Month: April 2022

Herzig, Maryanne C. S.; Weigel, Paul H. published an article about the compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate( cas:70539-42-3,SMILESS:O=C(ON1C(CCC1=O)=O)CCC(OCCOC(CCC(ON2C(CCC2=O)=O)=O)=O)=O ).Product Details of 70539-42-3. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:70539-42-3) through the article.

Asialoorosomucoid (ASOR) was derivatized with 5 homobifunctional N-hydroxysuccinimide (NHS) ester crosslinkers. NHS/ASOR derivatives were synthesized, purified, and applied within 10 min to isolated rat hepatocytes at 4°. Specific binding of these 125I-labeled derivatives was ∼90% in the presence of either EGTA or excess ASOR. Specific crosslinking, assessed by the resistance of specifically bound NHS/125I-ASOR to release by EGTA, was 50-75% of the specifically bound ligand. The extent of specific crosslinking correlated with the average number of NHS groups per ASOR and was controlled by varying the molar ratio of crosslinker to ASOR during the synthesis. Crosslinking proceeded rapidly at 4° as a 1st-order process (k = 0.25 min-1, t1/2 = 2.8 min). After being crosslinked with any of the NHS/125I-ASOR derivatives, cells were washed with EGTA, solubilized in Triton X 100, and analyzed by SDS-PAGE and autoradiog. Major bands were observed at Mr ≃ 83, 94, and 105 kilodaltons corresponding to the expected size of 1:1 adducts between NHS/ASOR (Mr ≃ 41.3 kilodaltons) and the 3 subunits of the receptor, Mr ≃ 43, 50, and 60 kilodaltons. The 3 subunits, rat hepatic lectin (RHL) 1, 2, and 3, were labeled in the ratio of about 1.0:1.2:1.0, resp. After crosslinking, a polyclonal goat antibody to the receptor immunoprecipitated up to 100% of the specifically crosslinked NHS/125I-ASOR. Preimmune IgG immunoprecipitated <1% of the radiolabeled ligand. Cell surface receptors were crosslinked to NHS-ASOR, extracted with Triton X 100, immunoprecipitated with anti-orosomucoid-Sepharose, and subjected to Western blot anal. By use of antisera specific for RHL 1 or RHL 2/3 (from K. Drickamer), crosslinked complexes of Mr ∼85 kilodaltons or ∼90-115 kilodaltons, resp., were detected as were uncrosslinked native subunits. The ratio of free to crosslinked subunits was ∼10:1 for RHL 1 and ∼0.5:1 for RHL 2/3. Apparently, all 3 receptor subunits can crosslink to ligand. A model is proposed in which the native receptor is a heterohexamer composed of 4 subunits of RHL 1 and 2 subunits of RHL 2 and/or RHL 3. From this literature《Synthesis and characterization of N-hydroxysuccinimide ester chemical affinity derivatives of asialoorosomucoid that covalently crosslink to galactosyl receptors on isolated rat hepatocytes》,we know some information about this compound(70539-42-3)Product Details of 70539-42-3, but this is not all information, there are many literatures related to this compound(70539-42-3).

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Benzofuran – Wikipedia,
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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Biotechnology called Effective biosynthesis of ethyl (R)-4-chloro-3-hydroxybutanoate by supplementation of L-glutamine, D-xylose and β-cyclodextrin in n-butyl acetate-water media, Author is He, Yu-Cai; Tao, Zhi-Cheng; Ding, Yun; Zhang, Dan-Ping; Wu, Yin-Qin; Lu, Yun; Liu, Feng; Xue, Yu-Feng; Wang, Cheng; Xu, Jian-He, which mentions a compound: 90866-33-4, SMILESS is O=C(OCC)C[C@@H](O)CCl, Molecular C6H11ClO3, Application of 90866-33-4.

To avoid adding NAD+ and effectively transform Et 4-chloro-3-oxobutanoate, the mixture of L-glutamine (200 mM) and D-xylose (250 mM) was added into in Bu acetate-water (10:90, volume/volume) biphasic system instead of NAD+ for increasing the biocatalytic efficiency. To further improve the synthesis of optically pure Et (R)-4-chloro-3-hydroxybutanoate (>99% ee), β-cyclodextrin was also added into this reaction media, and Et (R)-4-chloro-3-hydroxybutanoate (>99% ee) could be effectively synthesized from 800 mM Et 4-chloro-3-oxobutanoate in the yield of 100% by whole-cells of recombinant Escherichia coli CCZU-A13. Finally, the possible mechanism for improving the reductase activity by supplementation of L-glutamine, D-xylose and β-CD was proposed. In conclusion, this strategy has high potential for the effective biosynthesis of Et (R)-4-chloro-3-hydroxybutanoate (>99% ee).

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Garcia-Romero, Alvaro; Martin-Alvarez, Jose M.; Miguel, Daniel; Wright, Dominic S.; Alvarez, Celedonio M.; Garcia-Rodriguez, Raul published the article 《Cation- and Anion-Mediated Supramolecular Assembly of Bismuth and Antimony Tris(3-pyridyl) Complexes》. Keywords: pyridyl bismuth antimony ligand preparation crystal mol structure complexation; copper silver complexation supramol bismuth antimony pyridyl.They researched the compound: Silver(I) trifluoromethanesulfonate( cas:2923-28-6 ).Quality Control of Silver(I) trifluoromethanesulfonate. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:2923-28-6) here.

The use of antimony and bismuth in supramol. chem. has been largely overlooked in comparison to the lighter elements of Group 15, and the coordination chem. of the tripodal ligands [Sb(3-py)3] and [Bi(3-py)3] (L) containing the heaviest p-block element bridgehead atoms has been unexplored. Authors show that these ligands form a common hybrid metal-organic framework (MOF) structure with Cu(I) and Ag(I) (M) salts of weakly coordinating anions (PF6-, SbF6-, and OTf-), composed of a cationic substructure of rhombic cage (M)4(L)4 units linked by Sb/Bi-M bonding. The greater Lewis acidity of Bi compared to Sb can, however, allows anion···Bi interactions to overcome Bi-metal bonding in the case of BF4-, leading to collapse of the MOF structure (which is also seen where harder metals like Li+ are employed). This study therefore provides insight into the way in which the electronic effects of the bridgehead atom in these ligand systems can impact their supramol. chem.

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Benzofuran | C8H6O – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Tetrahedron Letters called A practical asymmetric synthesis of carnitine, Author is Kitamura, M.; Ohkuma, T.; Takaya, H.; Noyori, R., which mentions a compound: 90866-33-4, SMILESS is O=C(OCC)C[C@@H](O)CCl, Molecular C6H11ClO3, Name: (R)-Ethyl 4-chloro-3-hydroxybutanoate.

The asym. hydrogenation of ClCH2COCH2CO2Et (I) catalyzed by Ru(OAc)2[(S)-binap] [binap = 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl] gave 97% (R)-ClCH2CH(OH)CH2CO2Et [(R)-II] with 97% enantiomeric excess. (R)-II can be converted to (R)-carnitine (III) by standard methods. The asym. hydrogenation of I catalyzed by Ru(OAc)2[(R)-binap] gave (S)-II.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Analytical study of phenylbutazone》. Authors are Breugelmans, J. G.; Braun, J..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Product Details of 129-18-0. Through the article, more information about this compound (cas:129-18-0) is conveyed.

A review of tests, standards, and assay procedures for phenylbutazone (I) and its Na salt. Adapted methods are given for the determination of I in binary association with antipyrine, aminopyrine, phenacetin, novalgin, aspirin, atophan, caffeine, medonine, and quaternary mixtures in suppositories containing I, aminopyrine, medonine, codeine phosphate, and neutral fat.

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Benzofuran – Wikipedia,
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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Silver(I) trifluoromethanesulfonate( cas:2923-28-6 ) is researched.Electric Literature of CAgF3O3S.Han, Jingqi; Cheng, Shun-Cheung; Yiu, Shek-Man; Tse, Man-Kit; Ko, Chi-Chiu published the article 《Luminescent monomeric and dimeric Ru(II) acyclic carbene complexes as selective sensors for NH3/amine vapor and humidity》 about this compound( cas:2923-28-6 ) in Chemical Science. Keywords: ruthenium acyclic carbene ammonia amine vapor humidity sensor. Let’s learn more about this compound (cas:2923-28-6).

A new class of luminescent bis(bipyridyl) Ru(II) pyridyl acyclic carbene complexes with environmentally-sensitive dimerization equilibrium have been developed. Owing to the involvement of the orbitals of the diaminocarbene ligand in the emissive excited state, the phosphorescence properties of these complexes are strongly affected by H-bonding interactions with various H-bonding donor/acceptor mols. With the remarkable differences in the emission properties of the monomer, dimer, and H-bonded amine adducts together with the change of the dimerization equilibrium, these complexes can be used as luminescent gas sensors for humidity, ammonia, and amine vapors. With the responses to amines and humidity and the corresponding change in the luminescence properties, a proof-of-principle for binary optical data storage with a reversible concealment process has been described.

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Benzofuran – Wikipedia,
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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Riether, Doris; Zindell, Renee; Wu, Lifen; Betageri, Raj; Jenkins, James E.; Khor, Someina; Berry, Angela K.; Hickey, Eugene R.; Ermann, Monika; Albrecht, Claudia; Ceci, Angelo; Gemkow, Mark J.; Nagaraja, Nelamangala V.; Romig, Helmut; Sauer, Achim; Thomson, David S. researched the compound: 6-Fluoronicotinonitrile( cas:3939-12-6 ).HPLC of Formula: 3939-12-6.They published the article 《Selective CB2 receptor agonists. Part 2: Structure-activity relationship studies and optimization of proline-based compounds》 about this compound( cas:3939-12-6 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: proline based compound oxazole derivative preparation CB2 receptor agonist; structure activity relationship proline based compound cannabinoid receptor selectivity; pharmacokinetic properties proline based compound aryl oxazolyl derivative; Cannabinoid receptor 2 (CB2); Metabolic stability; Pharmacokinetic properties; Proline; Solubility. We’ll tell you more about this compound (cas:3939-12-6).

Through a ligand-based pharmacophore model (S)-proline based compounds were identified as potent cannabinoid receptor 2 (CB2) agonists with high selectivity over the cannabinoid receptor 1 (CB1). Structure-activity relationship investigations for this compound class lead to oxo-proline compounds I and II which combine an impressive CB1 selectivity profile with good pharmacokinetic properties. In a streptozotocin induced diabetic neuropathy model, II demonstrated a dose-dependent reversal of mech. hyperalgesia.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Application In Synthesis of Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, is researched, Molecular C18H20N2O12, CAS is 70539-42-3, about Collagen Stiffness and Architecture Regulate Fibrotic Gene Expression in Engineered Adipose Tissue. Author is Di Caprio, Nikolas; Bellas, Evangelia.

Adipose tissue (AT) has a dynamic extracellular matrix (ECM) surrounding adipocytes that allows for remodeling during metabolic fluctuations. During the progression of obesity, AT has increased ECM deposition, stiffening, and remodeling, resulting in a pro-fibrotic dysfunctional state. Here, the incorporation of ethylene glycol-bis-succinic acid N-hydroxysuccinimide ester (PEGDS) allows for control over 3D collagen hydrogel stiffness and architecture to investigate its influence on adipocyte metabolic and fibrotic function. Upon stiffening and altering ECM architecture, adipocytes did not alter their expression of key adipokines, leptin, and adiponectin. However, they do increase actin cytoskeletal fiber formation, pro-fibrotic gene expression, ECM deposition, and remodeling within a stiffer, 3D collagen hydrogel. For example, COL6A3 gene expression is upregulated approx. twofold, resulting in increased deposition of pericellular collagen VI alpha 3 surrounding adipocytes. Furthermore, inhibition of actin contractility results in a reversal of pro-fibrotic gene expression and ECM deposition, indicating that adipocytes are mediating mech. cues through actin cytoskeletal networks. This study demonstrates that ECM stiffness and architecture plays a critical regulatory role in adipocyte fibrotic function and contributes to the overall pro-fibrotic dysfunctional state of AT during the progression of obesity and AT fibrosis.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The antianaphylactic activity of pyrazolone derivatives in the rabbit》. Authors are Lecomte, J..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Recommanded Product: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide. Through the article, more information about this compound (cas:129-18-0) is conveyed.

Intravenous injection of 1,5-dimethyl-2-phenyl-3-pyrazolone (antipyrine), 4-dimethylamino-1,5-dimethyl-2-phenyl-3-pyrazolone (pyramidon), Na (antipyrinylmethylamino)methanesulfonate (Noval-gin), or 4-butyl-1-phenyl-3,5-dioxopyrazolidine piperazine salt (I) (all at 10 mg./kg.) into rabbits produced a decrease in blood pressure of 1-2 cm., which lasted for 2 min. A similar injection of phenylbutazone II, 4-butyl-1,2-diphenyl-3,5-dioxopyrazolidine piperazine salt (III), or irgapyrine (a 1:1 mixture of pyramidon and phenylbutazone) produced a hypotension of 2-4 cm.; II produced generalized convulsions in some rabbits. Intravenous injection of II or III; irgapyrine; pyramidon, antipyrine, or Novalgin; or I (in order of decreasing activity) (all at 100 mg./kg.) suppressed or reduced arterial hypotension during anaphylactic shock in rabbits previously sensitized with egg white albumin. Only the diphenyl derivatives of pyrazolone completely suppressed the hypotension, which was often replaced by hypertension; this latter effect depends on a direct stimulation of the adrenal medulla by antigen-antibody reactions. The piperazine salt of II showed the same protective activity as the Na salt of II, while I was less active than III. Intravenous injection of 150 mg. II/kg. also showed antiallergic action in rabbits sensitized with human erythrocytes, which shows that this action is independent of the nature of the antigen. However, II did not suppress all the effects of anaphylactic shock, since the formation of clumps of erythrocytes in the blood and thrombopenia were not inhibited. The protective action of II is not directed against immunological phenomena in the plasma, but probably lies in a modification of tissue reactions during shock. 15 references.

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Benzofuran – Wikipedia,
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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Anionic Boron- and Carbon-Based Hetero-Diradicaloids Spanned by a p-Phenylene Bridge, published in 2021-03-17, which mentions a compound: 2923-28-6, mainly applied to anionic boron carbon based hetero diradicaloid phenylene bridge, Recommanded Product: Silver(I) trifluoromethanesulfonate.

Herein we report the synthesis and characterization of anionic boron- and carbon-based Kekulé diradicaloids spanned by a p-phenylene bridge. In contrast to Thiele’s hydrocarbon, a closed-shell singlet system, they show an appreciable population of the triplet state at room temperature, as evidenced by both NMR and EPR spectroscopy. Moreover, en route to these anionic boron- and carbon-based hetero-diradicaloids, the formation of an isolable diamino(4-diarylboryl-phenyl)methyl radical was observed

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem