Day: April 7, 2022

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate(SMILESS: O=C(OCC)C[C@@H](O)CCl,cas:90866-33-4) is researched.Recommanded Product: 4774-24-7. The article 《Synthesis of ethyl (S)-4-chloro-3-hydroxybutanoate using fabG-homologues》 in relation to this compound, is published in Applied Microbiology and Biotechnology. Let’s take a look at the latest research on this compound (cas:90866-33-4).

This paper is a report on the successful application of bioinformatics to enzyme screening. The synthesis of Et (S)-4-chloro-3-hydroxybutanoate (ECHB) by asym. reduction of Et 4-chloroacetoacetate (ECAA) using fabG-homolog was studied. β-Ketoacyl-acyl carrier protein reductases from both Escherichia coli and Bacillus subtilis, which are components of type II fatty acid synthase, could reduce ECAA to (S)-ECHB with 94-98% ee. Furthermore, acetoacetyl-CoA reductases (ARs) from both Ralstonia eutropha and Zoogloea ramigera, whose genes are significantly similar to fabG genes and play a physiol. role in the biosynthesis of poly-β-3-hydroxybutyrate, could also catalyze the asym. reduction of ECAA to (S)-ECHB with >99% ee. (S)-ECHB was synthesized to 48.7 g/l with an optical purity of 99.8% ee, using recombinant E. coli cells coexpressing AR from R. eutropha and glucose dehydrogenase from B. subtilis for the regeneration of NADPH.

Compound(90866-33-4)Synthetic Route of C6H11ClO3 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((R)-Ethyl 4-chloro-3-hydroxybutanoate), if you are interested, you can check out my other related articles.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Related Products of 2923-28-6. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Silver(I) trifluoromethanesulfonate, is researched, Molecular CAgF3O3S, CAS is 2923-28-6, about Alternative Synthesis and Structural Analysis of the Antioxidant and Antitumor Agent 2-(3,5-Dimethoxyphenyl)-2,3-Dihydroquinolin-4(1H)-One. Author is Parry, Christopher S.; Grossmann, Matthew D.; Thomas, Amy; Majireck, Max M.; Reinheimer, Eric W.; Kriley, Charles E..

Herein we present the synthesis, structure and NMR and mass spectroscopic analyses of the antioxidant 2-(3,5-dimethoxyphenyl)-2,3-dihydroquinolin-4(1H)-one (1), a member of the 2-aryl-2,3-dihydroquinolin-4(1H)-one family of mols. that have been shown to display a range of potent biol. properties. The title mol., prepared by an alternative methodol. to that recently reported, crystallizes in the centrosym. space group P21/c with unit cell dimensions a = 11.775(17) Å, b = 5.3592(8) Å, c = 22.462(3) Å and β = 96.576(11)β. Close anal. of the solid state structure reveals an array of weak N-H•••O hydrogen bonding as well as C-H•••O, and C-H•••π interactions between the neighboring mols. The presence of 1 was also confirmed via NMR and mass spectroscopic analyses.

Compound(2923-28-6)Related Products of 2923-28-6 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(Silver(I) trifluoromethanesulfonate), if you are interested, you can check out my other related articles.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Journal of the American Chemical Society called Preparation and Reactions of Enantiomerically Pure α-Functionalized Grignard Reagents, Author is Rayner, Peter J.; O’Brien, Peter; Horan, Richard A. J., which mentions a compound: 767291-67-8, SMILESS is CN(CCC(C)(C)C)[C@@H]1[C@@H](N(CCC(C)(C)C)C)CCCC1, Molecular C20H42N2, Recommanded Product: (1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine.

A strategy for the generation of enantiomerically pure α-functionalized chiral Grignard reagents is presented. The approach involves the synthesis of α-alkoxy and α-amino sulfoxides in ≥99:1 dr and ≥99:1 er via asym. deprotonation (s-BuLi/chiral diamine) and trapping with Andersen’s sulfinate (menthol derived). Subsequent sulfoxide → Mg exchange (room temperature, 1 min) and electrophilic trapping delivers a range of enantiomerically pure α-alkoxy and α-amino substituted products. Using this approach, either enantiomer of products can be accessed in 99:1 er from asym. deprotonation protocols without the use of (-)-sparteine as the chiral ligand. Two addnl. discoveries are noteworthy: (i) for the deprotonation and trapping with Andersen’s sulfinate, there is a lack of stereospecificity at sulfur due to attack of a lithiated intermediate onto the α-alkoxy and α-amino sulfoxides as they form, and (ii) the α-alkoxy-substituted Grignard reagent is configurationally stable at room temperature for 30 min.

Compound(767291-67-8)Recommanded Product: (1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine), if you are interested, you can check out my other related articles.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Microbial asymmetric reduction of ethyl 4-chloro-3-oxobutanoate to optically active ethyl 4-chloro-3-hydroxybutanoate, published in 1990-08-31, which mentions a compound: 90866-33-4, Name is (R)-Ethyl 4-chloro-3-hydroxybutanoate, Molecular C6H11ClO3, Recommanded Product: 90866-33-4.

The synthesis of Et (R)-4-chloro-3-hydroxybutanoate through the asym. reduction of Et 4-chloro-3-oxobutanoate with the NADPH-dependent aldehyde reductase of Sporobolomyces salmonicolor AKU 4429 is described. Under preparative scale reaction conditions with the acetone-fractionated aldehyde reductase, the amount of Et 4-chloro-3-hydroxybutanoate reached 33.2 mg/mL (molar yield, 74.0%). Furthermore, conversion to Et (S)-4-chloro-3-hydroxybutanoate occurred on incubation with washed cells of Trichosporon cutaneum AKU 4864 as the catalyst.

Compound(90866-33-4)Recommanded Product: 90866-33-4 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((R)-Ethyl 4-chloro-3-hydroxybutanoate), if you are interested, you can check out my other related articles.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Tethered CAAC-CAAC dimers: oxidation to persistent radical cations and bridging-unit dependent reactivity/stability of the dications, published in 2021, which mentions a compound: 2923-28-6, mainly applied to cyclic alkyl amino carbene dimer stability oxidation potential, Formula: CAgF3O3S.

Herein, we report tethered cyclic(alkyl)(amino)carbene (CAAC) dimers in which two CAAC-motifs are connected by an ethylene-, trans-1,2-cyclohexylene- and propylene-spacer through their N-centers. The 1-electron oxidized radical cations are isolable, whereas a significant influence of the bridging unit on the chem. reactivity becomes apparent in and with the 2-electron oxidized products.

Compound(2923-28-6)Formula: CAgF3O3S received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(Silver(I) trifluoromethanesulfonate), if you are interested, you can check out my other related articles.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

HPLC of Formula: 129-18-0. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Effect of some antipyretic drugs on Herpes simplex virus infection in tissue culture. Author is Olkowska, Danuta; Wroblewska-Mularczykowa, Zofia.

Among 8 analgesic, antipyretic drugs tested for activity against herpesvirus in epithelial monkey kidney cell cultures, acetylsalicylic acid (I) [50-78-2], sodium salicylate [54-21-7], phenylbutazone sodium salt [129-18-0], and a combination of the latter and aminopyrine (II) [58-15-1] were cytotoxic at concentrations higher than those which were virustatic. Sodium salicylate and I were active only 1-4 hr after infection, or after adsorption and penetration of the virus through the cellular membrane.

Compound(129-18-0)HPLC of Formula: 129-18-0 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide), if you are interested, you can check out my other related articles.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Name: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, is researched, Molecular C18H20N2O12, CAS is 70539-42-3, about α-Conotoxins, small peptide probes of nicotinic acetylcholine receptors. Author is Myers, Richard A.; Zafaralla, Glenn C.; Gray, William R.; Abbott, Jeff; Cruz, Lourdes J.; Olivera, Baldomero M..

α-Conotoxins, a family of small peptides from the venoms of the Conus marine molluscs, are selective, snake α-neurotoxin-competitive antagonists of the nicotinic acetylcholine receptor. A new α-conotoxin, SIA, has been purified, sequenced, and synthesized. Crosslinking with bivalent reagents and photoaffinity labeling of the acetylcholine receptor with α-conotoxin yield covalent adducts. Surprisingly, crosslinking to other subunits is considerably more efficient than to the α subunit. The relative efficiency of photoactivatable crosslinking to different subunits of the receptor is a function of placement of the photoactivatable group on the toxin. Since the structures of α-conotoxins can be solved by 2D NMR (Pardi, A. et al., 1989 and Kobayashi, Y. et al., 1989) this family of toxins should provide a set of new ligands for probing the acetylcholine receptor with considerable precision.

Compound(70539-42-3)Name: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate), if you are interested, you can check out my other related articles.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Self-healing and shape memory functions exhibited by supramolecular liquid-crystalline networks formed by combination of hydrogen bonding interactions and coordination bonding, published in 2021, which mentions a compound: 2923-28-6, Name is Silver(I) trifluoromethanesulfonate, Molecular CAgF3O3S, Application In Synthesis of Silver(I) trifluoromethanesulfonate.

We here report a new approach to develop self-healing shape memory supramol. liquid-crystalline (LC) networks through self-assembly of mol. building blocks via combination of hydrogen bonding and coordination bonding. We have designed and synthesized supramol. LC polymers and networks based on the complexation of a fork like mesogenic ligand with Ag+ ions and carboxylic acids. Unidirectionally aligned fibers and free-standing films forming layered LC nanostructures have been obtained for the supramol. LC networks. We have found that hybrid supramol. LC networks formed through metal-ligand interactions and hydrogen bonding exhibit both self-healing properties and shape memory functions, while hydrogen-bonded LC networks only show self-healing properties. The combination of hydrogen bonds and metal-ligand interactions allows the tuning of intermol. interactions and self-assembled structures, leading to the formation of the dynamic supramol. LC materials. The new material design presented here has potential for the development of smart LC materials and functional LC membranes with tunable responsiveness.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate(SMILESS: O=C(OCC)C[C@@H](O)CCl,cas:90866-33-4) is researched.Safety of Tri-n-octylphosphine Oxide. The article 《Yeast catalyzed reduction of β-keto esters (1): Factors affecting whole-cell catalytic activity and stereoselectivity》 in relation to this compound, is published in Biocatalysis and Biotransformation. Let’s take a look at the latest research on this compound (cas:90866-33-4).

Six yeasts were studied for their ability to reduce Et 4-chloroacetoacetate (Et 4-chloro-3-oxobutanoate) stereoselectively. Five species reduced the substrate to Et (S)-4-chloro-3-hydroxybutanoate of high (92-99%) optical purity. With glucose-grown cells, substrate reduction could only be demonstrated when growth was oxygen-limited, whereas xylose-grown Pichia capsulata could be grown under conditions of oxygen excess without losing its reducing ability. Zygosaccharomyces rouxii exhibited high enantioselectivity (≥98% ee (S)-enantiomer) under all conditions tested, while in P. capsulata, a novel switch was observed from producing mainly the (S)-enantiomer using glucose as co-substrate to producing mainly the (R)-enantiomer using 2-propanol as co-substrate. This switch was correlated with a change in reduction predominantly from an NADPH-dependent dehydrogenase system to an NADH-dependent system. In the production of Et (R)-4-chloro-3-hydroxybutanoate with P. capsulata, the enantioselectivity was also found to depend upon growth conditions. With glucose-grown cells, higher enantioselectivity was observed using cells harvested in stationary phase (93-94% ee) compared with cells harvested in exponential phase (43-60% ee). Growing P. capsulata with xylose rather than glucose as the major source of carbon for growth resulted in an eight-fold increase in the specific rate of Et (R)-4-chloro-3-hydroxybutanoate production using 2-propanol as co-substrate, although enantioselectivity was slightly reduced (65-81% ee) compared with the maximum achieved with glucose-grown cells. The effect of growth on xylose could also be correlated with enhanced activity of an NADH-dependent (R)-selective dehydrogenase system.

From this literature《Yeast catalyzed reduction of β-keto esters (1): Factors affecting whole-cell catalytic activity and stereoselectivity》,we know some information about this compound(90866-33-4)COA of Formula: C6H11ClO3, but this is not all information, there are many literatures related to this compound(90866-33-4).

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate( cas:90866-33-4 ) is researched.Synthetic Route of C6H11ClO3.Jung, Jihye; Park, Hyun Joo; Uhm, Ki-Nam; Kim, Dooil; Kim, Hyung-Kwoun published the article 《Asymmetric synthesis of (S)-ethyl-4-chloro-3-hydroxy butanoate using a Saccharomyces cerevisiae reductase: Enantioselectivity and enzyme-substrate docking studies》 about this compound( cas:90866-33-4 ) in Biochimica et Biophysica Acta, Proteins and Proteomics. Keywords: ethylchlorohydroxy butanoate Saccharomyces reductase enantioselectivity. Let’s learn more about this compound (cas:90866-33-4).

Et (S)-4-chloro-3-hydroxy butanoate (ECHB) is a building block for the synthesis of hypercholesterolemia drugs. In this study, various microbial reductases have been cloned and expressed in Escherichia coli. Their reductase activities toward ethyl-4-chloro oxobutanoate (ECOB) have been assayed. Amidst them, Baker’s yeast YDL124W, YOR120W, and YOL151W reductases showed high activities. YDL124W produced (S)-ECHB exclusively, whereas YOR120W and YOL151W made (R)-form alc. The homol. models and docking models with ECOB and NADPH elucidated their substrate specificities and enantioselectivities. A glucose dehydrogenase-coupling reaction was used as NADPH recycling system to perform continuously the reduction reaction. Recombinant E. coli cell co-expressing YDL124W and Bacillus subtilis glucose dehydrogenase produced (S)-ECHB exclusively.

From this literature《Asymmetric synthesis of (S)-ethyl-4-chloro-3-hydroxy butanoate using a Saccharomyces cerevisiae reductase: Enantioselectivity and enzyme-substrate docking studies》,we know some information about this compound(90866-33-4)Synthetic Route of C6H11ClO3, but this is not all information, there are many literatures related to this compound(90866-33-4).

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem