So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Riether, Doris; Zindell, Renee; Wu, Lifen; Betageri, Raj; Jenkins, James E.; Khor, Someina; Berry, Angela K.; Hickey, Eugene R.; Ermann, Monika; Albrecht, Claudia; Ceci, Angelo; Gemkow, Mark J.; Nagaraja, Nelamangala V.; Romig, Helmut; Sauer, Achim; Thomson, David S. researched the compound: 6-Fluoronicotinonitrile( cas:3939-12-6 ).HPLC of Formula: 3939-12-6.They published the article 《Selective CB2 receptor agonists. Part 2: Structure-activity relationship studies and optimization of proline-based compounds》 about this compound( cas:3939-12-6 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: proline based compound oxazole derivative preparation CB2 receptor agonist; structure activity relationship proline based compound cannabinoid receptor selectivity; pharmacokinetic properties proline based compound aryl oxazolyl derivative; Cannabinoid receptor 2 (CB2); Metabolic stability; Pharmacokinetic properties; Proline; Solubility. We’ll tell you more about this compound (cas:3939-12-6).
Through a ligand-based pharmacophore model (S)-proline based compounds were identified as potent cannabinoid receptor 2 (CB2) agonists with high selectivity over the cannabinoid receptor 1 (CB1). Structure-activity relationship investigations for this compound class lead to oxo-proline compounds I and II which combine an impressive CB1 selectivity profile with good pharmacokinetic properties. In a streptozotocin induced diabetic neuropathy model, II demonstrated a dose-dependent reversal of mech. hyperalgesia.
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem