Name: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, is researched, Molecular C18H20N2O12, CAS is 70539-42-3, about α-Conotoxins, small peptide probes of nicotinic acetylcholine receptors. Author is Myers, Richard A.; Zafaralla, Glenn C.; Gray, William R.; Abbott, Jeff; Cruz, Lourdes J.; Olivera, Baldomero M..
α-Conotoxins, a family of small peptides from the venoms of the Conus marine molluscs, are selective, snake α-neurotoxin-competitive antagonists of the nicotinic acetylcholine receptor. A new α-conotoxin, SIA, has been purified, sequenced, and synthesized. Crosslinking with bivalent reagents and photoaffinity labeling of the acetylcholine receptor with α-conotoxin yield covalent adducts. Surprisingly, crosslinking to other subunits is considerably more efficient than to the α subunit. The relative efficiency of photoactivatable crosslinking to different subunits of the receptor is a function of placement of the photoactivatable group on the toxin. Since the structures of α-conotoxins can be solved by 2D NMR (Pardi, A. et al., 1989 and Kobayashi, Y. et al., 1989) this family of toxins should provide a set of new ligands for probing the acetylcholine receptor with considerable precision.
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem