Heterocyclic Building Block-benzofuran

799766-13-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.799766-13-5,7-Bromo-4-methylbenzofuran,as a common compound, the synthetic route is as follows.

To a solution of 7-bromo-4-methylbenzofuran (9.61 g) in THF (228 mL) at -78 ¡ãC was slowly added 2.5 M nBuLi in hexanes (21.9 mL, 54.6 mmol, 1.2 equiv). The resultant reaction mixture was stirred for 1 h, then quenched by the addition of water. The mixture was allowed to warm to RT extracted with EtOAc. The organic extracts were dried over Na2SO4 and evaporated. The oily residue was heated at 80 ¡ãC in the presence of CaH2, then distilled under vacuum at 110 ¡ãC to afford the product as a clear oil(4.51 g, 75percent). ?H NMR (500 MHz, CDC13) (57.64 (d, I = 2.2 Hz, 1H), 7.40 (d, I = 7.8 Hz, 1H), 7.22 (dd, I = 8.2, 7.3 Hz, 1H), 7.06 (m, 1H), 6.81 (d, I = 2.2 Hz, 1H), 2.54 (s, 3H).

As the paragraph descriping shows that 799766-13-5 is playing an increasingly important role.

Reference£º
Patent; FORUM PHARMCEUTICALS INC.; ACHARYA, Raksha; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; COOK, Andrew, Simon; HARRISON, Bryce, Alden; MCRINER, Andrew, J.; (451 pag.)WO2016/201168; (2016); A1;,
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Benzofuran | C8H6O – PubChem

24673-56-1, 3-Methylbenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-methylbenzofuran-2-carboxylic acid (35.2 mg, 0.2 mmol), NIS (47.3 mg, 0.21 mmol), palladium acetate(0.9 mg, 0.002 mmol), and a stirrer were placed in the reaction tube. After replacing the inert gas, 1 ml of solvent DMF was added, Sealed reaction tube. The reaction tube was placed in an oil bath reaction reactor at 80 C and stirred for 12 hours. After cooling to room temperature, use 2 mol / L Sodium hydroxide solution to adjust pH = 10. The reaction tube was diluted with 5 ml of water and extracted with ethyl acetate. Combined extract, And dried over anhydrous sodium sulfate. The filtrate was concentrated under reduced pressure and then extracted with ethyl acetate: petroleum ether = 0 to 1: 30 (volume ratio) The eluate was subjected to column chromatography on the crude product to give pure 3-methyl-2-iodobenzofuran (39.2 mg, 76%).

24673-56-1, As the paragraph descriping shows that 24673-56-1 is playing an increasingly important role.

Reference£º
Patent; Xiangtan University; Gong Xing; Cai Changqun; Yang Yun; (24 pag.)CN106748604; (2017); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

57319-65-0, 6-Aminoisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

57319-65-0, A mixture of 6-aminoisobenzofuran-1(3H)-one 1 (1.0 g, 6.70 mmol) and methanamine (2M in MeOH, 16.76 mL, 33.5 mmol) in DCM (5 mL) was stirred for 3 days. LCMS (M+H-H2O=163.0) showed the presence of ring-opened product. The solvent was evaporated to obtain compound 2 as a colorless paste (quantitative yield).

57319-65-0 6-Aminoisobenzofuran-1(3H)-one 93631, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; POUDEL, Yam B.; GANGWAR, Sanjeev; (37 pag.)US2019/365915; (2019); A1;,
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Benzofuran | C8H6O – PubChem

10242-12-3, 5-Nitrobenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a suspension of 5-nitro-2-benzofurancarboxylic acid (5 g, 24.15 mmol) in CH2Cl2 (250 mL) at 0 C. was added DMF (0.100 mL) followed by (COCl)2 (2M in CH2Cl2, 36.23 mL, 72.46 mL) over a period of 10 min. The reaction was stirred at 0 C. for 1 h and then at room temperature for 30 min. The reaction solvent was removed under a reduced pressure, dried under high vacuum and again suspended in CH2Cl2 (250 mL). The solution was cooled to 0 C., were added pyridine (4.8 mL, 48.03 mmol) followed by McOH (10 mL, excess) and stirred overnight. The extractive work-up with CH2Cl2 gave the expected 2-methoxycarbonyl-5-nitrobenzofuran (R926609). 1H NMR (CDCl3): delta 8.66 (d, 1H, J=2.4 Hz), 8.36 (dd, 1H, J=2.4 and 9.6 Hz), 7.71 (d, 1H, J=9.3 Hz), 7.65 (s, 1H), 4.01 (s, 3H); LCMS: ret. time: 26.94 min.

10242-12-3, As the paragraph descriping shows that 10242-12-3 is playing an increasingly important role.

Reference£º
Patent; RIGEL PHARMACEUTICALS, INC.; Singh, Rajinder; Argade, Ankush; Payan, Donald; Molineaux, Susan; Holland, Sacha; Clough, Jeffrey; Keim, Holger; Bhamidipati, Somasekhar; Sylvain, Catherine; Li, Hui; Rossi, Alexander; US2015/266828; (2015); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.496-16-2,2,3-Dihydrobenzo[b]furan,as a common compound, the synthetic route is as follows.

To a solution of 2,3-dihydrobenzofuran (1 g, 8.3mmol) in DCM (10mL) was added acetyl chloride (1.3g, 16.6mmol) and AICI3 (3.3g, 24.6mmol) slowly at -10C. The reaction mixture was stirred at -10C for 3h. The TLC showed the reaction to be complete. The reaction mixture was diluted with 5% aqueous HCI (10ml_) and extracted with DCM (3×1 OmL). The combined organic layers were washed with saturated aqueous bicarbonate solution (100ml_), brine (100ml_), dried (Na2S04), filtered and concentrated under reduced pressure to afford 1-(2,3- dihydrobenzofuran-5-yl)ethan-1-one as a brown liquid. Yield: 1.34g (97%); MS (ESI+) for CHNOS m/z 163.0[M+H]+; 1 H NMR (400 MHz, CDCI3): <5 7.86 (s, 1 H), 7.79 (d, J = 8.4Hz, 1 H), 6.80 (d, J = 8.4 Hz, 1 H), 4.66 (t, J = 8.8 Hz, 2H), 3.25 (t, J = 8.8 Hz, 2H), 2.52 (s, 3H)., 496-16-2

The synthetic route of 496-16-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DISCUVA LTD.; MEO, Paul; KHAN, Nawaz; CHARRIER, Cedric; (252 pag.)WO2019/86890; (2019); A1;,
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Benzofuran | C8H6O – PubChem

7169-34-8, Benzofuran-3(2H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Salicylaldehyde (IIe, 1.06mL, 10mmol) was added to a stirred solution of benzofuranone (III, 1.34g, 10mmol) in CH2Cl2 under an argon atmosphere at room temperature. The mixture was then allowed to react for 5min. Aluminum Oxide (2g) was then added and the reaction was carried out at room temperature for 3h. The reaction was stirred for 30min until precipitation occurred. The mixture was filtered, washed with ethyl acetate, and dried to yield 1.57g (6.6mmol, 66.0%) as an orange solid., 7169-34-8

The synthetic route of 7169-34-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kadayat, Tara Man; Banskota, Suhrid; Gurung, Pallavi; Bist, Ganesh; Thapa Magar, Til Bahadur; Shrestha, Aarajana; Kim, Jung-Ae; Lee, Eung-Seok; European Journal of Medicinal Chemistry; vol. 137; (2017); p. 575 – 597;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

10242-12-3, 5-Nitrobenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 11 (0.414 g, 2 mmol), dichloromethane (5 mL), DMF (0.1 mL) was added to the reaction flask,(0.519 g, 6 mmol) oxalyl chloride. The reaction solution was allowed to stand at room temperature for 2 hours and concentrated. The residue was dissolved in acetone at 0 C, and then concentrated aqueous ammonia (7.5 mL) was added dropwise. The mixture was stirred for 10 minutes. A large amount of water was added to the reaction solution to precipitate a solid, And dried to give 0.28 g of compound 12 in a yield of 68%., 10242-12-3

Big data shows that 10242-12-3 is playing an increasingly important role.

Reference£º
Patent; Luoyang Juhui Pharmaceutical Technology Co., Ltd.; Zhang Hongli; Yang Songfeng; (36 pag.)CN106749203; (2017); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

90843-31-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.90843-31-5,5-Acetyl-2,3-dihydrobenzo[b]furan,as a common compound, the synthetic route is as follows.

To a stirred solution of 1-(2,3-dihydro-benzofuran-5-yl)-ethanone (2.5 g, 15.4 mmol) (Lancaster) in dioxane (20 mL) was added dropwise a solution of bromine (2.96 g, 18.5 mmol) in dioxane (60 mL). After stirring 15 minute the mixture was concentrated in vacuo and the residue was purified by chromatography on silica gel (2:1 hexane-dichloromethane) to provide 1.41 g (38%) of 2-bromo-1-(2,3-dihydro-benzofuran-5-yl)-ethanone.

90843-31-5 5-Acetyl-2,3-dihydrobenzo[b]furan 145220, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Chu, Xin-Jie; Ding, Qingjie; Jiang, Nan; Kim, Kyungjin; Lovey, Allen John; McComas, Warren William; Mullin JR., John Guilfoyle; Tilley, Jefferson Wright; US2004/6058; (2004); A1;,
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Benzofuran | C8H6O – PubChem

23681-89-2, 2,3-Dihydrobenzofuran-6-ol is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 15 10.9 g. of 6-hydroxy-2,3-dihydrobenzofuran are dissolved in 80 ml. of anhydrous dimethylformamide and treated, while stirring and with ice cooling at 0¡ã C. with 5.3 g. of freshly powdered potassium hydroxide. The mixture is stirred for 1 hour at 0¡ã C. under a nitrogen atmosphere and then added dropwise within 1 hour to a solution of 19.6 g. of 1-bromo-7-ethyl-3-methyl-2,6-nonadiene in 10 ml. of absolute tetrahydrofuran. The mixture is allowed to stir for 2 hours at 0¡ã C. and for 2 hours at room temperature and then poured onto a mixture of 100 ml. of 10percent by weight aqueous sodium hydroxide and 100 ml. of ice-water. The mixture is extracted three times with pentane, the extracts are washed successively with 10percent by weight aqueous sodium hydroxide, water and saturated sodium chloride solution, dried over sodium sulfate and evaporated. By chromatography on silica gel with hexane/diethyl ether (19:1 parts by volume) there is obtained pure 6-[(7-ethyl-3-methyl-2,6-nonadienyl)-oxy]-2,3-dihydrobenzofuran which is distilled in a bulb-tube at 132¡ã C./0.02 mmHg; nD20 = 1.5350., 23681-89-2

The synthetic route of 23681-89-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hoffmann-La Roche Inc.; US4002647; (1977); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23145-07-5,5-Bromobenzofuran,as a common compound, the synthetic route is as follows.

To a solution of 5-bromobenzofuran (3.9 g, 20 mmol) in dry THF (30 mL) cooled to -78C under N2-protected LDA (prepared from n-BuLi and /Pr2NH in THF (-30 mmol)) was slowly added. The mixture was stirred at the same temperature for 30 minutes, then triz’wpropylborate (5.64 g, 30 mmol) was added to the mixture. The mixture was allowed to warm to RT and stirred for 2 hours. The mixture was then quenched with IN HCl to pH=3 and extracted with EtOAc. The combined organic phases were combined, dried and filtered. The filtrate was concentrated to afford the desired product (4.3 g). MS (ESI) m/e (M+Ff1): 241., 23145-07-5

As the paragraph descriping shows that 23145-07-5 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP &; DOHME CORP.; COBURN, Craig, A.; MCCAULEY, John, A.; LUDMERER, Steven, W.; LIU, Kun; VACCA, Joseph, P.; WU, Hao; HU, Bin; SOLL, Richard; SUN, Fei; WANG, Xinghai; YAN, Man; ZHANG, Chengren; ZHENG, Mingwei; ZHONG, Bin; ZHU, Jian; WO2010/111483; (2010); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem