Day: April 20, 2022

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 90866-33-4, is researched, SMILESS is O=C(OCC)C[C@@H](O)CCl, Molecular C6H11ClO3Journal, Industrial & Engineering Chemistry Research called A Complex Process of Asymmetric Synthesis of β-Hydroxy Ester by Baker’s Yeast Accompanied by Resin Adsorption, Author is Yang, Zhong-Hua; Yao, Shan-Jing; Guan, Yi-Xin, the main research direction is bakers yeast asym reduction resin adsorption.SDS of cas: 90866-33-4.

Asym. reduction of β-oxo ester to chiral β-hydroxy ester by yeast cells is one of the most promising routes for synthesis of chiral pharmaceutical intermediates. But the stereoselectivity and initial substrate concentration of this asym. reduction reaction are usually unsatisfactory. When asym. reduction of Et 4-chloro-3-oxobutanoate to chiral Et 4-chloro-3-hydroxybutanoate by baker’s yeast was chosen as the model reaction, it was investigated to improve the stereoselectivity and initial substrate concentration of this asym. reduction reaction by introducing resin to slowly release the substrate and in situ adsorb the product. The experiments indicated that the stereoselectivity could be promoted from about 78% to 95% with this technique, and the initial substrate concentration could be increased from 70 to 150 mmol/L, but the yield and stereoselectivity were still satisfactory with introducing resin.

Different reactions of this compound((R)-Ethyl 4-chloro-3-hydroxybutanoate)SDS of cas: 90866-33-4 require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about A recombinant ketoreductase tool-box. Assessing the substrate selectivity and stereoselectivity toward the reduction of β-ketoesters, the main research direction is ketoreductase reduction stereoselective beta keto ester.Recommanded Product: (R)-Ethyl 4-chloro-3-hydroxybutanoate.

The substrate selectivity and stereoselectivity of a series of ketoreductases were evaluated toward the reduction of two sets of β-ketoesters. Both the structural variety at β-position and the substituent at α-position greatly affected the activity and stereoselectivity of these ketoreductases. For the first set of β-ketoesters, at least one ketoreductase was found that catalyzed the formation of either (D) or (L) enantiomer of β-hydroxyesters from each substrate with high optical purity, with the only exception of Et (D)-3-hydroxy-3-phenylpropionate. For the second set of β-ketoesters with α-substituents, the situation is more complex. More commonly, a ketoreductase was found that formed one of the four diastereomers in optically pure form, with only a few cases in which enzymes could be found that formed two or more of the diastereomers in high optical purity. The continued development of new, more diverse ketoreductases will create the capability to produce a wider range of single diastereomers of 2-substituted-3-hydroxy acids and their derivatives

Different reactions of this compound((R)-Ethyl 4-chloro-3-hydroxybutanoate)Recommanded Product: (R)-Ethyl 4-chloro-3-hydroxybutanoate require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

HPLC of Formula: 2923-28-6. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Silver(I) trifluoromethanesulfonate, is researched, Molecular CAgF3O3S, CAS is 2923-28-6, about Di-μ-chlorido-bis[(2,2′:6′,2′′-terpyridine-κ3N,N′,N′′)copper(II)] bis(trifluoromethanesulfonate). Author is Adrian, Rafael A.; Duarte, Jose J.; Arman, Hadi D..

In the centrosym. title complex, [Cu2Cl2(C15H11N3)2](CF3O3S)2, the CuII metal center is fivefold coordinated by two chloride ions and three nitrogen atoms of the terpyridine ligand in a distorted square-pyramidal geometry; two trifluoromethanesulfonate ions complete the outer coordination sphere. π-π stacking interactions between the pyridyl rings in adjacent mols. contribute to the alignment of the complexes in columns along the a-axis. This structure represents the first example of a binuclear dication of formula [Cu(terpy)2Cl2]2+ with trifluoromethanesulfonate as counter-ions.

Different reactions of this compound(Silver(I) trifluoromethanesulfonate)HPLC of Formula: 2923-28-6 require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Silver(I) trifluoromethanesulfonate( cas:2923-28-6 ) is researched.Category: benzofurans.Dang, Li-Long; Li, Ting-Ting; Cui, Zheng; Sui, Dong; Ma, Lu-Fang; Jin, Guo-Xin published the article 《Selective construction and stability studies of a molecular trefoil knot and Solomon link》 about this compound( cas:2923-28-6 ) in Dalton Transactions. Keywords: trefoil knot Solomon link selective construction stability mol structure. Let’s learn more about this compound (cas:2923-28-6).

Two novel compounds, a mol. trefoil knot and a Solomon link, were constructed successfully through the cooperation of multiple π-π stacking interactions. A reversible transformation between the trefoil knot and the corresponding [2 + 2] macrocycle could be achieved by solvent- and guest-induced effects. However, the Solomon link maintains its stability in different concentrations, solvents and guest mols. Single-crystal X-ray crystallog. data, NMR spectroscopic experiments and ESI-MS support the synthesis and structural assignments. These synthesis methods open the door to the further development of smart materials, which will push the advancement of rational design of biomaterials.

Different reactions of this compound(Silver(I) trifluoromethanesulfonate)Category: benzofurans require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, is researched, Molecular C18H20N2O12, CAS is 70539-42-3, about Chemical stabilization of recombinant horseradish peroxidase, the main research direction is stabilization peroxidase ethylene glycol ester.Related Products of 70539-42-3.

Unglycosylated recombinant horseradish peroxidase (HRP C°) had a half life of 21 min at 65° compared with only 5 min for the plant enzyme (HRP). The half life of HRP C* at 65° increased by 5-fold following modification with ethylene glycol bis(succinic acid N-hydroxysuccinimide ester). Tolerance to 60% 1,4-dioxan also increased while tolerance to 30% DMF was unchanged.

Different reactions of this compound(Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate)Related Products of 70539-42-3 require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Reference of Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, is researched, Molecular C18H20N2O12, CAS is 70539-42-3, about A mitogenic fibrinogen receptor that differs from glycoprotein IIb-IIIa. Identification by affinity chromatography and by covalent cross-linking. Author is Levesque, Jean Pierre; Hatzfeld, Jacques; Hatzfeld, Antoinette.

The mitogenic effect of human fibrinogen on the hemopoietic cell lines Raji and JM is mediate by a specific receptor with biochem. and functional properties different from those of the platelet fibrinogen receptor, the glycoprotein complex IIb-IIIa. This work describes the identification of the mitogenic fibrinogen receptor (MFR) by 2 independent methods, affinity chromatog. and covalent crosslinking. Affinity chromatog. of surface-labeled cell extracts on fibrinogen-Sepharose revealed a 94-kDa membrane protein that bound specifically to fibrinogen-Sepharose only on cells that expressed the MFR. Its mol. mass was not modified after reduction This was confirmed by crosslinking fibrinogen to surface-labeled Raji cells using the cleavable crosslinkers, ethyleneglycolbis(succinimidyl succinate) and dithiobis(succinimidyl propionate). Complexes between fibrinogen and iodinated cell membrane proteins were immunoprecipitated by anti-fibrinogen antibodies. The biochem. cleavage of these immunoprecipitated conjugates gave rise to a 92-kDa membrane protein whose mol. mass was not modified after reduction Thus, fibrinogen binds specifically to a 92-94-kDa MFR which does not belong to the integrin family.

Different reactions of this compound(Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate)Reference of Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Von Bruchhausen, V.; Lohmann, H.; Osvath, J. published the article 《The pharmacokinetic profile of pyrazinobutazone in man》. Keywords: pyrazinobutazone formulation pharmacokinetics.They researched the compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide( cas:129-18-0 ).SDS of cas: 129-18-0. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:129-18-0) here.

The rate of absorption of phenylbutazone (I) [50-33-9] from pyrazinobutazone [4985-25-5] capsules was lower than that from I capsules. The capsules were bioequivalent to an equimolar dose of Na phenylbutazone [129-18-0] in solution, as judged by both the area under the plasma level curves and the sum of the unchanged I excreted in the urine. A single dose of 300 mg pyrazinobutazone produced maximum plasma levels of 35.2 μg/mL at 5.5 h after administration. Two dosage schedules for long-term therapy were tested (2400 and 1500 mg/wk). Both produced accumulation to saturation plasma levels within approx. 3 days. The concentration of I obtained with the lower dosage was about 110 μg/mL plasma. This corresponded with the recommendations for long-term therapy with I. With the higher dosage, the plasma levels were elevated by only 25%, however, the renal elimination of unchanged drug and the number of side-effects were remarkably increased. The recommended dosage scheme is specifically adapted to the pharmacokinetics of pyrazinobutazone.

Different reactions of this compound(Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide)SDS of cas: 129-18-0 require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Cuellar, Elena; Pastor, Laura; Garcia-Herbosa, Gabriel; Nganga, John; Angeles-Boza, Alfredo M.; Diez-Varga, Alberto; Torroba, Tomas; Martin-Alvarez, Jose M.; Miguel, Daniel; Villafane, Fernando published the article 《(1,2-Azole)bis(bipyridyl)ruthenium(II) Complexes: Electrochemistry, Luminescent Properties, And Electro- And Photocatalysts for CO2 Reduction》. Keywords: ruthenium azole bipyridyl complex preparation electrochem luminescence photocatalyst; crystal structure ruthenium azole bipyridyl complex.They researched the compound: Silver(I) trifluoromethanesulfonate( cas:2923-28-6 ).Product Details of 2923-28-6. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:2923-28-6) here.

New cis-(1,2-azole)-aquo bis(2,2′-bipyridyl)ruthenium(II) (1,2-azole (az*H) = pzH (pyrazole), dmpzH (3,5-dimethylpyrazole), and indzH (indazole)) complexes are synthesized via chlorido abstraction from cis-[Ru(bipy)2Cl(az*H)]OTf. The latter are obtained from cis-[Ru(bipy)2Cl2] after the subsequent coordination of the 1,2-azole. All the compounds are characterized by 1H, 13C, 15N NMR spectroscopy as well as IR spectroscopy. Two chlorido complexes (pzH and indzH) and two aquo complexes (indzH and dmpzH) are also characterized by X-ray diffraction. Photophys. and electrochem. studies were carried out on all the complexes. The photophys. data support the phosphorescence of the complexes. The electrochem. behavior of all the complexes in an Ar atm. indicate that the oxidation processes assigned to Ru(II) → Ru(III) occurs at higher potentials in the aquo complexes. The reduction processes under Ar lead to several waves, indicating that the complexes undergo successive electron-transfer reductions that are centered in the bipy ligands. The first electron reduction is reversible. The electrochem. behavior in CO2 media is consistent with CO2 electrocatalyzed reduction, where the values of the catalytic activity [icat(CO2)/ip(Ar)] ranged from 2.9 to 10.8. Controlled potential electrolysis of the chlorido and aquo complexes affords CO and formic acid, with the latter as the major product after 2 h. Photocatalytic experiments in MeCN with [Ru(bipy)3]Cl2 as the photosensitizer and TEOA as the electron donor, which were irradiated with >300 nm light for 24 h, led to CO and HCOOH as the main reduction products, achieving a combined turnover number (TONCO+HCOO-) as high as 107 for 2c after 24 h of irradiation

Different reactions of this compound(Silver(I) trifluoromethanesulfonate)Product Details of 2923-28-6 require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

COA of Formula: C6H11ClO3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about How cell physiology affects enantioselectivity of the biotransformation of ethyl 4-chloro-acetoacetate with Saccharomyces cerevisiae. Author is Bertau, M..

Saccharomyces cerevisiae (baker’s yeast) reduces Et 4-chloro-acetoacetate enantioselectively to (R)- or (S)-Et 4-chloro-3-hydroxybutyrate depending on the reaction conditions and the physiol. state of the yeast cells. The (S)-enantiomer is obtained under batch conditions with resting cells (55%, enantiomeric excess [ee]), and 4-chloro-acetate fed-batch actively metabolizing yeast affords the (R)-isomer (54%, ee). The enantioselective reduction of the substrate is accompanied by competing enzyme actions. Of the metabolites formed from the substrate, chloroacetone and the target compound (R)-Et 4-chloro-3-hydroxybutyrate emerged as most important effectors of enantioselectivity of the microbial reduction As a minor side-reaction, an aerobic reductive dehalogenation of the substrate was observed The unusual high enantiopurity of the dehalo-product (S)-Et 3-hydroxybutyrate confirms the stereo-directing effect of chloroacetone impressively. Hence, with S. cerevisiae either enantiomer can be obtained by variation of reaction conditions. The yeast further turned out to be a promising biocatalyst for dehalogenations.

Different reactions of this compound((R)-Ethyl 4-chloro-3-hydroxybutanoate)COA of Formula: C6H11ClO3 require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Application In Synthesis of (R)-Ethyl 4-chloro-3-hydroxybutanoate. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about Cloning, expression, and characterization of an (R)-specific alcohol dehydrogenase from Lactobacillus kefir. Author is Weckbecker, Andrea; Hummel, Werner.

Lactobacillus kefir DSM 20587 produces an (R)-specific NADP-dependent alc. dehydrogenase (ADH) with a broad substrate specificity. The gene of this ADH was isolated and the complete nucleotide sequence determined The adh gene comprises 759 bp and encodes a protein of 252 amino acids with a calculated mol. weight of 26 781 Da. The deduced amino acid sequence indicated a high degree of similarity to short-chain dehydrogenases. After cloning and expression in Escherichia coli the enzyme was purified and characterized. For the reduction of acetophenone the specific activity of the homogeneous recombinant ADH was 558 U mg-1. The enzyme shows its maximum activity at 50°C while the pH optimum was at pH 7.0. In order to demonstrate its preparative application, purified ADH was used for the stereoselective reduction of several aliphatic and aromatic ketones as well as β-keto esters. Glucose dehydrogenase was added for the regeneration of NADPH. All prochiral ketones were stereoselectively reduced to the corresponding alcs. with >99% ee and in the case of diketones >99% de.

Different reactions of this compound((R)-Ethyl 4-chloro-3-hydroxybutanoate)Application In Synthesis of (R)-Ethyl 4-chloro-3-hydroxybutanoate require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem