Day: April 7, 2022

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about Purification and characterization of a novel carbonyl reductase with high stereo-selectivity.Recommanded Product: 90866-33-4.

A novel NADPH dependent carbonyl reductase was separated from Candida parapsilosis CCTCC 203011. The enzyme gave a single band on SDS-PAGE, which was purified through ammonium sulfate, DEAE Sepharose FF, Phenyl-Sepharose FF and Blue Sepharose FF chromatog. from cell-free extract The mol. mass of the enzyme was about 30 kD. The optimum pH and temperature for reduction were 4.5 and 35°C, resp. The Cu2+ had strong restrictive effect on enzyme activity. In addition, the carbonyl reductase was an enzyme with high substrate specificity and stereo-selectivity, and showed high asym. reduction activity toward α-hydroxyacetophenone and Et 4-chloroacetoacetate. For the asym. reduction of α-hydroxyacetophenone and Et 4-chloroacetoacetate, (S)-1-phenyl-1,2-ethanediol and (R)-Et 4-chloro-3-hydroxybutanoate were produced by the purified enzyme, with the 100% and 94.3% e.e value, resp. So the enzyme could be one of the effective biocatalysts for asym. synthesis of chiral alcs. The amino acid sequences of one peptide from the purified enzyme were analyzed by LC-MASS-MASS, and the carbonyl reductase showed some identity to the hypothetical protein CaO19.10414 reported.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 3939-12-6, is researched, SMILESS is N#CC1=CC=C(F)N=C1, Molecular C6H3FN2Journal, Article, Chemistry – A European Journal called Radical C-H Trifluoromethoxylation of (Hetero)arenes with Bis(trifluoromethyl)peroxide, Author is Dix, Stefan; Golz, Paul; Schmid, Jonas R.; Riedel, Sebastian; Hopkinson, Matthew N., the main research direction is trifluoromethoxylated hetero arene preparation; bis trifluoromethyl peroxide hetero arene radical CH trifluoromethoxylation photochem; (hetero)arenes; TEMPO; fluorine; photocatalysis; trifluoromethoxylation.HPLC of Formula: 3939-12-6.

Herein, bis(trifluoromethyl)peroxide (BTMP, CF3OOCF3) as a practical and efficient trifluoromethoxylating reagent, which easily accessible from inexpensive bulk chems. was introduced. Using either visible light photoredox or TEMPO catalysis, trifluoromethoxylated arenes could be prepared in good yields under mild conditions directly from unactivated aromatics Moreover, TEMPO catalysis allowed for the one-step synthesis of valuable pyridine derivatives, which was previously prepared via multi-step approaches.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate(SMILESS: O=C(ON1C(CCC1=O)=O)CCC(OCCOC(CCC(ON2C(CCC2=O)=O)=O)=O)=O,cas:70539-42-3) is researched.Recommanded Product: 591-12-8. The article 《Subunit structure of the nonactivated human estrogen receptor》 in relation to this compound, is published in Proceedings of the National Academy of Sciences of the United States of America. Let’s take a look at the latest research on this compound (cas:70539-42-3).

The nonactivated estrogen receptor of human MCF-7 mammary carcinoma cells was investigated with respect to stoichiometry of protein subunits. The native receptor complex stabilized by molybdate had a mol. mass of ≈300 kDa. Chem. crosslinking with several bifunctional reagents resulted in complete stabilization of the same receptor form of ≈300 kDa and was achieved both in cell extracts and in intact cells. Incubation of the cross-linked receptor with a receptor-specific monoclonal IgG1 antibody increased the mol. mass by ≈135 kDa-i.e., no more than one Ig mol. bound to the complex. Partial and progressive crosslinking of affinity-labeled receptors revealed patterns of labeled bands upon denaturing gel electrophoresis indicative of a heteromeric structure. The completely cross-linked receptor was purified to homogeneity and analyzed for protein components. In addition to the receptor polypeptide of ≈65 kDa, the authors detected the heat shock proteins hsp90 and p59; the hsp90 band was roughly twice as intense as the p59 band. The heat shock protein hsp70 and the 40-kDa cyclophilin were not detected as components of the highly purified cross-linked receptor of ≈300 kDa. The authors suggest a heterotetrameric structure consisting of one receptor polypeptide, two hsp90 mols., and one p59 subunit, for which the mol. mass adds up to ≈300 kDa. Thus, the nonactivated estrogen receptor has a mol. architecture homologous to those of glucocorticoid and progesterone receptors, even though phylogenetically the estrogen receptor gene forms a distinct subgroup within the gene family of nuclear hormone receptors.

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Benzofuran – Wikipedia,
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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 70539-42-3, is researched, SMILESS is O=C(ON1C(CCC1=O)=O)CCC(OCCOC(CCC(ON2C(CCC2=O)=O)=O)=O)=O, Molecular C18H20N2O12Journal, Article, Research Support, U.S. Gov’t, Non-P.H.S., Protein Science called Structural analysis of the multienzyme aminoacyl-tRNA synthetase complex: a three-domain model based on reversible chemical crosslinking, Author is Norcum, Mona T.; Warrington, J. Anthony, the main research direction is aminoacyl tRNA synthetase protein conformation interaction.Electric Literature of C18H20N2O12.

A subset of eukaryotic aminoacyl-tRNA synthetases (a-RS) are contained in a multienzyme complex for which little structural detail is known. Three reversible chem. crosslinking reagents have been used to investigate the arrangement of polypeptides within this particle as isolated from rabbit reticulocytes. Identification of the crosslinked protein pairs was accomplished by two-dimensional SDS diagonal gel electrophoresis. Seventeen neighboring protein pairs have been identified. Eight are seen with at least two reagents: K-RS:p38, D-RS:K-RS, R-RS dimer, K-RS dimer, K-RS:Q-RS, E/P-RS:K-RS, E/P-RS:I-RS, and Q-RS with one of the nonsynthetase proteins. Nine more are observed with one reagent: D-RS dimer, R-RS:p43, D-RS:Q-RS, D-RS:M-RS, K-RS:L-RS, I-RS:R-RS, D-RS:E/P-RS, I-RS:Q-RS, I-RS:L-RS. One trimeric association is seen: E/P-RS:I-RS:L-RS. The observed neighboring protein pairs suggest that the polypeptides within the aminoacyl-tRNA synthetase complex are distributed in three structural domains of similar mass. These can be arranged in a U-shaped particle in which each “”arm”” is considered a domain and the third forms the “”base”” of the structure. The arms have been termed domain I (D-RS, M-RS, Q-RS) and domain II (K-RS, R-RS), with domain III (E/P-RS, I-RS, L-RS) assigned to the base. The smaller proteins (p38, p43) may bridge the domains. This proposed spatial relationship of these domains, as well as their compositions, are consistent with earlier studies. Thus, this study provides an initial three-dimensional working model of the arrangement of polypeptides within the multienzyme aminoacyl-tRNA synthetase complex.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Actions of anti-inflammatory drugs on smooth muscle.Name: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide.

The concentration-dependent relaxation of guinea pig tracheal muscle for a number of antiinflammatory drugs such as phenylbutazone Na salt (I) [129-18-0] was demonstrated. The concentration-response curves obtained with these drugs were parallel, and the progressive decrease in tone of tracheal muscle appeared to be due to the inhibition of prostaglandin synthesis.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Herzig, Maryanne C. S.; Weigel, Paul H. published an article about the compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate( cas:70539-42-3,SMILESS:O=C(ON1C(CCC1=O)=O)CCC(OCCOC(CCC(ON2C(CCC2=O)=O)=O)=O)=O ).Product Details of 70539-42-3. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:70539-42-3) through the article.

Asialoorosomucoid (ASOR) was derivatized with 5 homobifunctional N-hydroxysuccinimide (NHS) ester crosslinkers. NHS/ASOR derivatives were synthesized, purified, and applied within 10 min to isolated rat hepatocytes at 4°. Specific binding of these 125I-labeled derivatives was ∼90% in the presence of either EGTA or excess ASOR. Specific crosslinking, assessed by the resistance of specifically bound NHS/125I-ASOR to release by EGTA, was 50-75% of the specifically bound ligand. The extent of specific crosslinking correlated with the average number of NHS groups per ASOR and was controlled by varying the molar ratio of crosslinker to ASOR during the synthesis. Crosslinking proceeded rapidly at 4° as a 1st-order process (k = 0.25 min-1, t1/2 = 2.8 min). After being crosslinked with any of the NHS/125I-ASOR derivatives, cells were washed with EGTA, solubilized in Triton X 100, and analyzed by SDS-PAGE and autoradiog. Major bands were observed at Mr ≃ 83, 94, and 105 kilodaltons corresponding to the expected size of 1:1 adducts between NHS/ASOR (Mr ≃ 41.3 kilodaltons) and the 3 subunits of the receptor, Mr ≃ 43, 50, and 60 kilodaltons. The 3 subunits, rat hepatic lectin (RHL) 1, 2, and 3, were labeled in the ratio of about 1.0:1.2:1.0, resp. After crosslinking, a polyclonal goat antibody to the receptor immunoprecipitated up to 100% of the specifically crosslinked NHS/125I-ASOR. Preimmune IgG immunoprecipitated <1% of the radiolabeled ligand. Cell surface receptors were crosslinked to NHS-ASOR, extracted with Triton X 100, immunoprecipitated with anti-orosomucoid-Sepharose, and subjected to Western blot anal. By use of antisera specific for RHL 1 or RHL 2/3 (from K. Drickamer), crosslinked complexes of Mr ∼85 kilodaltons or ∼90-115 kilodaltons, resp., were detected as were uncrosslinked native subunits. The ratio of free to crosslinked subunits was ∼10:1 for RHL 1 and ∼0.5:1 for RHL 2/3. Apparently, all 3 receptor subunits can crosslink to ligand. A model is proposed in which the native receptor is a heterohexamer composed of 4 subunits of RHL 1 and 2 subunits of RHL 2 and/or RHL 3. From this literature《Synthesis and characterization of N-hydroxysuccinimide ester chemical affinity derivatives of asialoorosomucoid that covalently crosslink to galactosyl receptors on isolated rat hepatocytes》,we know some information about this compound(70539-42-3)Product Details of 70539-42-3, but this is not all information, there are many literatures related to this compound(70539-42-3).

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Benzofuran – Wikipedia,
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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Biotechnology called Effective biosynthesis of ethyl (R)-4-chloro-3-hydroxybutanoate by supplementation of L-glutamine, D-xylose and β-cyclodextrin in n-butyl acetate-water media, Author is He, Yu-Cai; Tao, Zhi-Cheng; Ding, Yun; Zhang, Dan-Ping; Wu, Yin-Qin; Lu, Yun; Liu, Feng; Xue, Yu-Feng; Wang, Cheng; Xu, Jian-He, which mentions a compound: 90866-33-4, SMILESS is O=C(OCC)C[C@@H](O)CCl, Molecular C6H11ClO3, Application of 90866-33-4.

To avoid adding NAD+ and effectively transform Et 4-chloro-3-oxobutanoate, the mixture of L-glutamine (200 mM) and D-xylose (250 mM) was added into in Bu acetate-water (10:90, volume/volume) biphasic system instead of NAD+ for increasing the biocatalytic efficiency. To further improve the synthesis of optically pure Et (R)-4-chloro-3-hydroxybutanoate (>99% ee), β-cyclodextrin was also added into this reaction media, and Et (R)-4-chloro-3-hydroxybutanoate (>99% ee) could be effectively synthesized from 800 mM Et 4-chloro-3-oxobutanoate in the yield of 100% by whole-cells of recombinant Escherichia coli CCZU-A13. Finally, the possible mechanism for improving the reductase activity by supplementation of L-glutamine, D-xylose and β-CD was proposed. In conclusion, this strategy has high potential for the effective biosynthesis of Et (R)-4-chloro-3-hydroxybutanoate (>99% ee).

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Garcia-Romero, Alvaro; Martin-Alvarez, Jose M.; Miguel, Daniel; Wright, Dominic S.; Alvarez, Celedonio M.; Garcia-Rodriguez, Raul published the article 《Cation- and Anion-Mediated Supramolecular Assembly of Bismuth and Antimony Tris(3-pyridyl) Complexes》. Keywords: pyridyl bismuth antimony ligand preparation crystal mol structure complexation; copper silver complexation supramol bismuth antimony pyridyl.They researched the compound: Silver(I) trifluoromethanesulfonate( cas:2923-28-6 ).Quality Control of Silver(I) trifluoromethanesulfonate. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:2923-28-6) here.

The use of antimony and bismuth in supramol. chem. has been largely overlooked in comparison to the lighter elements of Group 15, and the coordination chem. of the tripodal ligands [Sb(3-py)3] and [Bi(3-py)3] (L) containing the heaviest p-block element bridgehead atoms has been unexplored. Authors show that these ligands form a common hybrid metal-organic framework (MOF) structure with Cu(I) and Ag(I) (M) salts of weakly coordinating anions (PF6-, SbF6-, and OTf-), composed of a cationic substructure of rhombic cage (M)4(L)4 units linked by Sb/Bi-M bonding. The greater Lewis acidity of Bi compared to Sb can, however, allows anion···Bi interactions to overcome Bi-metal bonding in the case of BF4-, leading to collapse of the MOF structure (which is also seen where harder metals like Li+ are employed). This study therefore provides insight into the way in which the electronic effects of the bridgehead atom in these ligand systems can impact their supramol. chem.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Tetrahedron Letters called A practical asymmetric synthesis of carnitine, Author is Kitamura, M.; Ohkuma, T.; Takaya, H.; Noyori, R., which mentions a compound: 90866-33-4, SMILESS is O=C(OCC)C[C@@H](O)CCl, Molecular C6H11ClO3, Name: (R)-Ethyl 4-chloro-3-hydroxybutanoate.

The asym. hydrogenation of ClCH2COCH2CO2Et (I) catalyzed by Ru(OAc)2[(S)-binap] [binap = 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl] gave 97% (R)-ClCH2CH(OH)CH2CO2Et [(R)-II] with 97% enantiomeric excess. (R)-II can be converted to (R)-carnitine (III) by standard methods. The asym. hydrogenation of I catalyzed by Ru(OAc)2[(R)-binap] gave (S)-II.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Analytical study of phenylbutazone》. Authors are Breugelmans, J. G.; Braun, J..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Product Details of 129-18-0. Through the article, more information about this compound (cas:129-18-0) is conveyed.

A review of tests, standards, and assay procedures for phenylbutazone (I) and its Na salt. Adapted methods are given for the determination of I in binary association with antipyrine, aminopyrine, phenacetin, novalgin, aspirin, atophan, caffeine, medonine, and quaternary mixtures in suppositories containing I, aminopyrine, medonine, codeine phosphate, and neutral fat.

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Reference:
Benzofuran – Wikipedia,
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