]n (Ag2) and [Ag2(1,8-naph)2(H2O)1.2](PF6)2 (Ag3), where tia is thianthrene and 1,8-naph is 1,8-naphthyridine, were synthesized and structurally characterized by different spectroscopic and electrochem. methods and their crystal structures were determined by single-crystal X-ray diffraction anal. Their antimicrobial potential was evaluated against four bacterial and three Candida species, and the obtained results revealed that these complexes showed significant activity toward the Gram-pos. Staphylococcus aureus, Gram-neg. Pseudomonas aeruginosa and the investigated Candida species with minimal inhibitory concentration (MIC) values in the range 1.56-7.81 μg/mL. On the other hand, tia and 1,8-naph ligands were not active against the investigated strains, suggesting that their complexation with Ag(I) ion results in the formation of antimicrobial compounds Moreover, low toxicity of the complexes was detected by in vivo model Caenorhabditis elegans. The interaction of the complexes with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) was studied to evaluate their binding affinity towards these biomols. for possible insights into the mode of antimicrobial activity. The binding affinity of Ag1-3 to BSA was higher than that for DNA, indicating that proteins could be more favorable binding sites for these complexes in comparison to the nucleic acids.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Fibrinolytic activity of antiinflammatory drugs》. Authors are Gryglewski, R..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Product Details of 129-18-0. Through the article, more information about this compound (cas:129-18-0) is conveyed.

The fibrinolytic activity of antiinflammatory drugs was studied in vitro by incubating them with human plasma clots. Na salicylate, Na acetylsalicylate, and Na amidopyrine exhibited trace fibrinolytic activity, while Na phenylbutazone, Na mefenamate, and Na flufenamate showed full fibrinolytic activity.

There is still a lot of research devoted to this compound(SMILES：O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+])Product Details of 129-18-0, and with the development of science, more effects of this compound(129-18-0) can be discovered.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem